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Conserved domains on  [gi|767965898|ref|XP_011518406|]
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low-density lipoprotein receptor-related protein 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-603 1.02e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 68.81  E-value: 1.02e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   568 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 603
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 63-105 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898     63 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 105
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 261-298 4.34e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767965898   261 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 298
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 434-474 1.13e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965898   434 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 474
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 738-779 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   738 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 779
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 762-802 1.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.75e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    762 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 802
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 150-192 1.80e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.80e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    150 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 192
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
587-838 5.28e-11

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 64.66  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  587 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 666
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  667 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 742
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  743 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 816
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 767965898  817 LT-QQDRWIYWTDWQTKSIQRVD 838
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 126-167 2.81e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.40  E-value: 2.81e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   126 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 167
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 340-532 8.47e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 60.80  E-value: 8.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  340 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 414
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  415 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 484
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767965898  485 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 532
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
4-237 3.26e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898    4 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 83
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   84 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 162
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  163 LAIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRET 236
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLAT 236


                  .
gi 767965898  237 L 237
Cdd:COG3391   237 L 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 872-903 3.97e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 3.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   872 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 903
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-603 1.02e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 68.81  E-value: 1.02e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   568 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 603
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 63-105 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898     63 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 105
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 261-298 4.34e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767965898   261 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 298
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 434-474 1.13e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965898   434 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 474
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 738-779 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   738 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 779
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 762-802 1.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.75e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    762 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 802
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 150-192 1.80e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.80e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    150 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 192
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
587-838 5.28e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 64.66  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  587 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 666
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  667 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 742
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  743 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 816
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 767965898  817 LT-QQDRWIYWTDWQTKSIQRVD 838
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 126-167 2.81e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.40  E-value: 2.81e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   126 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 167
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 340-532 8.47e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 60.80  E-value: 8.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  340 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 414
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  415 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 484
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767965898  485 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 532
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 718-761 1.21e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.21e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    718 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 35-224 1.45e-09

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 60.29  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   35 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 106
Cdd:COG3386    15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  107 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 182
Cdd:COG3386    92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 767965898  183 ---EFAGlDG--SKRKVLIGSQLPHPF--GLTLYGE-RIYWTDWQTKSIQ 224
Cdd:COG3386   162 yrfDLDA-DGtlGNRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVV 210
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 675-715 1.57e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    675 ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 715
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 373-413 1.75e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.75e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    373 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 413
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 638-837 3.01e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.17  E-value: 3.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  638 ELNNVISLDYDSvDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRL 712
Cdd:cd05819    53 QFNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  713 DGSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTr 782
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG- 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767965898  783 RIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 837
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
4-237 3.26e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898    4 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 83
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   84 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 162
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  163 LAIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRET 236
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLAT 236


                  .
gi 767965898  237 L 237
Cdd:COG3391   237 L 237
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 29-182 9.34e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.63  E-value: 9.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   29 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 101
Cdd:cd05819   105 RGIAVD---SSGNIYVADTGNHRIQ--KFDPDGEFLTTfgsggsgPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPD 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  102 GsmRTVLIW-------ENLDRPRDIVVEPmGGYMYWTDWGASpKIER-----AGMDASGRQVIISSNLTWPNGLAIDyGS 169
Cdd:cd05819   179 G--NFLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SD 253

