NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755548669|ref|XP_011243434|]
View 

exportin-7 isoform X3 [Mus musculus]

Protein Classification

importin-beta N-terminal domain-containing protein( domain architecture ID 10510703)

importin-beta N-terminal domain-containing protein similar to Homo sapiens transportin-1 isoform 5

CATH:  1.25.10.10
Gene Ontology:  GO:0031267|GO:0006886
SCOP:  4001298

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
4-48 1.39e-04

Importin-beta N-terminal domain;


:

Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.07  E-value: 1.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 755548669     4 SGRKSSYSQLLAATCLTKLVSR----TNNPLPLEQRIDIRNYVLNYLAT 48
Cdd:pfam03810   24 NSENPLEVRQLAALYLKNLITRhweeEKNSLPPEEKEQIKNNLLNLLGS 72
 
Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
4-48 1.39e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.07  E-value: 1.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 755548669     4 SGRKSSYSQLLAATCLTKLVSR----TNNPLPLEQRIDIRNYVLNYLAT 48
Cdd:pfam03810   24 NSENPLEVRQLAALYLKNLITRhweeEKNSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 7-48 2.24e-04

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 40.30  E-value: 2.24e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 755548669      7 KSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLAT 48
Cdd:smart00913   26 EDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
4-48 1.39e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.07  E-value: 1.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 755548669     4 SGRKSSYSQLLAATCLTKLVSR----TNNPLPLEQRIDIRNYVLNYLAT 48
Cdd:pfam03810   24 NSENPLEVRQLAALYLKNLITRhweeEKNSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 7-48 2.24e-04

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 40.30  E-value: 2.24e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 755548669      7 KSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLAT 48
Cdd:smart00913   26 EDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH