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Conserved domains on  [gi|755550407|ref|XP_011243672|]
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regulator of G-protein signaling 22 isoform X1 [Mus musculus]

Protein Classification

regulator of G-protein signaling domain-containing protein; G protein-coupled receptor kinase( domain architecture ID 10246706)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)| G protein-coupled receptor kinase is a serine/threonine-protein kinase that phosphorylate and regulate G protein-coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 5.09e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188681  Cd Length: 130  Bit Score: 218.89  E-value: 5.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 755550407  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1019-1141 6.98e-64

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188680  Cd Length: 123  Bit Score: 212.25  E-value: 6.98e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755550407 1099 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1141
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.35e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755550407  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 408-530 6.03e-03

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08730:

Pssm-ID: 470619  Cd Length: 165  Bit Score: 38.87  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730     6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755550407  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730    78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 5.09e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 218.89  E-value: 5.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 755550407  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1019-1141 6.98e-64

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 212.25  E-value: 6.98e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755550407 1099 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1141
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.35e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755550407  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1015-1129 2.31e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.73  E-value: 2.31e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407   1015 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLchshCDESIIHKKITTIINCFINSYIPPALQIDI-PVEQ 1093
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 755550407   1094 AQKILEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1129
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 846-969 3.20e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 3.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407   846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYikNKYLNKKyffgprSPASLHQQNQIM 925
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 755550407   926 -LLSGGwgriLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 845-969 1.07e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 48.80  E-value: 1.07e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407    845 TFTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIifKDQKQREEKSIYIKNKYLNKKyffGPRSPASLHQ-QNQ 923
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKA--EDDEERIAKAREIYDKFLSPN---APKEVNLDSDlREK 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 755550407    924 IMLlsggwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:smart00315   76 IEE------NLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS-like_3 cd08730
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These ...
 408-530 6.03e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188685  Cd Length: 165  Bit Score: 38.87  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730     6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755550407  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730    78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 5.09e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 218.89  E-value: 5.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 755550407  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1019-1141 6.98e-64

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 212.25  E-value: 6.98e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755550407 1099 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1141
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.35e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755550407  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 850-969 1.31e-16

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 77.05  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  850 LNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIfKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLhqQNQIMLlsg 929
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTT-SSDEELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 755550407  930 gwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:cd07440    75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 670-777 4.75e-09

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 55.48  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  670 FFFTKFCENSGNKlwkHSVYFWFDLQAYHQLFYQETlqpfKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYMKIQPP- 748
Cdd:cd07440     8 EYFRQFLKSEHCE---ENLEFWLAVEKFKKTTSSDE----ELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPy 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 755550407  749 -FEDLFDTAEEFILLSLL-EPWTQMVMSDKM 777
Cdd:cd07440    81 pDPDCFDEAQEHILNLLEkDSYPRFLKSDLY 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1015-1129 2.31e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.73  E-value: 2.31e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407   1015 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLchshCDESIIHKKITTIINCFINSYIPPALQIDI-PVEQ 1093
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 755550407   1094 AQKILEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1129
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 846-969 3.20e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 3.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407   846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYikNKYLNKKyffgprSPASLHQQNQIM 925
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 755550407   926 -LLSGGwgriLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 845-969 1.07e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 48.80  E-value: 1.07e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407    845 TFTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIifKDQKQREEKSIYIKNKYLNKKyffGPRSPASLHQ-QNQ 923
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKA--EDDEERIAKAREIYDKFLSPN---APKEVNLDSDlREK 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 755550407    924 IMLlsggwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:smart00315   76 IEE------NLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 850-1032 1.01e-04

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 44.45  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  850 LNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYiknkylnKKYFFGPRSPASLHQQNQIMLLSG 929
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAIIIREI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  930 GWGRILHEqldaSVLVEIQKHVLNRLENVWLPLF---LSSEQFASRQKIKTQMKDIADELLLQR-HDRKIGVWkpveSKW 1005
Cdd:cd08728    74 AMMKVVTT----SMLLSIQHLVSKSLEERWFKKYqdtFPDCPHEVEPDEEIKVPLKPTKLKAPHvISSQKRAW----EIF 145

                         170       180
                  ....*....|....*....|....*..
gi 755550407 1006 ISSSCEIIAFRKALLNPVIARQFQRFV 1032
Cdd:cd08728   146 ISFIRSFIKFRRFMVNREIRQEFEDYL 172
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 690-760 1.17e-03

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 39.91  E-value: 1.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755550407  690 FWFDLQAYHQLFYQetlqpFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYMKIQPPFEDLFDTAEEFI 760
Cdd:cd08716    29 FWLACETYKKIASQ-----RKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQEPTQSCFDEAQRIV 94
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1019-1134 1.33e-03

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 39.68  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407 1019 LLNPVIARQFQRFVALKGDLlENgVLFWQEVQKFKDLCHSHcdesiihkkiTTIINCFI---NSYIPP--ALQIDIPvEQ 1093
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCE-EN-LEFWLAVEKFKKTTSSD----------EELKSKAKeiyDKYISKdaPKEINIP-ES 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755550407 1094 AQKILEHR---KELGPYVFREAQMTIFGVLFK-FWPQFCEFRKNL 1134
Cdd:cd07440    68 IREEIEENleePYPDPDCFDEAQEHILNLLEKdSYPRFLKSDLYL 112
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 1015-1123 3.80e-03

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 38.50  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407 1015 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLCHShcDESIIHKKITTIINCFINSYIPPALQIDIPVEQA 1094
Cdd:cd08742     1 FERLLQDPVGVRYFSEF--LRKEFSEENILFWQACEYFNHVPAH--DKKELSYRAREIFSKFLCSKATTPVNIDSQAQLA 76

                          90       100
                  ....*....|....*....|....*....
gi 755550407 1095 QKILEHRKelgPYVFREAQMTIFGvLFKF 1123
Cdd:cd08742    77 DDILNAPH---PDMFKEQQLQIFN-LMKF 101
RGS-like_3 cd08730
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These ...
 408-530 6.03e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188685  Cd Length: 165  Bit Score: 38.87  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755550407  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730     6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755550407  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730    78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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