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Conserved domains on  [gi|767948304|ref|XP_011514719|]
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aldo-keto reductase family 1 member B10 isoform X3 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 10-144 3.50e-99

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19107:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 307  Bit Score: 288.16  E-value: 3.50e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  10 KAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLV 89
Cdd:cd19107    1 GAKMPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  90 RKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19107   81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEA 135
 
Name Accession Description Interval E-value
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 10-144 3.50e-99

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 288.16  E-value: 3.50e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  10 KAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLV 89
Cdd:cd19107    1 GAKMPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  90 RKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19107   81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEA 135
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 11-113 2.03e-49

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 159.84  E-value: 2.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  11 AKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVR 90
Cdd:COG0656    3 VEIPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEA----IAASGVPREELFVTTKVWNDNHGYDDTL 78

                         90       100
                 ....*....|....*....|...
gi 767948304  91 KAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:COG0656   79 AAFEESLERLGLDYLDLYLIHWP 101
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
3-147 1.24e-30

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 112.09  E-value: 1.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   3 TFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPT 82
Cdd:PRK11565   5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWND 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  83 FFERPlvRKAFEKTLKDLKLSYLDVYLIHWPqgfksgddlFPKDDkgnaiggkaTFLDAWEaQLI 147
Cdd:PRK11565  81 DHKRP--REALEESLKKLQLDYVDLYLMHWP---------VPAID---------HYVEAWK-GMI 124
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 16-113 2.01e-23

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 93.53  E-value: 2.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   16 VGLGTWKSPLG-------KVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAiqekIQEKAVKREDLFIVSKL------ 79
Cdd:pfam00248   1 IGLGTWQLGGGwgpiskeEALEALRAALEAGINFIDTAEVYgdgKSEELLGEA----LKDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767948304   80 WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP 110
 
Name Accession Description Interval E-value
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 10-144 3.50e-99

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 288.16  E-value: 3.50e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  10 KAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLV 89
Cdd:cd19107    1 GAKMPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  90 RKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19107   81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEA 135
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 7-144 3.51e-68

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 209.55  E-value: 3.51e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   7 LSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQE-KAVKREDLFIVSKLWPTFFE 85
Cdd:cd19106    1 LHTGQKMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPgKAVPREDLFVTSKLWNTKHH 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  86 RPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19106   81 PEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKA 139
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 3-144 2.19e-64

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 199.76  E-value: 2.19e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   3 TFVELSTKAKMPIVGLGTWKS---PLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKL 79
Cdd:cd19108    1 QRVKLNDGHFIPVLGFGTYAPeevPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  80 WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19108   81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEA 145
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 12-144 8.04e-62

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 193.25  E-value: 8.04e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRK 91
Cdd:cd19110    3 DIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLVKT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767948304  92 AFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19110   83 ACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEA 135
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 13-144 4.84e-57

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 179.21  E-value: 4.84e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIqekaVKREDLFIVSKLWPTFFERPLVRKA 92
Cdd:cd19071    1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERVREA 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWPQGFKSGDDlfpkddkgnaiggKATFLDAWEA 144
Cdd:cd19071   77 LEESLKDLGLDYLDLYLIHWPVPGKEGGS-------------KEARLETWRA 115
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 12-144 4.44e-56

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 178.24  E-value: 4.44e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKS-PLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVR 90
Cdd:cd19116   10 EIPAIALGTWKLkDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWNSYHEREQVE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767948304  91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDlfpKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19116   90 PALRESLKRLGLDYVDLYLIHWPVAFKENND---SESNGDGSLSDIDYLETWRG 140
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 13-144 2.83e-55

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 176.53  E-value: 2.83e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTW----KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPL 88
Cdd:cd19109    4 IPIIGLGTYsepkTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHPPEL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767948304  89 VRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19109   84 VRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEA 139
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 3-128 3.60e-55

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 175.61  E-value: 3.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   3 TFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPT 82
Cdd:cd19125    1 RFFKLNTGAKIPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767948304  83 FFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDK 128
Cdd:cd19125   81 DHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGAHMPEPEEV 126
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 1-127 9.89e-55

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 174.91  E-value: 9.89e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   1 MATFvELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLW 80
Cdd:cd19123    1 MKTL-PLSNGDLIPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLW 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767948304  81 PTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFK-------SGDDLFPKDD 127
Cdd:cd19123   80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKkgvgfpeSGEDLLSLSP 133
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 7-144 1.25e-54

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 174.14  E-value: 1.25e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   7 LSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEK-AVKREDLFIVSKLWPTFFE 85
Cdd:cd19118    1 LNTGNKIPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEEpGVKREDLFITSKLWNNSHR 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767948304  86 RPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPK----DDKGN-AIGGKATFLDAWEA 144
Cdd:cd19118   81 PEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPLtavpTNGGEvDLDLSVSLVDTWKA 144
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 14-170 8.30e-53

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 169.24  E-value: 8.30e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAF 93
Cdd:cd19128    2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVKEQL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767948304  94 EKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAQLILYLKDSPDNCGlyVSLLSLPFLT 170
Cdd:cd19128   82 LITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIG--VSNYSTKLLT 156
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 2-144 4.52e-50

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 162.97  E-value: 4.52e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   2 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWP 81
Cdd:cd19154    1 SASITLSNGVKMPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948304  82 TFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19154   81 HEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRG 143
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 11-113 2.03e-49

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 159.84  E-value: 2.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  11 AKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVR 90
Cdd:COG0656    3 VEIPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEA----IAASGVPREELFVTTKVWNDNHGYDDTL 78

                         90       100
                 ....*....|....*....|...
gi 767948304  91 KAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:COG0656   79 AAFEESLERLGLDYLDLYLIHWP 101
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 2-169 3.60e-45

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 149.99  E-value: 3.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   2 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIqEKAVKREDLFIVSKLWP 81
Cdd:cd19121    1 MTSFKLNTGASIPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  82 TFFERPlvRKAFEKTLKDLKLSYLDVYLIHWPQGF--KSGDDLFPKDDKGN-AIGGKATFLDAWEAQLILYLKDSPDNCG 158
Cdd:cd19121   80 TYHRRV--ELCLDRSLKSLGLDYVDLYLVHWPVLLnpNGNHDLFPTLPDGSrDLDWDWNHVDTWKQMEKVLKTGKTKAIG 157

                        170
                 ....*....|.
gi 767948304 159 lyVSLLSLPFL 169
Cdd:cd19121  158 --VSNYSIPYL 166
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 12-144 1.68e-42

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 143.02  E-value: 1.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRK 91
Cdd:cd19111    3 PMPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEFKDTEK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767948304  92 AFEKTLKDLKLSYLDVYLIHWPQGFKSgddlfpKDDKGNAIGGKATFLDAWEA 144
Cdd:cd19111   83 SLEKSLENLKLPYVDLYLIHHPCGFVN------KKDKGERELASSDVTSVWRA 129
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 13-144 6.65e-42

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 141.83  E-value: 6.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKA 92
Cdd:cd19129    6 IPALGFGTLIPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNHRPERVKPA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKA-TFLDAWEA 144
Cdd:cd19129   86 FEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIYDDGvTLLDTWRA 138
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 4-144 3.86e-40

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 137.66  E-value: 3.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   4 FVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTF 83
Cdd:cd19155    3 CVTFNNGEKMPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPPGG 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948304  84 FERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKS-GDDLFPKDDKGNAIGGKAT-FLDAWEA 144
Cdd:cd19155   83 NRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLSkEDDSGKLDPTGEHKQDYTTdLLDIWKA 145
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 5-169 3.94e-39

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 134.55  E-value: 3.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWkSP---LGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWP 81
Cdd:cd19119    4 FKLNTGASIPALGLGTA-SPhedRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  82 TFFERplVRKAFEKTLKDLKLSYLDVYLIHWPQGFK-----SGDDLFPKDDKGNAIGGKAT-FLDAWEAQLILYLKDSPD 155
Cdd:cd19119   83 TFYDE--VERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFTPVNDDGKTRYAASGdHITTYKQLEKIYLDGRAK 160

                        170
                 ....*....|....
gi 767948304 156 NCGlyVSLLSLPFL 169
Cdd:cd19119  161 AIG--VSNYSIVYL 172
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 13-120 1.97e-38

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 131.99  E-value: 1.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKspLGKVKEAVKV---AIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLV 89
Cdd:cd19136    1 MPILGLGTFR--LRGEEEVRQAvdaALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEKA 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  90 RKAFEKTLKDLKLSYLDVYLIHWP--QGFKSGD 120
Cdd:cd19136   79 RAACLGSLERLGTDYLDLYLIHWPgvQGLKPSD 111
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 5-115 1.14e-37

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 129.62  E-value: 1.14e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWK-SPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIqekaVKREDLFIVSKLWPTF 83
Cdd:cd19133    1 VTLNNGVEMPILGFGVFQiPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSG----IPREELFITTKLWIQD 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767948304  84 FERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 115
Cdd:cd19133   77 AGYEKAKKAFERSLKRLGLDYLDLYLIHQPFG 108
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 12-113 1.45e-37

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 130.76  E-value: 1.45e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRK 91
Cdd:cd19114    3 KMPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGKDHVRE 82

                         90       100
                 ....*....|....*....|..
gi 767948304  92 AFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19114   83 AFDRQLKDYGLDYIDLYLIHFP 104
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 11-129 3.80e-37

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 129.31  E-value: 3.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  11 AKMPIVGLGTWKSPLGK--VKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVK-REDLFIVSKLWPTFFERP 87
Cdd:cd19124    3 QTMPVIGMGTASDPPSPedIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDAHPD 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767948304  88 LVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG--------DDLFPKDDKG 129
Cdd:cd19124   83 LVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGkfsfpieeEDFLPFDIKG 132
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 4-133 5.52e-37

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 128.28  E-value: 5.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   4 FVELSTKAKMPIVGLGTWKSPLGK-VKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIqekaVKREDLFIVSKLWPT 82
Cdd:cd19157    1 TVTLNNGVKMPWLGLGVFKVEEGSeVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESG----IPREELFITSKVWNA 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  83 --FFERPLvrKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD------DLFpKDDKGNAIG 133
Cdd:cd19157   77 dqGYDSTL--KAFEASLERLGLDYLDLYLIHWPVKGKYKEtwkaleKLY-KDGRVRAIG 132
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 7-143 5.94e-37

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 128.77  E-value: 5.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   7 LSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFER 86
Cdd:cd19117    8 LNTGAEIPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQG----IKDSGVPREEIFITTKLWCTWHRR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  87 PlvRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG--DDLFPKDDKGNAIGGKATFLDAWE 143
Cdd:cd19117   84 V--EEALDQSLKKLGLDYVDLYLMHWPVPLDPDgnDFLFKKDDGTKDHEPDWDFIKTWE 140
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 5-117 6.53e-37

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 129.14  E-value: 6.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTff 84
Cdd:cd19112    3 ITLNSGHKMPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWNS-- 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  85 ERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFK 117
Cdd:cd19112   81 DHGHVIEACKDSLKKLQLDYLDLYLVHFPVATK 113
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 13-113 1.81e-36

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 126.23  E-value: 1.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKiqekAVKREDLFIVSKLWPTFFERPLVRKA 92
Cdd:cd19073    1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAES----GVPREDLFITTKVWRDHLRPEDLKKS 76

