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Conserved domains on  [gi|1720389475|ref|XP_011244638|]
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serum response factor isoform X2 [Mus musculus]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 734)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 16-67 1.51e-08

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member cd00266:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 83  Bit Score: 51.11  E-value: 1.51e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLNSPD 67
Cdd:cd00266    31 ASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKKAVD 83
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 16-67 1.51e-08

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 51.11  E-value: 1.51e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLNSPD 67
Cdd:cd00266    31 ASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKKAVD 83
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 16-74 2.90e-08

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 55.02  E-value: 2.90e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQT-CLNSPDSPPRSDP 74
Cdd:COG5068   112 AFELSVLTGTEVLLLVISENGLVHTFTTPKLESVVKSLEGKSLIQSpCSNAPSDSSEEPS 171
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
16-41 6.37e-07

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 45.50  E-value: 6.37e-07
                          10        20
                  ....*....|....*....|....*.
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTF 41
Cdd:pfam00319  23 ASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS smart00432
MADS domain;
16-44 5.65e-06

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 43.31  E-value: 5.65e-06
                           10        20
                   ....*....|....*....|....*....
gi 1720389475   16 AYELSTLTGTQVLLLVASETGHVYTFATR 44
Cdd:smart00432  31 AHELSVLCDAEVALIVFSPTGKLYEFASP 59
 
Name Accession Description Interval E-value
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 16-67 1.51e-08

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 51.11  E-value: 1.51e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTFATRK-LQPMITSETGKALIQTCLNSPD 67
Cdd:cd00266    31 ASELSTLCGAEVAVIVYSPSGKLYVFWPSSeVEGVISRFEVLSALERKKKAVD 83
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 16-74 2.90e-08

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 55.02  E-value: 2.90e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQT-CLNSPDSPPRSDP 74
Cdd:COG5068   112 AFELSVLTGTEVLLLVISENGLVHTFTTPKLESVVKSLEGKSLIQSpCSNAPSDSSEEPS 171
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
16-41 6.37e-07

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 45.50  E-value: 6.37e-07
                          10        20
                  ....*....|....*....|....*.
gi 1720389475  16 AYELSTLTGTQVLLLVASETGHVYTF 41
Cdd:pfam00319  23 ASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS smart00432
MADS domain;
16-44 5.65e-06

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 43.31  E-value: 5.65e-06
                           10        20
                   ....*....|....*....|....*....
gi 1720389475   16 AYELSTLTGTQVLLLVASETGHVYTFATR 44
Cdd:smart00432  31 AHELSVLCDAEVALIVFSPTGKLYEFASP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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