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Conserved domains on  [gi|767910074|ref|XP_011508141|]
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leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein; leucine-rich repeat and calponin homology domain-containing protein( domain architecture ID 11469450)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions| leucine-rich repeat and calponin homology (LRCH) domain-containing protein similar to human LRCH4 which is a Toll-like receptor (TLR) accessory protein that regulates signaling by multiple TLRs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 495-767 5.56e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 5.56e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 654
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-375 1.09e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLHLHNNRIQHLGThSFEGLHN 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 193 LETLDLNYNKLQEFPvAIRTLGRLQELGFHNNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 272
Cdd:COG4886  230 LETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 273 MDIQEFPDLKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS 352
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLL---LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        330       340
                 ....*....|....*....|...
gi 767910074 353 QLSSLQALDLTDNQLTTLPLAGL 375
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLA 406
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 495-767 5.56e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 5.56e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 654
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-375 1.09e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLHLHNNRIQHLGThSFEGLHN 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 193 LETLDLNYNKLQEFPvAIRTLGRLQELGFHNNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 272
Cdd:COG4886  230 LETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 273 MDIQEFPDLKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS 352
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLL---LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        330       340
                 ....*....|....*....|...
gi 767910074 353 QLSSLQALDLTDNQLTTLPLAGL 375
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLA 406
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-393 1.30e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 107.63  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLRLD 103
Cdd:PLN00113 146 DLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-LGQMKSLKWIYLG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 104 ANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAF--QNLTSL---------- 169
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFslQKLISLdlsdnslsge 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 170 ---VVLHLHNNRIQHLGTHSFEGL--------------------------------HNLETLDLNYNKLQ---------- 204
Cdd:PLN00113 300 ipeLVIQLQNLEILHLFSNNFTGKipvaltslprlqvlqlwsnkfsgeipknlgkhNNLTVLDLSTNNLTgeipeglcss 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 205 ---------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 269
Cdd:PLN00113 380 gnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 270 NGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLEEIGLQHNRIWEI 346
Cdd:PLN00113 460 ARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHNQLSGQ 538

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767910074 347 GADTFSQLSSLQALDLTDNQLTTLPLAGLGG--------LMHLKLKGNLALSQAF 393
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQNQLSGEIPKNLGNveslvqvnISHNHLHGSLPSTGAF 593
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-230 5.31e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 5.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  30 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 107
Cdd:cd21340    7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 108 SLVpErSFEGLSSLRHLWLDDNalteipvralnNLPALQAMTLALNRISHIpdyafqnLTSLVVLHLHNNRIQHLgtHSF 187
Cdd:cd21340   81 SVV-E-GLENLTNLEELHIENQ-----------RLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767910074 188 EGLHNLETLDLNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIP 230
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
143-203 5.68e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910074  143 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 203
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 495-767 5.56e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 481.60  E-value: 5.56e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 654
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 495-767 8.45e-147

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 434.67  E-value: 8.45e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 654
Cdd:cd15138   80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15138  160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15138  238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 495-767 7.01e-96

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 302.15  E-value: 7.01e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 654
Cdd:cd15363   80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15363  159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15363  238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 495-767 3.77e-76

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 249.78  E-value: 3.77e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 574
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 575 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 654
Cdd:cd15361   80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 655 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 734
Cdd:cd15361  159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767910074 735 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15361  238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 495-767 6.19e-39

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 146.23  E-value: 6.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNGLVLLTVF----AGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWE 570
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHIsskkKKKKVP----KLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 571 TGLGCRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalpl 638
Cdd:cd14980   77 RSPPCLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY----------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 639 aSVGE------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRH 707
Cdd:cd14980  146 -SINQpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIR 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 708 VAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd14980  223 LALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-375 1.09e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLHLHNNRIQHLGThSFEGLHN 192
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 193 LETLDLNYNKLQEFPvAIRTLGRLQELGFHNNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 272
Cdd:COG4886  230 LETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 273 MDIQEFPDLKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS 352
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLL---LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        330       340
                 ....*....|....*....|...
gi 767910074 353 QLSSLQALDLTDNQLTTLPLAGL 375
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLA 406
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 495-767 3.15e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 138.12  E-value: 3.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 495 WGIRLAVWAIVLLSVLCNG---LVLLTVFAGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWET 571
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIivlLVLLTSRTKLTVP----RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 572 GLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 651
Cdd:cd15136   77 GAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 652 PYAppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASM 730
Cdd:cd15136  157 PFE--TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAA 234

