NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755566436|ref|XP_011246095|]
View 

phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X2 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 13-208 4.71e-110

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03796:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 398  Bit Score: 322.65  E-value: 4.71e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:cd03796  205 RKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCI 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  93 AIVEAASCGLQVVSTKVGGIPEVLPESLIILCEPSVKSLCDGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTEK 172
Cdd:cd03796  285 AIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEK 363

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755566436 173 VYERVSKETVLPMHKRLdRLISHCGPVTGYMFALLA 208
Cdd:cd03796  364 VYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 13-208 4.71e-110

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 322.65  E-value: 4.71e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:cd03796  205 RKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCI 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  93 AIVEAASCGLQVVSTKVGGIPEVLPESLIILCEPSVKSLCDGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTEK 172
Cdd:cd03796  285 AIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEK 363

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755566436 173 VYERVSKETVLPMHKRLdRLISHCGPVTGYMFALLA 208
Cdd:cd03796  364 VYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
13-139 9.72e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 87.57  E-value: 9.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436   13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVREryqLHDRVQLLGALEhkDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:pfam13692  14 VKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 755566436   93 AIVEAASCGLQVVSTKVGGIPEVLPESLIILCEP-SVKSLCDGLEKAI 139
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 79-179 1.37e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 68.48  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  79 HIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPESLI-ILCEP-SVKSLCDGLEKAIfqvKSGTLPA--PENIH 154
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRLL---EDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|....*
gi 755566436 155 NVVKTFYTWRNVAERTEKVYERVSK 179
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEELLA 123
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
88-175 1.53e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 45.55  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  88 EAFCMAIVEAASCGLQVVSTKVGGIPEVLPESLI--ILCEP-SVKSLCDGLEKAIFQVKSGTLpaPENIHNVVKTFYTWR 164
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTLADPELTQI--AEQAKDFVFSKYSWE 365

                         90
                 ....*....|.
gi 755566436 165 NVAERTEKVYE 175
Cdd:PRK15484 366 GVTQRFEEQIH 376
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
 80-137 2.75e-03

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 38.99  E-value: 2.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755566436    80 IFLNTSLTEAFCMAIVEAASCGLQVVSTKVGG---IPEVLPESLIIlcEP-SVKSLCDGLEK 137
Cdd:TIGR02468  574 VFINPAFIEPFGLTLIEAAAHGLPMVATKNGGpvdIHRVLDNGLLV--DPhDQQAIADALLK 633
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 13-208 4.71e-110

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 322.65  E-value: 4.71e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:cd03796  205 RKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCI 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  93 AIVEAASCGLQVVSTKVGGIPEVLPESLIILCEPSVKSLCDGLEKAIFQVKSGTlPAPENIHNVVKTFYTWRNVAERTEK 172
Cdd:cd03796  285 AIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEK 363

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755566436 173 VYERVSKETVLPMHKRLdRLISHCGPVTGYMFALLA 208
Cdd:cd03796  364 VYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 9-175 6.10e-24

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 98.76  E-value: 6.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436   9 RNSLREGTDLLSGIIPELCQKYQELHFLI-GGEGPKRiilEEVRER-YQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL 86
Cdd:cd03801  200 RLSPRKGVDLLLEALAKLLRRGPDVRLVIvGGDGPLR---AELEELeLGLGDRVRFLGFVPDEELPALYAAADVFVLPSR 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  87 TEAFCMAIVEAASCGLQVVSTKVGGIPEVLP-ESLIILCEP-SVKSLCDGLEKAIfqvKSGTLPAP--ENIHNVVKTFYT 162
Cdd:cd03801  277 YEGFGLVVLEAMAAGLPVVATDVGGLPEVVEdGEGGLVVPPdDVEALADALLRLL---ADPELRARlgRAARERVAERFS 353

                        170
                 ....*....|...
gi 755566436 163 WRNVAERTEKVYE 175
Cdd:cd03801  354 WERVAERLLDLYR 366
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
13-139 9.72e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 87.57  E-value: 9.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436   13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVREryqLHDRVQLLGALEhkDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:pfam13692  14 VKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 755566436   93 AIVEAASCGLQVVSTKVGGIPEVLPESLIILCEP-SVKSLCDGLEKAI 139
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 13-139 4.03e-18

