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Conserved domains on  [gi|741956780|ref|XP_010812308|]
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mitochondrial translation release factor in rescue isoform X1 [Bos taurus]

Protein Classification

peptide chain release factor family protein( domain architecture ID 10452619)

peptide chain release factor family protein such as mitochondrial translation release factor in rescue (MTRFR) that is part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation

CATH:  3.30.160.20
Gene Ontology:  GO:0003747
PubMed:  1408743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 53-158 3.64e-23

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


:

Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 88.25  E-value: 3.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780   53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfyngenslvcrekR 132
Cdd:pfam00472   5 IEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL---------------Y 69

                          90       100
                  ....*....|....*....|....*.
gi 741956780  133 EAEKRKQERKKRAKETLEKKKLLKEQ 158
Cdd:pfam00472  70 ELEEEKEEEKKRRIKSQVGSGDRSEQ 95
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 53-158 3.64e-23

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 88.25  E-value: 3.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780   53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfyngenslvcrekR 132
Cdd:pfam00472   5 IEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL---------------Y 69

                          90       100
                  ....*....|....*....|....*.
gi 741956780  133 EAEKRKQERKKRAKETLEKKKLLKEQ 158
Cdd:pfam00472  70 ELEEEKEEEKKRRIKSQVGSGDRSEQ 95
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 53-156 2.94e-19

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 79.02  E-value: 2.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780  53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLRH------------VPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfy 120
Cdd:COG1186   21 IEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALL---- 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 741956780 121 ngenslvcrekREAEKRKQERKKRAKETLEKKKLLK 156
Cdd:COG1186   97 -----------YEAELEPKERRATKPTRGSKKRRLW 121
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 24-143 2.98e-11

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 60.44  E-value: 2.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780  24 RLCEKLPLLSPG---TVATPVQAAGKKDRPTLLSLDERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRS 100
Cdd:PRK08787 139 RLVRKSPFDSDNrrhTSFTSVFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRS 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 741956780 101 VDQNRKLARRILQEKVdvfYNGEnslvcREKREAEKRKQERKK 143
Cdd:PRK08787 219 QHQNRDNAMKMLAAKL---YELE-----VQKRNAEKDALEATK 253
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 57-144 1.64e-09

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 54.39  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780   57 ERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfyngenslvcrEKREAEK 136
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRL-------------ADLQQEQ 171


                  ....*...
gi 741956780  137 RKQERKKR 144
Cdd:TIGR03072 172 AAALRAER 179
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 53-158 3.64e-23

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 88.25  E-value: 3.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780   53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfyngenslvcrekR 132
Cdd:pfam00472   5 IEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL---------------Y 69

                          90       100
                  ....*....|....*....|....*.
gi 741956780  133 EAEKRKQERKKRAKETLEKKKLLKEQ 158
Cdd:pfam00472  70 ELEEEKEEEKKRRIKSQVGSGDRSEQ 95
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 53-156 2.94e-19

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 79.02  E-value: 2.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780  53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLRH------------VPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfy 120
Cdd:COG1186   21 IEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALL---- 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 741956780 121 ngenslvcrekREAEKRKQERKKRAKETLEKKKLLK 156
Cdd:COG1186   97 -----------YEAELEPKERRATKPTRGSKKRRLW 121
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 24-143 2.98e-11

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 60.44  E-value: 2.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780  24 RLCEKLPLLSPG---TVATPVQAAGKKDRPTLLSLDERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRS 100
Cdd:PRK08787 139 RLVRKSPFDSDNrrhTSFTSVFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRS 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 741956780 101 VDQNRKLARRILQEKVdvfYNGEnslvcREKREAEKRKQERKK 143
Cdd:PRK08787 219 QHQNRDNAMKMLAAKL---YELE-----VQKRNAEKDALEATK 253
prfA PRK00591
peptide chain release factor 1; Validated
 69-142 1.56e-10

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 58.55  E-value: 1.56e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 741956780  69 GPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfYNGEnslvcREKREAEkRKQERK 142
Cdd:PRK00591 232 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARL---YDAE-----RQKAQAE-EAATRK 296
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 69-142 6.05e-10

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 56.55  E-value: 6.05e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 741956780  69 GPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfYNGEnslvcREKREAEkRKQERK 142
Cdd:COG0216  230 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARL---YEAE-----QQKQQAE-IAAERK 294
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 57-144 1.64e-09

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 54.39  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780   57 ERELEEQFVKGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfyngenslvcrEKREAEK 136
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRL-------------ADLQQEQ 171


                  ....*...
gi 741956780  137 RKQERKKR 144
Cdd:TIGR03072 172 AAALRAER 179
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
53-114 5.00e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 52.08  E-value: 5.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741956780  53 LSLDERELEEQFVKGHGPGGQATNKTSNCVVLR------HVP-----------------SG-IVVKCHQTRSVDQNRKLA 108
Cdd:PRK09256   8 LVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghritkDGvIVIKAQEFRSQERNREDA 87


                 ....*.
gi 741956780 109 RRILQE 114
Cdd:PRK09256  88 LERLVA 93
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 69-116 1.33e-08

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 52.88  E-value: 1.33e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 741956780  69 GPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKV 116
Cdd:PRK05589 207 GAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKL 254
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 69-143 3.19e-08

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 51.80  E-value: 3.19e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 741956780  69 GPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKVdvfYNGEnslvcREKREAEKRKQERKK 143
Cdd:PRK07342 210 GAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARL---YEEE-----LKKREEATNAAAASK 276
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 66-116 5.00e-05

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 42.41  E-value: 5.00e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 741956780  66 KGHGPGGQATNKTSNCVVLRHVPSGIVVKCHQTRSVDQNRKLARRILQEKV 116
Cdd:PRK06746 205 RASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKL 255
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 129-168 1.52e-03

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 38.09  E-value: 1.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 741956780 129 REKREAEKRKQERKKRAKETlEKKKLLKEQWESSKNVPGE 168
Cdd:PTZ00399 557 KEEKEALKEQKRLRKLKKQE-EKKKKELEKLEKAKIPPAE 595
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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