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767910074 731 LGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15136  235 FGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-250 7.34e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 7.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLIS 108
Cdd:COG4886  119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 109 LVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthSFE 188
Cdd:COG4886  196 DLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLA 269

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767910074 189 GLHNLETLDLNYNKLQEFpvAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 250
Cdd:COG4886  270 NLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-398 1.35e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 134.29  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  78 LQNNQLGGIPAEALWELPSLQSLRLDANlislvpeRSFEGLSSLRHLWLDDNALTEIPVrALNNLPALQAMTLALNRISH 157
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 158 IPDyAFQNLTSLVVLHLHNNRIQHLGThSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgn 237
Cdd:COG4886  151 LPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE------ 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 238 pllqtihfydnpiqfvgrsAFQYLPKLHTLSLNGAmDIQEFPDLKgttsleiltltragirllpsgmcqQLPRLRVLELS 317
Cdd:COG4886  223 -------------------PLANLTNLETLDLSNN-QLTDLPELG------------------------NLTNLEELDLS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 318 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDS 397
Cdd:COG4886  259 NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338


                 .
gi 767910074 398 F 398
Cdd:COG4886  339 T 339
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 497-767 3.99e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 108.84  E-value: 3.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 497 IRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 576
Cdd:cd15964    3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 577 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 656
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 657 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 735
Cdd:cd15964  162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910074 736 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15964  240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-393 1.30e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 107.63  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLRLD 103
Cdd:PLN00113 146 DLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-LGQMKSLKWIYLG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 104 ANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAF--QNLTSL---------- 169
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFslQKLISLdlsdnslsge 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 170 ---VVLHLHNNRIQHLGTHSFEGL--------------------------------HNLETLDLNYNKLQ---------- 204
Cdd:PLN00113 300 ipeLVIQLQNLEILHLFSNNFTGKipvaltslprlqvlqlwsnkfsgeipknlgkhNNLTVLDLSTNNLTgeipeglcss 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 205 ---------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 269
Cdd:PLN00113 380 gnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 270 NGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLEEIGLQHNRIWEI 346
Cdd:PLN00113 460 ARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHNQLSGQ 538

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767910074 347 GADTFSQLSSLQALDLTDNQLTTLPLAGLGG--------LMHLKLKGNLALSQAF 393
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQNQLSGEIPKNLGNveslvqvnISHNHLHGSLPSTGAF 593
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 497-767 4.76e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 99.93  E-value: 4.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 497 IRLAVWAIVLLSVLCNgLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 576
Cdd:cd15360    3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 577 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 656
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 657 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 735
Cdd:cd15360  162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910074 736 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15360  240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-252 1.54e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLIS 108
Cdd:COG4886  165 DLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 109 LVPErsFEGLSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNRISHIpdyafqNLTSLVVLHLHNNRIQHLGT-HSF 187
Cdd:COG4886  242 DLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDL------KLKELELLLGLNSLLLLLLLlNLL 311

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910074 188 EGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQF 252
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 497-767 2.48e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 94.93  E-value: 2.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 497 IRLAVWAIVLLSVLCNGLVLLtVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 576
Cdd:cd15359    3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 577 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 656
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 657 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 735
Cdd:cd15359  162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767910074 736 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15359  240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-368 4.93e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 96.07  E-value: 4.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGQAFSGLYSLKILMLQNNQL-GGIPAEALwelPSLQSLRLDANL 106
Cdd:PLN00113  75 DLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSI---PNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 107 ISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-------------------------HIPd 160
Cdd:PLN00113 152 LSGEIPNDIGSFSSLKVLDLGGNVLVgKIPN-SLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIP- 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 161 YAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKA-IPE-KAFMGN 237
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPElVIQLQN 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 238 plLQTIHFYDNpiQFVGR--SAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIR-LLPSGMCQQlPRLRV 313
Cdd:PLN00113 310 --LEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTgEIPEGLCSS-GNLFK 384

