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Conserved domains on  [gi|767985832|ref|XP_011520537|]
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GPI mannosyltransferase 3 isoform X1 [Homo sapiens]

Protein Classification

Glyco_transf_22 domain-containing protein( domain architecture ID 10511211)

Glyco_transf_22 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-434 1.27e-112

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


:

Pssm-ID: 281842  Cd Length: 414  Bit Score: 340.50  E-value: 1.27e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  140 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 216
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  217 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSL----SLMIDRIFFGQ-------- 282
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLvlgaVILIDSYFYGRfvftplnf 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  283 -------NWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 351
Cdd:pfam03901 240 lkynvlsNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  352 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 419
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985832  420 IMMPCHSTPYYSHVH 434
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-434 1.27e-112

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 340.50  E-value: 1.27e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  140 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 216
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  217 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSL----SLMIDRIFFGQ-------- 282
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLvlgaVILIDSYFYGRfvftplnf 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  283 -------NWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 351
Cdd:pfam03901 240 lkynvlsNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  352 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 419
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985832  420 IMMPCHSTPYYSHVH 434
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
63-525 1.33e-106

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 329.69  E-value: 1.33e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  63 LLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWI 142
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 143 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 219
Cdd:PLN02816 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 220 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGqNW-------------- 284
Cdd:PLN02816 201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYG-SWvivplnflkfnfls 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 285 --GTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS 362
Cdd:PLN02816 280 sgGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYA 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 363 LTHLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaS 417
Cdd:PLN02816 358 FAQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---S 434
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 418 IFIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFL 497
Cdd:PLN02816 435 ILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFM 512
                        490       500
                 ....*....|....*....|....*....
gi 767985832 498 ISSNYKRTAVFFHTHLPEGR-IGSHIYVY 525
Cdd:PLN02816 513 IQHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
62-434 1.27e-112

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 340.50  E-value: 1.27e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832   62 YLLLFTIALRILNCFLVQTSfVPDEYWQSLEVSHHMVFNYGYLTWEWTER--LRSYTYPLIFASIYKILHLLGKDSVQLL 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  140 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 216
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  217 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSL----SLMIDRIFFGQ-------- 282
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLvlgaVILIDSYFYGRfvftplnf 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  283 -------NWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 351
Cdd:pfam03901 240 lkynvlsNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  352 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 419
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399
                         410
                  ....*....|....*
gi 767985832  420 IMMPCHSTPYYSHVH 434
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
63-525 1.33e-106

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 329.69  E-value: 1.33e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832  63 LLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWI 142
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 143 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 219
Cdd:PLN02816 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 220 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGqNW-------------- 284
Cdd:PLN02816 201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYG-SWvivplnflkfnfls 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 285 --GTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS 362
Cdd:PLN02816 280 sgGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYA 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 363 LTHLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaS 417
Cdd:PLN02816 358 FAQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---S 434
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985832 418 IFIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFL 497
Cdd:PLN02816 435 ILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFM 512
                        490       500
                 ....*....|....*....|....*....
gi 767985832 498 ISSNYKRTAVFFHTHLPEGR-IGSHIYVY 525
Cdd:PLN02816 513 IQHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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