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Conserved domains on  [gi|755502798|ref|XP_011248012|]
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leucine-rich repeat and IQ domain-containing protein 4 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-447 6.43e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.42  E-value: 6.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 179 SLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVA 258
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 259 SNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPrllcswvslhllylrntslhglrdSF 338
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP------------------------EL 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 339 KRLINLRFLDLSQNHIEHFPvQICALKNLEILALDDNKVRQLP----PSISLLSNLKILGLTGNDLLSFPEEIFSLISLE 414
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                        250       260       270
                 ....*....|....*....|....*....|...
gi 755502798 415 KLYIGQDQGSKLSSLPENIKRLMLPTRTLTDLH 447
Cdd:COG4886  326 LLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-447 6.43e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.42  E-value: 6.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 179 SLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVA 258
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 259 SNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPrllcswvslhllylrntslhglrdSF 338
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP------------------------EL 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 339 KRLINLRFLDLSQNHIEHFPvQICALKNLEILALDDNKVRQLP----PSISLLSNLKILGLTGNDLLSFPEEIFSLISLE 414
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                        250       260       270
                 ....*....|....*....|....*....|...
gi 755502798 415 KLYIGQDQGSKLSSLPENIKRLMLPTRTLTDLH 447
Cdd:COG4886  326 LLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-405 7.72e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 7.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  53 VLQKKEPHQLTDRT---FFIDGSNQGLKTIPSEILALKELEEVHL-ENNQIAEIPQGIQQLQNTKVLYL-HNNSLQDLCP 127
Cdd:PLN00113 175 VLVGKIPNSLTNLTsleFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLvYNNLTGPIPS 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 128 ELGALSSLESLDLSGNPL---VISSLHVVSRLRTLRELRLYRTGltEIPTGIC--KSLHHLELFglSENFLESLPEEIVN 202
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLsgpIPPSIFSLQKLISLDLSDNSLSG--EIPELVIqlQNLEILHLF--SNNFTGKIPVALTS 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 203 QTKLREIYLKQNHFE-VFPCDLCVLYNLEVIDLDENKLKS-IPG---DIGHLVRLQKFyvaSNHLMS-LPESLSQCSKLS 276
Cdd:PLN00113 331 LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEglcSSGNLFKLILF---SNSLEGeIPKSLGACRSLR 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 277 VLDLTHNSIH-SLPSSLELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYL-RNTSLHGLRDSFkRLINLRFLDLSQNH 353
Cdd:PLN00113 408 RVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLaRNKFFGGLPDSF-GSKRLENLDLSRNQ 486

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755502798 354 I-EHFPVQICALKNLEILALDDNKVR-QLPPSISLLSNLKILGLTGNDL-----LSFPE 405
Cdd:PLN00113 487 FsGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLsgqipASFSE 545
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 222-398 2.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 222 DLCVLYNLEVIDLDENKLKSIPGdIGHLVRLQKFYVASNHLMSLpESLSQCSKLSVLDLTHNSIHSLpSSLELLTELTEV 301
Cdd:cd21340   19 NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 302 GLSGNRLEKVPRLLcswvslhllyLRNTSLHGLRDSfkrlinLRFLDLSQNHIEhFPVQICALKNLEILALDDNKVR--- 378
Cdd:cd21340   96 HIENQRLPPGEKLT----------FDPRSLAALSNS------LRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISdle 158

                        170       180
                 ....*....|....*....|
gi 755502798 379 QLPPSISLLSNLKILGLTGN 398
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
320-377 8.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  320 SLHLLYLRNTSLHGLRD-SFKRLINLRFLDLSQNHIEHF-PVQICALKNLEILALDDNKV 377
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-447 6.43e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.42  E-value: 6.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 179 SLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVA 258
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 259 SNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPrllcswvslhllylrntslhglrdSF 338
Cdd:COG4886  191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP------------------------EL 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 339 KRLINLRFLDLSQNHIEHFPvQICALKNLEILALDDNKVRQLP----PSISLLSNLKILGLTGNDLLSFPEEIFSLISLE 414
Cdd:COG4886  247 GNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325

                        250       260       270
                 ....*....|....*....|....*....|...
gi 755502798 415 KLYIGQDQGSKLSSLPENIKRLMLPTRTLTDLH 447
Cdd:COG4886  326 LLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
185-448 9.34e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 9.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 185 LFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNhlms 264
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 265 lpESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINL 344
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 345 RFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPeEIFSLISLEKLYIGQDQGS 424
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                        250       260
                 ....*....|....*....|....*.
gi 755502798 425 KLSSLPE--NIKRLMLPTRTLTDLHV 448
Cdd:COG4886  264 DLPPLANltNLKTLDLSNNQLTDLKL 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-420 5.36e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 5.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  80 PSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGalsslesldlsgnplvisslhvvsrlrtl 159
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG----------------------------- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 160 relrlyrtglteiptgickSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKL 239
Cdd:COG4886  157 -------------------NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 240 KSIPGDIGHLVRLQKFYVASNHLMSLPEsLSQCSKLSVLDLTHNSIHSLPSSLELlTELTEVGLSGNRLEKVPRLLCSWV 319
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 320 SLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGND 399
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375

                        330       340
                 ....*....|....*....|.
gi 755502798 400 LLSFPEEIFSLISLEKLYIGQ 420
Cdd:COG4886  376 EATLLTLALLLLTLLLLLLTT 396
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-387 4.37e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 4.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  69 IDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALSSLESLDLSGNPlvis 148
Cdd:COG4886  118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ---- 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 149 slhvvsrlrtlrelrlyrtgLTEIPTGICKsLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPcDLCVLYN 228
Cdd:COG4886  194 --------------------ITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 229 LEVIDLDENKLKSIPgDIGHLVRLQKFYVASNHLMSLpeSLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRL 308
Cdd:COG4886  252 LEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755502798 309 EKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLL 387
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-405 7.72e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 7.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  53 VLQKKEPHQLTDRT---FFIDGSNQGLKTIPSEILALKELEEVHL-ENNQIAEIPQGIQQLQNTKVLYL-HNNSLQDLCP 127
Cdd:PLN00113 175 VLVGKIPNSLTNLTsleFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLvYNNLTGPIPS 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 128 ELGALSSLESLDLSGNPL---VISSLHVVSRLRTLRELRLYRTGltEIPTGIC--KSLHHLELFglSENFLESLPEEIVN 202
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLsgpIPPSIFSLQKLISLDLSDNSLSG--EIPELVIqlQNLEILHLF--SNNFTGKIPVALTS 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 203 QTKLREIYLKQNHFE-VFPCDLCVLYNLEVIDLDENKLKS-IPG---DIGHLVRLQKFyvaSNHLMS-LPESLSQCSKLS 276
Cdd:PLN00113 331 LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEglcSSGNLFKLILF---SNSLEGeIPKSLGACRSLR 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 277 VLDLTHNSIH-SLPSSLELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYL-RNTSLHGLRDSFkRLINLRFLDLSQNH 353
Cdd:PLN00113 408 RVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLaRNKFFGGLPDSF-GSKRLENLDLSRNQ 486

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755502798 354 I-EHFPVQICALKNLEILALDDNKVR-QLPPSISLLSNLKILGLTGNDL-----LSFPE 405
Cdd:PLN00113 487 FsGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLsgqipASFSE 545
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
168-445 2.92e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.04  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 168 GLTEIPTGICKSLHHLELfglSENFLESLPEEIvnQTKLREIYLKQNHFEVFPCDLCvlYNLEVIDLDENKLksipgdig 247
Cdd:PRK15370 189 GLTTIPACIPEQITTLIL---DNNELKSLPENL--QGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRI-------- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 248 hlvrlqkfyvasnhlMSLPESLSqcSKLSVLDLTHNSIHSLPSSLEllTELTEVGLSGNRLEKVPRLLCSwvSLHLLYLR 327
Cdd:PRK15370 254 ---------------TELPERLP--SALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 328 NTSLHGLRDSFKrlINLRFLDLSQNHIEHFPVQI-CALKNLEIlalDDNKVRQLPPsiSLLSNLKILGLTGNDLLSFPEE 406
Cdd:PRK15370 313 SNSLTALPETLP--PGLKTLEAGENALTSLPASLpPELQVLDV---SKNQITVLPE--TLPPTITTLDVSRNALTNLPEN 385

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 755502798 407 IFSlisleKLYIGQDQGSKLSSLPENIKRLM----LPTRTLTD 445
Cdd:PRK15370 386 LPA-----ALQIMQASRNNLVRLPESLPHFRgegpQPTRIIVE 423
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-401 5.17e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 5.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  62 LTDRTFFIDGSNQGLKTIPSEILALKELEEVHLENNQIA-EIPQGIQQLQNTKVLYLHNNSLQDLCPE-LGALSSLESLD 139
Cdd:PLN00113 259 LKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVaLTSLPRLQVLQ 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 140 LSGNPL---VISSLHVVSRLRTLRELRLYRTGltEIPTGICKSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHF 216
Cdd:PLN00113 339 LWSNKFsgeIPKNLGKHNNLTVLDLSTNNLTG--EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF 416

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 217 E-VFPCDLCVLYNLEVIDLDENKLK-SIPGDIGHLVRLQKFYVASNHLM-SLPESlSQCSKLSVLDLTHNSIH-SLPSSL 292
Cdd:PLN00113 417 SgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDS-FGSKRLENLDLSRNQFSgAVPRKL 495

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 293 ELLTELTEVGLSGNRLE-KVPRLLCSWVSLHLLYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQICALKNLEI 369
Cdd:PLN00113 496 GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                        330       340       350
                 ....*....|....*....|....*....|..
gi 755502798 370 LALDDNKVRQLPPSISLLSNLKILGLTGNDLL 401
Cdd:PLN00113 576 VNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-400 1.60e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  72 SNQGLKTIPSEILAL-KELEEVHLENNQIA-EIPQGiqQLQNTKVLYLHNNSLQDLCP-ELGALSSLESLDLSGNPLVis 148
Cdd:PLN00113 102 NNQLSGPIPDDIFTTsSSLRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSGEIPnDIGSFSSLKVLDLGGNVLV-- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 149 slhvvsrlrtlrelrlyrtglTEIPTGICKsLHHLELFGLSEN-FLESLPEEIVNQTKLREIYLKQNHFE-VFPCDLCVL 226
Cdd:PLN00113 178 ---------------------GKIPNSLTN-LTSLEFLTLASNqLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGL 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 227 YNLEVIDLDENKLK-SIPGDIGHLVRLQKFYVASNHLM-SLPESLSQCSKLSVLDLTHNSIH-SLPSSLELLTELTEVGL 303
Cdd:PLN00113 236 TSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 304 SGNRLE-KVPRLLCSWVSLHLLYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQICALKNLEILALDDNKVR-Q 379
Cdd:PLN00113 316 FSNNFTgKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgE 395

                        330       340
                 ....*....|....*....|.
gi 755502798 380 LPPSISLLSNLKILGLTGNDL 400
Cdd:PLN00113 396 IPKSLGACRSLRRVRLQDNSF 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 222-398 2.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 222 DLCVLYNLEVIDLDENKLKSIPGdIGHLVRLQKFYVASNHLMSLpESLSQCSKLSVLDLTHNSIHSLpSSLELLTELTEV 301
Cdd:cd21340   19 NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 302 GLSGNRLEKVPRLLcswvslhllyLRNTSLHGLRDSfkrlinLRFLDLSQNHIEhFPVQICALKNLEILALDDNKVR--- 378
Cdd:cd21340   96 HIENQRLPPGEKLT----------FDPRSLAALSNS------LRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISdle 158

                        170       180
                 ....*....|....*....|
gi 755502798 379 QLPPSISLLSNLKILGLTGN 398
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
169-412 8.15e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 57.86  E-value: 8.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 169 LTEIPtGICKSLHHLELFGlseNFLESLPeeiVNQTKLREIYLKQN---HFEVFPCDLCVLYnlevidLDENKLKSIP-- 243
Cdd:PRK15387 234 LTSLP-ALPPELRTLEVSG---NQLTSLP---VLPPGLLELSIFSNpltHLPALPSGLCKLW------IFGNQLTSLPvl 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 244 --GdighlvrLQKFYVASNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLEllteltEVGLSGNRLEKVPRLLCSWVSL 321
Cdd:PRK15387 301 ppG-------LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQ------ELSVSDNQLASLPTLPSELYKL 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 322 HLLYLRNTSLHGLRDSFKRLInlrfldLSQNHIEHFPVQICALKNLEIlalDDNKVRQLPpsiSLLSNLKILGLTGNDLL 401
Cdd:PRK15387 368 WAYNNRLTSLPALPSGLKELI------VSGNRLTSLPVLPSELKELMV---SGNRLTSLP---MLPSGLLSLSVYRNQLT 435

                        250
                 ....*....|.
gi 755502798 402 SFPEEIFSLIS 412
Cdd:PRK15387 436 RLPESLIHLSS 446
PLN03150 PLN03150
hypothetical protein; Provisional
 232-312 5.49e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 5.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 232 IDLDENKLKS-IPGDIGHLVRLQKFYVASNHLM-SLPESLSQCSKLSVLDLTHNSIH-SLPSSLELLTELTEVGLSGNRL 308
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*
gi 755502798 309 E-KVP 312
Cdd:PLN03150 503 SgRVP 507
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 239-400 1.07e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 239 LKSIPGDIGHLVRLQKFYVASN----HLMSLPESLSQCSKLSVLDLTHNSI------HSLPSSLELLTELTEVGLSGNRL 308
Cdd:cd00116   70 LQSLLQGLTKGCGLQELDLSDNalgpDGCGVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPPALEKLVLGRNRL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 309 EKVP-----RLLCSWVSLHLLYLRNTSLHG-----LRDSFKRLINLRFLDLSQNHIEHFPVQICA-----LKNLEILALD 373
Cdd:cd00116  150 EGAScealaKALRANRDLKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTDEGASALAetlasLKSLEVLNLG 229

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755502798 374 DNKVRQ------LPPSISLLSNLKILGLTGNDL 400
Cdd:cd00116  230 DNNLTDagaaalASALLSPNISLLTLSLSCNDI 262
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 168-376 2.82e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 168 GLTEIPT-GICKSLHHLELFglsENFLESLpEEIVNQTKLREIYLKQNHFEVFpCDLCVLYNLEVIDLDENKLKSIPGdI 246
Cdd:cd21340   13 NITKIDNlSLCKNLKVLYLY---DNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVEG-L 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 247 GHLVRLQKFYVASNHL---MSL---PESLSQCSK-LSVLDLTHNSIHSLpSSLELLTELTEVGLSGNRLEkvprllcswv 319
Cdd:cd21340   87 ENLTNLEELHIENQRLppgEKLtfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS---------- 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755502798 320 slhllylrntSLHGLRDSFKRLINLRFLDLSQNHIEHFP----VQICALKNLEILaldDNK 376
Cdd:cd21340  156 ----------DLEELLDLLSSWPSLRELDLTGNPVCKKPkyrdKIILASKSLEVL---DGK 203
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
231-448 6.57e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 6.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 231 VIDLDENKLKSIPGDI-GHLVRLqkfYVASNHLMSLPeslSQCSKLSVLDLTHNSIHSLPSsleLLTELTEVGLSGNRLE 309
Cdd:PRK15387 205 VLNVGESGLTTLPDCLpAHITTL---VIPDNNLTSLP---ALPPELRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 310 KVPRLLCSWVSLHLLYLRNTSLHGLRDSfkrlinLRFLDLSQNHIEHFPV---QICALKNLeilaldDNKVRQLPpsiSL 386
Cdd:PRK15387 276 HLPALPSGLCKLWIFGNQLTSLPVLPPG------LQELSVSDNQLASLPAlpsELCKLWAY------NNQLTSLP---TL 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755502798 387 LSNLKILGLTGNDLLSFPeeifSLIS-LEKLYIGQDQGSKLSSLPENIKRLMLPTRTLTDLHV 448
Cdd:PRK15387 341 PSGLQELSVSDNQLASLP----TLPSeLYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPV 399
LRR_8 pfam13855
Leucine rich repeat;
320-377 8.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  320 SLHLLYLRNTSLHGLRD-SFKRLINLRFLDLSQNHIEHF-PVQICALKNLEILALDDNKV 377
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
251-308 3.02e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  251 RLQKFYVASNHLMSL-PESLSQCSKLSVLDLTHNSIHSL-PSSLELLTELTEVGLSGNRL 308
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 324-400 5.32e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 5.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 324 LYLRNTSLHG-LRDSFKRLINLRFLDLSQNHIE-HFPVQICALKNLEILALDDNKVR-QLPPSISLLSNLKILGLTGNDL 400
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
167-310 1.39e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 167 TGLTEIPTGICKslhhLELFGlseNFLESLPeeiVNQTKLREIYLKQNHFE---VFPCDLCVL--YN------------L 229
Cdd:PRK15387 275 THLPALPSGLCK----LWIFG---NQLTSLP---VLPPGLQELSVSDNQLAslpALPSELCKLwaYNnqltslptlpsgL 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 230 EVIDLDENKLKSIPGDIGHLVRL-----------------QKFYVASNHLMSLPESLSQCSKLSV--------------- 277
Cdd:PRK15387 345 QELSVSDNQLASLPTLPSELYKLwaynnrltslpalpsglKELIVSGNRLTSLPVLPSELKELMVsgnrltslpmlpsgl 424

