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Conserved domains on  [gi|767939352|ref|XP_011512641|]
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dynein regulatory complex subunit 5 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10061432)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-390 2.60e-67

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 216.07  E-value: 2.60e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352  80 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 158
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 159 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 229
Cdd:cd00116   79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 230 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 307
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 308 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 387
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                 ...
gi 767939352 388 FMS 390
Cdd:cd00116  317 DSF 319
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-390 2.60e-67

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 216.07  E-value: 2.60e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352  80 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 158
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 159 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 229
Cdd:cd00116   79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 230 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 307
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 308 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 387
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                 ...
gi 767939352 388 FMS 390
Cdd:cd00116  317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 169-375 1.28e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 135.69  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 169 CLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-SRLRVLNLANNQV 247
Cdd:COG5238  197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 248 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 327
Cdd:COG5238  277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767939352 328 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 375
Cdd:COG5238  357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
LRR_6 pfam13516
Leucine Rich repeat;
261-284 3.85e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 3.85e-04
                          10        20
                  ....*....|....*....|....
gi 767939352  261 HNTNLISLNLRLNCIEDEGGQALA 284
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
207-234 7.03e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.92  E-value: 7.03e-03
                           10        20
                   ....*....|....*....|....*...
gi 767939352   207 HPVLEELDLSQNLIGDRGARGAAKLLSH 234
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-390 2.60e-67

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 216.07  E-value: 2.60e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352  80 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 158
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 159 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 229
Cdd:cd00116   79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 230 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 307
Cdd:cd00116  159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 308 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 387
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                 ...
gi 767939352 388 FMS 390
Cdd:cd00116  317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 169-375 1.28e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 135.69  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 169 CLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-SRLRVLNLANNQV 247
Cdd:COG5238  197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 248 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 327
Cdd:COG5238  277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767939352 328 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 375
Cdd:COG5238  357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 180-374 2.50e-31

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 123.75  E-value: 2.50e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 180 HTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS-RLRVLNLANNQVRAPGAQSLAHA 258
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNkSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 259 LAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQ 338
Cdd:COG5238  260 LKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIA 339

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767939352 339 LLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYAN 374
Cdd:COG5238  340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 210-375 7.80e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 119.51  E-value: 7.80e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 210 LEELDLSQNLIGDRGARGAAK-LLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ 288
Cdd:COG5238  182 VETVYLGCNQIGDEGIEELAEaLTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 289 TNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIG 368
Cdd:COG5238  262 NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALA 341


                 ....*..
gi 767939352 369 QALYANR 375
Cdd:COG5238  342 KALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 195-374 5.62e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 99.86  E-value: 5.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 195 DKARIIIRSLLDHPVLEE--LDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRL 272
Cdd:COG5238  138 PRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKR 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 273 NCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEF 352
Cdd:COG5238  218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSL 297

                        170       180
                 ....*....|....*....|..
gi 767939352 353 DLRLSDVAQESEYLIGQALYAN 374
Cdd:COG5238  298 DLSVNRIGDEGAIALAEGLQGN 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 240-375 5.49e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 5.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 240 LNLANNQVRAPGAQsLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ-----------TNKCLTTLHLGGNELSEPTA 308
Cdd:COG5238  119 LRRIMAKTLEDSLI-LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGllaaismakalQNNSVETVYLGCNQIGDEGI 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767939352 309 TLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANR 375
Cdd:COG5238  198 EELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 131-261 9.69e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.72  E-value: 9.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 131 LGDLVAGLSHLEELDLVYD-VKDCGMNFewnlflftyrdclsLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV 209
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNgIGAQGAIA--------------LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT 377

