NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767917233|ref|XP_011509119|]
View 

zinc finger protein Helios isoform X7 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-457 1.08e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 145 RPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACR--RRDALTGHLRTHSVGKPHKCNYCGRSYKQ-RSSLEEH 221
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 222 KERCHNYLQNvsmeaAGQVMSHHGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEAL-HPLMQHPP 300
Cdd:COG5048  112 SSSSNSNDNN-----LLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkDPSSNLSL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 301 STIAEVAPVISSAYSQvyHPNRIERPISRETADSHENNMDGP--------ISLIRPKSRPQEREASPSNSCLDSTDSESS 372
Cdd:COG5048  187 LISSNVSTSIPSSSEN--SPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 373 HDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEH--CRVLFLDHVMYTIHMG 450
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHIL 344

                 ....*..
gi 767917233 451 CHGYRDP 457
Cdd:COG5048  345 LHTSISP 351
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-457 1.08e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 145 RPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACR--RRDALTGHLRTHSVGKPHKCNYCGRSYKQ-RSSLEEH 221
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 222 KERCHNYLQNvsmeaAGQVMSHHGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEAL-HPLMQHPP 300
Cdd:COG5048  112 SSSSNSNDNN-----LLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkDPSSNLSL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 301 STIAEVAPVISSAYSQvyHPNRIERPISRETADSHENNMDGP--------ISLIRPKSRPQEREASPSNSCLDSTDSESS 372
Cdd:COG5048  187 LISSNVSTSIPSSSEN--SPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 373 HDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEH--CRVLFLDHVMYTIHMG 450
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHIL 344

                 ....*..
gi 767917233 451 CHGYRDP 457
Cdd:COG5048  345 LHTSISP 351
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 8.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 767917233  161 NLLRHIKLHSGEKPFKCPFCSYACRR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-457 1.08e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 145 RPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACR--RRDALTGHLRTHSVGKPHKCNYCGRSYKQ-RSSLEEH 221
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 222 KERCHNYLQNvsmeaAGQVMSHHGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEAL-HPLMQHPP 300
Cdd:COG5048  112 SSSSNSNDNN-----LLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkDPSSNLSL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 301 STIAEVAPVISSAYSQvyHPNRIERPISRETADSHENNMDGP--------ISLIRPKSRPQEREASPSNSCLDSTDSESS 372
Cdd:COG5048  187 LISSNVSTSIPSSSEN--SPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917233 373 HDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEH--CRVLFLDHVMYTIHMG 450
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHIL 344

                 ....*..
gi 767917233 451 CHGYRDP 457
Cdd:COG5048  345 LHTSISP 351
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 8.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 767917233  161 NLLRHIKLHSGEKPFKCPFCSYACRR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
134-158 1.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.54e-04
                          10        20
                  ....*....|....*....|....*
gi 767917233  134 LMVHKRSHTGERPFHCNQCGASFTQ 158
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
147-169 7.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.58e-03
                          10        20
                  ....*....|....*....|...
gi 767917233  147 FHCNQCGASFTQKGNLLRHIKLH 169
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH