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Conserved domains on  [gi|755559009|ref|XP_011244918|]
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WD repeat-containing protein 27 isoform X7 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-236 1.75e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  43 AFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDYIIM-WNVAECRE-KTLKGL 111
Cdd:COG2319  211 AFSPDGKLLasgsadgtvRLWDLATGK-LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRlWDLATGELlRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 112 TPRgtilgsllqtVLCLRFSLDDRAIAV-CAGNKISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKV 190
Cdd:COG2319  288 SGG----------VNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755559009 191 WDFCVGSLIYSssiLTAY--PLLNLLINEENQQLVTGSADGQLWIFSL 236
Cdd:COG2319  357 WDLATGELLRT---LTGHtgAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 1.40e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.40e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-236 1.75e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  43 AFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDYIIM-WNVAECRE-KTLKGL 111
Cdd:COG2319  211 AFSPDGKLLasgsadgtvRLWDLATGK-LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRlWDLATGELlRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 112 TPRgtilgsllqtVLCLRFSLDDRAIAV-CAGNKISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKV 190
Cdd:COG2319  288 SGG----------VNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755559009 191 WDFCVGSLIYSssiLTAY--PLLNLLINEENQQLVTGSADGQLWIFSL 236
Cdd:COG2319  357 WDLATGELLRT---LTGHtgAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-235 2.46e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 2.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  47 DGSrLCVWSSKDPShQLLTLQGHHQLITAVVFgNQIDPLLLCSASEDYIIMWNVAECRE-KTLKGLTprgtilgsllQTV 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHT----------GEV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 126 LCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPWQaHTLISVSEDRSFKVWDFCVGSLIYSssi 204
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--- 256

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755559009 205 LTAY--PLLNLLINEENQQLVTGSADGQLWIFS 235
Cdd:cd00200  257 LSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 1.40e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.40e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-606 6.96e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 6.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLV 592
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90
                 ....*....|....*....
gi 755559009 593 -----MCSRCFSQASNICT 606
Cdd:cd00200  217 ghengVNSVAFSPDGYLLA 235
WD40 pfam00400
WD domain, G-beta repeat;
549-581 4.51e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.51e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 755559009  549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-581 6.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.45e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755559009   549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-192 6.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 6.31e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 755559009   152 KQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 8.67e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755559009  154 SVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-236 1.75e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  43 AFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDYIIM-WNVAECRE-KTLKGL 111
Cdd:COG2319  211 AFSPDGKLLasgsadgtvRLWDLATGK-LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRlWDLATGELlRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 112 TPRgtilgsllqtVLCLRFSLDDRAIAV-CAGNKISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKV 190
Cdd:COG2319  288 SGG----------VNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755559009 191 WDFCVGSLIYSssiLTAY--PLLNLLINEENQQLVTGSADGQLWIFSL 236
Cdd:COG2319  357 WDLATGELLRT---LTGHtgAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-235 2.46e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 2.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  47 DGSrLCVWSSKDPShQLLTLQGHHQLITAVVFgNQIDPLLLCSASEDYIIMWNVAECRE-KTLKGLTprgtilgsllQTV 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHT----------GEV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 126 LCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPWQaHTLISVSEDRSFKVWDFCVGSLIYSssi 204
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--- 256

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755559009 205 LTAY--PLLNLLINEENQQLVTGSADGQLWIFS 235
Cdd:cd00200  257 LSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-236 7.17e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 7.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009   9 STDGHTRAIVTERYVVESKKSAAHVPLACSTQH------CAFPLDGSRL---------CVWSSKDPShQLLTLQGHHQLI 73
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHtgavrsVAFSPDGKTLasgsadgtvRLWDLATGK-LLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  74 TAVVF---GNqidpLLLcSASEDY-IIMWNVAECRE-KTLKGLTPRgtilgsllqtVLCLRFSLDDRAIAVCAGNK-ISV 147
Cdd:COG2319  166 TSVAFspdGK----LLA-SGSDDGtVRLWDLATGKLlRTLTGHTGA----------VRSVAFSPDGKLLASGSADGtVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 148 MDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSSSILTAyPLLNLLINEENQQLVTGSA 227
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSD 308


                 ....*....
gi 755559009 228 DGQLWIFSL 236
Cdd:COG2319  309 DGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-257 4.48e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 4.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  65 TLQGHHQLITAVVFGNqiDPLLLCSASED-YIIMWNVAECR-EKTLKGLTprgtilgsllQTVLCLRFSLDDRAIAVCAG 142
Cdd:cd00200    4 TLKGHTGGVTCVAFSP--DGKLLATGSGDgTIKVWDLETGElLRTLKGHT----------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 143 NK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSssiLTAY--PLLNLLINEEN 219
Cdd:cd00200   72 DKtIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTT---LRGHtdWVNSVAFSPDG 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755559009 220 QQLVTGSADGQLWIFSLMEG-------HHYHCVAHVDVRKKRETF 257
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGkcvatltGHTGEVNSVAFSPDGEKL 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-239 6.14e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 6.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  51 LCVWSSKDPsHQLLTLQGHHQLITAVVFGNqiDPLLLCSASEDY-IIMWNVAECR-EKTLKGLTprgtilgsllQTVLCL 128
Cdd:cd00200   75 IRLWDLETG-ECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKtIKVWDVETGKcLTTLRGHT----------DWVNSV 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 129 RFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDF----CVGSLIYSSS 203
Cdd:cd00200  142 AFSPDGTFVASSSQDGtIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLstgkCLGTLRGHEN 220

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755559009 204 ILTAypllnLLINEENQQLVTGSADGQLWIFSLMEG 239
Cdd:cd00200  221 GVNS-----VAFSPDGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-247 5.34e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 5.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  42 CAFPLDGSRLC---------VWSSKDPShQLLTLQGHHQLITAVVFGNQiDPLLLCSASEDYIIMWNvaecrektLKGLT 112
Cdd:cd00200   15 VAFSPDGKLLAtgsgdgtikVWDLETGE-LLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWD--------LETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 113 PRGTILGSLlQTVLCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVW 191
Cdd:cd00200   85 CVRTLTGHT-SYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLW 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755559009 192 DFCVGSLIYSSSILTAyPLLNLLINEENQQLVTGSADGQLWIFSLMEGHHYH-CVAH 247
Cdd:cd00200  163 DLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGH 218
WD40 COG2319
WD40 repeat [General function prediction only];
46-582 2.86e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009  46 LDGSRLCVWSSKDPSHQLLTLQGHHQLITAVVFgnQIDPLLLCSASEDYII-MWNVAEcrektlkglTPRGTILGSLLQT 124
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF--SPDGRLLASASADGTVrLWDLAT---------GLLLRTLTGHTGA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 125 VLCLRFSLDDRAIAVCAGNK-ISVMDVEKQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWDFCVGSLIYSss 203
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRT-- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 204 iLTAY--PLLNLLINEENQQLVTGSADG--QLWifslmeghhyhcvahvDVRKKRETFTtrrmmaeqcslPEDHqcrcrh 279
Cdd:COG2319  200 -LTGHtgAVRSVAFSPDGKLLASGSADGtvRLW----------------DLATGKLLRT-----------LTGH------ 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 280 eadkrgeaeaTFPILSLApcdlCLPDSQRGAFASE-CTKCLWigsstalfilNLASFELEAALHFKEFQSLSVqvagsca 358
Cdd:COG2319  246 ----------SGSVRSVA----FSPDGRLLASGSAdGTVRLW----------DLATGELLRTLTGHSGGVNSV------- 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 359 mvsepmsakAFcmlsSMFGSKIAVLEIDlaallstqqypragkvlsvlasscvlptsplyfGIIKekfpklantkqhavk 438
Cdd:COG2319  295 ---------AF----SPDGKLLASGSDD---------------------------------GTVR--------------- 313

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 439 svvedrplVFHTKVRSSGYTLAPHmamfspktnikhhnkrsskyknnykckecslenflprnlsrqvavaqkPVAVSCLQ 518
Cdd:COG2319  314 --------LWDLATGKLLRTLTGH------------------------------------------------TGAVRSVA 337

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755559009 519 FSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSV 582
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 1.40e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.40e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 3.62e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 3.62e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284
WD40 COG2319
WD40 repeat [General function prediction only];
513-587 2.86e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 2.86e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTEL 587
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 2.89e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 2.89e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
513-591 1.12e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 1.12e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL 591
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326
WD40 COG2319
WD40 repeat [General function prediction only];
513-587 6.68e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 6.68e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTEL 587
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-606 6.96e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 6.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLV 592
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90
                 ....*....|....*....
gi 755559009 593 -----MCSRCFSQASNICT 606
Cdd:cd00200  217 ghengVNSVAFSPDGYLLA 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-582 3.49e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 3.49e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSV 582
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-617 4.52e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 514 VSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTElmlllvm 593
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE------- 84

                         90       100
                 ....*....|....*....|....*
gi 755559009 594 CSRCFSQ-ASNICTVLLHGHLHTAV 617
Cdd:cd00200   85 CVRTLTGhTSYVSSVAFSPDGRILS 109
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-593 7.30e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 7.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 514 VSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLLVM 593
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 pfam00400
WD domain, G-beta repeat;
549-581 4.51e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.51e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 755559009  549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-581 6.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.45e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 755559009   549 FSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-581 2.39e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 2.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWS 581
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 547-624 4.16e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 547 AAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSVHRTELMLLL---------VMCS---------------RCFSQAS 602
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghtgpvrdVAASadgtylasgssdktiRLWDLET 82

                         90       100
                 ....*....|....*....|..
gi 755559009 603 NICTVLLHGHLHtAVFWPRVLP 624
Cdd:cd00200   83 GECVRTLTGHTS-YVSSVAFSP 103
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-192 6.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 6.31e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 755559009   152 KQSVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-582 1.46e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 1.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 513 AVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLRVWSV 582
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
WD40 pfam00400
WD domain, G-beta repeat;
154-192 8.67e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755559009  154 SVLVELKGHQGSVTAVEFCPwQAHTLISVSEDRSFKVWD 192
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
499-591 9.80e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559009 499 RNLSRQVAVAQKPVAVSCLQFSGDGQKLACGLGNHLSLVFNASLSGPPAAFSGHDGAVSTICWSHDKRWLLSTGRDRTLR 578
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90
                 ....*....|...
gi 755559009 579 VWSVHRTELMLLL 591
Cdd:COG2319  104 LWDLATGLLLRTL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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