NCBI Conserved Domain Search

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.

Pssm-ID: 467144 Cd Length: 102 Bit Score: 175.19 E-value: 1.19e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 592 LSCYRGVMFELGNGFAEEPVKWTAPGSQVCAPDEICQETLLLIDVGQKSAFLGSKGCSSPGAQDNIGVSIFSRLPGMLVA 671
Cdd:cd23624    2 LTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQKVSIHSGPPGILVA 81

                         90       100
                 ....*....|....*....|.
gi 755520056 672 SYTKFCSSHLCNGADSSSVLL 692
Cdd:cd23624   82 SYVHFCSSDLCNRANSSSVLL 102

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467143 Cd Length: 100 Bit Score: 174.43 E-value: 2.38e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 213 ALDCNSGSLETVRNVSDLHLSWTTGWQTCEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKARLTRHRTGPGISIVSY 292
Cdd:cd23623    1 ALTCQKGTLETVRNVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 293 VHVCRDRDFCNDLSTTDPLW 312
Cdd:cd23623   81 TRVCRHQDLCNDLSSTLPLW 100

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467143 Cd Length: 100 Bit Score: 174.04 E-value: 2.88e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 402 ALKCQHGTLKTIQDISKLPLQWTAGQKICNVGEGCQDTLMLIENGEQVNLVLTKGCTTAKDQEAKVTEHRTGPGLSVTSY 481
Cdd:cd23623    1 ALTCQKGTLETVRNVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 482 TRVCRKKDFCNDLSTTAPLW 501
Cdd:cd23623   81 TRVCRHQDLCNDLSSTLPLW 100

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467143 Cd Length: 100 Bit Score: 160.95 E-value: 1.39e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056  21 ALTCQKSSAQAVRNVAELPLrWWGAGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRTGPGLSVVS 100
Cdd:cd23623    1 ALTCQKGTLETVRNVSELPL-WWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVS 79

                         90       100
                 ....*....|....*....|
gi 755520056 101 YTRVCRHGDLCNDVNSTKIL 120
Cdd:cd23623   80 YTRVCRHQDLCNDLSSTLPL 99

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.

Pssm-ID: 467800 Cd Length: 77 Bit Score: 133.64 E-value: 3.19e-37

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755520056 132 PGSLRCPLCLSNDSCENAPEQ-VCPVGSTHCYDGVLRLRGDGIRTNLKVQGCMAQPDCNLLNGTQAIGTLYMSENCD 207
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLvPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENCN 77

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.

Pssm-ID: 467800 Cd Length: 77 Bit Score: 131.33 E-value: 2.26e-36

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755520056 509 PGTTRCPLCFSEQACENAPEQ-VCPAGSTHCYSGVLSLRGGGIISDLKVQGCMSQPGCNLLNGTQTIGPVDVSERC 583
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLvPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.

Pssm-ID: 467801 [Multi-domain] Cd Length: 77 Bit Score: 129.74 E-value: 8.13e-36

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755520056 703 PGDVQCPMCVELFGSCKSTDSVTCPRGATHCYKGDIALQGGGLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEESSN 779
Cdd:cd23637    1 PGDLQCPVCVNFFGSCSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTENSE 77

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.

Pssm-ID: 467800 Cd Length: 77 Bit Score: 125.55 E-value: 2.31e-34

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755520056 320 LGTLRCRHCLSTGSCVSASEL-VCPAGSTHCYSGVLSLRGGGVISDLKVQGCIsqSQPGCNLLNGTQTIGPVDVREDC 396
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLvPCPAGTTHCYSGVLRLRGGGISTNLKVQGCM--PQPGCNLLNGTQTIGPISVSENC 76

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.

Pssm-ID: 467094 Cd Length: 99 Bit Score: 116.76 E-value: 6.17e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 403 LKCQHGT-LKTIQDISKLPLQWTAGQKICNVGEGCQDTLMLIENGEQVNLVLTKGCTTAKDQEAKVTEHRTGPGLSVTSY 481
Cdd:cd23564    1 LTCYRGTsLYVGANLANEPNWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 482 TRVCRkKDFCNDLSTTAPLW 501
Cdd:cd23564   81 TRVCN-SDFCNNLSSTSPFL 99

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.

