LURP-one-related/scramblase family protein similar to Arabidopsis thaliana protein LURP16, which might be related to the phospholipid scramblase and tubby-like superfamily of membrane tethered transcription factors
LURP-one-related; The structure of this family has been solved. It comprises a 12-stranded ...
28-215
1.43e-95
LURP-one-related; The structure of this family has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein. In plants it plays a role in defense against pathogens.
The actual alignment was detected with superfamily member pfam03803:
Pssm-ID: 470445 Cd Length: 221 Bit Score: 277.70 E-value: 1.43e-95
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
28-215
1.43e-95
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.
Pssm-ID: 252175 Cd Length: 221 Bit Score: 277.70 E-value: 1.43e-95
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
28-215
1.43e-95
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.
Pssm-ID: 252175 Cd Length: 221 Bit Score: 277.70 E-value: 1.43e-95
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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