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Conserved domains on  [gi|767960542|ref|XP_011517979|]
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uncharacterized protein C10orf68 isoform X20 [Homo sapiens]

Protein Classification

UBX domain-containing protein; FRMD7 family protein( domain architecture ID 13867420)

UBX domain-containing protein similar to Schizosaccharomyces pombe protein C17C9.11c| FRMD7 family protein similar to Homo sapiens FERM domain-containing protein 7 (FRMD7) that plays a role in neurite development, and N-terminal region of Homo sapiens FERM, ARHGEF and pleckstrin domain-containing protein 1/2 that functions as guanine nucleotide exchange factor for RAC1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BioT2 pfam15368
Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the ...
 1-170 2.29e-94

Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis.


:

Pssm-ID: 464678  Cd Length: 169  Bit Score: 300.23  E-value: 2.29e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542     1 MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPE 80
Cdd:pfam15368    1 MKPAKHLLTTSKKLANVPELPYKKGLLNLPLSPKTKEKHSAKLVHDKIEPMVLRSPPTGESIVRYALPIPSSKTKDLTAE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542    81 DEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEElSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKW 160
Cdd:pfam15368   81 DEMLRKITKHLKMVVSTLEDTYGATIQNGEKEFVKPEQEE-RLSVGDDMNSFLTCCSQFAAQLEEAVKEERNILESLFKW 159

                          170
                   ....*....|
gi 767960542   161 FQWQVNQMEE 170
Cdd:pfam15368  160 FQQQVNQMEE 169
PTZ00121 super family cl31754
MAEBL; Provisional
 200-938 1.33e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  200 VQRFEELKNRLKQRSKSSVKVM--LSKTMDKENRPEAVKSCEALaQKIEEFLEAHSTDEFKDVSATEPQTAHSMtnRFNA 277
Cdd:PTZ00121 1211 ERKAEEARKAEDAKKAEAVKKAeeAKKDAEEAKKAEEERNNEEI-RKFEEARMAHFARRQAAIKAEEARKADEL--KKAE 1287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  278 MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK-LKDKEKTKPTNNRTKKAVKTVKKKDKGKSE 356
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKkAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  357 DSEKKMSPEK----EFKIK-EDLDQVQKVARLEIENKVLQEQLKQALQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQ 431
Cdd:PTZ00121 1368 AAEKKKEEAKkkadAAKKKaEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD 1447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  432 DESaflESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSvgtlAQKNETVISPFILPPVLTESKKADVSEEQLQ 511
Cdd:PTZ00121 1448 EAK---KKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK----KKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  512 KMTEEQTYQAAEKSQADSEVPDENlmVENKDSVTKVqiEQMKQ----RTSSMERHEEtlttpqlpEDMVLVSRIQSETKN 587
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEE--KKKADELKKA--EELKKaeekKKAEEAKKAE--------EDKNMALRKAEEAKK 1588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  588 LKATRNES----FHSHNDVPEENLMLEQDTKSKTEvEVKK----QKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIK 659
Cdd:PTZ00121 1589 AEEARIEEvmklYEEEKKMKAEEAKKAEEAKIKAE-ELKKaeeeKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA 1667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  660 KQE-----TSTEQPLTTPDKEPNENLILRHQDSMSKSE-MQVKEQRTLKGQRIITHDEEPGKNLVLEHQDSVSKLEMQIE 733
Cdd:PTZ00121 1668 KKAeedkkKAEEAKKAEEDEKKAAEALKKEAEEAKKAEeLKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  734 KTKKLPREKR---HSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRSIPDKNSMFvhqdsvSKLQMQEKKKITPG 810
Cdd:PTZ00121 1748 EAKKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNF------ANIIEGGKEGNLVI 1821

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  811 RERRNTRIVVPNENVISvhqdskSKLQMQEKKQinsgVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTkkLQAKV 890
Cdd:PTZ00121 1822 NDSKEMEDSAIKEVADS------KNMQLEEADA----FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEI--EEADE 1889

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 767960542  891 TSRKIKNEAASELPDTaENLPAMYPSISDliiQFDLNKVVETDIESLR 938
Cdd:PTZ00121 1890 IEKIDKDDIEREIPNN-NMAGKNNDIIDD---KLDKDEYIKRDAEETR 1933
 
Name Accession Description Interval E-value
BioT2 pfam15368
Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the ...
 1-170 2.29e-94

Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis.


Pssm-ID: 464678  Cd Length: 169  Bit Score: 300.23  E-value: 2.29e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542     1 MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPE 80
Cdd:pfam15368    1 MKPAKHLLTTSKKLANVPELPYKKGLLNLPLSPKTKEKHSAKLVHDKIEPMVLRSPPTGESIVRYALPIPSSKTKDLTAE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542    81 DEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEElSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKW 160
Cdd:pfam15368   81 DEMLRKITKHLKMVVSTLEDTYGATIQNGEKEFVKPEQEE-RLSVGDDMNSFLTCCSQFAAQLEEAVKEERNILESLFKW 159

                          170
                   ....*....|
gi 767960542   161 FQWQVNQMEE 170
Cdd:pfam15368  160 FQQQVNQMEE 169
PTZ00121 PTZ00121
MAEBL; Provisional
 200-938 1.33e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  200 VQRFEELKNRLKQRSKSSVKVM--LSKTMDKENRPEAVKSCEALaQKIEEFLEAHSTDEFKDVSATEPQTAHSMtnRFNA 277
Cdd:PTZ00121 1211 ERKAEEARKAEDAKKAEAVKKAeeAKKDAEEAKKAEEERNNEEI-RKFEEARMAHFARRQAAIKAEEARKADEL--KKAE 1287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  278 MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK-LKDKEKTKPTNNRTKKAVKTVKKKDKGKSE 356
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKkAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  357 DSEKKMSPEK----EFKIK-EDLDQVQKVARLEIENKVLQEQLKQALQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQ 431
Cdd:PTZ00121 1368 AAEKKKEEAKkkadAAKKKaEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD 1447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  432 DESaflESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSvgtlAQKNETVISPFILPPVLTESKKADVSEEQLQ 511
Cdd:PTZ00121 1448 EAK---KKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK----KKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  512 KMTEEQTYQAAEKSQADSEVPDENlmVENKDSVTKVqiEQMKQ----RTSSMERHEEtlttpqlpEDMVLVSRIQSETKN 587
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEE--KKKADELKKA--EELKKaeekKKAEEAKKAE--------EDKNMALRKAEEAKK 1588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  588 LKATRNES----FHSHNDVPEENLMLEQDTKSKTEvEVKK----QKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIK 659
Cdd:PTZ00121 1589 AEEARIEEvmklYEEEKKMKAEEAKKAEEAKIKAE-ELKKaeeeKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA 1667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  660 KQE-----TSTEQPLTTPDKEPNENLILRHQDSMSKSE-MQVKEQRTLKGQRIITHDEEPGKNLVLEHQDSVSKLEMQIE 733
Cdd:PTZ00121 1668 KKAeedkkKAEEAKKAEEDEKKAAEALKKEAEEAKKAEeLKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  734 KTKKLPREKR---HSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRSIPDKNSMFvhqdsvSKLQMQEKKKITPG 810
Cdd:PTZ00121 1748 EAKKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNF------ANIIEGGKEGNLVI 1821

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  811 RERRNTRIVVPNENVISvhqdskSKLQMQEKKQinsgVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTkkLQAKV 890
Cdd:PTZ00121 1822 NDSKEMEDSAIKEVADS------KNMQLEEADA----FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEI--EEADE 1889

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 767960542  891 TSRKIKNEAASELPDTaENLPAMYPSISDliiQFDLNKVVETDIESLR 938
Cdd:PTZ00121 1890 IEKIDKDDIEREIPNN-NMAGKNNDIIDD---KLDKDEYIKRDAEETR 1933
 
Name Accession Description Interval E-value
BioT2 pfam15368
Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the ...
 1-170 2.29e-94

Spermatogenesis family BioT2; BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis.


Pssm-ID: 464678  Cd Length: 169  Bit Score: 300.23  E-value: 2.29e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542     1 MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPE 80
Cdd:pfam15368    1 MKPAKHLLTTSKKLANVPELPYKKGLLNLPLSPKTKEKHSAKLVHDKIEPMVLRSPPTGESIVRYALPIPSSKTKDLTAE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542    81 DEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEElSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKW 160
Cdd:pfam15368   81 DEMLRKITKHLKMVVSTLEDTYGATIQNGEKEFVKPEQEE-RLSVGDDMNSFLTCCSQFAAQLEEAVKEERNILESLFKW 159

                          170
                   ....*....|
gi 767960542   161 FQWQVNQMEE 170
Cdd:pfam15368  160 FQQQVNQMEE 169
PTZ00121 PTZ00121
MAEBL; Provisional
 200-938 1.33e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  200 VQRFEELKNRLKQRSKSSVKVM--LSKTMDKENRPEAVKSCEALaQKIEEFLEAHSTDEFKDVSATEPQTAHSMtnRFNA 277
Cdd:PTZ00121 1211 ERKAEEARKAEDAKKAEAVKKAeeAKKDAEEAKKAEEERNNEEI-RKFEEARMAHFARRQAAIKAEEARKADEL--KKAE 1287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  278 MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK-LKDKEKTKPTNNRTKKAVKTVKKKDKGKSE 356
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKkAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  357 DSEKKMSPEK----EFKIK-EDLDQVQKVARLEIENKVLQEQLKQALQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQ 431
Cdd:PTZ00121 1368 AAEKKKEEAKkkadAAKKKaEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD 1447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  432 DESaflESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSvgtlAQKNETVISPFILPPVLTESKKADVSEEQLQ 511
Cdd:PTZ00121 1448 EAK---KKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK----KKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  512 KMTEEQTYQAAEKSQADSEVPDENlmVENKDSVTKVqiEQMKQ----RTSSMERHEEtlttpqlpEDMVLVSRIQSETKN 587
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEE--KKKADELKKA--EELKKaeekKKAEEAKKAE--------EDKNMALRKAEEAKK 1588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  588 LKATRNES----FHSHNDVPEENLMLEQDTKSKTEvEVKK----QKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIK 659
Cdd:PTZ00121 1589 AEEARIEEvmklYEEEKKMKAEEAKKAEEAKIKAE-ELKKaeeeKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA 1667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  660 KQE-----TSTEQPLTTPDKEPNENLILRHQDSMSKSE-MQVKEQRTLKGQRIITHDEEPGKNLVLEHQDSVSKLEMQIE 733
Cdd:PTZ00121 1668 KKAeedkkKAEEAKKAEEDEKKAAEALKKEAEEAKKAEeLKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  734 KTKKLPREKR---HSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRSIPDKNSMFvhqdsvSKLQMQEKKKITPG 810
Cdd:PTZ00121 1748 EAKKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNF------ANIIEGGKEGNLVI 1821

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960542  811 RERRNTRIVVPNENVISvhqdskSKLQMQEKKQinsgVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTkkLQAKV 890
Cdd:PTZ00121 1822 NDSKEMEDSAIKEVADS------KNMQLEEADA----FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEI--EEADE 1889

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 767960542  891 TSRKIKNEAASELPDTaENLPAMYPSISDliiQFDLNKVVETDIESLR 938
Cdd:PTZ00121 1890 IEKIDKDDIEREIPNN-NMAGKNNDIIDD---KLDKDEYIKRDAEETR 1933
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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