NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767918405|ref|XP_011509593|]
View 

peroxynitrite isomerase THAP4 isoform X2 [Homo sapiens]

Protein Classification

lipocalin/fatty acid-binding family protein; lipocalin family protein( domain architecture ID 10527263)

lipocalin/fatty acid-binding family protein contains a large beta-barrel cavity that binds hydrophobic ligands| lipocalin/fatty-acid binding family protein similar to Arabidopsis thaliana temperature-induced lipocalin-1, which is involved in basal (BT) and acquired thermotolerance (AT), probably by preventing plasma membrane lipids peroxidation induced by severe heat-shock (HS)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 446-626 7.17e-56

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


:

Pssm-ID: 381185  Cd Length: 150  Bit Score: 185.91  E-value: 7.17e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 446 VEPLSWMLGTWlsDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQ 525
Cdd:cd07828    1 LEPLSWLLGTW--RGSGKGGYPTIKDFSYGEEITFSHDGQPFLNYTARTWTLDTGKPMHRESGFLRIKPDGNKVELLIAH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 526 NTGVVEVEEGEVNGQELCIASHSIARISFAKEPHveqvspallparscllfaavcgvslflfrEITRKFRLNSEGKLEQT 605
Cdd:cd07828   79 NTGLVEIEEGEVTGNTLELTTDAVARTSFAPEVT-----------------------------AIKRLFGLVDGNTLEYT 129

                        170       180
                 ....*....|....*....|.
gi 767918405 606 VSMATTTQPMTQHLHVTYKKV 626
Cdd:cd07828  130 VDMATAGKPLTPHLSARLKKV 150
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 50-109 1.38e-16

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 461662  Cd Length: 76  Bit Score: 74.49  E-value: 1.38e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405   50 RFPlKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRleDQHRLLKPTAVPSIF 109
Cdd:pfam05485  20 KFP-KDPERRKKWLNACKRKDLPPPSNSYVCSLHFEENDFEKS--GGKRKLKPGAIPTLF 76
 
Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 446-626 7.17e-56

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 185.91  E-value: 7.17e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 446 VEPLSWMLGTWlsDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQ 525
Cdd:cd07828    1 LEPLSWLLGTW--RGSGKGGYPTIKDFSYGEEITFSHDGQPFLNYTARTWTLDTGKPMHRESGFLRIKPDGNKVELLIAH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 526 NTGVVEVEEGEVNGQELCIASHSIARISFAKEPHveqvspallparscllfaavcgvslflfrEITRKFRLNSEGKLEQT 605
Cdd:cd07828   79 NTGLVEIEEGEVTGNTLELTTDAVARTSFAPEVT-----------------------------AIKRLFGLVDGNTLEYT 129

                        170       180
                 ....*....|....*....|.
gi 767918405 606 VSMATTTQPMTQHLHVTYKKV 626
Cdd:cd07828  130 VDMATAGKPLTPHLSARLKKV 150
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 446-625 2.79e-48

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 165.83  E-value: 2.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405  446 VEPLSWMLGTWLSDppGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQ 525
Cdd:pfam08768   2 LGPLAWLLGTWRGE--GEGGYPTIEDFTYGEEITFSHDGRPFLNYTSRTWRLDDGKPLHRETGFWRWEPGTGEVELVLAH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405  526 NT--GVVEVEEGEVNGQELCIASHSIARISFAKEPHveqvspallparscllfaavcgvslflfrEITRKFRLNsEGKLE 603
Cdd:pfam08768  80 PTgvVEIEEGTVKNGGNTIELATDAIARTSFAKEVT-----------------------------AGKRLYGLV-DGDLS 129

                         170       180
                  ....*....|....*....|..
gi 767918405  604 QTVSMATTTQPMTQHLHVTYKK 625
Cdd:pfam08768 130 YTVDMATVGGPLQHHLSATLKR 151
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 50-109 1.38e-16

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 74.49  E-value: 1.38e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405   50 RFPlKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRleDQHRLLKPTAVPSIF 109
Cdd:pfam05485  20 KFP-KDPERRKKWLNACKRKDLPPPSNSYVCSLHFEENDFEKS--GGKRKLKPGAIPTLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 50-109 2.27e-16

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 74.01  E-value: 2.27e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918405    50 RFPLKDSKRLIQWLKAVQRDN---WTPTKYSFLCSEHFTKDSFSKRledqHRLLKPTAVPSIF 109
Cdd:smart00980  21 RFPKEDPELRKKWLENLGLPDdpnRKPKKRSRICSRHFEPDDFDNS----GRRLKPGAVPTLF 79
 
Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 446-626 7.17e-56

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 185.91  E-value: 7.17e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 446 VEPLSWMLGTWlsDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQ 525
Cdd:cd07828    1 LEPLSWLLGTW--RGSGKGGYPTIKDFSYGEEITFSHDGQPFLNYTARTWTLDTGKPMHRESGFLRIKPDGNKVELLIAH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405 526 NTGVVEVEEGEVNGQELCIASHSIARISFAKEPHveqvspallparscllfaavcgvslflfrEITRKFRLNSEGKLEQT 605
Cdd:cd07828   79 NTGLVEIEEGEVTGNTLELTTDAVARTSFAPEVT-----------------------------AIKRLFGLVDGNTLEYT 129

                        170       180
                 ....*....|....*....|.
gi 767918405 606 VSMATTTQPMTQHLHVTYKKV 626
Cdd:cd07828  130 VDMATAGKPLTPHLSARLKKV 150
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 446-625 2.79e-48

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 165.83  E-value: 2.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405  446 VEPLSWMLGTWLSDppGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQ 525
Cdd:pfam08768   2 LGPLAWLLGTWRGE--GEGGYPTIEDFTYGEEITFSHDGRPFLNYTSRTWRLDDGKPLHRETGFWRWEPGTGEVELVLAH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405  526 NT--GVVEVEEGEVNGQELCIASHSIARISFAKEPHveqvspallparscllfaavcgvslflfrEITRKFRLNsEGKLE 603
Cdd:pfam08768  80 PTgvVEIEEGTVKNGGNTIELATDAIARTSFAKEVT-----------------------------AGKRLYGLV-DGDLS 129

                         170       180
                  ....*....|....*....|..
gi 767918405  604 QTVSMATTTQPMTQHLHVTYKK 625
Cdd:pfam08768 130 YTVDMATVGGPLQHHLSATLKR 151
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 50-109 1.38e-16

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 74.49  E-value: 1.38e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918405   50 RFPlKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRleDQHRLLKPTAVPSIF 109
Cdd:pfam05485  20 KFP-KDPERRKKWLNACKRKDLPPPSNSYVCSLHFEENDFEKS--GGKRKLKPGAIPTLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 50-109 2.27e-16

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 74.01  E-value: 2.27e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918405    50 RFPLKDSKRLIQWLKAVQRDN---WTPTKYSFLCSEHFTKDSFSKRledqHRLLKPTAVPSIF 109
Cdd:smart00980  21 RFPKEDPELRKKWLENLGLPDdpnRKPKKRSRICSRHFEPDDFDNS----GRRLKPGAVPTLF 79
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
50-109 4.73e-08

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 50.00  E-value: 4.73e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918405    50 RFPlKDSKRLIQWLKAVQ-RDNWTPTKYSFLCSEHFTKDSFSKRledqhRLLKPTAVPSIF 109
Cdd:smart00692   3 RFP-KDPELLKKWEHNLRlSPDEKKLKNSRICSRHFEPECFGKR-----RRLKPGAVPTLE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH