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Conserved domains on  [gi|767913261|ref|XP_011508658|]
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trafficking protein particle complex subunit 12 isoform X7 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11469162)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-331 5.16e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 186 SRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 265
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767913261 266 VLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 331
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-331 5.16e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 186 SRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 265
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767913261 266 VLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 331
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 193-252 7.61e-05

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 41.88  E-value: 7.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767913261  193 YSMANCLLLMKDYVLAVEAYHSVIKYYPEQE--PQLLSGIGRISLQIGDIKTAEKYFQDVEK 252
Cdd:TIGR02795  41 YWLGEAYYAQGDYADAAKAFLAVVKKYPKSPkaPDALLKLGMSLQELGDKEKAKATLQQVIK 102
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-331 5.16e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 186 SRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVekvtqkLDGLQGKIM 265
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767913261 266 VLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 331
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
190-346 1.31e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 190 RVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEqEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVTQKLdglqgkIMVLMN 269
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEALNN 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767913261 270 SAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 346
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALE 155
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 190-370 1.07e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 190 RVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVEKVTQKldglqgKIMVLMN 269
Cdd:COG2956   77 EALLELAQDYLKAGLLDRAEELLEKLLELDPDD-AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE------NAHAYCE 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 270 SAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYElES 349
Cdd:COG2956  150 LAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL---PALPRLAELYE-KL 225

                        170       180
                 ....*....|....*....|.
gi 767913261 350 SRSMQKKQALLEAVAGKEGDS 370
Cdd:COG2956  226 GDPEEALELLRKALELDPSDD 246
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
190-362 1.30e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 190 RVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQdvekvtQKLDGLQGKIMVLMN 269
Cdd:COG0457   43 EALYNLGLAYLRLGRYEEALADYEQALELDPDD-AEALNNLGLALQALGRYEEALEDYD------KALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 270 SAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYLHESVLFNLTTMYELES 349
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEV 195

                        170
                 ....*....|...
gi 767913261 350 SRSMQKKQALLEA 362
Cdd:COG0457  196 LLALLLALEQALR 208
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 174-364 3.82e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 174 QEGRQASIRLWRSRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEqEPQLLSGIGRISLQIGDIKTAEKYFQDVEKV 253
Cdd:COG3914   63 AAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPD-NAEALFNLGNLLLALGRLEEALAALRRALAL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 254 TQKLdglqgkIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH-Y 332
Cdd:COG3914  142 NPDF------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNaD 215

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767913261 333 LHESVLFnltTMYELESSRSMQKKQALLEAVA 364
Cdd:COG3914  216 AHSNLLF---ALRQACDWEVYDRFEELLAALA 244
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 193-335 6.26e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 6.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 193 YSMANCLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVEKVTQKldglqgKIMVLMNSAF 272
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD------RAEALLELAQ 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767913261 273 LHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPR--HYLHE 335
Cdd:COG2956   85 DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEnaHAYCE 149
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 193-252 7.61e-05

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 41.88  E-value: 7.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767913261  193 YSMANCLLLMKDYVLAVEAYHSVIKYYPEQE--PQLLSGIGRISLQIGDIKTAEKYFQDVEK 252
Cdd:TIGR02795  41 YWLGEAYYAQGDYADAAKAFLAVVKKYPKSPkaPDALLKLGMSLQELGDKEKAKATLQQVIK 102
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 186-252 1.29e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.13  E-value: 1.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767913261 186 SRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQE--PQLLSGIGRISLQIGDIKTAEKYFQDVEK 252
Cdd:COG1729   27 PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkaPDALLKLGLSYLELGDYDKARATLEELIK 95
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 199-379 4.64e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261  199 LLLMKDYVLAVEAYHSVIKYYPEqEPQLLSGIGRISLQIGDIKTAEKYFQDV-EKVTQKLDGLQGKIMVlmnsaflHLGQ 277
Cdd:TIGR02917 203 LLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEAGEFEEAEKHADALlKKAPNSPLAHYLKALV-------DFQK 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261  278 NNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhyLHESVLfnLTTMYELESSRSMQkKQ 357
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPN--SHQARR--LLASIQLRLGRVDE-AI 349

                         170       180
                  ....*....|....*....|..
gi 767913261  358 ALLEAVAGKegDSFNTQCLKLA 379
Cdd:TIGR02917 350 ATLSPALGL--DPDDPAALSLL 369
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 197-295 5.82e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 197 NCLLLMKDYVLAVEAYHSVIKYYPEqEPQLLSGIGRISLQIGDIKTAEKYFQDVekvtqkLDGLQGKIMVLMNSAFLHLG 276
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPN-NPELYYNLALLYSRSGDKDEAKEYYEKA------LALSPDNPNAYSNLAALLLS 134

                         90
                 ....*....|....*....
gi 767913261 277 QNNFAEAHRFFTEILRMDP 295
Cdd:COG5010  135 LGQDDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 199-295 1.19e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.43  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 199 LLLMKDYVLAVEAYHSVIKYYPEQE--PQLLSGIGRISLQIGDIKTAEKYFQDVEKV---TQKLDglqgkiMVLMNSAFL 273
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPlaPDALYWLGEAYYALGDYDEAAEAFEKLLKRypdSPKAP------DALLKLGLS 76

                         90       100
                 ....*....|....*....|..
gi 767913261 274 HLGQNNFAEAHRFFTEILRMDP 295
Cdd:COG1729   77 YLELGDYDKARATLEELIKKYP 98
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
198-296 2.14e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 198 CLLLMKDYVLAVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQdvekvTQKLDglQGKIMVLMNSAFLHLGQ 277
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDN-ADALNNLGLLLLEQGRYDEAIALEK-----ALKLD--PNNAEALLNLAELLLEL 72

                         90
                 ....*....|....*....
gi 767913261 278 NNFAEAHRFFTEILRMDPR 296
Cdd:COG3063   73 GDYDEALAYLERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
235-332 2.31e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 235 LQIGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNSAFLHLGQNNFAEAHRFfTEILRMDPRNAVANNNAAVCLLYLGKL 314
Cdd:COG3063    3 LKLGDLEEAEEYYEKA----LELDP--DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDY 75

                         90
                 ....*....|....*...
gi 767913261 315 KDSLRQLEAMVQQDPRHY 332
Cdd:COG3063   76 DEALAYLERALELDPSAL 93
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 208-329 2.45e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.68  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 208 AVEAYHSVIKYYPEQePQLLSGIGRISLQIGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNSAFLHLGQNNFAEAHRFF 287
Cdd:COG4235    2 AIARLRQALAANPND-AEGWLLLGRAYLRLGRYDEALAAYEKA----LRLDP--DNADALLDLAEALLAAGDTEEAEELL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767913261 288 TEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDP 329
Cdd:COG4235   75 ERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 190-294 5.34e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 5.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913261 190 RVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQEPqLLSGIGRISLQIGDIKTAEKYFQDVEKvtqkldgLQGKIMVLMN 269
Cdd:COG2956  179 RALLLLAELYLEQGDYEEAIAALERALEQDPDYLP-ALPRLAELYEKLGDPEEALELLRKALE-------LDPSDDLLLA 250

                         90       100
                 ....*....|....*....|....*
gi 767913261 270 SAFLHLGQNNFAEAHRFFTEILRMD 294
Cdd:COG2956  251 LADLLERKEGLEAALALLERQLRRH 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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