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755502798 278 --LDLTHNSIHSLPSSLELLTELTEVGLSGNRLEK 310
Cdd:PRK15387 425 lsLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 188-436 1.66e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  188 LSENFLESLPEEIVNQTKLREIYLK--QNHFEVfPcDLCVLYNLEVIDL-DENKLKSIPGDIGHLVRLQKFYVAS-NHLM 263
Cdd:PLN03210  618 MQGSKLEKLWDGVHSLTGLRNIDLRgsKNLKEI-P-DLSMATNLETLKLsDCSSLVELPSSIQYLNKLEDLDMSRcENLE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  264 SLPE----------SLSQCSKL----------SVLDLTHNSIHSLPSSLElLTELTEVGLSGNRLEKV--------PRLL 315
Cdd:PLN03210  696 ILPTginlkslyrlNLSGCSRLksfpdistniSWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLwervqpltPLMT 774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  316 CSWVSLHLLYLRNT-SLHGLRDSFKRLINLRFLDLSQ-NHIEHFPVQIcalkNLEIL-ALDDNKVRQLP--PSISllSNL 390
Cdd:PLN03210  775 MLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENcINLETLPTGI----NLESLeSLDLSGCSRLRtfPDIS--TNI 848

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 755502798  391 KILGLTGNDLLSFPEEIFSLISLEklYIGQDQGSKLSSLPENIKRL 436
Cdd:PLN03210  849 SDLNLSRTGIEEVPWWIEKFSNLS--FLDMNGCNNLQRVSLNISKL 892
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 48-309 1.97e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798  48 EHLPKVLQKKEPhQLTDRTFfidgSNQGLKTIPSEILALKELEEVHLENNQIAEIPQG----IQQLQNT---KVLYLHNN 120
Cdd:cd00116   17 ELLPKLLCLQVL-RLEGNTL----GEEAAKALASALRPQPSLKELCLSLNETGRIPRGlqslLQGLTKGcglQELDLSDN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 121 SLQ-DLCPELGALsslesldlsgnpLVISSLHVVSrlrtLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFL-----E 194
Cdd:cd00116   92 ALGpDGCGVLESL------------LRSSSLQELK----LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLegascE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502798 195 SLPEEIVNQTKLREIYLKQNH-----FEVFPCDLCVLYNLEVIDLDENKLKSIpGDIghlvrlqkfyvasnhlmSLPESL 269
Cdd:cd00116  156 ALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDE-GAS-----------------ALAETL 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755502798 270 SQCSKLSVLDLTHNSIHS------LPSSLELLTELTEVGLSGNRLE 309
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDIT 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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