                         170
                  ....*....|...
gi 767965898  170 QRLYWADAGMKTI 182
Cdd:cd05819   254 GNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 872-903 3.97e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 3.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   872 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 903
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 83-123 7.01e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 7.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898    83 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 123
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 391-431 1.35e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.00  E-value: 1.35e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   391 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 431
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 107-149 1.62e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 1.62e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    107 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASGR 149
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 695-735 1.63e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 1.63e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   695 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 735
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
293-494 1.76e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  293 SDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHED 372
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  373 IITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGEN--AKLEr 449
Cdd:COG3391   105 TIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNtvSVIV- 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767965898  450 SGMDGSDRAVLINNNLG-WPNGLTVDKASSQLLWADAHTERIEAAD 494
Cdd:COG3391   181 SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTSNGGS 226
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 21-61 1.87e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 1.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898     21 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 61
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 40-80 4.04e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 4.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898    40 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 80
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 170-209 9.97e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.61  E-value: 9.97e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965898   170 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 209
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 414-457 1.07e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    414 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 457
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 782-818 7.97e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.21  E-value: 7.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767965898   782 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 818
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-603 1.02e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 68.81  E-value: 1.02e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   568 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 603
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 63-105 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898     63 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 105
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 261-298 4.34e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767965898   261 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 298
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 434-474 1.13e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.25  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965898   434 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 474
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 738-779 1.44e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   738 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 779
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 762-802 1.75e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.75e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    762 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 802
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 150-192 1.80e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.80e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    150 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 192
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
587-838 5.28e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 64.66  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  587 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 666
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  667 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 742
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  743 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 816
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 767965898  817 LT-QQDRWIYWTDWQTKSIQRVD 838
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 126-167 2.81e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.40  E-value: 2.81e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   126 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 167
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 340-532 8.47e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 60.80  E-value: 8.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  340 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 414
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  415 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 484
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767965898  485 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 532
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 718-761 1.21e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.21e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    718 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 35-224 1.45e-09

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 60.29  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   35 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 106
Cdd:COG3386    15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  107 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 182
Cdd:COG3386    92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 767965898  183 ---EFAGlDG--SKRKVLIGSQLPHPF--GLTLYGE-RIYWTDWQTKSIQ 224
Cdd:COG3386   162 yrfDLDA-DGtlGNRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVV 210
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 675-715 1.57e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    675 ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 715
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 373-413 1.75e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 1.75e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898    373 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 413
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
11-178 1.42e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.01  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   11 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 89
Cdd:COG3391    51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   90 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASGRQVI--ISSNLTwPNGLAI 165
Cdd:COG3391   129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                         170
                  ....*....|...
gi 767965898  166 DYGSQRLYWADAG 178
Cdd:COG3391   206 SPDGRRLYVANRG 218
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 638-837 3.01e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.17  E-value: 3.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  638 ELNNVISLDYDSvDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRL 712
Cdd:cd05819    53 QFNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  713 DGSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTr 782
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG- 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767965898  783 RIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 837
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
4-237 3.26e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898    4 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 83
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   84 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 162
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  163 LAIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRET 236
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLAT 236


                  .
gi 767965898  237 L 237
Cdd:COG3391   237 L 237
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 459-500 8.06e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 8.06e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767965898    459 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 500
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 29-182 9.34e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.63  E-value: 9.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   29 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 101
Cdd:cd05819   105 RGIAVD---SSGNIYVADTGNHRIQ--KFDPDGEFLTTfgsggsgPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPD 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  102 GsmRTVLIW-------ENLDRPRDIVVEPmGGYMYWTDWGASpKIER-----AGMDASGRQVIISSNLTWPNGLAIDyGS 169
Cdd:cd05819   179 G--NFLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SD 253

                         170
                  ....*....|...
gi 767965898  170 QRLYWADAGMKTI 182
Cdd:cd05819   254 GNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 872-903 3.97e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 3.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767965898   872 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 903
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 334-410 6.11e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 52.20  E-value: 6.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767965898  334 TMKNTIAIGVDPQeGKVYWSDSTLHRISRANLDGsQHEDIITTGLQTTD--GLAVDAIGRKVYWTDTGTNRIEVGNLDG 410
Cdd:cd14962    55 RFVSPIGVAIDAN-GNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDG 131
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 83-123 7.01e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 7.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898    83 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 123
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 391-431 1.35e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.00  E-value: 1.35e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   391 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 431
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 340-370 1.57e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 1.57e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767965898    340 AIGVDPQEGKVYWSDSTLHRISRANLDGSQH 370
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 107-149 1.62e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 1.62e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    107 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASGR 149
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 695-735 1.63e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 1.63e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   695 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 735
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
293-494 1.76e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  293 SDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHED 372
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  373 IITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGEN--AKLEr 449
Cdd:COG3391   105 TIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNtvSVIV- 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767965898  450 SGMDGSDRAVLINNNLG-WPNGLTVDKASSQLLWADAHTERIEAAD 494
Cdd:COG3391   181 SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTSNGGS 226
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 342-497 2.12e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 50.75  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  342 GVDPQEGKVYWSDSTLHRISRANLDGSQ-----HEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRIEVGNLDGSMRKVL 416
Cdd:cd14963    14 GVAVSDGRIYVADTNNHRVQVFDYEGKFkksfgGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  417 VWQ----NLDSPRAIVLYHemGFMYWTDWGENA--------KLERS-GMDGSDRAvlinnNLGWPNGLTVDKAsSQLLWA 483
Cdd:cd14963    93 PEKkdrvKLISPAGLAIDD--GKLYVSDVKKHKvivfdlegKLLLEfGKPGSEPG-----ELSYPNGIAVDED-GNIYVA 164

                         170
                  ....*....|....
gi 767965898  484 DAHTERIEAADLNG 497
Cdd:cd14963   165 DSGNGRIQVFDKNG 178
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 30-177 4.90e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 49.59  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   30 AVALDwdsRDDHVYWTDVSTDTIS--------RAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 101
Cdd:cd14956    17 GIAVD---ADDNVYVADARNGRIQvfdkdgtfLRRFGTTGDG---PGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  102 GSMRTvlIWEN-------LDRPRDIVVEPmGGYMYWTDWGaSPKIERAGMDAS-----GRQVIISSNLTWPNGLAIDyGS 169
Cdd:cd14956    90 GELQT--IGGSsgsgpgqFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSflrqwGGTGIEPGSFNYPRGVAVD-PD 164


                  ....*...
gi 767965898  170 QRLYWADA 177
Cdd:cd14956   165 GTLYVADT 172
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 29-224 6.55e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.24  E-value: 6.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   29 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 101
Cdd:cd05819    11 QGIAVD---SSGNIYVADTGNNRIQ--VFDPDGNFITSfgsfgsgDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  102 GSMRTVLI-----WENLDRPRDIVVEPMgGYMYWTDWGASpKIERagMDASGR-QVIISSNLTW------PNGLAIDyGS 169
Cdd:cd05819    85 GNFLASFGgsgdgDGEFNGPRGIAVDSS-GNIYVADTGNH-RIQK--FDPDGEfLTTFGSGGSGpgqfngPTGVAVD-SD 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767965898  170 QRLYWADAGMKTI-------EFAGLDGSkrKVLIGSQLPHPFGLTLYGE-RIYWTDWQTKSIQ 224
Cdd:cd05819   160 GNIYVADTGNHRIqvfdpdgNFLTTFGS--TGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 21-61 1.87e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 1.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767965898     21 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 61
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 286-530 3.26e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  286 PTGINLLSDGKtcspgmnsflIFA-----RRIDIrmVSLD---IPYFADVVVPINITMKNTIAIgvdpQEGKVYWSDSTL 357
Cdd:cd14963    58 PYGIAVDSDGN----------IYVadlynGRIQV--FDPDgkfLKYFPEKKDRVKLISPAGLAI----DDGKLYVSDVKK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  358 HRISRANLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGSmrkvlvwqnldspraivlyhe 432
Cdd:cd14963   122 HKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGK--------------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  433 mgFMYWtdwgenaklersgMDGSDRAvliNNNLGWPNGLTVDKaSSQLLWADAHTERIEAADLNGANRHTLVSPVQ---- 508
Cdd:cd14963   180 --FIKE-------------LNGSPDG---KSGFVNPRGIAVDP-DGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKddgq 240

