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Conserved domains on  [gi|741980643|ref|XP_010819550|]
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tetraspanin-32 isoform X8 [Bos taurus]

Protein Classification

tetraspanin family protein( domain architecture ID 10123560)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-195 1.95e-37

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


:

Pssm-ID: 239406  Cd Length: 87  Bit Score: 128.03  E-value: 1.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643 113 AHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLCQGEEAAR----QDCLRGIQ 188
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRevamLLCLFLWF 80


                 ....*..
gi 741980643 189 SFLRVHG 195
Cdd:cd03153   81 AILSGHG 87
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-195 1.95e-37

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 128.03  E-value: 1.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643 113 AHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLCQGEEAAR----QDCLRGIQ 188
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRevamLLCLFLWF 80


                 ....*..
gi 741980643 189 SFLRVHG 195
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
82-221 4.92e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 37.30  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643   82 ATVRGAGGLMAAAFLSFALVFCALVQAAFWRAHSPTQMEDAVLDAYDRAYERALRSASGS---GRQELVAIQDTFLCCGk 158
Cdd:pfam00335  65 GALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLyscLNSALDSLQSEFGCCG- 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 741980643  159 ssplgllggleadlcqgeeaarqDCLRGIQSFLRVHGNIVSTLIGLGLAFTVYAMLLSSFIWF 221
Cdd:pfam00335 144 -----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-195 1.95e-37

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 128.03  E-value: 1.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643 113 AHSPTQMEDAVLDAYDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLCQGEEAAR----QDCLRGIQ 188
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRevamLLCLFLWF 80


                 ....*..
gi 741980643 189 SFLRVHG 195
Cdd:cd03153   81 AILSGHG 87
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 127-191 2.42e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 42.02  E-value: 2.42e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 741980643 127 YDRAYERALRSASGSGRQELVAIQDTFLCCGKSSPLGLLGGLEADLC-QGEEAARQDCLRGIQSFL 191
Cdd:cd03151   15 YDSAYQDAVTDTRSKGTAVLKTFHSTLDCCGKGNLTALLSLLSTDLCpKKLLLDTKDCHQEIDDLF 80
Tetraspanin pfam00335
Tetraspanin family;
82-221 4.92e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 37.30  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643   82 ATVRGAGGLMAAAFLSFALVFCALVQAAFWRAHSPTQMEDAVLDAYDRAYERALRSASGS---GRQELVAIQDTFLCCGk 158
Cdd:pfam00335  65 GALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLyscLNSALDSLQSEFGCCG- 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 741980643  159 ssplgllggleadlcqgeeaarqDCLRGIQSFLRVHGNIVSTLIGLGLAFTVYAMLLSSFIWF 221
Cdd:pfam00335 144 -----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 117-192 6.30e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 35.17  E-value: 6.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741980643 117 TQMEDAVLDAYDRAYERalRSASGSGRQELVAIQDTFLCCGKSSP---LGLLGGLEADLCQGEEAA------RQDCLRGI 187
Cdd:cd03127    5 DQLESLVSDTLNDAWDE--YYVDDDFQEAMDALQSTFECCGVNGPtdyLDLRLLVPSSCCKGTDGNcglnlyTEGCLEKL 82


                 ....*
gi 741980643 188 QSFLR 192
Cdd:cd03127   83 VDFLR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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