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Conserved domains on  [gi|755546340|ref|XP_011242964|]
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cell division cycle protein 20 homolog B isoform X5 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-463 8.93e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 8.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755546340 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATG 463
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASG 306
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-463 8.93e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 8.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755546340 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATG 463
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASG 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-463 2.27e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755546340 390 VqglPLKVIPQST-AVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATG 463
Cdd:cd00200  168 K---CVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASG 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 2.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.63e-05
                           10        20
                   ....*....|....*....|....*....
gi 755546340   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 9.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.76e-05
                          10        20
                  ....*....|....*....|....*....
gi 755546340  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-463 8.93e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 8.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755546340 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATG 463
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASG 306
WD40 COG2319
WD40 repeat [General function prediction only];
235-463 3.81e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 3.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 235 NTLDWS--SQNLVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLH 312
Cdd:COG2319  166 TSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 313 GHLSVVGALSWNH--CTLSSGSRLGRVHHHDVRvAQHRVGTL-YHKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAG 389
Cdd:COG2319  244 GHSGSVRSVAFSPdgRLLASGSADGTVRLWDLA-TGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755546340 390 VQGLPlkviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPST-QSQICSLIWLPKTKEIATG 463
Cdd:COG2319  323 LRTLT----GHTGAVRSVAFSP-DGKTLASGSD--DGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
237-463 8.30e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 8.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 237 LDWSSQNLVAVALGTSVYIWNGQNHSWIENIDLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLS 316
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 317 VVGALSW--NHCTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGL 393
Cdd:COG2319  122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLR 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755546340 394 PLKviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATG 463
Cdd:COG2319  199 TLT--GHTGAVRSVAFSP-DGKLLASGSA--DGTVRLWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-463 2.27e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755546340 390 VqglPLKVIPQST-AVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATG 463
Cdd:cd00200  168 K---CVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
235-382 2.25e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 235 NTLDWSSQN--LVAVALGTSVYIWNGQNHSWIENidLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLH 312
Cdd:COG2319  250 RSVAFSPDGrlLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755546340 313 GHLSVVGALSW--NHCTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:COG2319  328 GHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGE-LLRTLTgHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
276-463 1.24e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 276 VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVG--ALSWNHCTLSSGSRLGRVHHHDVRVAQHRVGTLY 353
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDI 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLT--GHSGAVTSVAFSP-DGKLLASGSD--DGTVRLWDL 191

                        170       180       190
                 ....*....|....*....|....*....|.
gi 755546340 434 NTGKNIQT-PSTQSQICSLIWLPKTKEIATG 463
Cdd:COG2319  192 ATGKLLRTlTGHTGAVRSVAFSPDGKLLASG 222
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 235-382 4.37e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 4.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 235 NTLDWSSQN-LVAVALG-TSVYIWNGQNHSWIENIDLSVCchYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLH 312
Cdd:cd00200  139 NSVAFSPDGtFVASSSQdGTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755546340 313 GHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRvAQHRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:cd00200  217 GHENGVNSVAFSPDGylLASGSEDGTIRVWDLR-TGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-474 3.07e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 3.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 274 HYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW--NHCTLSSGSRlgrvhHHDVRV----AQH 347
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSS-----DKTIRLwdleTGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 348 RVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPhdpgaGVQGLPLKVIP-QSTAVKAMEWCPwQSEVLAvgGGVKD 425
Cdd:cd00200   85 CVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETGKCLTTLRgHTDWVNSVAFSP-DGTFVA--SSSQD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755546340 426 GCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALW 474
Cdd:cd00200  157 GTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-430 9.33e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 9.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 233 YLNTLDWSSQNLVAVALGT--SVYIWNgqnhswienIDLSVCCH-------YVSSVTWMREGSCLAVGTSEGEVQLWDAI 303
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRdkTIKVWD---------VETGKCLTtlrghtdWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 304 TKKQLRNLHGHLSVVGALSWNH--CTLSSGSRLGRVHHHDVRVAQHrVGTL-YHKEAVCSLKWSPDGRLLSSGCNDGLLT 380
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKC-LGTLrGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755546340 381 IWPHDPGAgvqglPLKVIPQ-STAVKAMEWCPwQSEVLAVGGgvKDGCLHV 430
Cdd:cd00200  245 VWDLRTGE-----CVQTLSGhTNSVTSLAWSP-DGKRLASGS--ADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
288-463 1.25e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 288 LAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSWNHC--TLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSP 365
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 366 DGRLLSSGCNDGLLTIWPHDPGAGVQGLplkvIPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPST- 444
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSP-DGKTLASGSA--DGTVRLWDLATGKLLRTLTGh 161

                        170
                 ....*....|....*....
gi 755546340 445 QSQICSLIWLPKTKEIATG 463
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASG 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 2.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.63e-05
                           10        20
                   ....*....|....*....|....*....
gi 755546340   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-474 2.93e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546340 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAGVQGLPLKVIPqstaVKAMEWCPWQSEVLAVGggvKDGCLHVLDI 433
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP----VRDVAASADGTYLASGS---SDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755546340 434 NTGKNIQT-PSTQSQICSLIWLPKTKEIATGQGApkNDVALW 474
Cdd:cd00200   81 ETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRD--KTIKVW 120
WD40 pfam00400
WD domain, G-beta repeat;
354-382 9.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.76e-05
                          10        20
                  ....*....|....*....|....*....
gi 755546340  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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