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Conserved domains on  [gi|755532618|ref|XP_011248168|]
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uncharacterized protein LOC630836 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 50-90 6.27e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 6.27e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755532618   50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 90
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-475 1.80e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 119 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 195
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 196 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 252
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 253 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 308
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 309 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 371
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 372 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 440
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 755532618 441 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 475
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 50-90 6.27e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 6.27e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755532618   50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 90
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
50-91 1.03e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 1.03e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 755532618    50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIGY 91
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 50-87 6.85e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 6.85e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 755532618  50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLT 87
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-475 1.80e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 119 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 195
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 196 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 252
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 253 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 308
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 309 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 371
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 372 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 440
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 755532618 441 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 475
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 2.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 755532618  247 HLQRHKRTHTGEKPYVCNQCGKAFAY 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 50-90 6.27e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 6.27e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755532618   50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 90
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
50-91 1.03e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 1.03e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 755532618    50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIGY 91
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 50-87 6.85e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 6.85e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 755532618  50 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLT 87
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-475 1.80e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 119 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 195
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 196 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 252
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 253 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 308
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 309 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 371
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 372 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 440
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 755532618 441 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 475
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-478 1.65e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 175 KPYECDQCGTAFASHCRLQRHKRTHTGEKPYECNQ--CGKAFTQHSTLQVHKRTHTGEKPYECS-QCGKAYSRHSHLQRH 251
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 252 KRTHTGEKPYVCNQCGKAFAYQNSLQYHKRTHTGEKSYECKQCGKFFP-----------------------CRKHLQIHK 308
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpssNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 309 RTHAGQKGYECNKCGKAFAFHSHFQRHKRHIGEKPYECNHCDKAF------ASHNNLQKHIRRHTGEKPYKCNLCDKAYA 382
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 383 HHSHLQTHERVHT-EEKPYKCNQCDKAFSQQSSLQVHKR--IHTGE--KPYEC--NQCGKAFTCHRYLQRHKRTHTGEKP 455
Cdd:COG5048  272 SSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340
                 ....*....|....*....|...
gi 755532618 456 YECnqfgkIFAQHSTVHSIKKGN 478
Cdd:COG5048  352 AKE-----KLLNSSSKFSPLLNN 369
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-446 9.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 9.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 215 TQHSTLQVHKRTHTGE----KPYECSQCGKAYSRHSHLQRHKRTHTGEKPYVCNQCGKAFAYQN--SLQYHKRTHTGEKS 288
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 289 YEC-KQCGKFFPCRKHLQIHKRTHAGQKGYECNKCGKAFAFHS---HFQRHKRHIGEKPYE-CNHCDKAFASHNNLQKHI 363
Cdd:COG5048   92 DLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDpqlPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 364 RRHtgekpykcNLCDKAYAHHSHLqTHERVHTEEKPYKCNQCDKAFSQQSSLQVHKRIHTGEKPYECNQCGKAFTCHRYL 443
Cdd:COG5048  172 PAN--------SLSKDPSSNLSLL-ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLS 242


                 ...
gi 755532618 444 QRH 446
Cdd:COG5048  243 QSP 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 2.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 755532618  247 HLQRHKRTHTGEKPYVCNQCGKAFAY 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
191-216 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 755532618  191 RLQRHKRTHTGEKPYECNQCGKAFTQ 216
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 201-284 5.38e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 201 GEKPYECN--QCGKAFTQHSTLQVHKRThtgekpyecSQCGKAYSRHSHLQRHKRTHTGEKPYVCNQCGKAFAYQNSLQY 278
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 755532618 279 HkRTHT 284
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-383 8.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 755532618  358 NLQKHIRRHTGEKPYKCNLCDKAYAH 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-439 9.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 755532618  414 SLQVHKRIHTGEKPYECNQCGKAFTC 439
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-419 9.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 339 IGEKPYECN--HCDKAFASHNNLQKHiRRHTGEKPYKCNLCDKayahhshlQTHERVHTEEKPYKCNQCDKAFSQQSSLQ 416
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 755532618 417 VHK 419
Cdd:COG5189  416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-411 2.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 755532618  386 HLQTHERVHTEEKPYKCNQCDKAFSQ 411
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-451 3.36e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532618 368 GEKPYKCNL--CDKAYAHHSHLQTHeRVHteekpykcNQCDKAFSQQSSLQVHKRIHTGEKPYECNQCGKAFTCHRYLQR 445
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 755532618 446 HkRTHT 451
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-244 4.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.17e-03
                          10        20
                  ....*....|....*....|....*
gi 755532618  220 LQVHKRTHTGEKPYECSQCGKAYSR 244
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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