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 78.86  E-value: 4.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436   13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:pfam00534  14 EKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGI 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755566436   93 AIVEAASCGLQVVSTKVGGIPEVL-PESLIILCEP-SVKSLCDGLEKAI 139
Cdd:pfam00534  94 VLLEAMACGLPVIASDVGGPPEVVkDGETGFLVKPnNAEALAEAIDKLL 142
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 26-139 6.93e-18

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 81.98  E-value: 6.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  26 LCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVV 105
Cdd:cd03807  215 LVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHLLG--ERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVV 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755566436 106 STKVGGIPEVLPESLIILCEP-SVKSLCDGLEKAI 139
Cdd:cd03807  293 ATDVGGAAELVDDGTGFLVPAgDPQALADAIRALL 327
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 13-177 2.26e-17

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 80.50  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 92
Cdd:cd03798  212 RKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  93 AIVEAASCGLQVVSTKVGGIPEVL-PESLIILCEP-SVKSLCDGLEKAIFQVKSGTLPApENIHNVVKTFyTWRNVAERT 170
Cdd:cd03798  292 VLLEAMACGLPVVATDVGGIPEVVgDPETGLLVPPgDADALAAALRRALAEPYLRELGE-AARARVAERF-SWVKAADRI 369


                 ....*..
gi 755566436 171 EKVYERV 177
Cdd:cd03798  370 AAAYRDV 376
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 13-116 4.08e-16

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 75.13  E-value: 4.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQG-HIFLNTSLTEAFC 91
Cdd:cd01635  122 EKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAaDVFVLPSRSEGFG 201

                         90       100
                 ....*....|....*....|....*
gi 755566436  92 MAIVEAASCGLQVVSTKVGGIPEVL 116
Cdd:cd01635  202 LVLLEAMAAGKPVIATDVGGIPEFV 226
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 29-143 4.27e-15

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 73.93  E-value: 4.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  29 KYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTK 108
Cdd:cd03811  216 KYPDVKLVILGDGPLREELEKLAKELGLAERVIFLG--FQSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTD 293

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755566436 109 VGGIPEVLPESL-IILCEPSVKSLCDGLEKAIFQVK 143
Cdd:cd03811  294 CPGPREILDDGEnGLLVPDGDAAALAGILAALLQKK 329
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 79-179 1.37e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 68.48  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  79 HIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPESLI-ILCEP-SVKSLCDGLEKAIfqvKSGTLPA--PENIH 154
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRLL---EDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|....*
gi 755566436 155 NVVKTFYTWRNVAERTEKVYERVSK 179
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEELLA 123
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 28-139 3.32e-14

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 71.09  E-value: 3.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  28 QKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 107
Cdd:cd03808  216 KKGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITT 293

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755566436 108 KVGGIPE-VLPESLIILCEP-SVKSLCDGLEKAI 139
Cdd:cd03808  294 DVPGCRElVIDGVNGFLVPPgDVEALADAIEKLI 327
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 34-118 1.53e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 69.31  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  34 HFLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIP 113
Cdd:cd03819  214 RLLVAGDGPERDEIRRLVERLGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAR 291


                 ....*
gi 755566436 114 EVLPE 118
Cdd:cd03819  292 EIVVH 296
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 39-118 9.24e-13

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 66.99  E-value: 9.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  39 GEGPKRIILEEVRERYQLHDRVQLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPE 118
Cdd:cd04962  233 GDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKH 310
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 29-177 1.32e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 66.53  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  29 KYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTK 108
Cdd:cd03817  228 KEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAK 307

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436 109 VGGIPEVLPESLI-ILCEPSVKSLCDGLEKAIFQVKSGTLPApENIHNVVKTFytwrNVAERTEKVYERV 177
Cdd:cd03817  308 DPAASELVEDGENgFLFEPNDETLAEKLLHLRENLELLRKLS-KNAEISAREF----AFAKSVEKLYEEV 372
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 32-171 2.04e-12

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 66.11  E-value: 2.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  32 ELHFLIGGEGPK----RIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 107
Cdd:cd03800  253 NLVLVGGPSDDPlsmdREELAELAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVAT 332

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755566436 108 KVGGIPE-VLPESLIILCEP-SVKSLCDGLEKaIFQVKSGTLPAPENIHNVVKTFYTWRNVAERTE 171
Cdd:cd03800  333 AVGGLQDiVRDGRTGLLVDPhDPEALAAALRR-LLDDPALWQRLSRAGLERARAHYTWESVADQLL 397
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 23-116 2.23e-12

