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Conserved domains on  [gi|755511505|ref|XP_011239032|]
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protein sel-1 homolog 3 isoform X1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 6.85e-37

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.29  E-value: 6.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790   53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 606 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 682
Cdd:COG0790  131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755511505 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790  208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 6.85e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.29  E-value: 6.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790   53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 606 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 682
Cdd:COG0790  131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755511505 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790  208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-681 1.95e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 1.95e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 755511505   643 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 681
Cdd:smart00671   1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 578-608 1.98e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 1.98e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755511505  578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:pfam08238   5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 6.85e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.29  E-value: 6.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790   53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 606 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 682
Cdd:COG0790  131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755511505 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790  208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
524-678 1.03e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 121.57  E-value: 1.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 524 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 603
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755511505 604 AASKGLHQAVNGLGWYYHKFR---KNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQ 678
Cdd:COG0790  165 AAEQGDADAQYNLGVLYENGRgvpKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
525-749 9.28e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 112.71  E-value: 9.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 525 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 604
Cdd:COG0790   15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 605 ASKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 681
Cdd:COG0790   94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755511505 682 IEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKngylGHV--IRKGLNAYLEGLW-----HEALLYYVLAAE 749
Cdd:COG0790  171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQ----GDAdaQYNLGRLYLNGEGvekdlEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
548-765 7.37e-20

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 89.99  E-value: 7.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 548 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FR 624
Cdd:COG0790    1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 625 KNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHIEGTLWCSLYYITGnlETFPRDP 704
Cdd:COG0790   81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755511505 705 EKAVVWAKHVAEKN-----GYLGhvirkglNAYLEGL-----WHEALLYYVLAAETGIEVSQTNLAHICEE 765
Cdd:COG0790  156 AKAAEWYRKAAEQGdadaqYNLG-------VLYENGRgvpkdPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
595-848 2.35e-10

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 61.87  E-value: 2.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 595 RLALELMKKAASKGLHQAVNGLGWYYHKFRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFH 674
Cdd:COG0790   15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 675 KAAQGGHIEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnayleglwheallyYVLAAETGIEV 754
Cdd:COG0790   92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 755 SQTNLahiceerpdlagrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 834
Cdd:COG0790  137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                        250
                 ....*....|....
gi 755511505 835 FNLAALIEEGAVIP 848
Cdd:COG0790  175 YNLGVLYENGRGVP 188
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 534-645 1.97e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 534 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 610
Cdd:COG4235   15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755511505 611 QAVNGLGWYYHKfRKNYAKAAKYWLKAEEMGNPDA 645
Cdd:COG4235   86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-681 1.95e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.46  E-value: 1.95e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 755511505   643 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 681
Cdd:smart00671   1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 578-608 1.98e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 1.98e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755511505  578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:pfam08238   5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 536-568 1.32e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.12  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 755511505  536 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 568
Cdd:pfam08238   1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 643-680 3.11e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.96  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755511505  643 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGG 680
Cdd:pfam08238   1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
535-655 3.20e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 535 NAAAQQRLAQMLFwgQQGvakNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKgqgvKKNRRLALELMKKAASK--GLHQ 611
Cdd:COG0457    7 DAEAYNNLGLAYR--RLG---RYEEAIEDYEKAlELDPDDAEALYNLGLAYLR----LGRYEEALADYEQALELdpDDAE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 755511505 612 AVNGLGWYYHKfRKNYAKAAKYWLKAEEM--GNPDASYNLGVLYLD 655
Cdd:COG0457   78 ALNNLGLALQA-LGRYEEALEDYDKALELdpDDAEALYNLGLALLE 122
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 578-608 4.12e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 4.12e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 755511505   578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 527-654 5.40e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755511505 527 LKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGAL-ETEDPALIYDYAIVLFKGQGvkkNRRLALELMKKA- 604
Cdd:COG5010    5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRdKLAKAFAIESPSDNLYNKLG---DFEESLALLEQAl 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755511505 605 -ASKGLHQAVNGLGWYYHKfRKNYAKAAKYWLKAEEM--GNPDASYNLGVLYL 654
Cdd:COG5010   82 qLDPNNPELYYNLALLYSR-SGDKDEAKEYYEKALALspDNPNAYSNLAALLL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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