Pssm-ID: 467094 Cd Length: 99 Bit Score: 102.13 E-value: 8.83e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 592 LSCYRGVMFELGNGFAEEPvKWTAPGSQVCAPDEICQETLLLIDVGQKSAFLGSKGCSSPGAQdNIGVSIFSRLPGMLVA 671
Cdd:cd23564    1 LTCYRGTSLYVGANLANEP-NWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQ-SSRVTEHVSPPGLIIT 78

                         90       100
                 ....*....|....*....|.
gi 755520056 672 SYTKFCSSHLCNGADSSSVLL 692
Cdd:cd23564   79 SYTRVCNSDFCNNLSSTSPFL 99

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.

Pssm-ID: 467094 Cd Length: 99 Bit Score: 100.58 E-value: 2.98e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 214 LDCNSGSLETVRNVSDLHLSWTTGW-QTCEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKARLTRHRTGPGISIVSY 292
Cdd:cd23564    1 LTCYRGTSLYVGANLANEPNWTTSRnETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 293 VHVCRDrDFCNDLSTTDPLW 312
Cdd:cd23564   81 TRVCNS-DFCNNLSSTSPFL 99

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.

Pssm-ID: 467094 Cd Length: 99 Bit Score: 93.27 E-value: 9.85e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056  22 LTCQKSSAQAVRNVAELPLRWWGAGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRTGPGLSVVSY 101
Cdd:cd23564    1 LTCYRGTSLYVGANLANEPNWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80

                         90
                 ....*....|....*.
gi 755520056 102 TRVCRhGDLCNDVNST 117
Cdd:cd23564   81 TRVCN-SDFCNNLSST 95

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.

Pssm-ID: 467798 Cd Length: 83 Bit Score: 89.75 E-value: 1.13e-21

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755520056 510 GTTRCPLCFSEQACENAPEQVCPAGSTHCYSGVLSLRGGGIISDLKVQGCMSQPGCNLLNGTQTIGPVDVSERCSPPS 587
Cdd:cd23634    1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQS 78

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.

Pssm-ID: 467801 [Multi-domain] Cd Length: 77 Bit Score: 83.13 E-value: 1.66e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755520056 132 PGSLRCPLCLS-NDSCENAPEQVCPVGSTHCYDGVLRLRGDGIRTNLKVQGCMAQPDCNLLNGTQAIGTLYMSEN 205
Cdd:cd23637    1 PGDLQCPVCVNfFGSCSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTEN 75

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.

Pssm-ID: 467798 Cd Length: 83 Bit Score: 83.20 E-value: 2.22e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755520056 321 GTLRCRHCLSTGSCVSASELVCPAGSTHCYSGVLSLRGGGVISDLKVQGCisQSQPGCNLLNGTQTIGPVDVREDCGLQ 399
Cdd:cd23634    1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGC--TTMIGCRLLGGIQTIGPIEVSEKCPRQ 77

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.

Pssm-ID: 467797 Cd Length: 76 Bit Score: 82.35 E-value: 3.18e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755520056 704 GDVQCPMCVELFGSCKS-TDSVTCPRGaTHCYKGDIALQGGGLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEESSN 779
Cdd:cd23633    1 GTLQCPVCLHFKGSCSSnSNLVLCPKN-TRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.

Pssm-ID: 467798 Cd Length: 83 Bit Score: 80.89 E-value: 1.54e-18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755520056 133 GSLRCPLCLSNDSCENAPEQVCPVGSTHCYDGVLRLRGDGIRTNLKVQGCMAQPDCNLLNGTQAIGTLYMSENCD 207
Cdd:cd23634    1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCP 75

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.

Pssm-ID: 467797 Cd Length: 76 Bit Score: 78.89 E-value: 5.30e-18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755520056 133 GSLRCPLCLS-NDSC-ENAPEQVCPVGsTHCYDGVLRLRGDGIRTNLKVQGCMAQPDCNLLNGTQAIGTLYMSENCD 207
Cdd:cd23633    1 GTLQCPVCLHfKGSCsSNSNLVLCPKN-TRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.

Pssm-ID: 467144 Cd Length: 102 Bit Score: 79.66 E-value: 6.80e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 402 ALKCQHGTL-KTIQDISKLPLQWTA-GQKICNVGEGCQDTLMLIENGEQVNLVLTKGCTTAKDQEA-KVTEHRTGPGLSV 478
Cdd:cd23624    1 FLTCHQGVMvKFGSNLSKEPVEWTTsGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSqKVSIHSGPPGILV 80

                         90       100
                 ....*....|....*....|..
gi 755520056 479 TSYTRVCrKKDFCNDLSTTAPL 500
Cdd:cd23624   81 ASYVHFC-SSDLCNRANSSSVL 101

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.

Pssm-ID: 467797 Cd Length: 76 Bit Score: 77.73 E-value: 1.72e-17

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755520056 510 GTTRCPLCFSEQ-AC-ENAPEQVCPAGsTHCYSGVLSLRGGGIISDLKVQGCMSQPGCNLLNGTQTIGPVDVSERC 583
Cdd:cd23633    1 GTLQCPVCLHFKgSCsSNSNLVLCPKN-TRCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREIL 75

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.

Pssm-ID: 467801 [Multi-domain] Cd Length: 77 Bit Score: 75.04 E-value: 1.29e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755520056 509 PGTTRCPLC--FSEQaCENAPEQVCPAGSTHCYSGVLSLRGGGIISDLKVQGCMSQPGCNLLNGTQTIGPVDVSE 581
Cdd:cd23637    1 PGDLQCPVCvnFFGS-CSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTE 74

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.

Pssm-ID: 467797 Cd Length: 76 Bit Score: 72.72 E-value: 9.65e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755520056 321 GTLRCRHCLS-TGSCVSASELV-CPAGsTHCYSGVLSLRGGGVISDLKVQGCIsqSQPGCNLLNGTQTIGPVDVREDC 396
Cdd:cd23633    1 GTLQCPVCLHfKGSCSSNSNLVlCPKN-TRCYTGDLEVRGGGLSATFSIKGCL--AQSTKNLLNNQTSIGIFSVREIL 75

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467142 Cd Length: 99 Bit Score: 72.00 E-value: 2.80e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 403 LKCQHGTLKTIQDISKLPLQWTAGQ-KICNVGEGCQDTLMLIENGEQVNLVLTKGCTTAKDQEAKVTEHRTGPGLSVTSY 481
Cdd:cd23622    1 LYCHKGISMTIEEDPRNTFNWTTEKvETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 482 TRVCrKKDFCNDLSTTAPLW 501
Cdd:cd23622   81 SNYC-EDSLCNNKKSLSSFW 99

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.

Pssm-ID: 467801 [Multi-domain] Cd Length: 77 Bit Score: 71.19 E-value: 2.80e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755520056 321 GTLRCRHCLS-TGSCVSASELVCPAGSTHCYSGVLSLRGGGVISDLKVQGCIsqSQPGCNLLNGTQTIGPVDVRED 395
Cdd:cd23637    2 GDLQCPVCVNfFGSCSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCM--AQPSSSLLNHTQNIGIFSVTEN 75

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.

Pssm-ID: 467800 Cd Length: 77 Bit Score: 70.85 E-value: 4.34e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755520056 703 PGDVQCPMCVELFGSCKSTDSVTCPRGATHCYKGDIALQGGGLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEESSN 779
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLVPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENCN 77

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.

Pssm-ID: 467798 Cd Length: 83 Bit Score: 67.02 E-value: 1.18e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 707 QCPMCVELfGSCKSTDSVTCPRGATHCYKGDIALQGGGLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEE 776
Cdd:cd23634    4 HCPTCVAL-GSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSE 72

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.

Pssm-ID: 467144 Cd Length: 102 Bit Score: 63.86 E-value: 2.37e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056  21 ALTCQKSSA-QAVRNVAELPLRWWGAGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRT-GPGLSV 98
Cdd:cd23624    1 FLTCHQGVMvKFGSNLSKEPVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQKVSIHSgPPGILV 80

                         90       100
                 ....*....|....*....|..
gi 755520056  99 VSYTRVCrHGDLCNDVNSTKIL 120
Cdd:cd23624   81 ASYVHFC-SSDLCNRANSSSVL 101

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.

Pssm-ID: 467144 Cd Length: 102 Bit Score: 62.71 E-value: 6.60e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 213 ALDCNSGSL-ETVRNVSDLHLSWTTGW-QTCEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKAR-LTRHRTGPGISI 289
Cdd:cd23624    1 FLTCHQGVMvKFGSNLSKEPVEWTTSGtQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQkVSIHSGPPGILV 80

                         90
                 ....*....|....*....
gi 755520056 290 VSYVHVCrDRDFCNDLSTT 308
Cdd:cd23624   81 ASYVHFC-SSDLCNRANSS 98

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467142 Cd Length: 99 Bit Score: 61.98 E-value: 8.45e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 214 LDCNSGSLETVRNVSDLHLSWTTG-WQTCEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKARLTRHRTGPGISIVSY 292
Cdd:cd23622    1 LYCHKGISMTIEEDPRNTFNWTTEkVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                         90       100
                 ....*....|....*....|
gi 755520056 293 VHVCRDrDFCNDLSTTDPLW 312
Cdd:cd23622   81 SNYCED-SLCNNKKSLSSFW 99

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467142 Cd Length: 99 Bit Score: 61.21 E-value: 1.79e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 592 LSCYRGVMFELGNgFAEEPVKWTAPGSQVCAPDEICQETLLLIDVGQKSAFLGSKGCSSPGAQDNIGVSiFSRLPGMLVA 671
Cdd:cd23622    1 LYCHKGISMTIEE-DPRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQ-HTPPPGLVAV 78

                         90
                 ....*....|....*...
gi 755520056 672 SYTKFCSSHLCNGADSSS 689
Cdd:cd23622   79 SYSNYCEDSLCNNKKSLS 96

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467141 Cd Length: 103 Bit Score: 59.10 E-value: 1.04e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056  21 ALTCQKSSAQAVRNVAELPLRWWGAGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRTGPGLSVVS 100
Cdd:cd23621    1 ALLCYEATASRFRAVALHNWKWLLMRSMVCKLNEGCEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIAS 80

                         90
                 ....*....|....
gi 755520056 101 YTRVCRhGDLCNDV 114
Cdd:cd23621   81 YSRVCR-SYLCNNL 93

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467141 Cd Length: 103 Bit Score: 57.94 E-value: 3.03e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 402 ALKCQHGTLKTIQDISKLPLQWTAGQK-ICNVGEGCQDTLMLIENGEQVNLVLTKGCTTAKDQEAKVTEHRTGPGLSVTS 480
Cdd:cd23621    1 ALLCYEATASRFRAVALHNWKWLLMRSmVCKLNEGCEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIAS 80

                         90       100
                 ....*....|....*....|
gi 755520056 481 YTRVCRKKdFCNDLSTTAPL 500
Cdd:cd23621   81 YSRVCRSY-LCNNLTNMEPF 99

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467141 Cd Length: 103 Bit Score: 55.25 E-value: 2.76e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755520056 612 KWTAPGSQVCAPDEICQETLLLIDVGQKSAFLGSKGCsSPGAQDNIGVSIFSRLPGMLVASYTKFCSSHLCN 683
Cdd:cd23621   21 KWLLMRSMVCKLNEGCEETLVFIETGTARGVVGFKGC-SPASSYPPQISYLVSPPGVSIASYSRVCRSYLCN 91

