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Conserved domains on  [gi|755502375|ref|XP_011238257|]
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uncharacterized protein LOC626802 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-315 1.70e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 106 KAFARISHLRVHKRTHTG-EKPYECNQCGKAFASSSDLQKHKRT--HTGE--KPYEC--NQCGKAFAQSSHLRIHKRTHA 178
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 179 GDKRYEC--NQCGKAFTQSNN------LQIHKGTHAgEKRYEC--NQCGKAFASSSDLQKHKRTHTGEKPYECNqcgkaf 248
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK------ 420

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755502375 249 akscdlqkhkrthtgekpyeCKQCGKAFAVSYTLQIHNRTHTGEKPYECKQCGKAFAQSSNLRIHKQ 315
Cdd:COG5048  421 --------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-315 1.70e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 106 KAFARISHLRVHKRTHTG-EKPYECNQCGKAFASSSDLQKHKRT--HTGE--KPYEC--NQCGKAFAQSSHLRIHKRTHA 178
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 179 GDKRYEC--NQCGKAFTQSNN------LQIHKGTHAgEKRYEC--NQCGKAFASSSDLQKHKRTHTGEKPYECNqcgkaf 248
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK------ 420

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755502375 249 akscdlqkhkrthtgekpyeCKQCGKAFAVSYTLQIHNRTHTGEKPYECKQCGKAFAQSSNLRIHKQ 315
Cdd:COG5048  421 --------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
141-166 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 755502375  141 DLQKHKRTHTGEKPYECNQCGKAFAQ 166
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-315 1.70e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 106 KAFARISHLRVHKRTHTG-EKPYECNQCGKAFASSSDLQKHKRT--HTGE--KPYEC--NQCGKAFAQSSHLRIHKRTHA 178
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 179 GDKRYEC--NQCGKAFTQSNN------LQIHKGTHAgEKRYEC--NQCGKAFASSSDLQKHKRTHTGEKPYECNqcgkaf 248
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK------ 420

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755502375 249 akscdlqkhkrthtgekpyeCKQCGKAFAVSYTLQIHNRTHTGEKPYECKQCGKAFAQSSNLRIHKQ 315
Cdd:COG5048  421 --------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-326 4.48e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 4.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375  88 IHKRTHTGEKPYDCNQYGKAFARISHLRVHKRTHTGEKPYECNQCGKAFASSSDLQKHKRT------HTGEKPYECNQCG 161
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPT 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 162 KAFAQSSHLRIHKRTHAG-DKRYECNQCGKAFTQSNNLQIHKGT--HAGEKRYEC----NQCGKAFASSSDLQKHKRTHT 234
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFscpySLCGKLFSRNDALKRHILLHT 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 235 GEKPYEC--NQCGKAF------AKSCDLQKHKRTHTgEKPYEC--KQCGKAFAVSYTLQIHNRTHTGEKPYECK--QCGK 302
Cdd:COG5048  348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        250       260
                 ....*....|....*....|....
gi 755502375 303 AFAQSSNLRIHKQTHTGERLYECN 326
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
69-231 6.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 6.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375  69 KHHDCNQCGKDFRTRNVPQIHKRT--HTGE--KPYDC--NQYGKAFARISHLRVHKRTHTGEKPYEC--NQCGKAFASSS 140
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 141 D------LQKHKRTHTgEKPYEC--NQCGKAFAQSSHLRIHKRTHAGDKRYECN--QCGKAFTQSNNLQIHKGTHAGEKR 210
Cdd:COG5048  368 NneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|.
gi 755502375 211 YECNQCGKaFASSSDLQKHKR 231
Cdd:COG5048  447 LLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
141-166 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 755502375  141 DLQKHKRTHTGEKPYECNQCGKAFAQ 166
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 755502375  113 HLRVHKRTHTGEKPYECNQCGKAFAS 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-277 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|....*
gi 755502375  253 DLQKHKRTHTGEKPYECKQCGKAFA 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-325 2.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375  71 HDCNQCGKDFRTRNVPQIHKRTHTGEKPYDCNQYG--KAFARISHLRVHKRTHTGEKPYECNQCGKAFASSSDLQKHKRT 148
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 149 HTGEkPYECNQCGKAFAQSSHLRIHK----RTHAGDKRYE-CNQCGKAFTQSNNLQ-------------------IHKGT 204
Cdd:COG5048  114 SSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 205 HAGEKRYECNQCGKAFASSSDLQKHKRTHTGEKPYECNQCGKAFAKSCDLQ-------KHKRTHTGE------------- 264
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslssSDSSSSASEsprsslptassqs 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502375 265 ---------------KPYECKQCGKAFAVSYTLQIHNRT--HTGE--KPYEC--KQCGKAFAQSSNLRIHKQTHTGERLY 323
Cdd:COG5048  273 sspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352


                 ..
gi 755502375 324 EC 325
Cdd:COG5048  353 KE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 2.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 755502375  225 DLQKHKRTHTGEKPYECNQCGKAFAK 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-306 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*
gi 755502375  282 LQIHNRTHTGEKPYECKQCGKAFAQ 306
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-162 5.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 5.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755502375  97 KPYDCNQYGKAFARISHLRVHKRTHTGEKPYECNQ--CGKAFASSSDLQKHKRTHTGEKPYECNQCGK 162
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
169-194 9.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.11  E-value: 9.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 755502375  169 HLRIHKRTHAGDKRYECNQCGKAFTQ 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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