CUE domain-containing protein 2 isoform X2 [Mus musculus]
Protein Classification
CUE domain-containing protein 2( domain architecture ID 10198899)
CUE domain-containing protein 2 (CUEDC2) is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED2 | cd14367 | CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ... |
133-172 | 1.34e-12 | ||
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain. : Pssm-ID: 270550 Cd Length: 42 Bit Score: 60.72 E-value: 1.34e-12
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| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED2 | cd14367 | CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ... |
133-172 | 1.34e-12 | ||
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain. Pssm-ID: 270550 Cd Length: 42 Bit Score: 60.72 E-value: 1.34e-12
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
135-172 | 3.39e-03 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 34.76 E-value: 3.39e-03
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| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED2 | cd14367 | CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ... |
133-172 | 1.34e-12 | ||
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain. Pssm-ID: 270550 Cd Length: 42 Bit Score: 60.72 E-value: 1.34e-12
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
135-172 | 3.39e-03 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 34.76 E-value: 3.39e-03
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| CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
135-168 | 4.10e-03 | ||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. Pssm-ID: 270465 Cd Length: 38 Bit Score: 34.37 E-value: 4.10e-03
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