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Conserved domains on  [gi|767959650|ref|XP_011517608|]
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lysozyme-like protein 2 isoform X1 [Homo sapiens]

Protein Classification

lysozyme family protein( domain architecture ID 63)

lysozyme family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lyz-like super family cl00222
lysozyme-like domains; This family contains several members, including soluble lytic ...
 66-168 4.77e-45

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


The actual alignment was detected with superfamily member cd16897:

Pssm-ID: 469668  Cd Length: 126  Bit Score: 144.72  E-value: 4.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACS 145
Cdd:cd16897    1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPDGSTDYGIFQINSRYWCNDGKTPSKNLCHISCS 80

                         90       100
                 ....*....|....*....|...
gi 767959650 146 GKAGRNTVRGETCptGKKTVRFP 168
Cdd:cd16897   81 DLLNDDITDDIKC--AKKIVKDP 101
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 66-168 4.77e-45

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 144.72  E-value: 4.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACS 145
Cdd:cd16897    1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPDGSTDYGIFQINSRYWCNDGKTPSKNLCHISCS 80

                         90       100
                 ....*....|....*....|...
gi 767959650 146 GKAGRNTVRGETCptGKKTVRFP 168
Cdd:cd16897   81 DLLNDDITDDIKC--AKKIVKDP 101
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
66-145 1.89e-28

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 102.37  E-value: 1.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650    66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGK-LKENNHCHVAC 144
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNGGSTDYGIFQINSKYWCNDGKtPGSVNACGISC 80


                   .
gi 767959650   145 S 145
Cdd:smart00263  81 S 81
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 66-145 8.80e-28

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 100.57  E-value: 8.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650   66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAqTVLDDGSIDYGIFQINSFAWCRRGKLKEN-NHCHVAC 144
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQA-IVYNNGSTDYGIFQINDKYWCKDGKTPQSvNICGISC 79


                  .
gi 767959650  145 S 145
Cdd:pfam00062  80 D 80
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 66-168 4.77e-45

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 144.72  E-value: 4.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACS 145
Cdd:cd16897    1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPDGSTDYGIFQINSRYWCNDGKTPSKNLCHISCS 80

                         90       100
                 ....*....|....*....|...
gi 767959650 146 GKAGRNTVRGETCptGKKTVRFP 168
Cdd:cd16897   81 DLLNDDITDDIKC--AKKIVKDP 101
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
66-145 1.89e-28

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 102.37  E-value: 1.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650    66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGK-LKENNHCHVAC 144
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNGGSTDYGIFQINSKYWCNDGKtPGSVNACGISC 80


                   .
gi 767959650   145 S 145
Cdd:smart00263  81 S 81
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 66-145 8.80e-28

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 100.57  E-value: 8.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650   66 KIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAqTVLDDGSIDYGIFQINSFAWCRRGKLKEN-NHCHVAC 144
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQA-IVYNNGSTDYGIFQINDKYWCKDGKTPQSvNICGISC 79


                  .
gi 767959650  145 S 145
Cdd:pfam00062  80 D 80
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 66-145 1.10e-23

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 89.98  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  66 KIYTRCKLAKIFSRAGLDNYWgfsLGNWICMAYYESGYNTTAQTVL-DDGSIDYGIFQINSFAWCRRGKlKENNHCHVAC 144
Cdd:cd16899    1 KIFTRCELARELRKLGVPRSQ---LANWVCLAEHESSFNTTAVGGPnSDGSGDYGLFQINDKYWCSPGG-GSGNGCNVKC 76


                 .
gi 767959650 145 S 145
Cdd:cd16899   77 E 77
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 66-145 1.65e-20

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 81.85  E-value: 1.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  66 KIYTRCKLAKIFSRagLDNYWGFSLGNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKE-NNHCHVAC 144
Cdd:cd00119    1 KVFTRCELARLLKD--IGGYGGISLPNWVCLMKHESGYDTQATNENNNGSTDYGLFQINSRYWCKDGQTPGaRNICDISC 78


                 .
gi 767959650 145 S 145
Cdd:cd00119   79 S 79
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 67-145 5.95e-17

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 72.85  E-value: 5.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  67 IYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTTAQtVLDDGSIDYGIFQINSFAWCRRGK-LKENNHCHVACS 145
Cdd:cd16898    2 IFTKCELSQILKEHGLDGFNGISLPEWICVTFHTSGYDTQAL-VYNNGSTEYGLFQISNKGWCDDSQePVSRNICGISCS 80
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 97-125 1.00e-04

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 39.82  E-value: 1.00e-04
                         10        20
                 ....*....|....*....|....*....
gi 767959650  97 AYYESGYNTTAQTVLDDGSIDYGIFQINS 125
Cdd:cd13400   12 AKVESGFNPNAINRNKNGSYDIGLMQINS 40
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 92-150 3.07e-04

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 37.39  E-value: 3.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767959650  92 NWICMAYYESGYNttAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNH-CHVACSGKAGR 150
Cdd:cd00442    1 VLAAIIGQESGGN--KPANAGSGSGAAGLFQFMPGTWKAYGKNSSSDLnDPEASIEAAAK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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