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 65.93  E-value: 2.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  23 IPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGL 102
Cdd:cd04951  210 ISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQ--ISNISEYYNAADLFVLSSEWEGFGLVVAEAMACER 287

                         90
                 ....*....|....
gi 755566436 103 QVVSTKVGGIPEVL 116
Cdd:cd04951  288 PVVATDAGGVAEVV 301
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 26-116 6.75e-11

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 61.70  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  26 LCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLT------EAFCMAIVEAAS 99
Cdd:cd03799  199 LAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMA 278

                         90
                 ....*....|....*..
gi 755566436 100 CGLQVVSTKVGGIPEVL 116
Cdd:cd03799  279 MGLPVISTEHGGIPELV 295
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 15-106 9.65e-11

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 61.10  E-value: 9.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  15 GTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALehKDVRNVLVQGHIFLNTSLTEAFCMAI 94
Cdd:cd03820  195 GFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPT--KNIAEEYANSSIFVLSSRYEGFPMVL 272

                         90
                 ....*....|..
gi 755566436  95 VEAASCGLQVVS 106
Cdd:cd03820  273 LEAMAYGLPIIS 284
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 36-172 1.91e-10

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 60.07  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  36 LIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEV 115
Cdd:cd03809  228 IVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEV 307

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755566436 116 LPESlIILCEP-SVKSLCDGLEKAIFQvKSGTLPAPENIHNVVKTFyTWRNVAERTEK 172
Cdd:cd03809  308 AGDA-ALYFDPlDPESIADAILRLLED-PSLREELIRKGLERAKKF-SWEKTAEKTLE 362
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 13-114 2.73e-09

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 56.69  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYqlhDRVQLLGALEHKDVRNVLVQGHIFLNTSLT----- 87
Cdd:cd05844  201 KKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasgd 277

                         90       100
                 ....*....|....*....|....*...
gi 755566436  88 -EAFCMAIVEAASCGLQVVSTKVGGIPE 114
Cdd:cd05844  278 sEGLGIVLLEAAACGVPVVSSRHGGIPE 305
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 17-139 6.82e-09

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 55.54  E-value: 6.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  17 DLLSGIIPELCQKYQEL-----HflIGGeGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQG--HIFLNTSLTEA 89
Cdd:cd04946  240 DLIIETLNSLCVAHPSIciswtH--IGG-GPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKENdvDVFVNVSESEG 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755566436  90 FCMAIVEAASCGLQVVSTKVGGIPEVLPES---LIILCEPSVKSLCDGLEKAI 139
Cdd:cd04946  317 IPVSIMEAISFGIPVIATNVGGTREIVENEtngLLLDKDPTPNEIVSSIMKFY 369
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 13-171 8.92e-09

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 55.45  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  13 REGTDLLSGIIPELCQKYQELHFLIGGEGPKriiLEEVRERYQ----LHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTE 88
Cdd:cd03821  216 KKGLDLLIRAARKLAEQGRDWHLVIAGPDDG---AYPAFLQLQsslgLGDRVTFTGPLYGEAKWALYASADLFVLPSYSE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  89 AFCMAIVEAASCGLQVVSTKVGGIPEVLPESLIILCEPSVKSLCDGLEKAIfQVKSGTLPAPENIHNVVKT--FYTWRNV 166
Cdd:cd03821  293 NFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEAL-RDPADRKRLGEMARRARQVeeNFSWEAV 371


                 ....*
gi 755566436 167 AERTE 171
Cdd:cd03821  372 AGQLG 376
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 17-119 1.83e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 54.22  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  17 DLLSGIIPELCQKyQELHFLIGGEGPKRiilEEVRERYqlhDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVE 96
Cdd:cd03814  214 EALLDADLPLAAS-PPVRLVVVGDGPAR---AELEARG---PDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLE 286

                         90       100
                 ....*....|....*....|...
gi 755566436  97 AASCGLQVVSTKVGGIPEVLPES 119
Cdd:cd03814  287 AMASGLPVVAADAGGPRDIVRPG 309
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 29-111 5.90e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 52.66  E-value: 5.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  29 KYQELHFLIGGEGPKRIILEEVRErYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL--TEAFCMAIVEAASCGLQVVS 106
Cdd:cd03795  214 QYLNYPIVIGGEGPLKPDLEAQIE-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVIS 292


