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Conserved domains on  [gi|755510850|ref|XP_011248045|]
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voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X7 [Mus musculus]

Protein Classification

vWA domain-containing protein( domain architecture ID 10552118)

vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, hemostasis, signaling, chromosomal stability, malignant transformation, and immune defenses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWA_N pfam08399
VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand ...
 104-223 1.06e-55

VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.


:

Pssm-ID: 462464  Cd Length: 122  Bit Score: 175.95  E-value: 1.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755510850  104 AEKVQAAHQWREDFAsNEVVYYNAKDDLDPERNESEPGSQRIKPVF--IEDANFGRQ-ISYQHAAVHIPTDIYEGSTIVL 180
Cdd:pfam08399   1 AEKAAEDHEWNDNVP-NDFQYYNAKYSNDVGEDYEKGNNVPLSKEFvlTPNPHFYNIpVNTNYSAVHVPTNVYDRAPDVL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755510850  181 NELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPW 223
Cdd:pfam08399  80 NGINWSEALDDVFRDNYEEDPSLSWQYFGSATGFFRYYPASKW 122
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 239-293 3.05e-25

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01463:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 190  Bit Score: 99.39  E-value: 3.05e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755510850 239 RRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAS 293
Cdd:cd01463    1 RNRSWYIQAATSPKDIVILLDVSGSMTGQRLHLAKQTVSSILDTLSDNDFFNIIT 55
 
Name Accession Description Interval E-value
VWA_N pfam08399
VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand ...
 104-223 1.06e-55

VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.


Pssm-ID: 462464  Cd Length: 122  Bit Score: 175.95  E-value: 1.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755510850  104 AEKVQAAHQWREDFAsNEVVYYNAKDDLDPERNESEPGSQRIKPVF--IEDANFGRQ-ISYQHAAVHIPTDIYEGSTIVL 180
Cdd:pfam08399   1 AEKAAEDHEWNDNVP-NDFQYYNAKYSNDVGEDYEKGNNVPLSKEFvlTPNPHFYNIpVNTNYSAVHVPTNVYDRAPDVL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755510850  181 NELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPW 223
Cdd:pfam08399  80 NGINWSEALDDVFRDNYEEDPSLSWQYFGSATGFFRYYPASKW 122
vWA_VGCC_like cd01463
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five ...
 239-293 3.05e-25

VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at its N-terminus the VWA and cache domains, The alpha 2 delta gene family has orthologues in D. melanogaster and C. elegans but none have been detected in aither A. thaliana or yeast. The exact biochemical function of the VWA domain is not known but the alpha 2 delta complex has been shown to regulate various functional properties of the channel complex.


Pssm-ID: 238740 [Multi-domain]  Cd Length: 190  Bit Score: 99.39  E-value: 3.05e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755510850 239 RRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAS 293
Cdd:cd01463    1 RNRSWYIQAATSPKDIVILLDVSGSMTGQRLHLAKQTVSSILDTLSDNDFFNIIT 55
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 246-291 3.03e-04

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 41.63  E-value: 3.03e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755510850 246 QGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNV 291
Cdd:COG2304   86 AEERPPLNLVFVIDVSGSMSGDKLELAKEAAKLLVDQLRPGDRVSI 131
 
Name Accession Description Interval E-value
VWA_N pfam08399
VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand ...
 104-223 1.06e-55

VWA N-terminal; This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.


Pssm-ID: 462464  Cd Length: 122  Bit Score: 175.95  E-value: 1.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755510850  104 AEKVQAAHQWREDFAsNEVVYYNAKDDLDPERNESEPGSQRIKPVF--IEDANFGRQ-ISYQHAAVHIPTDIYEGSTIVL 180
Cdd:pfam08399   1 AEKAAEDHEWNDNVP-NDFQYYNAKYSNDVGEDYEKGNNVPLSKEFvlTPNPHFYNIpVNTNYSAVHVPTNVYDRAPDVL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755510850  181 NELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPW 223
Cdd:pfam08399  80 NGINWSEALDDVFRDNYEEDPSLSWQYFGSATGFFRYYPASKW 122
vWA_VGCC_like cd01463
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five ...
 239-293 3.05e-25

VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at its N-terminus the VWA and cache domains, The alpha 2 delta gene family has orthologues in D. melanogaster and C. elegans but none have been detected in aither A. thaliana or yeast. The exact biochemical function of the VWA domain is not known but the alpha 2 delta complex has been shown to regulate various functional properties of the channel complex.


Pssm-ID: 238740 [Multi-domain]  Cd Length: 190  Bit Score: 99.39  E-value: 3.05e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755510850 239 RRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAS 293
Cdd:cd01463    1 RNRSWYIQAATSPKDIVILLDVSGSMTGQRLHLAKQTVSSILDTLSDNDFFNIIT 55
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 246-291 3.03e-04

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 41.63  E-value: 3.03e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755510850 246 QGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNV 291
Cdd:COG2304   86 AEERPPLNLVFVIDVSGSMSGDKLELAKEAAKLLVDQLRPGDRVSI 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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