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467143 Cd Length: 100 Bit Score: 50.39 E-value: 1.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056 592 LSCYRGVMFELGNGfAEEPVKWTApGSQVCAPDEICQETLLLIDVGQKSAFLGSKGCSSpgAQDNIG-VSIFSRLPGMLV 670
Cdd:cd23623    2 LTCQKGTLETVRNV-SELPLWWTA-GQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQ--AEDQEPrVTQHRAGPGLSI 77

                         90
                 ....*....|....
gi 755520056 671 ASYTKFC-SSHLCN 683
Cdd:cd23623   78 VSYTRVCrHQDLCN 91

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467141 Cd Length: 103 Bit Score: 47.93 E-value: 1.04e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755520056 241 CEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKARLTRHRTGPGISIVSYVHVCRDRdFCNDLSTTDPL 311
Cdd:cd23621   30 CKLNEGCEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIASYSRVCRSY-LCNNLTNMEPF 99

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

Pssm-ID: 467142 Cd Length: 99 Bit Score: 46.19 E-value: 3.28e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520056  22 LTCQKSSAQAVRNVAELPLRWWGAGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRTGPGLSVVSY 101
Cdd:cd23622    1 LYCHKGISMTIEEDPRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                         90
                 ....*....|....*
gi 755520056 102 TRVCRHgDLCNDVNS 116
Cdd:cd23622   81 SNYCED-SLCNNKKS 94

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

Pssm-ID: 394978 Cd Length: 77 Bit Score: 44.84 E-value: 5.64e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755520056  514 CPLC--FSEQACenAPEQVCPAGSTHCYSGVLSLRGGGIISDLKVQGCmSQPGCN-LLNGTQTIGPVDVSERCS 584
Cdd:pfam00021   1 CYSClgVSNEDC--LSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGC-ARSSCPrLLSDFINGGIISVSESCC 71

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

Pssm-ID: 394978 Cd Length: 77 Bit Score: 43.30 E-value: 1.86e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755520056  137 CPLCLSNDSCENAPEQVCPVGSTHCYDGVLRLRGDGIRTNLKVQGCmAQPDCN-LLNGTQAIGTLYMSENC 206
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGC-ARSSCPrLLSDFINGGIISVSESC 70

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

Pssm-ID: 394978 Cd Length: 77 Bit Score: 41.37 E-value: 9.77e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755520056  325 CRHCL--STGSCvsASELVCPAGSTHCYSGVLSLRGGGVISDLKVQGCisqSQPGCN-LLNGTQTIGPVDVREDC 396
Cdd:pfam00021   1 CYSCLgvSNEDC--LSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGC---ARSSCPrLLSDFINGGIISVSESC 70

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

Pssm-ID: 394978 Cd Length: 77 Bit Score: 40.60 E-value: 1.74e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755520056  708 CPMCVELF-GSCKStdSVTCPRGATHCYKGDIALQGGGLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEES 777
Cdd:pfam00021   1 CYSCLGVSnEDCLS--EVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSES 69

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and shows snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD domain of LYPD4.

Pssm-ID: 467799 Cd Length: 88 Bit Score: 37.53 E-value: 3.49e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755520056 708 CPMCV-ELFGSCKST--DSVTCPRGATHCYKGDIALQGGGLTTRVSIQGCmAPPIKPLLGDSKTIGIFSAEESSN 779
Cdd:cd23635    5 CPTCVgRHTKECLPSfvSSESCPCAASTCYSSTLKFQAGFLNTTFLLMGC-AREQHKLLADFQHIGSIRVTEVIN 78

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and shows snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD domain of LYPD4.

Pssm-ID: 467799 Cd Length: 88 Bit Score: 36.38 E-value: 7.71e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755520056 514 CPLCFSEQACENAPEQV----CPAGSTHCYSGVLSLRGGGIISDLKVQGCMSQPGcNLLNGTQTIGPVDVSE 581
Cdd:cd23635    5 CPTCVGRHTKECLPSFVssesCPCAASTCYSSTLKFQAGFLNTTFLLMGCAREQH-KLLADFQHIGSIRVTE 75