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910074 314 LELSHNQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLT 368
Cdd:PLN00113 385 LILFSNSLEgEIPkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 497-767 1.93e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 89.57  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 497 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 573
Cdd:cd15137    3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 574 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 648
Cdd:cd15137   79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 649 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 722
Cdd:cd15137  157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767910074 723 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 767
Cdd:cd15137  237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-230 5.31e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 5.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  30 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 107
Cdd:cd21340    7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 108 SLVpErSFEGLSSLRHLWLDDNalteipvralnNLPALQAMTLALNRISHIpdyafqnLTSLVVLHLHNNRIQHLgtHSF 187
Cdd:cd21340   81 SVV-E-GLENLTNLEELHIENQ-----------RLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767910074 188 EGLHNLETLDLNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIP 230
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 118-371 1.00e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 1.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 118 LSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthSFEGLHNLETLD 197
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 198 LNYNKlqefpvaIRTLGRLQELgfhnnnikaipekafmgnPLLQTIHFyDNpiqfvgrsafQYLPKlhtlslngamdiqe 277
Cdd:cd21340   75 LGGNR-------ISVVEGLENL------------------TNLEELHI-EN----------QRLPP-------------- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 278 fpdlkgTTSLEILTLTRAGIRllpsgmcqqlPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIG--ADTFSQLS 355
Cdd:cd21340  105 ------GEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                        250
                 ....*....|....*.
gi 767910074 356 SLQALDLTDNQLTTLP 371
Cdd:cd21340  169 SLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
143-203 5.68e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910074  143 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 203
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
49-107 2.56e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 2.56e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767910074   49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-222 1.04e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgqAFSGLYSLKILMLQNNQLGGIPAEAlwELPSLQSLRLDANLIS 108
Cdd:COG4886  211 DLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 109 -LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF 187
Cdd:COG4886  286 dLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767910074 188 EGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFH 222
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR_8 pfam13855
Leucine rich repeat;
167-226 3.35e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 3.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910074  167 TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 226
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 263-406 5.75e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 5.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 263 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 342
Cdd:cd21340    3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 343 IWEI-GADTFSQLS---------------------------SLQALDLTDNQLTTL-PLAGLGGLMHLKLKGNL-----A 388
Cdd:cd21340   80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQisdleE 159

                        170
                 ....*....|....*...
gi 767910074 389 LSQAFSkdSFPKLRILEV 406
Cdd:cd21340  160 LLDLLS--SWPSLRELDL 175
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 540-767 1.03e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.65  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 540 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 615
Cdd:cd15966   45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 616 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 692
Cdd:cd15966  124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 693 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 763
Cdd:cd15966  203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                 ....
gi 767910074 764 NPHF 767
Cdd:cd15966  280 TSFF 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
76-325 1.70e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  76 LMLQNNQLGGIPAEalweLP-SLQSLRLDANLISLVPErSFEGlsSLRHLWLDDNALTEIPvralNNLP-ALQAMTLALN 153
Cdd:PRK15370 183 LRLKILGLTTIPAC----IPeQITTLILDNNELKSLPE-NLQG--NIKTLYANSNQLTSIP----ATLPdTIQEMELSIN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 154 RISHIPDYAFQNLTSLVVLHlhnNRIQHLGTHSFEGlhnLETLDLNYNKLQEFPVAIRTlgRLQELGFHNNNIKAIPEKA 233
Cdd:PRK15370 252 RITELPERLPSALQSLDLFH---NKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 234 FMGnplLQTIHFYDNPIQFVGRSafqYLPKLHTLSLNGAMdIQEFPDLKGTTsLEILTLTRAGIRLLPsgmcQQLP-RLR 312
Cdd:PRK15370 324 PPG---LKTLEAGENALTSLPAS---LPPELQVLDVSKNQ-ITVLPETLPPT-ITTLDVSRNALTNLP----ENLPaALQ 391

