NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767909083|ref|XP_011507760|]
View 

complement factor H-related protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 72-261 1.95e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.14  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083  72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKFSA 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 143 EKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYnikl 217
Cdd:PHA02927 146 VKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF---- 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767909083 218 kwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 261
Cdd:PHA02927 221 -----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-261 1.95e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.14  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083  72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKFSA 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 143 EKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYnikl 217
Cdd:PHA02927 146 VKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF---- 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767909083 218 kwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 261
Cdd:PHA02927 221 -----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 145-199 3.82e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 3.82e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083 145 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 145-199 1.59e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 1.59e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083   145 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
145-199 3.23e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.73  E-value: 3.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083  145 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-261 1.95e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.14  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083  72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKFSA 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 143 EKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYnikl 217
Cdd:PHA02927 146 VKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF---- 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767909083 218 kwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 261
Cdd:PHA02927 221 -----KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 145-199 3.82e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 3.82e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083 145 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 145-199 1.59e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 1.59e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083   145 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
145-199 3.23e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.73  E-value: 3.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083  145 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 199
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 107-241 2.28e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.81  E-value: 2.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 107 GDTVQIICNTGYRLQN-NENNISCVERGWSTPPKFSAEKCGPPPPIDNGDITsflLSVYAPGSSVEYQCQNLYQLEGNNQ 185
Cdd:PHA02927  47 GDTIEYLCLPGYRKQKmGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLD---IGGVDFGSSITYSCNSGYQLIGESK 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909083 186 ITCRNGQ-----WS------EPPKCLDPCVISQEIMEKYNiklkwtnqqKLYSrTGDIVEFVCKSGY 241
Cdd:PHA02927 124 SYCELGStgsmvWNpeapicESVKCQSPPSISNGRHNGYE---------DFYT-DGSVVTYSCNSGY 180
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 90-138 7.41e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 7.41e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767909083  90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WSTPP 138
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGgWSPPP 53
PHA02831 PHA02831
EEV host range protein; Provisional
 102-241 1.06e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 42.67  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 102 QTHLEGDTVQIICNTGYrlqnNENNISCVERGWSTPPK-FSAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQ----N 176
Cdd:PHA02831  38 KVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMcIGKRNCKDPVTILNGYIKN-KKDQYSFGDSVTYACKvnklE 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 177 LYQLEGNNQITCRNGQW-SEPPKC-LDPC---VISQEIMEKYniklkwtnQQKLYsrTGDIVEFVCKSGY 241
Cdd:PHA02831 113 KYSIVGNETVKCINKQWvPKYPVCkLIRCkypALQNGFLNVF--------EKKFY--YGDIVNFKCKKGF 172
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 90-138 5.44e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 5.44e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767909083    90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WSTPP 138
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGtWSPPP 53
PHA02817 PHA02817
EEV Host range protein; Provisional
 144-199 6.75e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 6.75e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767909083 144 KCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 199
Cdd:PHA02817  23 KCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
PHA02639 PHA02639
EEV host range protein; Provisional
 92-241 2.19e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 38.88  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083  92 VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG---WSTPPKFSAEK-CGPPPPIDNGDITSfLLSVYAPG 167
Cdd:PHA02639  28 ISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKeCNDPPSIINGKIYN-KREMYKVG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909083 168 SSVEYQCQN----LYQLEGNNQITC-RNGQWS-EPPKCLDPCVISQEIMEKYNIKLKwtNQQKLYSRTGdiVEFVCKSGY 241
Cdd:PHA02639 107 DEIYYVCNEhkgvQYSLVGNEKITCiQDKSWKpDPPICKMINCRFPALQNGYINGIP--SNKKFYYKTR--VGFSCKSGF 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH