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Conserved domains on  [gi|767944705|ref|XP_011513359|]
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leucine-rich repeat-containing protein 72 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-183 8.58e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 8.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  50 LFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSL---------------- 113
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLkklylggnrisvvegl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705 114 ---------HI-------------------------------------------------LLLHHNELTNIDATVKELKG 135
Cdd:cd21340   87 enltnleelHIenqrlppgekltfdprslaalsnslrvlnisgnnidsleplaplrnleqLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767944705 136 MLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMI 183
Cdd:cd21340  167 WPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLK 214
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-183 8.58e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 8.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  50 LFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSL---------------- 113
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLkklylggnrisvvegl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705 114 ---------HI-------------------------------------------------LLLHHNELTNIDATVKELKG 135
Cdd:cd21340   87 enltnleelHIenqrlppgekltfdprslaalsnslrvlnisgnnidsleplaplrnleqLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767944705 136 MLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMI 183
Cdd:cd21340  167 WPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLK 214
LRR_9 pfam14580
Leucine-rich repeat;
78-191 2.57e-14

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.79  E-value: 2.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705   78 KLHGITFLTRnycLTELYLNNNAIFEI-EGL-HYLPSLHILLLHHNELTNIdATVKELKGMLNLKILSLYQNPLCQYNLY 155
Cdd:pfam14580  56 KLDGFPLLRR---LKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQEL-GDLDPLASLKKLTFLSLLRNPVTNKPHY 131

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767944705  156 RLYIIYHLPGVELLDRNQVTEKERRSMITIFNHKKA 191
Cdd:pfam14580 132 RLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQG 167
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-176 8.12e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 8.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  49 ELFLSKKELTEVID-LSRFKKLKYLWLHHNKLHGITF----LTRnycLTELYLNNNAIFEI-EGLHYLPSLHILLLHHNE 122
Cdd:COG4886  140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEelgnLTN---LKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767944705 123 LTNIDATVKELKgmlNLKILSLYQNplcqyNLYRLYIIYHLPGVELLD--RNQVTE 176
Cdd:COG4886  217 LTDLPEPLANLT---NLETLDLSNN-----QLTDLPELGNLTNLEELDlsNNQLTD 264
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-183 8.58e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 8.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  50 LFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSL---------------- 113
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLkklylggnrisvvegl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705 114 ---------HI-------------------------------------------------LLLHHNELTNIDATVKELKG 135
Cdd:cd21340   87 enltnleelHIenqrlppgekltfdprslaalsnslrvlnisgnnidsleplaplrnleqLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767944705 136 MLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMI 183
Cdd:cd21340  167 WPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLK 214
LRR_9 pfam14580
Leucine-rich repeat;
78-191 2.57e-14

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.79  E-value: 2.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705   78 KLHGITFLTRnycLTELYLNNNAIFEI-EGL-HYLPSLHILLLHHNELTNIdATVKELKGMLNLKILSLYQNPLCQYNLY 155
Cdd:pfam14580  56 KLDGFPLLRR---LKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQEL-GDLDPLASLKKLTFLSLLRNPVTNKPHY 131

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767944705  156 RLYIIYHLPGVELLDRNQVTEKERRSMITIFNHKKA 191
Cdd:pfam14580 132 RLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQG 167
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-176 8.12e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 8.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  49 ELFLSKKELTEVID-LSRFKKLKYLWLHHNKLHGITF----LTRnycLTELYLNNNAIFEI-EGLHYLPSLHILLLHHNE 122
Cdd:COG4886  140 ELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEelgnLTN---LKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767944705 123 LTNIDATVKELKgmlNLKILSLYQNplcqyNLYRLYIIYHLPGVELLD--RNQVTE 176
Cdd:COG4886  217 LTDLPEPLANLT---NLETLDLSNN-----QLTDLPELGNLTNLEELDlsNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-178 2.22e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 2.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  49 ELFLSKKELTEV-IDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNID 127
Cdd:COG4886  209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767944705 128 ATVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKE 178
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-149 1.45e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  46 DVFELFLSKKELTEVIDLSRFKKLKYLWLHHNKlhGITFLTRnycLTELYLNNNAIFEI-EGLHYLPSLHILLLHHNELT 124
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--ELSNLTN---LESLDLSGNQLTDLpEELANLTNLKELDLSNNQLT 149

                         90       100
                 ....*....|....*....|....*
gi 767944705 125 NIDATVKELKgmlNLKILSLYQNPL 149
Cdd:COG4886  150 DLPEPLGNLT---NLKSLDLSNNQL 171
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 63-190 2.10e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  63 LSRFKKLKYLWLHHNKLHG------ITFLTRNYCLTELYLNNN------AIFEIEGLHYLPSLHILLLHHNELTNIDATV 130
Cdd:COG5238  288 LQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNgigaqgAIALAKALQENTTLHSLDLSDNQIGDEGAIA 367

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767944705 131 --KELKGMLNLKILSLYQNPLcqYNLYRLYIIYHLPGVEL----LDRNQVTEKERRSMITIFNHKK 190
Cdd:COG5238  368 laKYLEGNTTLRELNLGKNNI--GKQGAEALIDALQTNRLhtliLDGNLIGAEAQQRLEQLLERIK 431
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 91-128 3.90e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 3.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767944705   91 LTELYLNNNAIFEIEGLHYLPSLHIL-LLHHNELTNIDA 128
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSD 41
LRR_8 pfam13855
Leucine rich repeat;
91-149 4.49e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767944705   91 LTELYLNNNAIFEIEG--LHYLPSLHILLLHHNELTNIDAtvKELKGMLNLKILSLYQNPL 149
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP--GAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 67-107 7.11e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 7.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767944705   67 KKLKYLWLHHNKLHGITFLTRNYCLTELYL-NNNAIFEIEGL 107
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-147 1.22e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767944705  91 LTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDAtvkeLKGMLNLKILSLYQN 147
Cdd:cd21340    4 ITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN----LEFLTNLTHLYLQNN 56
LRR_8 pfam13855
Leucine rich repeat;
111-170 5.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767944705  111 PSLHILLLHHNELTNIDATVkeLKGMLNLKILSLYQNPLcqyNLYRLYIIYHLPGVELLD 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGA--FKGLSNLKVLDLSNNLL---TTLSPGAFSGLPSLRYLD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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