                         90       100
                 ....*....|....*....|.
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19073   77 VDRSLEKLGTDYVDLLLIHWP 97
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 11-113 2.26e-35

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 123.91  E-value: 2.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  11 AKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVR 90
Cdd:cd19140    6 VRIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDELFLTTKVWPDNYSPDDFL 81

                         90       100
                 ....*....|....*....|...
gi 767948304  91 KAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19140   82 ASVEESLRKLRTDYVDLLLLHWP 104
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 5-117 4.90e-35

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 124.48  E-value: 4.90e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFF 84
Cdd:cd19113    3 IKLNSGYKMPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFH 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  85 ERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFK 117
Cdd:cd19113   83 DPKNVETALNKTLSDLKLDYVDLFLIHFPIAFK 115
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 5-149 1.98e-34

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 121.33  E-value: 1.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFF 84
Cdd:cd19131    2 ITLNDGNTIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKA----IRASGVPREELFITTKLWNSDQ 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  85 ERPLVRKAFEKTLKDLKLSYLDVYLIHWPQgfksgddlfPKDDKgnaiggkatFLDAWEAQLILY 149
Cdd:cd19131   78 GYDSTLRAFDESLRKLGLDYVDLYLIHWPV---------PAQDK---------YVETWKALIELK 124
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 5-149 2.92e-34

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 121.47  E-value: 2.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKE-AVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPT- 82
Cdd:cd19156    1 VKLANGVEMPRLGLGVWRVQDGAEAEnAVKWAIEAGYRHIDTAAIYKNEEGVGQG----IRESGVPREEVFVTTKLWNSd 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767948304  83 -FFERPLvrKAFEKTLKDLKLSYLDVYLIHWPqgfksgddlfpkddkgnaigGKATFLDAWEAQLILY 149
Cdd:cd19156   77 qGYESTL--AAFEESLEKLGLDYVDLYLIHWP--------------------VKGKFKDTWKAFEKLY 122
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 5-133 7.74e-34

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 119.85  E-value: 7.74e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLG-KVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTF 83
Cdd:cd19126    1 VTLNNGTRMPWLGLGVFQTPDGdETERAVQTALENGYRSIDTAAIYKNEEGVGEA----IRESGVPREELFVTTKLWNDD 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767948304  84 FERPLVRKAFEKTLKDLKLSYLDVYLIHWP------QGFKSGDDLFpKDDKGNAIG 133
Cdd:cd19126   77 QRARRTEDAFQESLDRLGLDYVDLYLIHWPgkdkfiDTWKALEKLY-ASGKVKAIG 131
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 4-149 1.24e-33

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 119.74  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   4 FVELSTKAKMPIVGLGTWKSPlGKVKEAVKVAI-DAGYRHIDCAYVYQNEHEVGEAIQEKiqekAVKREDLFIVSKLWPT 82
Cdd:cd19135    4 TVRLSNGVEMPILGLGTSHSG-GYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAIKES----GVPREDLFLTTKLWPS 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767948304  83 FFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDlfpkddkgnaigGKATFLDAWEAQLILY 149
Cdd:cd19135   79 DYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKN------------VKETRAETWRALEELY 133
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 1-144 2.69e-32

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 117.14  E-value: 2.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   1 MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLW 80
Cdd:cd19115    1 ASPTVKLNSGYDMPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLW 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  81 PTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDL--FP---KDDKGNAIGGKATFLDAWEA 144
Cdd:cd19115   81 NTFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKYVDPAvrYPpgwFYDGKKVEFSNAPIQETWTA 149
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 7-125 4.68e-32

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 116.18  E-value: 4.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   7 LSTKAKMPIVGLGTWKS--PLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEK-AVKREDLFIVSKLWPTF 83
Cdd:cd19122    3 LNNGVKIPAVGFGTFANegAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWNHL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767948304  84 FERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPK 125
Cdd:cd19122   83 HEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPK 124
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 10-113 6.27e-31

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 112.71  E-value: 6.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  10 KAKMPIVGLGTWK------SPLGKVKEAVKV---AIDAGYRHIDCAYVYQN---EHEVGEAIqekiqeKAVKREDLFIVS 77
Cdd:cd19072    1 GEEVPVLGLGTWGigggmsKDYSDDKKAIEAlryAIELGINLIDTAEMYGGghaEELVGKAI------KGFDREDLFITT 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767948304  78 KLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19072   75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWP 110
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
3-147 1.24e-30

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 112.09  E-value: 1.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   3 TFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPT 82
Cdd:PRK11565   5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWND 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  83 FFERPlvRKAFEKTLKDLKLSYLDVYLIHWPqgfksgddlFPKDDkgnaiggkaTFLDAWEaQLI 147
Cdd:PRK11565  81 DHKRP--REALEESLKKLQLDYVDLYLMHWP---------VPAID---------HYVEAWK-GMI 124
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 5-113 4.68e-29

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 107.88  E-value: 4.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKiqekAVKREDLFIVSKLWPTFF 84
Cdd:cd19127    1 ITLNNGVEMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLWISDY 76

                         90       100
                 ....*....|....*....|....*....
gi 767948304  85 ERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19127   77 GYDKALRGFDASLRRLGLDYVDLYLLHWP 105
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 12-144 3.88e-28

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 105.39  E-value: 3.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGT----WKSPLG----KVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTF 83
Cdd:cd19120    3 KIPAIAFGTgtawYKSGDDdiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEA----LKESGVPREDLFITTKVSPGI 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767948304  84 ferPLVRKAFEKTLKDLKLSYLDVYLIHwpqgfksgddlFPKDDKgnaiGGKATFLDAWEA 144
Cdd:cd19120   79 ---KDPREALRKSLAKLGVDYVDLYLIH-----------SPFFAK----EGGPTLAEAWAE 121
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 12-144 1.02e-27

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 103.89  E-value: 1.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVRK 91
Cdd:cd19132    6 QIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEA----VRRSGVPREELFVTTKLPGRHHGYEEALR 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767948304  92 AFEKTLKDLKLSYLDVYLIHWPQgfksgddlfPKDDKgnaiggkatFLDAWEA 144
Cdd:cd19132   82 TIEESLYRLGLDYVDLYLIHWPN---------PSRDL---------YVEAWQA 116
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 13-113 6.02e-26

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 99.35  E-value: 6.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKiqekAVKREDLFIVSKLWPTFFERPLVRKA 92
Cdd:cd19139    1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAES----GVPRDELFITTKIWIDNLSKDKLLPS 76

                         90       100
                 ....*....|....*....|.
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19139   77 LEESLEKLRTDYVDLTLIHWP 97
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 5-115 1.13e-25

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 98.86  E-value: 1.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTW-----KSPLGKVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKiqekavkREDLFIV 76
Cdd:cd19138    3 VTLPDGTKVPALGQGTWymgedPAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKVFLV 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767948304  77 SKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 115
Cdd:cd19138   76 SKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRGG 114
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 13-113 2.47e-24

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 95.36  E-value: 2.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVRKA 92
Cdd:cd19130   10 IPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAA----IAASGIPRDELFVTTKLWNDRHDGDEPAAA 85

                         90       100
                 ....*....|....*....|.
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19130   86 FAESLAKLGLDQVDLYLVHWP 106
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
12-113 4.66e-24

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 94.71  E-value: 4.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFFERPLVRK 91
Cdd:PRK11172   2 SIPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQA----IAESGVPRDELFITTKIWIDNLAKDKLIP 77

                         90       100
                 ....*....|....*....|..
gi 767948304  92 AFEKTLKDLKLSYLDVYLIHWP 113
Cdd:PRK11172  78 SLKESLQKLRTDYVDLTLIHWP 99
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 16-113 2.01e-23

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 93.53  E-value: 2.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   16 VGLGTWKSPLG-------KVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAiqekIQEKAVKREDLFIVSKL------ 79
Cdd:pfam00248   1 IGLGTWQLGGGwgpiskeEALEALRAALEAGINFIDTAEVYgdgKSEELLGEA----LKDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767948304   80 WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP 110
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 12-113 7.64e-23

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 91.48  E-value: 7.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWK---------SPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHE---VGEAIqekiqeKAVKREDLFIVSKL 79
Cdd:cd19137    3 KIPALGLGTWGiggfltpdySRDEEMVELLKTAIELGYTHIDTAEMYGGGHTeelVGKAI------KDFPREDLFIVTKV 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948304  80 WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19137   77 WPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP 110
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 5-115 3.12e-21

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 87.22  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAiqekIQEKAVKREDLFIVSKLWPTFF 84
Cdd:cd19134    3 VTLNDDNTMPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRA----IAASGIPRGELFVTTKLATPDQ 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767948304  85 ERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 115
Cdd:cd19134   79 GFTASQAACRASLERLGLDYVDLYLIHWPAG 109
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 14-113 4.08e-20

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 84.56  E-value: 4.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTW----KSPLGKVKE-----AVKVAIDAGYRHIDCAYVYQNEHE---VGEAIQEKiqekavkREDLFIVSKLWP 81
Cdd:cd19085    2 SRLGLGCWqfggGYWWGDQDDeesiaTIHAALDAGINFFDTAEAYGDGHSeevLGKALKGR-------RDDVVIATKVSP 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767948304  82 TFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19085   75 DNLTPEDVRKSCERSLKRLGTDYIDLYQIHWP 106
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 9-111 8.40e-19

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 80.32  E-value: 8.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   9 TKAKMPIVGLGTWKSPlGKVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIqekiqeKAVKREDLFIVSKLWPTFFE 85
Cdd:cd19105    9 TGLKVSRLGFGGGGLP-RESPELLRRALDLGINYFDTAEGYGNgnsEEIIGEAL------KGLRRDKVFLATKASPRLDK 81

                         90       100
                 ....*....|....*....|....*...
gi 767948304  86 RPL--VRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19105   82 KDKaeLLKSVEESLKRLQTDYIDIYQLH 109
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 16-113 1.08e-17

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 77.17  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWK-SPLGKVKEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekaVKREDLFIVSKLWPTFFERPL 88
Cdd:cd06660    3 LGLGTMTfGGDGDEEEAFALldaALEAGGNFFDTADVYgdgRSERLLGRWLKGR-----GNRDDVVIATKGGHPPGGDPS 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  89 --------VRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd06660   78 rsrlspehIRRDLEESLRRLGTDYIDLYYLHRD 110
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
12-120 2.59e-17

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 77.94  E-value: 2.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEAVKV---AIDAGYRHIDCAYVY-QNEHEVGEAIQEKiqekavkREDLFIVSKLWPTFFERP 87
Cdd:COG1453   12 EVSVLGFGGMRLPRKDEEEAEALirrAIDNGINYIDTARGYgDSEEFLGKALKGP-------RDKVILATKLPPWVRDPE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767948304  88 LVRKAFEKTLKDLKLSYLDVYLIH-------WPQGFKSGD 120
Cdd:COG1453   85 DMRKDLEESLKRLQTDYIDLYLIHglnteedLEKVLKPGG 124
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 16-113 7.26e-17

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 75.99  E-value: 7.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWksPLGKV------KEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIqekiqeKAVKREDLFIVSKLWPTF 83
Cdd:COG0667   16 LGLGTM--TFGGPwggvdeAEAIAIldaALDAGINFFDTADVYgpgRSEELLGEAL------KGRPRDDVVIATKVGRRM 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767948304  84 FERPL--------VRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:COG0667   88 GPGPNgrglsrehIRRAVEASLRRLGTDYIDLYQLHRP 125
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 8-150 3.43e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 73.29  E-value: 3.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   8 STKAKMPIVGLGTWksPLGKV--KEAVKV---AIDAGYRHIDCAYVYQNEHE-VGEAIQEKiqekavkREDLFIVSKLWP 81
Cdd:cd19100    6 RTGLKVSRLGFGGG--PLGRLsqEEAAAIirrALDLGINYFDTAPSYGDSEEkIGKALKGR-------RDKVFLATKTGA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  82 TffERPLVRKAFEKTLKDLKLSYLDVYLIHwpqGFKSGDDLFPKDDKGNAIggkATFLDAWEAQLILYL 150
Cdd:cd19100   77 R--DYEGAKRDLERSLKRLGTDYIDLYQLH---AVDTEEDLDQVFGPGGAL---EALLEAKEEGKIRFI 137
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 16-127 3.51e-16

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 73.28  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWksPLG----------KVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKiqekavkREDLFIVSKLWPT 82
Cdd:cd19086    6 IGFGTW--GLGgdwwgdvddaEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKGR-------RDKVVIATKFGNR 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767948304  83 FFERPL---------VRKAFEKTLKDLKLSYLDVYLIH-WPqgfksgDDLFPKDD 127
Cdd:cd19086   77 FDGGPErpqdfspeyIREAVEASLKRLGTDYIDLYQLHnPP------DEVLDNDE 125
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 12-114 8.44e-16

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 72.94  E-value: 8.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWksPLG----------KVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKiqekavkREDLFIVSK 78
Cdd:cd19084    3 KVSRIGLGTW--AIGgtwwgevddqESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR-------RDDVVIATK 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767948304  79 ---LW--PTFFERPL----VRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Cdd:cd19084   74 cglRWdgGKGVTKDLspesIRKEVEQSLRRLQTDYIDLYQIHWPD 118
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 12-121 1.63e-14

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 69.56  E-value: 1.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWK---------SPLGK--VKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekaVKREDLFIVS 77
Cdd:cd19093    1 EVSPLGLGTWQwgdrlwwgyGEYGDedLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKEL-----GDRDEVVIAT 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767948304  78 KLWPTF--FERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDD 121
Cdd:cd19093   76 KFAPLPwrLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSQIE 121
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 16-111 3.35e-14

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 68.39  E-value: 3.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWKSPLGKV-----KEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEkiqekaVKREDLFIVSKL-WPT---F 83
Cdd:cd19074    7 LSLGTWLTFGGQVddedaKACVRKAYDLGINFFDTADVYaagQAEEVLGKALKG------WPRESYVISTKVfWPTgpgP 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767948304  84 FERPLVRK----AFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19074   81 NDRGLSRKhifeSIHASLKRLQLDYVDIYYCH 112
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 27-112 5.60e-13

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 64.89  E-value: 5.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  27 KVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIqekiqeKAVKREDLFIVSKLWPTFFERPL-VRKAFEKTLKDLKL 102
Cdd:cd19096   22 KAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEAL------KEGPREKFYLATKLPPWSVKSAEdFRRILEESLKRLGV 95

                         90
                 ....*....|
gi 767948304 103 SYLDVYLIHW 112
Cdd:cd19096   96 DYIDFYLLHG 105
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 14-114 3.56e-12

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 62.57  E-value: 3.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTwkSPLGKVK---------EAVKVAIDAGYRHIDCAYVYQN-EHEVGEAIQEkiqekaVKREDLFIVSKL---- 79
Cdd:cd19090    1 SALGLGT--AGLGGVFggvdddeavATIRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlp 72

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767948304  80 -WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 114
Cdd:cd19090   73 eDTADYSADRVRRSVEESLERLGRDRIDLLMIHDPE 108
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 29-132 3.92e-12

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 62.82  E-value: 3.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  29 KEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekavKREDLFIVSKLWPTFF--------ERPLVRKAFEKTL 97
Cdd:cd19083   36 KDLVREALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIATKGAHKFGgdgsvlnnSPEFLRSAVEKSL 109

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767948304  98 KDLKLSYLDVYLIHWPqgfksgDDLFPKDDKGNAI 132
Cdd:cd19083  110 KRLNTDYIDLYYIHFP------DGETPKAEAVGAL 138
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 16-113 6.51e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 62.34  E-value: 6.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWKSPLGK-----VKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKIQEKAVKREDLFIVSK--------- 78
Cdd:cd19099    6 LGLGTYRGDSDDetdeeYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgd 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767948304  79 ------LWPTFFERPLV------------------RKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19099   86 eplrplKYLEEKLGRGLidvadsaglrhcispaylEDQIERSLKRLGLDTIDLYLLHNP 144
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 14-111 1.54e-11

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 60.71  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTWK-------SPLGKVKEAVKVAIDAGYRHIDCAYVYQN-EHEVGEAIqekiqeKAVKREDLFIVSKLWPTF-- 83
Cdd:cd19095    1 SVLGLGTSGigrvwgvPSEAEAARLLNTALDLGINLIDTAPAYGRsEERLGRAL------AGLRRDDLFIATKVGTHGeg 74

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948304  84 ------FERPLVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19095   75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLH 108
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 19-112 8.17e-10

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 56.44  E-value: 8.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  19 GTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKIqekavKREDLFIVSKLWPTFFERP----LVRK 91
Cdd:cd19079   28 RPWVLDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYFPMGDGPngrgLSRK 102

                         90       100
                 ....*....|....*....|....*
gi 767948304  92 ----AFEKTLKDLKLSYLDVYLIHW 112
Cdd:cd19079  103 himaEVDASLKRLGTDYIDLYQIHR 127
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 16-113 1.61e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 55.37  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWksPLG--------------KVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekavkREDLFIVSK 78
Cdd:cd19102    4 IGLGTW--AIGgggwgggwgpqddrDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVATK 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767948304  79 ---LW-----PTFFERP-LVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19102   75 cglLWdeegrIRRSLKPaSIRAECEASLRRLGVDVIDLYQIHWP 118
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 26-128 1.79e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 55.23  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  26 GKV--KEAVKV---AIDAGYRHIDCAYVYQNEHEV-GEAIQEKiqekavkrEDLFIVSKL----WPTFFERPLVRKAFEK 95
Cdd:cd19097   21 GKPseKEAKKIleyALKAGINTLDTAPAYGDSEKVlGKFLKRL--------DKFKIITKLpplkEDKKEDEAAIEASVEA 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  96 TLKDLKLSYLDVYLIHWPqgfksgDDLFPKDDK 128
Cdd:cd19097   93 SLKRLKVDSLDGLLLHNP------DDLLKHGGK 119
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 16-124 1.79e-08

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 52.31  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTWKspLG-------KVKEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekaVKREDLFIVSKLWPT 82
Cdd:cd19148    7 IALGTWA--IGgwmwggtDEKEAIETihkALDLGINLIDTAPVYgfgLSEEIVGKALKEY-----GKRDRVVIATKVGLE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767948304  83 FFERPLV---------RKAFEKTLKDLKLSYLDVYLIHWPqgfksgDDLFP 124
Cdd:cd19148   80 WDEGGEVvrnsspariRKEVEDSLRRLQTDYIDLYQVHWP------DPLVP 124
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 17-113 2.86e-08

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 2.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  17 GLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKiqekAVKREDLFIVSK--LWPTFFERPL--- 88
Cdd:cd19092   15 RLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIQTKcgIRLGDDPRPGrik 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  89 --------VRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19092   91 hydtskehILASVEGSLKRLGTDYLDLLLLHRP 123
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 35-111 4.65e-08

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 51.03  E-value: 4.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  35 AIDAGYRHIDCAYVYQN---EHEVGEAIQEkiqekavKREDLFIVSKlwptFFERP------------LVRKAFEKTLKD 99
Cdd:cd19087   39 ALDAGINFFDTADVYGGgrsEEIIGRWIAG-------RRDDIVLATK----VFGPMgddpndrglsrrHIRRAVEASLRR 107

                         90
                 ....*....|..
gi 767948304 100 LKLSYLDVYLIH 111
Cdd:cd19087  108 LQTDYIDLYQMH 119
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 29-111 5.55e-08

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 51.08  E-value: 5.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  29 KEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIqekiqekAVKREDLFIVSKLWPTFFE----------RP-LVRK 91
Cdd:cd19078   25 EEMIELirkAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKFGFKIDGgkpgplgldsRPeHIRK 97

                         90       100
                 ....*....|....*....|
gi 767948304  92 AFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19078   98 AVEGSLKRLQTDYIDLYYQH 117
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 12-112 1.08e-07

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 50.30  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGT--------WKSPLGKV--KEA---VKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekavkREDLFI 75
Cdd:cd19091   12 KVSELALGTmtfgggggFFGAWGGVdqEEAdrlVDIALDAGINFFDTADVYsegESEEILGKALKGR-------RDDVLI 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767948304  76 VSKlwpTFF-------ERPLVR----KAFEKTLKDLKLSYLDVYLIHW 112
Cdd:cd19091   85 ATK---VRGrmgegpnDVGLSRhhiiRAVEASLKRLGTDYIDLYQLHG 129
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 12-113 1.86e-07

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 49.64  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWK--SPL-------------GKVKEAVKVAIDAGYRHIDCAYVYqnehevGEAIQEKIQE---KAVKREDL 73
Cdd:cd19103    3 KLPKIALGTWSwgSGGaggdqvfgnhldeDTLKAVFDKAMAAGLNLWDTAAVY------GMGASEKILGeflKRYPREDY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767948304  74 FIVSKLWPTF---FERPlVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19103   77 IISTKFTPQIagqSADP-VADMLEGSLARLGTDYIDIYWIHNP 118
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 16-113 4.81e-07

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 48.42  E-value: 4.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTW---------KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHevgeaiQEKIQEKAVK--REDLFIVSK---LWP 81
Cdd:cd19149   14 IGLGTWaigggpwwgGSDDNESIRTIHAALDLGINLIDTAPAYGFGH------SEEIVGKAIKgrRDKVVLATKcglRWD 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767948304  82 T-----FFERPLV-----------RKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19149   88 ReggsfFFVRDGVtvyknlspesiREEVEQSLKRLGTDYIDLYQTHWQ 135
YdhF COG4989
Predicted oxidoreductase YdhF [General function prediction only];
17-113 6.98e-07

Predicted oxidoreductase YdhF [General function prediction only];


Pssm-ID: 444013 [Multi-domain]  Cd Length: 299  Bit Score: 47.84  E-value: 6.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  17 GLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekAVKREDLFIVSK----LWPTFFERPL- 88
Cdd:COG4989   22 RLGEWDLSPAEAAALIEAALELGITTFDHADIYggyTCEALFGEALKLS----PSLREKIELQTKcgirLPSEARDNRVk 97

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767948304  89 --------VRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:COG4989   98 hydtskehIIASVEGSLRRLGTDYLDLLLLHRP 130
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 12-111 7.58e-07

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 47.64  E-value: 7.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWK-----SPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKI--QEKAVKREDLFIVSK----LW 80
Cdd:cd19089   10 HLPAISLGLWHnfgdyTSPEEARELLRTAFDLGITHFDLANNYGPPPGSAEENFGRIlkRDLRPYRDELVISTKagygMW 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767948304  81 P----TFFERPLVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19089   90 PgpygDGGSRKYLLASLDQSLKRMGLDYVDIFYHH 124
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 12-111 7.67e-07

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 47.55  E-value: 7.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTwkSPLGKV---------KEAVKVAIDAGYRHIDCAYVYqnehevGEAIQEKIQEKA---VKREDLFIVSK- 78
Cdd:cd19163   12 KVSKLGFGA--SPLGGVfgpvdeeeaIRTVHEALDSGINYIDTAPWY------GQGRSETVLGKAlkgIPRDSYYLATKv 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767948304  79 -----LWPTFF----ERplVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19163   84 gryglDPDKMFdfsaER--ITKSVEESLKRLGLDYIDIIQVH 123
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 15-113 2.38e-06

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 46.40  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  15 IVGLGTWKSPLG-----KVKEAVKVAIDAGYRHIDCAYVYQNehevGEAiqEKI--QEKAVKREdlFIVSKLWPTFFERP 87
Cdd:cd19075    4 ILGTMTFGSQGRfttaeAAAELLDAFLERGHTEIDTARVYPD----GTS--EELlgELGLGERG--FKIDTKANPGVGGG 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 767948304  88 L----VRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19075   76 LspenVRKQLETSLKRLKVDKVDVFYLHAP 105
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
 12-111 3.83e-06

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 45.53  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKSPLGKVKEA-----VKVAIDAGYRHIDCAYVYQN---EHEVGeAIqekIQEKAVKREDLFIVSKL-WPT 82
Cdd:cd19142   12 RVSNVGLGTWSTFSTAISEEqaeeiVTLAYENGINYFDTSDAFTSgqaETELG-RI---LKKKGWKRSSYIVSTKIyWSY 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767948304  83 F-FERPLVRK----AFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19142   88 GsEERGLSRKhiieSVRASLRRLQLDYIDIVIIH 121
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 14-111 7.56e-06

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 44.91  E-value: 7.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTwkSPLG---------KVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKIQEKAV-------KREDLF 74
Cdd:cd19152    1 PKLGFGT--APLGnlyeavsdeEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALRELGREDYVistkvgrLLVPLQ 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767948304  75 IVSKLWPTFFERPL------------VRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19152   79 EVEPTFEPGFWNPLpfdavfdysydgILRSIEDSLQRLGLSRIDLLSIH 127
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 28-113 8.95e-06

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 44.51  E-value: 8.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  28 VKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKiqekAVKREDLFIVSKLwptFF--------ERPLVRK----A 92
Cdd:cd19143   33 AKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIKEL----GWPRSDYVVSTKI---FWggggpppnDRGLSRKhiveG 105

                         90       100
                 ....*....|....*....|.
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19143  106 TKASLKRLQLDYVDLVFCHRP 126
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 36-111 9.47e-06

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 44.47  E-value: 9.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  36 IDAGYRHIDCAYVYQNEHEVG---EAIQEKIQEKAvKREDLFIVSK--------LWPTFFERPLVRKAFEKTLKDLKLSY 104
Cdd:cd19082   27 VELGGNFIDTARVYGDWVERGaseRVIGEWLKSRG-NRDKVVIATKgghpdledMSRSRLSPEDIRADLEESLERLGTDY 105


                 ....*..
gi 767948304 105 LDVYLIH 111
Cdd:cd19082  106 IDLYFLH 112
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 16-113 1.11e-05

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 44.48  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGT--WKSPLGKvKEAVK---VAIDAGYRHIDCAYVY---QNEHEVGEAiqEKI----QEKAVKREDLFIVSKL---- 79
Cdd:cd19094    4 ICLGTmtWGEQNTE-AEAHEqldYAFDEGVNFIDTAEMYpvpPSPETQGRT--EEIigswLKKKGNRDKVVLATKVagpg 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767948304  80 ----WP----TFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19094   81 egitWPrgggTRLDRENIREAVEGSLKRLGTDYIDLYQLHWP 122
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 31-111 2.84e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 43.02  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  31 AVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekavkREDLFIVSKLWPTFFERP----LVRKAFEKTLKDLKLS 103
Cdd:cd19104   37 AVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL-------PAGPYITTKVRLDPDDLGdiggQIERSVEKSLKRLKRD 109


                 ....*...
gi 767948304 104 YLDVYLIH 111
Cdd:cd19104  110 SVDLLQLH 117
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 35-111 3.06e-05

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 42.97  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  35 AIDAGYRHIDCAYVYQ---NEHEVGEAIQEKiqekavkREDLFIVSKLWPTFFERPL----------VRKAFEKTLKDLK 101
Cdd:cd19076   41 ALELGVTFLDTADMYGpgtNEELLGKALKDR-------RDEVVIATKFGIVRDPGSGfrgvdgrpeyVRAACEASLKRLG 113

                         90
                 ....*....|
gi 767948304 102 LSYLDVYLIH 111
Cdd:cd19076  114 TDVIDLYYQH 123
tas PRK10625
putative aldo-keto reductase; Provisional
 35-114 5.22e-05

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 42.53  E-value: 5.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  35 AIDAGYRHIDCAYVYQ----------NEHEVGEAIQekiqeKAVKREDLFIVSKL-WPT-----------FFERPLVRKA 92
Cdd:PRK10625  39 AVAQGINLIDVAEMYPvpprpetqglTETYIGNWLA-----KRGSREKLIIASKVsGPSrnndkgirpnqALDRKNIREA 113

                         90       100
                 ....*....|....*....|..
gi 767948304  93 FEKTLKDLKLSYLDVYLIHWPQ 114
Cdd:PRK10625 114 LHDSLKRLQTDYLDLYQVHWPQ 135
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 13-113 6.16e-05

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 41.82  E-value: 6.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  13 MPIVGLGTWKSPLGKvKEAVKV---AIDAGYRHIDCAYVYqnehevGEAIQEKIQEKAVK--REDLFIVSKL-------- 79
Cdd:cd19088    9 MRLTGPGIWGPPADR-EEAIAVlrrALELGVNFIDTADSY------GPDVNERLIAEALHpyPDDVVIATKGglvrtgpg 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767948304  80 -WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWP 113
Cdd:cd19088   82 wWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRI 116
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
 12-111 6.67e-05

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 42.28  E-value: 6.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  12 KMPIVGLGTWKS-----PLGKVKEAVKVAIDAGYRHIDCAYVY-----QNEHEVGEAIQEKIqekAVKREDLFIVSK--- 78
Cdd:PRK09912  24 RLPALSLGLWHNfghvnALESQRAILRKAFDLGITHFDLANNYgpppgSAEENFGRLLREDF---AAYRDELIISTKagy 100

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767948304  79 -LWPTFF----ERPLVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:PRK09912 101 dMWPGPYgsggSRKYLLASLDQSLKRMGLEYVDIFYSH 138
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 9-111 7.70e-05

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 41.75  E-value: 7.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304   9 TKAKMPIVGLGTwkSPLGKV----------KEAVKVAIDAGYRHIDCAYVYQNEhevgeaIQEKIQEKAVK-----REDL 73
Cdd:cd19153    8 ALGNVSPVGLGT--AALGGVygdgleqdeaVAIVAEAFAAGINHFDTSPYYGAE------SSEAVLGKALAalqvpRSSY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767948304  74 FIVSKLW----PTF-FERPLVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19153   80 TVATKVGryrdSEFdYSAERVRASVATSLERLHTTYLDVVYLH 122
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 36-113 1.04e-04

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 41.43  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  36 IDAGYRHIDCAYVY---QNEHEVGEAiqEKI----QEKAVKREDLFIVSKL-WPTFFERP-----LVRKAFEKTLKDLKL 102
Cdd:cd19081   36 VDAGGNFIDTADVYsawVPGNAGGES--ETIigrwLKSRGKRDRVVIATKVgFPMGPNGPglsrkHIRRAVEASLRRLQT 113

                         90
                 ....*....|.
gi 767948304 103 SYLDVYLIHWP 113
Cdd:cd19081  114 DYIDLYQAHWD 124
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 36-113 1.41e-04

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 41.05  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  36 IDAGYRHIDCAYVYQNEHE---VGEAIQEKiqekavkREDLFIVSKLwpTFFERP------------LVRkAFEKTLKDL 100
Cdd:cd19080   41 VEAGGNFIDTANNYTNGTSerlLGEFIAGN-------RDRIVLATKY--TMNRRPgdpnaggnhrknLRR-SVEASLRRL 110

                         90
                 ....*....|...
gi 767948304 101 KLSYLDVYLIHWP 113
Cdd:cd19080  111 QTDYIDLLYVHAW 123
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
 16-111 1.99e-04

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 40.77  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  16 VGLGTwkSPLG---------KVKEAVKVAIDAGYRHIDCAYVYQN---EHEVGEAIQEKIQEKAV-----------KRED 72
Cdd:cd19161    3 LGLGT--AGLGnlytavsnaDADATLDAAWDSGIRYFDTAPMYGHglaEHRLGDFLREKPRDEFVlstkvgrllkpAREG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767948304  73 lfivSKLWPTFFERPL------------VRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19161   81 ----SVPDPNGFVDPLpfeivydysydgIMRSFEDSLQRLGLNRIDILYVH 127
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 17-111 3.44e-04

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 39.72  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  17 GLGTWKSPLGKVKEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIQEKIQEK---AVKReDLFIVSKLWPTFFERP 87
Cdd:cd19145   21 GLSGDYGAPKPEEEGIALihhAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGPREKvqlATKF-GIHEIGGSGVEVRGDP 99

                         90       100
                 ....*....|....*....|....*
gi 767948304  88 -LVRKAFEKTLKDLKLSYLDVYLIH 111
Cdd:cd19145  100 aYVRAACEASLKRLDVDYIDLYYQH 124
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
 30-111 4.46e-04

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 39.57  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  30 EAVKVAIDAGYRHIDCAYVYQNEHEV-GEAIqeKIQEKAVKREDLFIVSK-----LWPTFFERPLVRKAFEKTLKDLKLS 103
Cdd:cd19164   38 DIVRRALELGIRAFDTSPYYGPSEIIlGRAL--KALRDEFPRDTYFIITKvgrygPDDFDYSPEWIRASVERSLRRLHTD 115


                 ....*...
gi 767948304 104 YLDVYLIH 111
Cdd:cd19164  116 YLDLVYLH 123
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 14-115 7.37e-04

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 38.88  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948304  14 PIVGLGTwkSPLGKVKE--------AVKVAIDAGYRHIDCAYVY---QNEHEVGEAIQEKiqekavKREDLFIVSKL--- 79
Cdd:cd19162    1 PRLGLGA--ASLGNLARagedeaaaTLDAAWDAGIRYFDTAPLYglgLSERRLGAALARH------PRAEYVVSTKVgrl 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767948304  80 -------WPTFFERPL------VRKAFEKTLKDLKLSYLDVYLIHWPQG 115
Cdd:cd19162   73 lepgaagRPAGADRRFdfsadgIRRSIEASLERLGLDRLDLVFLHDPDR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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