                         250       260
                  ....*....|....*....|....*
gi 767965898  509 --HPYGLTLLDS-YIYWTDWQTRSI 530
Cdd:cd14963   241 fnLPNGLFIDDDgRLYVTDRENNRV 265
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 40-80 4.04e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 4.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898    40 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 80
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 348-387 5.64e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 5.64e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   348 GKVYWSDSTLH-RISRANLDGSqHEDIITTG-LQTTDGLAVD 387
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGS-DRKTLFTDdLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 634-673 7.17e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 7.17e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 767965898    634 VPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 673
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 35-176 7.94e-05

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 45.72  E-value: 7.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898    35 WDSRDDHVYWTDVSTDTISRAkWDGTGQEVVVDTSleSPAGLAIDWVTNKLYWTDAgtDRIEVANTDGSMRTVLIWENLD 114
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRL-DPATGKETVWDTP--GPVGAIAPRDDGGLIVALK--DGVALLDLATGELTPLADPEDD 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767965898   115 -----RPRDIVVEPMGGYmywtdWGASPKIERAGM---------DASGRQVIISSNLTWPNGLAIDYGSQRLYWAD 176
Cdd:pfam08450   82 dwplnRFNDGKVDPDGRF-----WFGTMGDDEAPGgdpgalyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFAD 152
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 193-234 9.16e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 9.16e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    193 KVLIGSQLPHPFGLTL--YGERIYWTDWQTKSIQSADrLTGLDR 234
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
645-838 9.27e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 9.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  645 LDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGlavdwvaRNLYWTDTGRNTIeaSRLDGSCRKVLINNS 724
Cdd:COG3391    37 LAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-------RRLYVANSGSGRV--SVIDLATGKVVATIP 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  725 L-DEPRAIAVFPRKGYLFWTDW--GHIAKIeranlDGSERKVLINTDLG-WPNGLTLDYDTRRIYWVDAHLDR------- 793
Cdd:COG3391   108 VgGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTvsvivsv 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767965898  794 IESADLNgKLRQVLVSHVSHPFALTQQDRWIY-------WTDWQTKSIQRVD 838
Cdd:COG3391   183 IDTATGK-VVATIPVGGGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVID 233
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 170-209 9.97e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.61  E-value: 9.97e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767965898   170 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 209
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 414-457 1.07e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    414 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 457
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 341-538 1.27e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  341 IGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKV 415
Cdd:cd05819    13 IAVDSS-GNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVDSDGN-LYVADTGNHRIQKFDPDG--NFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  416 LVW-------QNLDSPRAIVLyHEMGFMYWTDWGENA---------KLERSGMDGSDRAVLINnnlgwPNGLTVDkaSSQ 479
Cdd:cd05819    89 ASFggsgdgdGEFNGPRGIAV-DSSGNIYVADTGNHRiqkfdpdgeFLTTFGSGGSGPGQFNG-----PTGVAVD--SDG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767965898  480 LLW-ADAHTERIEAADLNGA------NRHTLVSPVQHPYGLTlLDS--YIYWTDWQTRSIHRADKGTG 538
Cdd:cd05819   161 NIYvADTGNHRIQVFDPDGNflttfgSTGTGPGQFNYPTGIA-VDSdgNIYVADSGNNRVQVFDPDGA 227
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 21-178 1.73e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.51  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   21 VIPLADVRSAVALDWDSRDDhVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNkLYWTDAGTDRIEVANT 100
Cdd:cd14952     3 VLPFTGLDGPGGVAVDAAGN-VYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGT-VYVTDFGNNRVLKLAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767965898  101 DGSMRTVLIWENLDRPRDIVVEPmGGYMYWTDWGASPKIERAGmdASGRQVIIS-SNLTWPNGLAIDyGSQRLYWADAG 178
Cdd:cd14952    81 GSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNRVLKLAA--GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTG 155
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 211-251 2.80e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 2.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   211 ERIYWTDWQTKSIQSADRLTGLDRETL-QENLENLMDIHVFH 251
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLfTDDLQHPNAIAVDP 42
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 687-803 5.00e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 43.34  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  687 GLAVDWVARnLYWTDTGRNTIeaSRLDGSCRKV-LINNSLDE----PRAIAVFPrKGYLFWTDWGHiAKIERANLDGSER 761
Cdd:cd14962    16 GVAADGRGR-IYVADTGRGAV--FVFDLPNGKVfVIGNAGPNrfvsPIGVAIDA-NGNLYVSDAEL-GKVFVFDRDGKFL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767965898  762 KVlINTDLGW--PNGLTLDYDTRRIYWVDAHLDRIESADLNGKL 803
Cdd:cd14962    91 RA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 324-403 7.94e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.58  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  324 FADVVVPInitmkntiAIGVDPQeGKVYWSDSTLHRISRanLDGSQHEDIIT--TGLQTTDGLAVDAIGrKVYWTDTGTN 401
Cdd:cd14952   174 FTGLNSPS--------GVAVDTA-GNVYVTDHGNNRVLK--LAAGSTTPTVLpfTGLNGPLGVAVDAAG-NVYVADRGND 241


                  ..
gi 767965898  402 RI 403
Cdd:cd14952   242 RV 243
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 651-838 1.08e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.19  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  651 DGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTdGLAVDWvARNLYWTDTGRNTIEASRLDGSCRKVLinNSLDEPRA 730
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPN-GLAFDP-DGRLLVADHGRGLVRFDPADGEVTVLA--DEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  731 I---AVFPRKGYLFWTD---WGHIAKIERANLDGSERKVLinTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADL--NGK 802
Cdd:COG3386    94 RpndGVVDPDGRLYFTDmgeYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767965898  803 L--RQVLVSHVSHP-----FALTQQDRwIYWTDWQTKSIQRVD 838
Cdd:COG3386   172 LgnRRVFADLPDGPggpdgLAVDADGN-LWVALWGGGGVVRFD 213
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 651-802 1.10e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  651 DGKVYYTD-------VFldvirraDLNGSNMETVIGRG-----LKTTDGLAVDwVARNLYWTDTGRNTIEASRLDGSCRK 718
Cdd:cd14963    19 DGRIYVADtnnhrvqVF-------DYEGKFKKSFGGPGtgpgeFKYPYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  719 VL----INNSLDEPRAIAVFprKGYLFWTDWGHiAKIERANLDGseRKVLI-------NTDLGWPNGLTLDyDTRRIYWV 787
Cdd:cd14963    91 YFpekkDRVKLISPAGLAID--DGKLYVSDVKK-HKVIVFDLEG--KLLLEfgkpgsePGELSYPNGIAVD-EDGNIYVA 164

                         170
                  ....*....|....*
gi 767965898  788 DAHLDRIESADLNGK 802
Cdd:cd14963   165 DSGNGRIQVFDKNGK 179
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 348-476 1.15e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.19  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  348 GKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRieVGNLDG--SMRKVLVWQNLDSPR 425
Cdd:cd14952    63 GTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPD 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767965898  426 AIVLyHEMGFMYWTDWGENAKLERSGmDGSDRAVLINNNLGWPNGLTVDKA 476
Cdd:cd14952   140 GVAV-DGAGNVYVTDTGNNRVLKLAA-GSTTQTVLPFTGLNSPSGVAVDTA 188
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 643-814 1.20e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.19  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  643 ISLDYDSvDGKVYYTDVFLDVIRRADLNGsNMETVIGRGLKTTD--GLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 720
Cdd:cd14962    60 IGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  721 -----INNSLDEPRAIAVfPRKGYLFWTDWGHiAKIERANLDGSERKVL--INTDLGW---PNGLTLDYDTRrIYWVDAH 790
Cdd:cd14962   138 gkrgsGPGEFNLPTDLAV-DRDGNLYVTDTMN-FRVQIFDADGKFLRSFgeRGDGPGSfarPKGIAVDSEGN-IYVVDAA 214

                         170       180
                  ....*....|....*....|....
gi 767965898  791 LDRIESADLNGKLRQVLVSHVSHP 814
Cdd:cd14962   215 FDNVQIFNPEGELLLTVGGPGSGP 238
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 500-541 1.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767965898    500 RHTLVSPVQHPYGLTL--LDSYIYWTDWQTRSIHRADKgTGSNV 541
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 804-844 1.41e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.41e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767965898    804 RQVLVSHVSHP--FALTQQDRWIYWTDWQTKSIQRVDkYSGRN 844
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 343-403 3.25e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.65  E-value: 3.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767965898  343 VDPQeGKVYWSDSTLH----RISRANLDGSQHedIITTGLQTTDGLAVDAIGRKVYWTDTGTNRI 403
Cdd:COG3386   100 VDPD-GRLYFTDMGEYlptgALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 343-476 3.53e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.65  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  343 VDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGrKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLD 422
Cdd:cd14952   101 VDAA-GNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLPFTGLN 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767965898  423 SPRAIVLYHEmGFMYWTDWGENAKLE-RSGMDGSdrAVLINNNLGWPNGLTVDKA 476
Cdd:cd14952   179 SPSGVAVDTA-GNVYVTDHGNNRVLKlAAGSTTP--TVLPFTGLNGPLGVAVDAA 230
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 378-498 5.28e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898  378 LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKVLVW-----QNLDSPRAIVLyHEMGFMYWTDwGENAKLERSGM 452
Cdd:cd14962    11 LTRPYGVAADGRGR-IYVADTGRGAVFVFDLPN--GKVFVIgnagpNRFVSPIGVAI-DANGNLYVSD-AELGKVFVFDR 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767965898  453 DGSDRAVlINNNLGW--PNGLTVDKASSQLLWADAHTERIEAADLNGA 498
Cdd:cd14962    86 DGKFLRA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGR 132
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 341-411 6.96e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 39.94  E-value: 6.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767965898  341 IGVDpQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGrKVYWTDTGTNRIEVGNLDGS 411
Cdd:cd14957    70 IAVD-SNGNIYVADTDNNRIQVFNSSGVYQYSIGTGGSGDGQfngpyGIAVDSNG-NIYVADTGNHRIQVFTSSGT 143
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 652-692 7.29e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 7.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767965898   652 GKVYYTDVFLD-VIRRADLNGSNMETVIGRGLKTTDGLAVDW 692
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 341-405 7.43e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 7.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767965898  341 IGVDPqEGKVYWSDSTLHRISRANLDGsqhEDIITTGLQTTD--------GLAVDAIGRkVYWTDTGTNRIEV 405
Cdd:cd14963   200 IAVDP-DGNLYVVDNLSHRVYVFDEQG---KELFTFGGRGKDdgqfnlpnGLFIDDDGR-LYVTDRENNRVAV 267
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 335-405 7.60e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.57  E-value: 7.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767965898  335 MKNTIAIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEV 405
Cdd:cd14956   200 FNYPYGIAIDPD-GNVFVADFGNNRIQKFTADGTFLTSWGSPGtgpgqFKNPWGVVVDADGT-VYVADSNNNRVQR 273
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 782-818 7.97e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.21  E-value: 7.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767965898   782 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 818
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 73-198 8.41e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965898   73 PAGLAIDwVTNKLYWTDAGTDRIEVANTDGSMRTVL----IWENLDRPRDIVVEpmGGYMYWTDWGASpKIerAGMDASG 148
Cdd:cd14963    58 PYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVKKH-KV--IVFDLEG 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767965898  149 RQVII-------SSNLTWPNGLAIDyGSQRLYWADAGMKTIEFAGLDGSKRKVLIGS 198
Cdd:cd14963   132 KLLLEfgkpgsePGELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGS 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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