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Conserved domains on  [gi|767909087|ref|XP_011507762|]
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complement factor H-related protein 2 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 25-135 3.40e-12

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 63.52  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  25 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNeNNISCVERGWSTPPKFSAEKCgPPPPIDNGDITSFLLSVYAPGSS 104
Cdd:PHA02927 152 PSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGN-SGVLCSGGEWSDPPTCQIVKC-PHPTISNGYLSSGFKRSYSYNDN 229

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767909087 105 VEYQCQNLYQLEGNNQITCRNGQWSEP--PKCL 135
Cdd:PHA02927 230 VDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 25-135 3.40e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 63.52  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  25 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNeNNISCVERGWSTPPKFSAEKCgPPPPIDNGDITSFLLSVYAPGSS 104
Cdd:PHA02927 152 PSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGN-SGVLCSGGEWSDPPTCQIVKC-PHPTISNGYLSSGFKRSYSYNDN 229

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767909087 105 VEYQCQNLYQLEGNNQITCRNGQWSEP--PKCL 135
Cdd:PHA02927 230 VDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 1.08e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.08e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087  80 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-134 4.56e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 4.56e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087    80 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
80-134 6.97e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.89  E-value: 6.97e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087   80 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 25-135 3.40e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 63.52  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  25 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNeNNISCVERGWSTPPKFSAEKCgPPPPIDNGDITSFLLSVYAPGSS 104
Cdd:PHA02927 152 PSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGN-SGVLCSGGEWSDPPTCQIVKC-PHPTISNGYLSSGFKRSYSYNDN 229

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767909087 105 VEYQCQNLYQLEGNNQITCRNGQWSEP--PKCL 135
Cdd:PHA02927 230 VDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 27-196 6.53e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 62.75  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  27 VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKFSAEKCGPPPPIDNGDITSFLlSVY 99
Cdd:PHA02927  92 IDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICESVKCQSPPSISNGRHNGYE-DFY 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087 100 APGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKYniklkwtnqQKLYSRTgDIVEFVCKS 174
Cdd:PHA02927 167 TDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF---------KRSYSYN-DNVDFKCKY 236

                        170       180
                 ....*....|....*....|..
gi 767909087 175 GYHPTKSHSfrAMCQNGKLVYP 196
Cdd:PHA02927 237 GYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 80-134 1.08e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.08e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087  80 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 80-134 4.56e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 4.56e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087    80 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
80-134 6.97e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.89  E-value: 6.97e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087   80 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 134
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 42-176 1.01e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.81  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  42 GDTVQIICNTGYRLQN-NENNISCVERGWSTPPKFSAEKCGPPPPIDNGDITsflLSVYAPGSSVEYQCQNLYQLEGNNQ 120
Cdd:PHA02927  47 GDTIEYLCLPGYRKQKmGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLD---IGGVDFGSSITYSCNSGYQLIGESK 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909087 121 ITCRNGQ-----WS------EPPKCLDPCVISQEIMEKYNiklkwtnqqKLYSrTGDIVEFVCKSGY 176
Cdd:PHA02927 124 SYCELGStgsmvWNpeapicESVKCQSPPSISNGRHNGYE---------DFYT-DGSVVTYSCNSGY 180
PHA02831 PHA02831
EEV host range protein; Provisional
 37-176 3.50e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 43.44  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  37 QTHLEGDTVQIICNTGYrlqnNENNISCVERGWSTPPK-FSAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQ----N 111
Cdd:PHA02831  38 KVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMcIGKRNCKDPVTILNGYIKN-KKDQYSFGDSVTYACKvnklE 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087 112 LYQLEGNNQITCRNGQW-SEPPKC-LDPC---VISQEIMEKYniklkwtnQQKLYsrTGDIVEFVCKSGY 176
Cdd:PHA02831 113 KYSIVGNETVKCINKQWvPKYPVCkLIRCkypALQNGFLNVF--------EKKFY--YGDIVNFKCKKGF 172
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 25-73 3.69e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 3.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767909087  25 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WSTPP 73
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGgWSPPP 53
PHA02817 PHA02817
EEV Host range protein; Provisional
 79-134 2.61e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.31  E-value: 2.61e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767909087  79 KCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 134
Cdd:PHA02817  23 KCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 25-73 2.74e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 2.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767909087    25 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WSTPP 73
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGtWSPPP 53
PHA02639 PHA02639
EEV host range protein; Provisional
 27-176 8.32e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.26  E-value: 8.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  27 VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG---WSTPPKFSAEK-CGPPPPIDNGDITSfLLSVYAPG 102
Cdd:PHA02639  28 ISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKeCNDPPSIINGKIYN-KREMYKVG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087 103 SSVEYQCQN----LYQLEGNNQITC-RNGQWS-EPPKCLDPCVISQEIMEKYNIKLKwtNQQKLYSRTGdiVEFVCKSGY 176
Cdd:PHA02639 107 DEIYYVCNEhkgvQYSLVGNEKITCiQDKSWKpDPPICKMINCRFPALQNGYINGIP--SNKKFYYKTR--VGFSCKSGF 182
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 27-143 3.09e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 37.76  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909087  27 VENGHSESSGQTHLEGDTVQIICNTGYRLQNnENNISCVERGWSTPPKfSAEKCGPPPpIDNGDITSfllSVYAPGSSVE 106
Cdd:PHA02954 135 LEHGSCQPVKEKYSFGEHITINCDVGYEVIG-ASYISCTANSWNVIPS-CQQKCDIPS-LSNGLISG---STFSIGGVIH 208

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767909087 107 YQCQNLYQLEGNNQITCRNGQWSeppKCLDPCVISQE 143
Cdd:PHA02954 209 LSCKSGFTLTGSPSSTCIDGKWN---PVLPICVRSNE 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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