|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00491 |
PTZ00491 |
major vault protein; Provisional |
4-850 |
0e+00 |
|
major vault protein; Provisional
Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 1170.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 4 EEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDAQSSVLFDVTGQVRL 83
Cdd:PTZ00491 3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 84 RHADQEIRLAQDPFPLYPGELLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEII 163
Cdd:PTZ00491 83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 164 QATVIKQNQALRLRARKECFDRDGKERVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRARQNFKDLRG-VA 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDVYGgIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 243 HRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLER-GIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEGdGIQ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 322 DVYVLSEQQGLLLKALQPLEEGEGEEkvaHQAGDRWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRALETFTDEDGVE---REPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 402 IGSTYMLTQDEVLWEKELPSGVEELLN--LGHDPLADRGQKGTAKVLQPSAA-----RNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAqpRSSMAYSERSGQASGKVPYEENPgfeshRDKHRVVTYKVPHNAAVQLYDYK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 475 AKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELkNRND 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 555 PEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGfemSEDAGPDgallprARDRAVFPQNGLV 634
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFG---SNDETGE------VRDSLRFPANNLV 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 635 VSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSM 714
Cdd:PTZ00491 630 ITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAESA 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 715 AVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVKKVREMELIYSRAQLELEVSKAQQLADVEAKK 794
Cdd:PTZ00491 710 AVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEATK 789
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 755523315 795 FKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFNTAFGLLG 850
Cdd:PTZ00491 790 FERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
|
|
| MVP_shoulder |
cd08825 |
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ... |
509-670 |
6.55e-84 |
|
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Pssm-ID: 259807 Cd Length: 151 Bit Score: 264.86 E-value: 6.55e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELkNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825 1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDV-DDKKPEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 589 DDFHKNSARIIRMAVFGFemsEDAGPDgallpraRDRAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825 80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149
|
..
gi 755523315 669 QE 670
Cdd:cd08825 150 QE 151
|
|
| MVP_shoulder |
pfam11978 |
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ... |
519-647 |
4.68e-60 |
|
Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.
Pssm-ID: 463418 Cd Length: 118 Bit Score: 199.39 E-value: 4.68e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 519 GPDFFTDVITIETADHARLQLQLAYNWHFELkNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978 1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 755523315 599 IRMAVFGFemsEDAGpdgallpRARDRAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978 80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00491 |
PTZ00491 |
major vault protein; Provisional |
4-850 |
0e+00 |
|
major vault protein; Provisional
Pssm-ID: 240439 [Multi-domain] Cd Length: 850 Bit Score: 1170.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 4 EEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDAQSSVLFDVTGQVRL 83
Cdd:PTZ00491 3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 84 RHADQEIRLAQDPFPLYPGELLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEII 163
Cdd:PTZ00491 83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 164 QATVIKQNQALRLRARKECFDRDGKERVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRARQNFKDLRG-VA 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDVYGgIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 243 HRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLER-GIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEGdGIQ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 322 DVYVLSEQQGLLLKALQPLEEGEGEEkvaHQAGDRWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRALETFTDEDGVE---REPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 402 IGSTYMLTQDEVLWEKELPSGVEELLN--LGHDPLADRGQKGTAKVLQPSAA-----RNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAqpRSSMAYSERSGQASGKVPYEENPgfeshRDKHRVVTYKVPHNAAVQLYDYK 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 475 AKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELkNRND 554
Cdd:PTZ00491 480 TKKSRVVFGPDLVMLEPDEEFTVLSLSGGKPKVPNQIHSLHLFLGPDFMTDVIHVETSDHARLALQLSYNWYFDV-TDGN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 555 PEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGfemSEDAGPDgallprARDRAVFPQNGLV 634
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFG---SNDETGE------VRDSLRFPANNLV 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 635 VSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSM 714
Cdd:PTZ00491 630 ITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAESA 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 715 AVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVKKVREMELIYSRAQLELEVSKAQQLADVEAKK 794
Cdd:PTZ00491 710 AVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEATK 789
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 755523315 795 FKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFNTAFGLLG 850
Cdd:PTZ00491 790 FERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
|
|
| MVP_shoulder |
cd08825 |
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ... |
509-670 |
6.55e-84 |
|
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.
Pssm-ID: 259807 Cd Length: 151 Bit Score: 264.86 E-value: 6.55e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 509 HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELkNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTF 588
Cdd:cd08825 1 NQIKALCLLLGPDFMTDIITVETADHARLQLQLAYNWHFDV-DDKKPEEAAKLFSVPDFIGDACKAIASRIRGAVASVTF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 589 DDFHKNSARIIRMAVFGFemsEDAGPDgallpraRDRAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNS 668
Cdd:cd08825 80 DDFHKNSARIIRSAVFGD---DEKGEV-------RDELRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNS 149
|
..
gi 755523315 669 QE 670
Cdd:cd08825 150 QE 151
|
|
| MVP_shoulder |
pfam11978 |
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ... |
519-647 |
4.68e-60 |
|
Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.
Pssm-ID: 463418 Cd Length: 118 Bit Score: 199.39 E-value: 4.68e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 519 GPDFFTDVITIETADHARLQLQLAYNWHFELkNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARI 598
Cdd:pfam11978 1 GPDFMTDIITVETADHARLQLQLSYNWHFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 755523315 599 IRMAVFGFemsEDAGpdgallpRARDRAVFPQNGLVVSSVDVQSVEPVD 647
Cdd:pfam11978 80 IRRAVFGV---DENG-------EVRDSLLFPENNLVITSVDVQSVEPVD 118
|
|
| Vault_2 |
pfam17794 |
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ... |
50-109 |
5.60e-30 |
|
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.
Pssm-ID: 407666 [Multi-domain] Cd Length: 60 Bit Score: 112.57 E-value: 5.60e-30
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 50 MVTVPPRHYCIVANPVSRDAQSSVLFDVTGQVRLRHADQEIRLAQDPFPLYPGELLEKDI 109
Cdd:pfam17794 1 MITLPPRSYCVVANPVSRDGKGSPVLDQHGQVRLVHGDKEIRLAQDPFPLYPGEKLEGDI 60
|
|
| Vault_3 |
pfam17795 |
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein. |
457-518 |
1.74e-28 |
|
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.
Pssm-ID: 407667 Cd Length: 62 Bit Score: 108.31 E-value: 1.74e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755523315 457 VVSYRVPHNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLL 518
Cdd:pfam17795 1 VVTFRVPHNALVQLYDYKTKKSRVVFGPLLVSLEPHEHFTVLSLSGGQPKEPNAIHSLCLYL 62
|
|
| Vault_4 |
pfam17796 |
Major Vault Protein repeat domain; |
379-439 |
3.76e-23 |
|
Major Vault Protein repeat domain;
Pssm-ID: 407668 [Multi-domain] Cd Length: 61 Bit Score: 93.44 E-value: 3.76e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755523315 379 AIPLDQNEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQ 439
Cdd:pfam17796 1 AIPLDENEGIYVRNIRTGEVRVVTGQTYMLTESEELWEKELPPGVEVLLAEARDPLAGRDS 61
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
113-153 |
3.20e-15 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 70.15 E-value: 3.20e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 755523315 113 QVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIP 153
Cdd:pfam01505 1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
166-206 |
3.20e-14 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 67.07 E-value: 3.20e-14
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 755523315 166 TVIKQNQALRLRARKECFDRDGKERVTGEEWLVRSVGAYLP 206
Cdd:pfam01505 1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
324-367 |
1.18e-12 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 62.83 E-value: 1.18e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 755523315 324 YVLSEQQGLLLKALQPLEEGEGeekVAHQAGDRWLIRGPLEYVP 367
Cdd:pfam01505 1 YVLSENEALRLRALEDFTDRDG---VERKAGEEWLVRGPGTYIP 41
|
|
| Vault |
pfam01505 |
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ... |
220-261 |
2.24e-11 |
|
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Pssm-ID: 460235 [Multi-domain] Cd Length: 41 Bit Score: 58.98 E-value: 2.24e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 755523315 220 ILTEKTALHLRARQNFKDLRGVAHRTGEEWLVTvqDTEAHVP 261
Cdd:pfam01505 2 VLSENEALRLRALEDFTDRDGVERKAGEEWLVR--GPGTYIP 41
|
|
| SPFH_like |
cd02106 |
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ... |
525-616 |
8.75e-11 |
|
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons, and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.
Pssm-ID: 259797 [Multi-domain] Cd Length: 110 Bit Score: 59.68 E-value: 8.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 525 DVITIETADHARLQLQLAYNWHFELKNRNDpeETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNsARIIRMAVF 604
Cdd:cd02106 8 RVEPVGTADGVPVAVDLVVQFRITDYNALP--AFYLVDFVKDIKADIRRKIADVLRAAIGRMTLDQIISG-RDEIAKAVK 84
|
90
....*....|..
gi 755523315 605 GFEMsEDAGPDG 616
Cdd:cd02106 85 EDLE-EDLENFG 95
|
|
| Vault_2 |
pfam17794 |
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ... |
273-320 |
3.43e-10 |
|
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.
Pssm-ID: 407666 [Multi-domain] Cd Length: 60 Bit Score: 56.33 E-value: 3.43e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523315 273 ITTLGPRHYCVILDPMGPDGK-----NQLGQKRVVKGEKS-------FFLQPGERLERGI 320
Cdd:pfam17794 1 MITLPPRSYCVVANPVSRDGKgspvlDQHGQVRLVHGDKEirlaqdpFPLYPGEKLEGDI 60
|
|
| |