                        250
                 ....*....|...
gi 767910074 313 VLELSHNQIEELP 325
Cdd:PRK15370 392 IMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
119-179 2.17e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910074  119 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 179
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
29-83 1.92e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.92e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767910074   29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 83
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-349 2.83e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.68  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  88 AEALWELPSLQSLRLDANLISlvpERSFEGLS-------SLRHLWLDDNALTEIPV------RALNNLPALQAMTLALNR 154
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLG---EEAAKALAsalrpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 155 IShiPD-----YAFQNLTSLVVLHLHNNRIQHLGT-HSFEGL----HNLETLDLNYNKLqefpvairTLGRLQELGfhnn 224
Cdd:cd00116   93 LG--PDgcgvlESLLRSSSLQELKLNNNGLGDRGLrLLAKGLkdlpPALEKLVLGRNRL--------EGASCEALA---- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 225 nikaipeKAFMGNPLLQTIHFYDNPIQFVG-RSAFQYLP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL 292
Cdd:cd00116  159 -------KALRANRDLKELNLANNGIGDAGiRALAEGLKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNL 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910074 293 -----TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ------KLEEIGLQHNRIWEIGAD 349
Cdd:cd00116  229 gdnnlTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
LRR_8 pfam13855
Leucine rich repeat;
331-387 6.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 6.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  331 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTLP---LAGLGGLMHLKLKGNL 387
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
309-367 2.44e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.44e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910074  309 PRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQL 367
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 158-260 5.19e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 52.16  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  158 IPDYAFQN--LTSLVVlhlhNNRIQHLGTHSFEGLHNLETLDLNYNklqefpvaIRTLGR-------LQELGFhNNNIKA 228
Cdd:pfam13306   3 IGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCTSLKSITLPSS--------LTSIGSyafyncsLTSITI-PSSLTS 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767910074  229 IPEKAFMGNPLLQTIHFYDNpIQFVGRSAFQY 260
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN 100
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-368 1.43e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.80  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLTELQPGLFHHLRFLEEL-------------RLSGNHLSHIPGQAFSGLY-----SLKILMLQNNQLGGIPAEA 90
Cdd:COG5238  120 RRIMAKTLEDSLILYLALPRRINLiqvlkdplggnavHLLGLAARLGLLAAISMAKalqnnSVETVYLGCNQIGDEGIEE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  91 LWElpslqslRLDANlislvpersfeglSSLRHLWLDDNALTEipvralnnlpaLQAMTLAlnrishipdYAFQNLTSLV 170
Cdd:COG5238  200 LAE-------ALTQN-------------TTVTTLWLKRNPIGD-----------EGAEILA---------EALKGNKSLT 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 171 VLHLHNNRIQHLGTHSF-EGL---HNLETLDLNYNKLQEfpvairtlgrlqelgfhnNNIKAIpEKAFMGNPLLQTIHFY 246
Cdd:COG5238  240 TLDLSNNQIGDEGVIALaEALknnTTVETLYLSGNQIGA------------------EGAIAL-AKALQGNTTLTSLDLS 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 247 DNPIQFVGRSAFQylpklhtlslngamdiqefPDLKGTTSLEILTLTRAGIRllPSGM------CQQLPRLRVLELSHNQ 320
Cdd:COG5238  301 VNRIGDEGAIALA-------------------EGLQGNKTLHTLNLAYNGIG--AQGAialakaLQENTTLHSLDLSDNQ 359

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910074 321 I-----EEL-PSLHRCQKLEEIGLQHNRIWEIGADTF---SQLSSLQALDLTDNQLT 368
Cdd:COG5238  360 IgdegaIALaKYLEGNTTLRELNLGKNNIGKQGAEALidaLQTNRLHTLILDGNLIG 416
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-250 5.24e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 5.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  30 LSMNNLTELQPGLFHHLRfleELRLSGNHLSHIPGQAFSglySLKILMLQNNQLGGIPAEalweLPS-LQSLRLDANLIS 108
Cdd:PRK15370 206 LDNNELKSLPENLQGNIK---TLYANSNQLTSIPATLPD---TIQEMELSINRITELPER----LPSaLQSLDLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 109 LVPERSFEGL------------------SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTslv 170
Cdd:PRK15370 276 CLPENLPEELrylsvydnsirtlpahlpSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLD--- 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 171 vlhLHNNRIQHLGthsfEGL-HNLETLDLNYNKLQEFPVAIRtlGRLQELGFHNNNIKAIPEK--AFMGN-PLLQTIHFY 246
Cdd:PRK15370 353 ---VSKNQITVLP----ETLpPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESlpHFRGEgPQPTRIIVE 423


                 ....
gi 767910074 247 DNPI 250
Cdd:PRK15370 424 YNPF 427
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 540-762 6.71e-07

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 540 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ---CSV-SVSCVRAyGKSPS 615
Cdd:cd15965   45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEkyiCIVyPFRCLTP-GKCRT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 616 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 693
Cdd:cd15965  124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910074 694 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 762
Cdd:cd15965  204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-240 6.72e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 49.08  E-value: 6.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074   96 SLQSLRLDANLISlVPERSFEGLSSLRHLWLDDNaLTEIPVRALNNLPaLQAMTLAlNRISHIPDYAFQNLTSLVVLHLH 175
Cdd:pfam13306  12 SLTSITIPSSLTS-IGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910074  176 NNrIQHLGTHSFEGLhNLETLDLnynklqefpvairtlgrlqelgfhNNNIKAIPEKAFMGNPLL 240
Cdd:pfam13306  88 SN-LTSIGSYAFSNC-SLKSITI------------------------PSSVTTIGSYAFSNCSNL 126
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-156 9.53e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 9.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  29 DLSMNNLT----ELQPGLFHHLRFLEELRLSGNHLSH--IP--GQAFSGLYSLKILMLQNNQL----GGIPAEALWELPS 96
Cdd:cd00116  143 VLGRNRLEgascEALAKALRANRDLKELNLANNGIGDagIRalAEGLKANCNLEVLDLNNNGLtdegASALAETLASLKS 222

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910074  97 LQSLRLDANLISLVPERSF-----EGLSSLRHLWLDDNALTEIPV----RALNNLPALQAMTLALNRIS 156
Cdd:cd00116  223 LEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFG 291
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 187-375 1.49e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 187 FEGLHNLETLDLNYNKLQE------------FPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVG 254
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalasalrpQPSLKELCLSLNETGRIPRGLQSLLQ-GLTKGCGLQELDLSDNALGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 255 RSAFQYL---PKLHTLSLN--------GAMDIQEFPDLKgtTSLEILTLTRagiRLLPSGMCQQL-------PRLRVLEL 316
Cdd:cd00116   98 CGVLESLlrsSSLQELKLNnnglgdrgLRLLAKGLKDLP--PALEKLVLGR---NRLEGASCEALakalranRDLKELNL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910074 317 SHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIG----ADTFSQLSSLQALDLTDNQLTTLPLAGL 375
Cdd:cd00116  173 ANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAAL 241
LRR_8 pfam13855
Leucine rich repeat;
215-271 1.77e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.77e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767910074  215 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 271
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-228 3.74e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074   2 RLEGEGRSARAGQNLSRAGSARRGAPR-DLSMNNLTELQPGLFHHLRFLE------ELRLSGNHLS-HIPG--QAFSGLY 71
Cdd:cd00116   29 RLEGNTLGEEAAKALASALRPQPSLKElCLSLNETGRIPRGLQSLLQGLTkgcglqELDLSDNALGpDGCGvlESLLRSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  72 SLKILMLQNNQLGG----IPAEALWEL-PSLQSLRLDANLISlvpERSFEGLSSlrhlwlddnalteipvrALNNLPALQ 146
Cdd:cd00116  109 SLQELKLNNNGLGDrglrLLAKGLKDLpPALEKLVLGRNRLE---GASCEALAK-----------------ALRANRDLK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 147 AMTLALNRISH--IPDYA--FQNLTSLVVLHLHNNRIQHLG----THSFEGLHNLETLDLNYNKLQEFPVA------IRT 212
Cdd:cd00116  169 ELNLANNGIGDagIRALAegLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAalasalLSP 248

                        250
                 ....*....|....*.
gi 767910074 213 LGRLQELGFHNNNIKA 228
Cdd:cd00116  249 NISLLTLSLSCNDITD 264
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 49-169 2.44e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.46  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074   49 LEELRLSgNHLSHIPGQAFSGLYSLKILMLQNNqLGGIPAEALWELpSLQSLRLDANLISLvPERSFEGLSSLRHLWLDD 128
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSSLTSI-GEYAFSNCSNLKSITLPS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767910074  129 NaLTEIPVRALNNLPaLQAMTLALNrISHIPDYAFQNLTSL 169
Cdd:pfam13306  89 N-LTSIGSYAFSNCS-LKSITIPSS-VTTIGSYAFSNCSNL 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 309-341 6.22e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 6.22e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767910074  309 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHN 341
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
33-230 3.14e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  33 NNLTELqPGLFHHLRFLEelrLSGNHLSHIPGQAfSGLYSLKILmlqNNQLGGIPAealweLPSlqslrldanlislvpe 112
Cdd:PRK15387 232 NNLTSL-PALPPELRTLE---VSGNQLTSLPVLP-PGLLELSIF---SNPLTHLPA-----LPS---------------- 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 113 rsfeglsSLRHLWLDDNALTEIPVRAlnnlPALQAMTLALNRISHIPDYAfqnlTSLVVLHLHNNRIQHLGTHSfEGLHN 192
Cdd:PRK15387 283 -------GLCKLWIFGNQLTSLPVLP----PGLQELSVSDNQLASLPALP----SELCKLWAYNNQLTSLPTLP-SGLQE 346

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767910074 193 LETLDlnyNKLQEFPvairTL-GRLQELGFHNNNIKAIP 230
Cdd:PRK15387 347 LSVSD---NQLASLP----TLpSELYKLWAYNNRLTSLP 378
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 503-764 4.99e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 43.05  E-value: 4.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 503 AIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 582
Cdd:cd00637    7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 583 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 662
Cdd:cd00637   79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 663 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 728
Cdd:cd00637  159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767910074 729 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 764
Cdd:cd00637  239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-203 7.79e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 7.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767910074  167 TSLVVLHLHNNRIQHLGthSFEGLHNLETLDLNYNKL 203
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 262-378 2.35e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 262 PKLHTLSlnGAmDIQeFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELP-SLHRCQKLEEIGL 338
Cdd:PLN03150 399 PQQHPWS--GA-DCQ-FDSTKGKWFIDGLGLDNQGLRgFIPNDI-SKLRHLQSINLSGNSIRgNIPpSLGSITSLEVLDL 473

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767910074 339 QHNRIWEIGADTFSQLSSLQALDLTDNQLTTLPLAGLGGL 378
Cdd:PLN03150 474 SYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 165-382 3.04e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 165 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLG-RLQELGFHNNNikaipekafmgnpllqt 242
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNN----------------- 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074 243 ihfydnpiqFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ- 320
Cdd:PLN00113 130 ---------FTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQl 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910074 321 IEELPS-LHRCQKLEEIGLQHNRI-----WEIGadtfsQLSSLQALDLTDNQLTTLPLAGLGGLMHLK 382
Cdd:PLN00113 201 VGQIPReLGQMKSLKWIYLGYNNLsgeipYEIG-----GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQ 263
LRR_9 pfam14580
Leucine-rich repeat;
314-405 3.06e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  314 LELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTL----PLAGLGGLMHLKLKGNLAL 389
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgdldPLASLKKLTFLSLLRNPVT 126

                          90       100
                  ....*....|....*....|
gi 767910074  390 SQA----FSKDSFPKLRILE 405
Cdd:pfam14580 127 NKPhyrlYVIYKVPQLRLLD 146
LRR_8 pfam13855
Leucine rich repeat;
238-321 4.55e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  238 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 317
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 767910074  318 HNQI 321
Cdd:pfam13855  58 GNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 30-108 9.22e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 9.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910074  30 LSMNN--LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 107
Cdd:PLN03150 423 LGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 767910074 108 S 108
Cdd:PLN03150 503 S 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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