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Conserved domains on  [gi|741976408|ref|XP_010818326|]
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gamma-adducin isoform X1 [Bos taurus]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 137-385 4.51e-71

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 231.66  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 137 TRCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQgsTNLKIDHAGFSPH 216
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 217 AAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL-GDVAYYDYQGSLDDQEERIQLQKVLGPsCKVLVLRNHG 295
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 296 VVALGETVEEAFHYIFNVQIACETQVQALagAGGVDNLLVLDLQKYKASTHTVAASGGGGvnmgshqkwkvGEIEFEGLM 375
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ--AGGGELVLPPPEVAERTARQSLFDPGAGA-----------GELAWPALL 240

                        250
                 ....*....|..
gi 741976408 376 RTLD--NLGYRT 385
Cdd:PRK07044 241 RKLDriDPGYRD 252
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 137-385 4.51e-71

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 231.66  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 137 TRCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQgsTNLKIDHAGFSPH 216
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 217 AAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL-GDVAYYDYQGSLDDQEERIQLQKVLGPsCKVLVLRNHG 295
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 296 VVALGETVEEAFHYIFNVQIACETQVQALagAGGVDNLLVLDLQKYKASTHTVAASGGGGvnmgshqkwkvGEIEFEGLM 375
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ--AGGGELVLPPPEVAERTARQSLFDPGAGA-----------GELAWPALL 240

                        250
                 ....*....|..
gi 741976408 376 RTLD--NLGYRT 385
Cdd:PRK07044 241 RKLDriDPGYRD 252
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 139-321 4.79e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 172.73  E-value: 4.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  139 CKLASLYRLADLFGWAHLANTYISVRIskEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGstnLKIDhAGFSPHAA 218
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  219 IYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL--GDVAYYDYQGsLDDQEERIQLQKVLGPSCKVLVLRNHGV 296
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 741976408  297 VALGETVEEAFHYIFNVQIACETQV 321
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 134-343 1.32e-49

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 172.55  E-value: 1.32e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 134 EKLTRcKLASLYRLADLFGWAHLANTYISVRIsKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVV--DQGSTNLKIdha 211
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSARD-RDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETPL--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 212 gfspHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL---GDVAYYDYQGSLDdQEERIQLQKVLG-PSCK 287
Cdd:cd00398   76 ----HLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPET-GEDEIGTQRALGfPNSK 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741976408 288 VLVLRNHGVVALGETVEEAFHYIFNVQIACETQVQALAGAGGV--DNLLVLDLQKYKA 343
Cdd:cd00398  151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQLppISLELLNKEYLRK 208
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 141-321 4.56e-46

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 162.04  E-value: 4.56e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408   141 LASLYRLADLFGWAHLANTYISVRIsKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTnlKIDHAGFSPHAAIY 220
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408   221 STRPDVKCVIHIHTLATAAVSSM--KCGILPISQESLILG-DVAYYDYQGSLDDQEERIQ-LQKVLGP---SCKVLVLRN 293
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEGAeLAEALAEalpDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 741976408   294 HGVVALGETVEEAFHYIFNVQIACETQV 321
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 138-333 8.12e-44

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 156.53  E-value: 8.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 138 RCKLASLYRLADLFGWAHLANTYISVRIskEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTNlkidHAGFSPHA 217
Cdd:COG0235    7 REELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGDLKP----SSETPLHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 218 AIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQE--SLILGDVAYYDYQGSLDDqEERIQLQKVLGpSCKVLVLRNHG 295
Cdd:COG0235   81 AIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGPGTE-ELAEAIAEALG-DRPAVLLRNHG 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 741976408 296 VVALGETVEEAFHYIFNVQIACETQVQALAgAGGVDNL 333
Cdd:COG0235  159 VVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
salvage_mtnB TIGR03328
methylthioribulose-1-phosphate dehydratase; Members of this family are the ...
 161-317 4.00e-09

methylthioribulose-1-phosphate dehydratase; Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 274521 [Multi-domain]  Cd Length: 192  Bit Score: 56.89  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  161 ISVRISkeQDHIIIIPRGLSFSEATASNLVKVNIIGEVVdqgSTNLKIDhAGFSPHAAIYSTRpDVKCVIHIHTLAtAAV 240
Cdd:TIGR03328  21 LSARLD--EDEILITPSGVDKGRLTPEDFLVVDLQGKPV---SGGLKPS-AETLLHTQLYRLT-GAGAVLHTHSVE-ATV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  241 SSM---KCGILPISQESLILGDVAYYDYQGSLD------DQEERiQLQKVLGP-------SCKVLVlRNHGVVALGETVE 304
Cdd:TIGR03328  93 LSRlypSNGGFELEGYEMLKGLPGITTHEDTLVvpiienTQDIA-RLADSVAPalnaypdVPGVLI-RGHGLYAWGRDWE 170

                         170
                  ....*....|....*....
gi 741976408  305 ------EAFHYIFNVQIAC 317
Cdd:TIGR03328 171 eakrhlEALEFLFECELEM 189
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 137-385 4.51e-71

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 231.66  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 137 TRCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQgsTNLKIDHAGFSPH 216
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 217 AAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL-GDVAYYDYQGSLDDQEERIQLQKVLGPsCKVLVLRNHG 295
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGD-KPAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 296 VVALGETVEEAFHYIFNVQIACETQVQALagAGGVDNLLVLDLQKYKASTHTVAASGGGGvnmgshqkwkvGEIEFEGLM 375
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ--AGGGELVLPPPEVAERTARQSLFDPGAGA-----------GELAWPALL 240

                        250
                 ....*....|..
gi 741976408 376 RTLD--NLGYRT 385
Cdd:PRK07044 241 RKLDriDPGYRD 252
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 139-321 4.79e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 172.73  E-value: 4.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  139 CKLASLYRLADLFGWAHLANTYISVRIskEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGstnLKIDhAGFSPHAA 218
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  219 IYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL--GDVAYYDYQGsLDDQEERIQLQKVLGPSCKVLVLRNHGV 296
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 741976408  297 VALGETVEEAFHYIFNVQIACETQV 321
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 134-343 1.32e-49

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 172.55  E-value: 1.32e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 134 EKLTRcKLASLYRLADLFGWAHLANTYISVRIsKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVV--DQGSTNLKIdha 211
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSARD-RDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETPL--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 212 gfspHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL---GDVAYYDYQGSLDdQEERIQLQKVLG-PSCK 287
Cdd:cd00398   76 ----HLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPET-GEDEIGTQRALGfPNSK 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 741976408 288 VLVLRNHGVVALGETVEEAFHYIFNVQIACETQVQALAGAGGV--DNLLVLDLQKYKA 343
Cdd:cd00398  151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQLppISLELLNKEYLRK 208
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 141-321 4.56e-46

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 162.04  E-value: 4.56e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408   141 LASLYRLADLFGWAHLANTYISVRIsKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTnlKIDHAGFSPHAAIY 220
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408   221 STRPDVKCVIHIHTLATAAVSSM--KCGILPISQESLILG-DVAYYDYQGSLDDQEERIQ-LQKVLGP---SCKVLVLRN 293
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEGAeLAEALAEalpDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 741976408   294 HGVVALGETVEEAFHYIFNVQIACETQV 321
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 138-333 8.12e-44

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 156.53  E-value: 8.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 138 RCKLASLYRLADLFGWAHLANTYISVRIskEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTNlkidHAGFSPHA 217
Cdd:COG0235    7 REELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGDLKP----SSETPLHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 218 AIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQE--SLILGDVAYYDYQGSLDDqEERIQLQKVLGpSCKVLVLRNHG 295
Cdd:COG0235   81 AIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGPGTE-ELAEAIAEALG-DRPAVLLRNHG 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 741976408 296 VVALGETVEEAFHYIFNVQIACETQVQALAgAGGVDNL 333
Cdd:COG0235  159 VVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
PRK06661 PRK06661
hypothetical protein; Provisional
 141-325 9.09e-36

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 134.96  E-value: 9.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 141 LASLYRLADLFGWAHLANTYISVRiSKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDqgSTNLKIDHAGFSPHAAIY 220
Cdd:PRK06661   7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILE--GEEYQYNKTGYFIHGSIY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 221 STRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGD-VAYYDYQG-SLDDQEERIQLQKVLGpSCKVLVLRNHGVVA 298
Cdd:PRK06661  84 KTRPDISAIFHYHTPASIAVSALKCGLLPISQWALHFYDrISYHNYNSlALDADKQSSRLVNDLK-QNYVMLLRNHGAIT 162

                        170       180
                 ....*....|....*....|....*..
gi 741976408 299 LGETVEEAFHYIFNVQIACETQVQALA 325
Cdd:PRK06661 163 CGKTIHEAMFYTYHLEQACKTQCLLNS 189
PRK06208 PRK06208
class II aldolase/adducin family protein;
140-329 4.46e-26

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 108.15  E-value: 4.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 140 KLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDqgsTNLKIDHAGFSPHAAI 219
Cdd:PRK06208  46 RLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE---GDRPLNRAAFAIHSAI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 220 YSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLIL-GDVAYYD-YQGSLDDQEERIQLQKVLGPScKVLVLRNHGVV 297
Cdd:PRK06208 123 HEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDACAFyEDHALFDdFTGVVVDTSEGRRIAAALGTH-KAVILQNHGLL 201

                        170       180       190
                 ....*....|....*....|....*....|...
gi 741976408 298 ALGETVEEA-FHYIfNVQIACetQVQALAGAGG 329
Cdd:PRK06208 202 TVGPSVDAAaWWFI-ALERAC--QTQLLAEAAG 231
PRK06486 PRK06486
aldolase;
138-391 1.63e-22

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 97.47  E-value: 1.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 138 RCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVD-QGstnlKIDHAGFSPH 216
Cdd:PRK06486  28 RVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEITASDLLICDFDGNVLAgRG----EPEATAFFIH 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 217 AAIYSTRPDVKCVIHIHT-LATAAVSSMKCGILPISQESL-ILGDVAY-YDYQG-SLDDQE-ERIQlqKVLGPScKVLVL 291
Cdd:PRK06486 104 ARIHRAIPRAKAAFHTHMpYATALSLTEGRPLTTLGQTALkFYGRTAVdEDYNGlALDAAEgDRIA--RAMGDA-DIVFL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 292 RNHGVVALGETVEEAFHYIFNVQIACetQVQALAGAGGvdnllvldlQKYKASTHTVAASGGGGVNMGSHQKwkvGEIEF 371
Cdd:PRK06486 181 KNHGVMVCGPRIAEAWDDLYYLERAC--EVQVLAMSTG---------RPLVPVDPAIAAAVARQMREGDRES---ARLHL 246

                        250       260
                 ....*....|....*....|
gi 741976408 372 EGLMRTLDnlgyRTGYAYRH 391
Cdd:PRK06486 247 EALRRTLD----REEPAYRT 262
PRK07490 PRK07490
hypothetical protein; Provisional
 147-325 9.23e-20

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 89.01  E-value: 9.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 147 LADLFGW-AHL------ANtYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNiigevVDQGSTNLK---IDHAGFSPH 216
Cdd:PRK07490  15 LAAAFRWiARLgmheavAN-HFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLD-----ADDPSTAERpdvPDATAWAIH 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 217 AAIYSTRPDVKCVIHIHTLATAAVSSMKCG-ILPISQESLI-LGDVAYYDYQGSLDDQEERIQLQKVLGPScKVLVLRNH 294
Cdd:PRK07490  89 GQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNTARfFNRVAVDTLYGGMALEEEGERLAGLLGDK-RRLLMGNH 167

                        170       180       190
                 ....*....|....*....|....*....|.
gi 741976408 295 GVVALGETVEEAFHYIFNVQIACETQVQALA 325
Cdd:PRK07490 168 GVLVTGDTVAEAFDDLYYFERACQTYITALS 198
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 178-328 4.87e-13

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 69.66  E-value: 4.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 178 GLSFSEATASNLVKVNIIGEVVD-QGSTNlkidhagfsP----HAAIYSTRPDVKCVIHIHTLATAAVSSMKCGiLPISQ 252
Cdd:PRK07090  71 GLGFDEITASNLLLVDEDLNVLDgEGMPN---------PanrfHSWIYRARPDVNCIIHTHPPHVAALSMLEVP-LVVSH 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741976408 253 ESL--ILGDVAYY-DYQGSLDDQEERIQLQKVLGpSCKVLVLRNHGVVALGETVEEAFHYIFNVQIACETQVQALAgAG 328
Cdd:PRK07090 141 MDTcpLYDDCAFLkDWPGVPVGNEEGEIISAALG-DKRAILLSHHGQLVAGKSIEEACVLALLIERAARLQLLAMA-AG 217
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 161-306 1.76e-11

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 64.26  E-value: 1.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVRIsKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDqGSTNLKIDHAGfspHAAIYSTRPDVKCVIHIH-TLATA- 238
Cdd:PRK06557  35 VSARD-PGTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDTAS---HLYVYRHMPDVGGVVHTHsTYATAw 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 239 AV--SSMKCGILPISQEslILGDVAYYDYQGSLDDQEERIQLQKVLGPSCKVLVLRNHGVVALGETVEEA 306
Cdd:PRK06557 110 AArgEPIPCVLTAMADE--FGGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLMQNHGVFTIGKDAEDA 177
salvage_mtnB TIGR03328
methylthioribulose-1-phosphate dehydratase; Members of this family are the ...
 161-317 4.00e-09

methylthioribulose-1-phosphate dehydratase; Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 274521 [Multi-domain]  Cd Length: 192  Bit Score: 56.89  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  161 ISVRISkeQDHIIIIPRGLSFSEATASNLVKVNIIGEVVdqgSTNLKIDhAGFSPHAAIYSTRpDVKCVIHIHTLAtAAV 240
Cdd:TIGR03328  21 LSARLD--EDEILITPSGVDKGRLTPEDFLVVDLQGKPV---SGGLKPS-AETLLHTQLYRLT-GAGAVLHTHSVE-ATV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408  241 SSM---KCGILPISQESLILGDVAYYDYQGSLD------DQEERiQLQKVLGP-------SCKVLVlRNHGVVALGETVE 304
Cdd:TIGR03328  93 LSRlypSNGGFELEGYEMLKGLPGITTHEDTLVvpiienTQDIA-RLADSVAPalnaypdVPGVLI-RGHGLYAWGRDWE 170

                         170
                  ....*....|....*....
gi 741976408  305 ------EAFHYIFNVQIAC 317
Cdd:TIGR03328 171 eakrhlEALEFLFECELEM 189
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
161-318 2.16e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 52.06  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVrISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDqGStnlKIDHAGFSPHAAIYSTRPDVKCVIHIHTLATAAV 240
Cdd:PRK06833  30 ISI-FNREQGLMAITPSGIDYFEIKPEDIVIMDLDGKVVE-GE---RKPSSELDMHLIFYRNREDINAIVHTHSPYATTL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 241 SSMKCGILPISQESLILGD---VAYYDYQGSLDDQEERIQLQKvlgpSCKVLVLRNHGVVALGETVEEAFHYIFNVQIAC 317
Cdd:PRK06833 105 ACLGWELPAVHYLIAVAGPnvrCAEYATFGTKELAENAFEAME----DRRAVLLANHGLLAGANNLKNAFNIAEEIEFCA 180


                 .
gi 741976408 318 E 318
Cdd:PRK06833 181 E 181
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
161-325 5.23e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 50.89  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVRIskeQDHIIIIPRGLSFSEATASNLVKVNIIGEVvDQGstnlKIDHAGFSPHAAIYSTRPDVKCVIHIHTLATAAV 240
Cdd:PRK08087  30 VSVRY---QDGMLITPTGIPYEKLTESHIVFVDGNGKH-EEG----KLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 241 SSMKCGILPISQESLILGD-----VAYYDYqGSLDDQEERIQLQKvlgpSCKVLVLRNHGVVALGETVEEAFHYIFNVQI 315
Cdd:PRK08087 102 SILNRPIPAIHYMIAAAGGnsipcAPYATF-GTRELSEHVALALK----NRKATLLQHHGLIACEVNLEKALWLAHEVEV 176

                        170
                 ....*....|
gi 741976408 316 ACETQVQALA 325
Cdd:PRK08087 177 LAQLYLKTLA 186
PRK08130 PRK08130
putative aldolase; Validated
 161-306 9.23e-07

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 50.26  E-value: 9.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVRIskEQDHIIIIPRGLSFSEATASNLVKVNIIGEVV--DQGSTNLkidhagfSPHAAIYSTRPDVKCVIHIHTLATA 238
Cdd:PRK08130  30 ISARL--DDGGWLVTPTGSCLGRLDPARLSKVDADGNWLsgDKPSKEV-------PLHRAIYRNNPECGAVVHLHSTHLT 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 239 AVSS------------------MKCGILPIsqeslilgdVAYYDyQGSLDDQEERIQlqkvLGPSCKVLVLRNHGVVALG 300
Cdd:PRK08130 101 ALSClggldptnvlppftpyyvMRVGHVPL---------IPYYR-PGDPAIAEALAG----LAARYRAVLLANHGPVVWG 166


                 ....*.
gi 741976408 301 ETVEEA 306
Cdd:PRK08130 167 SSLEAA 172
PRK08333 PRK08333
aldolase;
135-308 2.48e-06

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 48.67  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 135 KLTRCKLASLYRLADLFGWAHLANTYISVRISkeqDHIIIIPRGLSFSEATASNLVKVNIIGEVVD--QGSTNLKIdhag 212
Cdd:PRK08333   2 RNVKAQLVKYSKLAHERGLTAAFGGNLSIRVG---NLVFIKATGSVMDELTREQVAVIDLNGNQLSsvRPSSEYRL---- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 213 fspHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPI--SQESLILGDVAYYDYQ--GSLDDQEERIQLQKvlgpSCKV 288
Cdd:PRK08333  75 ---HLAVYRNRPDVRAIAHLHPPYSIVASTLLEEELPIitPEAELYLKKIPILPFRpaGSVELAEQVAEAMK----EYDA 147

                        170       180
                 ....*....|....*....|
gi 741976408 289 LVLRNHGVVALGETVEEAFH 308
Cdd:PRK08333 148 VIMERHGIVTVGRSLREAFY 167
PRK08660 PRK08660
aldolase;
161-317 1.64e-05

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 46.10  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVRIskeQDHIIIIPRGLSFSEATASNLVKVNII--GEVVDQGSTNLKIdhagfspHAAIYsTRPDVKCVIHIHTLATA 238
Cdd:PRK08660  25 ISVRT---GDGLLITRTGSMLDEITEGDVIEVGIDddGSVDPLASSETPV-------HRAIY-RRTSAKAIVHAHPPYAV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 239 AVSSMKCGILPISQESL-ILGDVAYYDyqGSLDDQEERIQLQKVLGpSCKVLVLRNHGVVALGETVEEAFHYIFNVQIAC 317
Cdd:PRK08660  94 ALSLLEDEIVPLDSEGLyFLGTIPVVG--GDIGSGELAENVARALS-EHKGVVVRGHGTFAIGKTLEEAYIYTSQLEHSC 170
araD PRK13145
L-ribulose-5-phosphate 4-epimerase; Provisional
 165-309 2.20e-05

L-ribulose-5-phosphate 4-epimerase; Provisional


Pssm-ID: 183870 [Multi-domain]  Cd Length: 234  Bit Score: 46.37  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 165 ISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVdQGSTNLKIDhagFSPHAAIYSTRPDVKCVIHIHTlaTAAVS--- 241
Cdd:PRK13145  33 VCRELGRIVIKPSGVDYDELTPENMVVTDLDGNVV-EGDLNPSSD---LPTHVELYKAWPEVGGIVHTHS--TEAVGwaq 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 242 ---SMKC----------GILPISQeSLILGDV--AYYDYQGSLDDQE-ERIQLQKVLGPSckvLVLRNHGVVALGETVEE 305
Cdd:PRK13145 107 agrDIPFygtthadyfyGPIPCAR-SLTKDEVngAYEKETGSVIIEEfEKRGLDPMAVPG---IVVRNHGPFTWGKNPEQ 182


                 ....
gi 741976408 306 AFHY 309
Cdd:PRK13145 183 AVYH 186
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 165-308 6.41e-05

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 44.79  E-value: 6.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 165 ISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDqGSTNLKIDHAgfsPHAAIYSTRPDVKCVIHIH-TLATA-AVSS 242
Cdd:PRK12348  31 IDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVE-GEYRPSSDTA---THLELYRRYPSLGGIVHTHsTHATAwAQAG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 243 MKCGILPISQESLILGDVAyydYQGSLDDQEERIQLQKVLGpscKVL---------------VLRNHGVVALGETVEEAF 307
Cdd:PRK12348 107 LAIPALGTTHADYFFGDIP---CTRGLSEEEVQGEYELNTG---KVIietlgnaeplhtpgiVVYQHGPFAWGKDAHDAV 180


                 .
gi 741976408 308 H 308
Cdd:PRK12348 181 H 181
PRK06357 PRK06357
hypothetical protein; Provisional
 161-233 1.76e-04

hypothetical protein; Provisional


Pssm-ID: 180541 [Multi-domain]  Cd Length: 216  Bit Score: 43.61  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741976408 161 ISVRIS--KEQDHIIIIPRGLSfsEATASNLVKVNIIgeVVDQgSTNLKIDHAG-----FSPHAAIYSTRPDVKCVIHIH 233
Cdd:PRK06357  30 ISVRMTaeKNKEYIIMTPTLMS--EAKLCDLSPYQIL--VVDL-NTGEVIEGVGrvtreINMHEAAYVANPKIKCVYHSH 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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