                 ....*
gi 755566436 107 TKVGG 111
Cdd:cd03795  293 TNIGT 297
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 15-176 1.12e-06

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 48.86  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  15 GTDLLSGIIPELcqKYQELHFLIGGEGPKRIIleevrERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSL-TEAFCMA 93
Cdd:cd03823  205 GIDLLVEAFKRL--PREDIELVIAGHGPLSDE-----RQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLV 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  94 IVEAASCGLQVVSTKVGGIPE-VLPESLIILCEPSVKslcDGLEKAIFQV-KSGTLPAPENIHNVVKTFYTWRnvAERTE 171
Cdd:cd03823  278 VREAIAAGLPVIASDLGGIAElIQPGVNGLLFAPGDA---EDLAAAMRRLlTDPALLERLRAGAEPPRSTESQ--AEEYL 352


                 ....*
gi 755566436 172 KVYER 176
Cdd:cd03823  353 KLYRD 357
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 17-109 6.35e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 46.53  E-value: 6.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  17 DLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVE 96
Cdd:cd04949  176 DHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY--HSNLDQEYQDAYLSLLTSQMEGFGLTLME 253

                         90
                 ....*....|...
gi 755566436  97 AASCGLQVVSTKV 109
Cdd:cd04949  254 AIGHGLPVVSYDV 266
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
88-175 1.53e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 45.55  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  88 EAFCMAIVEAASCGLQVVSTKVGGIPEVLPESLI--ILCEP-SVKSLCDGLEKAIFQVKSGTLpaPENIHNVVKTFYTWR 164
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTLADPELTQI--AEQAKDFVFSKYSWE 365

                         90
                 ....*....|.
gi 755566436 165 NVAERTEKVYE 175
Cdd:PRK15484 366 GVTQRFEEQIH 376
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 36-116 2.37e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 45.02  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  36 LIGGEGPKRIILEEVRERYQ---LHDRVQLLGaleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGI 112
Cdd:cd03813  329 LIGPEDEDPEYAQECKRLVAslgLENKVKFLG---FQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSC 405


                 ....
gi 755566436 113 PEVL 116
Cdd:cd03813  406 RELI 409
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 32-116 5.16e-05

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 43.86  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  32 ELHFlIGGEGPKRIILE-EVRERYQLHDRVQLlgalehkdvRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVG 110
Cdd:cd03825  227 LLVV-FGKNDPQIVILPfDIISLGYIDDDEQL---------VDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTG 296


                 ....*.
gi 755566436 111 GIPEVL 116
Cdd:cd03825  297 GSPEIV 302
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 58-177 2.49e-04

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 41.50  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436  58 DRVQLLGALEHKDVRNVLVQGHIFLNTSL-TEAFCMAIVEAASCGLQVVSTKVGGIPEVLPESliilcepSVKSLCDGLE 136
Cdd:cd03802  220 PRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHG-------ETGFLVDSVE 292

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755566436 137 KAIFQVKS-GTLPaPENIHNVVKTFYTWRNVAERTEKVYERV 177
Cdd:cd03802  293 EMAEAIANiDRID-RAACRRYAEDRFSAARMADRYEALYRKV 333
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 6-105 9.67e-04

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 39.97  E-value: 9.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566436   6 NRQRNSLRegtdLLSgIIPELCQKYQELHFLIGGEGPKRI-ILEEVRERyQLHDRVQLLGalEHKDVRNVLVQGHIFLNT 84
Cdd:cd03812  201 NEQKNHSF----LID-IFEELKKKNPNVKLVLVGEGELKEkIKEKVKEL-GLEDKVIFLG--FRNDVSEILSAMDVFLFP 272

                         90       100
                 ....*....|....*....|.
gi 755566436  85 SLTEAFCMAIVEAASCGLQVV 105
Cdd:cd03812  273 SLYEGLPLVAVEAQASGLPCL 293
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
 80-137 2.75e-03

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 38.99  E-value: 2.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755566436    80 IFLNTSLTEAFCMAIVEAASCGLQVVSTKVGG---IPEVLPESLIIlcEP-SVKSLCDGLEK 137
Cdd:TIGR02468  574 VFINPAFIEPFGLTLIEAAAHGLPMVATKNGGpvdIHRVLDNGLLV--DPhDQQAIADALLK 633
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH