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Conserved domains on  [gi|755518585|ref|XP_011239876|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 6-272 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467717  Cd Length: 272  Bit Score: 561.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   6 LRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQID 85
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  86 EANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYY 165
Cdd:cd23989   86 RADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 166 TLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP 245
Cdd:cd23989  166 TLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLP 245

                        250       260
                 ....*....|....*....|....*..
gi 755518585 246 FSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23989  246 DSGFHAMPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 6-272 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 561.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   6 LRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQID 85
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  86 EANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYY 165
Cdd:cd23989   86 RADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 166 TLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP 245
Cdd:cd23989  166 TLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLP 245

                        250       260
                 ....*....|....*....|....*..
gi 755518585 246 FSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23989  246 DSGFHAMPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 22-267 3.43e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.06  E-value: 3.43e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   22 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 100
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  101 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 175
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  176 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 247
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 755518585  248 GYHAMPEEFLQLWYLHKIGA 267
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 6-272 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 561.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   6 LRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQID 85
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  86 EANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYY 165
Cdd:cd23989   86 RADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 166 TLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP 245
Cdd:cd23989  166 TLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLP 245

                        250       260
                 ....*....|....*....|....*..
gi 755518585 246 FSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23989  246 DSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 4-272 5.18e-166

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 460.96  E-value: 5.18e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   4 QILRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGR 82
Cdd:cd23971    4 QQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSnKPLKTCAVVGNGGILKNSSCGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  83 QIDEANFVMRCNLPPLSseYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLR 162
Cdd:cd23971   84 EIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 163 VYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDN 242
Cdd:cd23971  162 ALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDN 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 755518585 243 VLPFSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23971  242 VLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 7-272 5.62e-116

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 334.41  E-value: 5.62e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   7 RRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQID 85
Cdd:cd23991    7 RSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRgYPYKQCAVVGNGGILKNSSCGAEID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  86 EANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYY 165
Cdd:cd23991   87 QADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 166 TLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP 245
Cdd:cd23991  167 TLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLP 246

                        250       260
                 ....*....|....*....|....*..
gi 755518585 246 FSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23991  247 KPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 4-272 9.08e-109

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 316.13  E-value: 9.08e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   4 QILRRQMEDCCDPAHLFAmTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSGCGR 82
Cdd:cd23963    4 DKFRKELERLLNTRKLFL-TQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSGCGK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  83 QIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPS 160
Cdd:cd23963   83 EIDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 161 LRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIhAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYY 240
Cdd:cd23963  162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYY 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 755518585 241 DNVLP--FSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23963  241 DDLSPstKNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 22-267 3.43e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.06  E-value: 3.43e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   22 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 100
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  101 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 175
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  176 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 247
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 755518585  248 GYHAMPEEFLQLWYLHKIGA 267
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 1-270 1.14e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 287.89  E-value: 1.14e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   1 MEPQILRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSG 79
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYsRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  80 CGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEP 159
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 160 SLRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHY 239
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 755518585 240 YDNVLPFSGYHAMPEEFLQLWYLHKIGALRM 270
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 5-272 3.69e-74

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 228.43  E-value: 3.69e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   5 ILRRQMEDCCDPAHLFAMTKMNSPMGKSLWYD-GELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGR 82
Cdd:cd23970    8 HQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQnKHYNTCAVVGNSGILTNSQCGN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  83 QIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPS 160
Cdd:cd23970   88 EIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHTSATVT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 161 LRVYYTLKDVGANQTVLFANP-NFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHY 239
Cdd:cd23970  167 RTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHY 246

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 755518585 240 YDN-----VLPFSGYHAMPEEFLQLWYLHKIGALRMQL 272
Cdd:cd23970  247 YDKkgtkfTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 6-271 9.20e-70

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 216.90  E-value: 9.20e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585   6 LRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPL-KKCAVVGNGGILKMSGCGRQI 84
Cdd:cd23969    6 MRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHfRTCAVVGNSGILLNSGCGQEI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  85 DEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLLWS--RKKFVDNMKIYNHSYIYMPAFSMKTGTEpslR 162
Cdd:cd23969   86 DSHDFVIRCNLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKGGEE---H 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 163 VYYTLKDV---GANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHY 239
Cdd:cd23969  162 VQWTNEIIlkhKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHY 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755518585 240 YDNvLPFS---GYHAMPEEFLQLWYLHKIGALRMQ 271
Cdd:cd23969  242 YDN-RKYLttaRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 42-270 1.89e-57

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 185.53  E-value: 1.89e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  42 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 120
Cdd:cd23987   42 TMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 121 RQRFENLL---WsRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDV---GANQTVLFANPNFLRNIGKFWKSR 194
Cdd:cd23987  121 QRAFEDLVnetW-KEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDLIlkhHINVRTAYPSLRLLHAVRGYWLTN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 195 GIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 270
Cdd:cd23987  197 KVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLkygyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 42-270 3.99e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 177.07  E-value: 3.99e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  42 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 120
Cdd:cd23988   42 TLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV-EFAADVGTKSDFITMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 121 RQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDVGANQ-TVLFANPNF--LRNIGKFWKSRG 195
Cdd:cd23988  121 QRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKGGEK---HVEWVNALILKNKlKVRTAYPSLrlIHAVRGYWLTNK 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755518585 196 IHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 270
Cdd:cd23988  198 VNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLkyryFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 66-256 3.25e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 107.06  E-value: 3.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  66 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYnhsY 145
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVV---L 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 146 IYMPAFsmktgTEPSLRVYYTLKDVGANQT-VLFANPNF-------LRNIGKFWKSRGIHAkrlSTGLFLVSAALGLCEE 217
Cdd:cd19952   77 ILSRAA-----AADFKRLKRRKKRHDNAVLlLTDPAPDLlsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755518585 218 VSIYGFWPFSVNMQGDPisHHYYDNVLP--FSGYHAMPEEF 256
Cdd:cd19952  149 VDLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 65-269 9.38e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 103.11  E-value: 9.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  65 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLpPLSSEYTRDVGSKTQLVTANP--SIIRQRFENLLWSRKKFVDNM-KIY 141
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 142 nhSYIYMPAFS----MKTGTEPSLRVYYTLKDVGANQTVLFANPNFLRNIGKFW-KSRGIHakRLSTGLFLVSAALGLCE 216
Cdd:cd23964  163 --DYDYLDAVLsgkpVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCD 238

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755518585 217 EVSIYGF---WPFSVnmqgdpishHYYDN----VLPFSGYHAMPEEfLQLW-YLHKIGALR 269
Cdd:cd23964  239 QVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 65-270 1.50e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 80.95  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  65 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRKK 133
Cdd:cd23974   86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngppqSKETRYI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 134 FVDNmkiYNHSYIYMPAFSMKT----GTEPSLR-VYYTLKDVGANQTVLFaNPNFLRNI-GKFWKSRGIHAK-----RLS 202
Cdd:cd23974  165 FLPD---HDRDYLLVKAALTHTpidrGRDKSKRpSKYFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPS 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755518585 203 TGLFLVSAALGLCEEVSIYGFwpfsVNMQGDPISHHYYDNV---LPFSGYHAMPEEfLQLWY-LHKIGALRM 270
Cdd:cd23974  241 TGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTyhkVVFYANHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 65-270 1.11e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 77.71  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  65 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPsiirQRFENLLWSRKKFVDNMKIYNHS 144
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDLDPGVHLVLVPFKVLDLQ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 145 YIyMPAFSMKTGTepslRVYYTLKD-VGANQT-VLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYG 222
Cdd:cd23966  154 WL-ISALTTGEIT----RTYTPVKRfIKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFG 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 223 F-------WpfsvnmqgdpisHHYYDNVLPFS-----GYHAMPEEFLQLWYLHKIGALRM 270
Cdd:cd23966  227 FgadskgnW------------HHYWEKNRSAGafrktGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 64-242 3.56e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 73.76  E-value: 3.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  64 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFEN--LLWSRKKFVDNMKIY 141
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 142 --------NHSYIYMPAfsmktgtepSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALG 213
Cdd:cd23980  161 satttgtiSHTYVPVPR---------KIKV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLH 221

                        170       180
                 ....*....|....*....|....*....
gi 755518585 214 LCEEVSIYGfwpFSVNMQGDpiSHHYYDN 242
Cdd:cd23980  222 VCDEVDLYG---FGADSKGN--WHHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 46-270 2.09e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 71.78  E-value: 2.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  46 DNSTYSLFPqatPFQLPLK--KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLV-----TANPS 118
Cdd:cd23972   66 DSANAKLFF---PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNS 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 119 IIrqRFENLLWSRKKFVDNMKiynhsYIYMPAfsmktgtepSLRVYYTLK------------DVGANQTVLFA------- 179
Cdd:cd23972  142 LI--SYWNLGFTRTPQGQDLQ-----YIFIPS---------DIRDYVMLRsailgvpvpeglDKGDRPHKYFGpeasakk 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 180 ----NPNFLRNI-GKFWKSRGI-----HAKRLSTGLFLVSAALGLCEEVSIYGFwpfsVNMQGDPISHHYYDNV---LPF 246
Cdd:cd23972  206 fkllHPDFISYLtDRFLKSKLLnthygHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKkkpLVF 281

                        250       260
                 ....*....|....*....|....*
gi 755518585 247 SGYHAMPEEfLQLW-YLHKIGALRM 270
Cdd:cd23972  282 YANHDMLLE-AALWrRLHKAGILQL 305
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 62-265 2.50e-14

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 70.01  E-value: 2.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  62 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQRFENllwsrkkfvdnmkI 140
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPeSAFRDPEEY-------------D 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 141 YNHSYIYMPAFSMK--------TGTEPSLRVYYTLK-----DVGANQTVLFaNPNFLR----NIGKFWKSRGIHAKRLST 203
Cdd:cd23967   67 SDWLLVLVPFKSMDllwlqaviKGKKPNGKGGFWKKiatsvPKPPKKIRIL-NPYILQeaafDLIGLPMNGKQGKNVPTT 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755518585 204 GLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNVL----PFSGYHAMPEEFLqlwYLHKI 265
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHNVTKEKK---YLKKL 205
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 64-242 7.65e-14

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 69.90  E-value: 7.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  64 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT----------QLVTANPSIIRQRFE--NLLWsr 131
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmypesaKNLPANVSFVLVPFKtlDLLW-- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 132 kkFVDNMKIYNHSYIYMPafsmktgTEPSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAA 211
Cdd:cd23979  158 --ITSALSTGQIRFTYAP-------VKQFLRV--------DKDKVQIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFA 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 755518585 212 LGLCEEVSIYGfwpFSVNMQGDpiSHHYYDN 242
Cdd:cd23979  219 LHVCDEVNVYG---FGADSRGN--WHHYWEN 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 65-270 4.29e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 68.24  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  65 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLlwsRKKFVDNMKIYNH- 143
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYVHTAHSITSSLMIL---QKRGFKNIPQDKDi 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 144 SYIYMPAfsmktgtepSLRVYYTLKDVGANQTV-----------------------LFANPNFLRNI-GKFWKSRGIHAK 199
Cdd:cd23973  161 KYILFPE---------GPRDYQWLEALLKNKTIpsgayygrrprsyfsgdftedkyLVLHPDFLRYVkNRFLRSKTLKGK 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 200 -----RLSTGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LPFSGYHAMPEEfLQLW-YLHKIGAL 268
Cdd:cd23973  232 ywaiyRPTTGAFLLLTALHLCDTVSAYGF------ITEDyrKYPDHYYDKKktkLVFYINHDFRLE-KKLWkRLHDEKII 304