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767939352 210 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH 261
Cdd:COG5238  378 LRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
131-376 5.37e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 5.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 131 LGDLVAGLSHLEELDLVYDvkdcgmNFEwnlflftyrdclSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPVL 210
Cdd:COG4886  128 LPEELANLTNLKELDLSNN------QLT------------DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 211 EELDLSQNLIGDrgarGAAKLLSHSRLRVLNLANNQVRapgaqSLAHALAHNTNLISLNLRLNCIEDeggqalAHALQTN 290
Cdd:COG4886  185 KELDLSNNQITD----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTD------LPELGNL 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 291 KCLTTLHLGGNELSEPTAtllsqvLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQA 370
Cdd:COG4886  250 TNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                 ....*.
gi 767939352 371 LYANRE 376
Cdd:COG4886  324 LLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-331 6.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 6.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 156 NFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNligdrgargaAKLLSHS 235
Cdd:COG4886   44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----------EELSNLT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 236 RLRVLNLANNQVrapgaQSLAHALAHNTNLISLNLRLNCIEDeggqaLAHALQTNKCLTTLHLGGNELSEptatlLSQVL 315
Cdd:COG4886  114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEEL 178

                        170
                 ....*....|....*.
gi 767939352 316 AINTTLTSINLSCNHI 331
Cdd:COG4886  179 GNLTNLKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-374 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 130 QLGDLVAGLSHLEELDLvydvKDCGMNfewnlflftyrdclSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPV 209
Cdd:COG4886  150 DLPEPLGNLTNLKSLDL----SNNQLT--------------DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTN 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 210 LEELDLSQNLIGDRGargaAKLLSHSRLRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDEGgqalahALQT 289
Cdd:COG4886  207 LEELDLSGNQLTDLP----EPLANLTNLETLDLSNNQLT-----DLP-ELGNLTNLEELDLSNNQLTDLP------PLAN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 290 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 369
Cdd:COG4886  271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350


                 ....*
gi 767939352 370 ALYAN 374
Cdd:COG4886  351 TLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
210-374 2.63e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 210 LEELDLSQNLIGDrgargAAKLLSHSRLRVLNLANNQVRAPGAqslahaLAHNTNLISLNLRLNCIEDEGGQALAHALQT 289
Cdd:COG4886  230 LETLDLSNNQLTD-----LPELGNLTNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 290 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 369
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378


                 ....*
gi 767939352 370 ALYAN 374
Cdd:COG4886  379 LLTLA 383
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 210-301 3.83e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 210 LEELDLS-QNLigDRGAR-----GAAKLLSHSrLRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDegGQAL 283
Cdd:cd21340   92 LEELHIEnQRL--PPGEKltfdpRSLAALSNS-LRVLNISGNNID-----SLE-PLAPLRNLEQLDASNNQISD--LEEL 160

                         90
                 ....*....|....*...
gi 767939352 284 AHALQTNKCLTTLHLGGN 301
Cdd:cd21340  161 LDLLSSWPSLRELDLTGN 178
LRR_6 pfam13516
Leucine Rich repeat;
261-284 3.85e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 3.85e-04
                          10        20
                  ....*....|....*....|....
gi 767939352  261 HNTNLISLNLRLNCIEDEGGQALA 284
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-357 2.34e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 171 SLAAAIKACHTLKIFKLTRSKVDDdkariiIRSLLDHPVLEELDLSQNLIGDrgargAAKLLSHSRLRVLNLANNQVRAP 250
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939352 251 GAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNH 330
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                        170       180
                 ....*....|....*....|....*..
gi 767939352 331 IGLDGGKQLLEGMSDNKTLLEFDLRLS 357
Cdd:COG4886  368 TLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
207-234 7.03e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.92  E-value: 7.03e-03
                           10        20
                   ....*....|....*....|....*...
gi 767939352   207 HPVLEELDLSQNLIGDRGARGAAKLLSH 234
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
234-261 7.98e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.53  E-value: 7.98e-03
                           10        20
                   ....*....|....*....|....*...
gi 767939352   234 HSRLRVLNLANNQVRAPGAQSLAHALAH 261
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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