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Conserved domains on  [gi|767913254|ref|XP_011508655|]
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trafficking protein particle complex subunit 12 isoform X4 [Homo sapiens]

Protein Classification

ICP22 family protein( domain architecture ID 708738)

ICP22 family protein similar to Herpesvirus saimiri transcriptional regulator ICP22 homolog (also known as immediate-early protein) that regulates the transcription of alphaherpesviruses and their host genes

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PHA03169 super family cl27451
hypothetical protein; Provisional
 3-174 6.08e-06

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254   3 DAGGGEETPAPEAPHPPQLAPPEEQGLLFQEEtiDLGGDEFGSEENETASEGSSPLADKLNEHMMESvlisDSPNSEGDA 82
Cdd:PHA03169  92 PSGSGSESVGSPTPSPSGSAEELASGLSPENT--SGSSPESPASHSPPPSPPSHPGPHEPAPPESHN----PSPNQQPSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  83 GDLGRVRDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPG----------SEAARPEQE-P 151
Cdd:PHA03169 166 FLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSpntqqaveheDEPTEPEREgP 245

                        170       180
                 ....*....|....*....|...
gi 767913254 152 PVAEPVPVCTIFSQRAPPASGDG 174
Cdd:PHA03169 246 PFPGHRSHSYTVVGWKPSTRPGG 268
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
93-264 5.92e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  93 EPGGEGDPGPEPAGTPSPSGEADgdcAPEDAAPSSGGAPRQDAAREVPG--SEAARPEQEPPVAEPVPVCTIfSQRAPPA 170
Cdd:PRK07003 359 EPAVTGGGAPGGGVPARVAGAVP---APGARAAAAVGASAVPAVTAVTGaaGAALAPKAAAAAAATRAEAPP-AAPAPPA 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254 171 SGDGFEPQMVKSPSF--GGASEASARTPPQVVQPSPSLSTFFGDTAASHSLASDFFDSFTTSAFISVSnpgaGSPAPASP 248
Cdd:PRK07003 435 TADRGDDAADGDAPVpaKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAA----TPAAVPDA 510

                        170
                 ....*....|....*.
gi 767913254 249 PPLAVPGTEGRPEPVA 264
Cdd:PRK07003 511 RAPAAASREDAPAAAA 526
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 3-174 6.08e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254   3 DAGGGEETPAPEAPHPPQLAPPEEQGLLFQEEtiDLGGDEFGSEENETASEGSSPLADKLNEHMMESvlisDSPNSEGDA 82
Cdd:PHA03169  92 PSGSGSESVGSPTPSPSGSAEELASGLSPENT--SGSSPESPASHSPPPSPPSHPGPHEPAPPESHN----PSPNQQPSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  83 GDLGRVRDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPG----------SEAARPEQE-P 151
Cdd:PHA03169 166 FLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSpntqqaveheDEPTEPEREgP 245

                        170       180
                 ....*....|....*....|...
gi 767913254 152 PVAEPVPVCTIFSQRAPPASGDG 174
Cdd:PHA03169 246 PFPGHRSHSYTVVGWKPSTRPGG 268
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
93-264 5.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  93 EPGGEGDPGPEPAGTPSPSGEADgdcAPEDAAPSSGGAPRQDAAREVPG--SEAARPEQEPPVAEPVPVCTIfSQRAPPA 170
Cdd:PRK07003 359 EPAVTGGGAPGGGVPARVAGAVP---APGARAAAAVGASAVPAVTAVTGaaGAALAPKAAAAAAATRAEAPP-AAPAPPA 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254 171 SGDGFEPQMVKSPSF--GGASEASARTPPQVVQPSPSLSTFFGDTAASHSLASDFFDSFTTSAFISVSnpgaGSPAPASP 248
Cdd:PRK07003 435 TADRGDDAADGDAPVpaKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAA----TPAAVPDA 510

                        170
                 ....*....|....*.
gi 767913254 249 PPLAVPGTEGRPEPVA 264
Cdd:PRK07003 511 RAPAAASREDAPAAAA 526
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 3-174 6.08e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254   3 DAGGGEETPAPEAPHPPQLAPPEEQGLLFQEEtiDLGGDEFGSEENETASEGSSPLADKLNEHMMESvlisDSPNSEGDA 82
Cdd:PHA03169  92 PSGSGSESVGSPTPSPSGSAEELASGLSPENT--SGSSPESPASHSPPPSPPSHPGPHEPAPPESHN----PSPNQQPSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  83 GDLGRVRDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPG----------SEAARPEQE-P 151
Cdd:PHA03169 166 FLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSpntqqaveheDEPTEPEREgP 245

                        170       180
                 ....*....|....*....|...
gi 767913254 152 PVAEPVPVCTIFSQRAPPASGDG 174
Cdd:PHA03169 246 PFPGHRSHSYTVVGWKPSTRPGG 268
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 91-205 3.09e-04

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 43.46  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  91 EAEPGGEGDPGPEpAGTPSPSGEADGDcAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPvAEPVPvctifsqrAPPA 170
Cdd:PHA03264 259 EESKGYEPPPAPS-GGSPAPPGDDRPE-AKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAG-GEPKP--------GPPR 327

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767913254 171 SGdgfePQMVKsPSFGGASEASARTPPQVVQPSPS 205
Cdd:PHA03264 328 PA----PDADR-PEGWPSLEAITFPPPTPATPAVP 357
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 78-208 4.28e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  78 SEGDAGDLGRVRDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPVA--- 154
Cdd:PRK07764 636 PAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGqad 715

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767913254 155 ----EPVPVCTIFSQRAPPASGDGFEPQMVKSPSFGGASEASARTPPQVVQPSPSLST 208
Cdd:PRK07764 716 dpaaQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 89-205 6.41e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  89 RDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPVAEPVPVCTIFSQRAP 168
Cdd:PRK07764 377 RLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP 456

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767913254 169 PASGDGFEPQMVKSPSFGGASEASARTPPQVVQPSPS 205
Cdd:PRK07764 457 PPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA 493
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-202 1.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254   4 AGGGEETPAP-------EAPHPPQLAPPEEQGllfqeetidlggdefGSEENETASEGSSPLADKLNEHMMESVLISDSP 76
Cdd:PRK07764 594 AAGGEGPPAPassgppeEAARPAAPAAPAAPA---------------APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVA 658

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  77 NSEGDAGDLGRVRDEAEPGGEGD-PGPEPAGTPSPSGEADGDCAPEDAA-------PSSGGAPR---QDAAREVPGSEAA 145
Cdd:PRK07764 659 VPDASDGGDGWPAKAGGAAPAAPpPAPAPAAPAAPAGAAPAQPAPAPAAtppagqaDDPAAQPPqaaQGASAPSPAADDP 738

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767913254 146 RPEQEPPVAEPVPVCTIFSQRAPPASGDGFEPQMVKSPSFGGASEASARTPPQVVQP 202
Cdd:PRK07764 739 VPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDD 795
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 91-206 1.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  91 EAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPVAEPVPVCTIFSQRAPPA 170
Cdd:PRK07764 393 APAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAA 472

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767913254 171 SGDGfEPQMVKSPSFGGASEASARTPPQVVQPSPSL 206
Cdd:PRK07764 473 APEP-TAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 102-174 2.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 40.70  E-value: 2.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767913254 102 PEPAGTP---SPSGEADGDCAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPVAEPVPVCTIFSQRAPPASGDG 174
Cdd:PRK14954 382 PSPAGSPdvkKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASG 457
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
93-264 5.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  93 EPGGEGDPGPEPAGTPSPSGEADgdcAPEDAAPSSGGAPRQDAAREVPG--SEAARPEQEPPVAEPVPVCTIfSQRAPPA 170
Cdd:PRK07003 359 EPAVTGGGAPGGGVPARVAGAVP---APGARAAAAVGASAVPAVTAVTGaaGAALAPKAAAAAAATRAEAPP-AAPAPPA 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254 171 SGDGFEPQMVKSPSF--GGASEASARTPPQVVQPSPSLSTFFGDTAASHSLASDFFDSFTTSAFISVSnpgaGSPAPASP 248
Cdd:PRK07003 435 TADRGDDAADGDAPVpaKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAA----TPAAVPDA 510

                        170
                 ....*....|....*.
gi 767913254 249 PPLAVPGTEGRPEPVA 264
Cdd:PRK07003 511 RAPAAASREDAPAAAA 526
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
5-205 5.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254   5 GGGEETPAPEAPHPPQLAPPEEQGLLFQEETidlggdefgseeneTASEGSSPLADKLNEHMMESVLISDSPNSEGDAGd 84
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAAAPAAAAPA--------------PAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEA- 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  85 LGRVRDEAEPGGEGDPGPEPAGTPSPSGeadgdcAPEDAAPSSGGAPRQDA---AREVPGSEAARPEQEPPVAEPVPVCt 161
Cdd:PRK12323 433 LAAARQASARGPGGAPAPAPAPAAAPAA------AARPAAAGPRPVAAAAAaapARAAPAAAPAPADDDPPPWEELPPE- 505

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767913254 162 iFSQRAPPASGDGFEPQMVKSPSFGGASEASARTPPQVVQPSPS 205
Cdd:PRK12323 506 -FASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 100-212 6.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254 100 PGPEPAGTPSPSGEADGDCAPEDAAPSSGGAPRQDAAREVPGSEAARPEQEPPVAEPVPVCTIFSQRAPPASGDGFEPQM 179
Cdd:PRK14951 383 RPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAI 462

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767913254 180 VKSPSFGGASEASARTPPQVVQPSPSLSTFFGD 212
Cdd:PRK14951 463 PVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 73-204 8.86e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913254  73 SDSPNSEGDAGDLGRVRDEAEPGGEGDPGPEPAGTPSPSGEADGDCAPEDAAPSSG----GAPRQDAAREVPGSEAARPE 148
Cdd:PRK07764 641 AAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAapaqPAPAPAATPPAGQADDPAAQ 720

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767913254 149 QEPPVAEPVPVCTiFSQRAPPASGDGFEPQMVKSPSFGGASEASARTPPQVVQPSP 204
Cdd:PRK07764 721 PPQAAQGASAPSP-AADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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