                 ..
gi 755518585 269 RM 270
Cdd:cd23973  305 KL 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 58-245 7.28e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 66.82  E-value: 7.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  58 PFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQL-VTANPS---IIRQRFENLLWSRKK 133
Cdd:cd23976   10 PLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 134 FV------DNMK------IYNHsyiympaFSMKTGTEPSLRVYYTLKdvganQTVLFANPNFLRNIGKfwkSRGIHAKRL 201
Cdd:cd23976   89 VFifwgpsNYMRrdgkglVYNN-------LQLMNQILPKLKVYTITR-----HKMLQFDELFKRETGK---DRKISNTWL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755518585 202 STGLFLVSAALGLCEEVSIYGFWP--FSVNMQGDPISHHYYDNVLP 245
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 50-255 2.31e-12

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 65.37  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  50 YSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKT-------QLVTAN-----P 117
Cdd:cd23968   32 YPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTtlrlinsQILSKPefnflT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 118 SIIRQRFENLLWSRKKFVDNMKI--YNHSYIYMPAFSMKTGTEPSLRVYytlkdvganqtvlFANPNFLRNIgkfWK--- 192
Cdd:cd23968  111 DPLYRNVTLLVWDPSSYNVNLEKwyKKPDFDFFPNYIKYRRRHPEEPFY-------------LIDPRFLWRL---WDilq 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 193 ---SRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPfsvNMQGDPIShHYYDNVL----PFSGYHAMPEE 255
Cdd:cd23968  175 eytPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYDVEKdlacTLGAWHPLAAE 240
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 64-241 1.67e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 62.57  E-value: 1.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  64 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR---FEN------LLWS 130
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 131 RKKFVDNMKiynhSYIYMPAFSMKTGTEPSLRVYYTLKDVGANQTVLFANPNflrnigkfWKSRGIHAKRLSTGLFLVSA 210
Cdd:cd23977   81 PERNMDRDG----GGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNET--------GKNRMKSGSFLSTGWFTMIL 148

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755518585 211 ALGLCEEVSIYGFWPFSV--NMQGDPISHHYYD 241
Cdd:cd23977  149 ALELCEEILVYGMVSDSYcrNKNHSSVPYHYYE 181
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 62-244 3.35e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 61.22  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  62 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQL-------VTANPSIIRQRFENLLWSRKKF 134
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTIrlfypesAQFDPGIENDPDTLLVLVPFKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 135 VDNMKIYNhsyiympafsMKTGTEPSLRVYYT----LKDVGANQT-VLfaNPNFLRNIG-KFWKSRGIHAK--RLSTGLF 206
Cdd:cd23982   80 LDFYWLYE----------ILSNEKRVRKGFWKqpprIWDANPKQIrIL--NPYYTYVAAtKLLQVPGQRKKkqKPTTGLL 147

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 755518585 207 LVSAALGLCEEVSIYGF-WPFSVNmQGDPIshHYYDNVL 244
Cdd:cd23982  148 AITLALHLCDEVHIAGFgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 64-241 3.50e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 61.49  E-value: 3.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  64 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRQRFENLLWSRKKFVDNMKIyn 142
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNAILLLAGTRAPTVVV-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 143 hsyIYMPAFSMKTGTEPSLRV------------YYTLKDVGanqtVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSA 210
Cdd:cd23965   79 ---FWGPETKMNKDGAGKYNLlrslskkypdveFYSLTPEK----MDYADELFEKETG---KSRIKSGTWLSTGWFTMLL 148

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755518585 211 ALGLCEEVSIYGFWP--FSVNMQGDPISHHYYD 241
Cdd:cd23965  149 ALDVCDEIKVYGMVPenYCREHPNSKVPYHYYE 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 62-262 1.84e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 59.37  E-value: 1.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  62 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQ---------------RFE 125
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDpshydpnttvvlipfKPH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 126 NLLWSrkkfvdnMKIYNHSYIYMPAFSMKtgtePSLRVYYTLkdvgaNQTVLFaNPNFLR----NIGKFWKSRGIHAKRL 201
Cdd:cd23984   80 DLRWL-------LDLLMGKKVSAKGFWKK----PALNLIYKP-----NQIRIL-NPFILRiaayELLHFPKRFPKEKKPK 142

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755518585 202 --STGLFLVSAALGLCEEVSIYGF-WPFSvnmqgDPISH-HYYDN----VLPFSGYHAMPEEFLQLWYL 262
Cdd:cd23984  143 hpTTGIIAITLALHICNEVHIAGFkYDFS-----NLNSTlHYYGNetmsVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 62-243 1.09e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 57.06  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  62 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-----SIIRQRFENL--------- 127
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapkSEQEYDPTSLfvavlfksv 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 128 ---------------LWSRKKF-----------VDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVganqtvlfanP 181
Cdd:cd23983   80 dfawlkamvkkeplsFWSRLFFwkevadsiplkPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNV----------P 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755518585 182 nflrnigkfwksrgihakrlSTGLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 243
Cdd:cd23983  150 --------------------TLGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 64-243 1.22e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 56.85  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  64 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRK 132
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQyekdslfvlagFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 133 KFVDNMkiynhsyIYMPAFSMKTGTEPSLRVYYTlkdvGANQTVLFANPNFLRN-----IGKFWKSRGIHAKRLST-GLF 206
Cdd:cd23981   82 KWLKYI-------VYKEKVSASDGFWKSVATRVP----REPHEIRILNPYFIQEaafsfIGLPFNNGLMGRGNIPTlGSV 150

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755518585 207 LVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 243
Cdd:cd23981  151 AITMALHNCDEVAVAGF-GYDMNTPNAPL--HYYETI 184
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 62-114 3.44e-09

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 56.25  E-value: 3.44e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  62 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT-------QLVT 114
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP-TAGFQQDVGTKTtirlinsQLVT 102
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-257 4.24e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 56.00  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  63 LKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSII---RQRFEN---------LLWS 130
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILtnpNHHFIDsslykdvilVAWD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 131 RKKFVDNMKIYNHSyiymPAFSMKTgtePSLRvyYTLKDvgANQTVLFANPNFlrnIGKFWK------SRGIHAKRLSTG 204
Cdd:cd23986  128 PAPYSANLHKWYKK----PDYNLFT---PYVQ--YRKRN--PNQPFYILHPKF---IWQLWDiiqentQEKIQPNPPSSG 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755518585 205 LFLVSAALGLCEEVSIYGFWPfSVNmQGDPISHH--YYDNVLPFSGYHAMPEEFL 257
Cdd:cd23986  194 FIGILIMMSMCREVHVYEYIP-SVR-QTDLCHYHerYYDAACTLGAYHPLLYEKL 246
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 65-241 5.65e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 55.25  E-value: 5.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  65 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRqrfenLLWSRKKFVDnmKIYNH 143
Cdd:cd23978    3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYR-----VLRRPQEFLN--RTPET 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 144 SYIYM-PAFSMKTGTEPSL-RVYYTLKDVGANQTVLFANPNFLRNIGKFW-----KSRGIHAKRLSTGLFLVSAALGLCE 216
Cdd:cd23978   75 TLIFWgPPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFrgetgRDRKKSHSWLSTGWFTMVIAVELCD 154

                        170       180
                 ....*....|....*....|....*...
gi 755518585 217 EVSIYGFWPF---SVNMQGDPISHHYYD 241
Cdd:cd23978  155 NVHVYGMVPPnycSKRPTPKKMPYHYYE 182
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 66-222 1.60e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 41.84  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585  66 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQ----------LVTANPSIIRQRFENLLWSRKKFV 135
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTirvvshtsvpLLLKNPDYFFKETNETIYVIWGPF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518585 136 DNMKIYNHSYIYmPAFSMKTGTEPSLRVYYTlkdvgANQTVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSAALGLC 215
Cdd:cd23975   83 RNMRKDGKGIVY-NMLKKAVESYPQAKIYVT-----TEKRMSYCDTVFKKETG---KDRVQSGSYLSTGWFTLILAMDAC 153


                 ....*..
gi 755518585 216 EEVSIYG 222
Cdd:cd23975  154 YGIHVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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