NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767987143|ref|XP_011520765|]
View 

zinc finger CCCH domain-containing protein 7A isoform X1 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein 7A( domain architecture ID 13518798)

zinc finger CCCH domain-containing protein 7A (ZC3H7A) may be a specific regulator of miRNA biogenesis and binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop

Gene Symbol:  ZC3H7A
Gene Ontology:  GO:0008270|GO:0035198|GO:0005515
PubMed:  11179890|22803940

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.54e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 57.69  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143    6 EERRKRQQNIKEGLQF-------------IQSPLSYPGTQEQYAVYLRALVRN-----LFNEGNDVYREHDWNNSISQYT 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143   68 EALniadyakseeILIPKEIiekLYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPV---YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 767987143  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
ZnF_C3H1 smart00356
zinc finger;
906-926 4.67e-04

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 4.67e-04
                           10        20
                   ....*....|....*....|.
gi 767987143   906 ICDRYMNGTCPEGNSCKFAHG 926
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 857-882 1.98e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 767987143  857 FHCWMCGKNCNSEKQWQGHISSEKHK 882
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.54e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 57.69  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143    6 EERRKRQQNIKEGLQF-------------IQSPLSYPGTQEQYAVYLRALVRN-----LFNEGNDVYREHDWNNSISQYT 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143   68 EALniadyakseeILIPKEIiekLYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPV---YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 767987143  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
36-183 4.19e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  36 AVYLRAL------VRNLFNEGNDVYREHDWNNSISQYTEALNIA-DYAKSeeilipkeiieklYINRIACYSNMGFHDKV 108
Cdd:COG0457   63 ADYEQALeldpddAEALNNLGLALQALGRYEEALEDYDKALELDpDDAEA-------------LYNLGLALLELGRYDEA 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767987143 109 LEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVRAEL 183
Cdd:COG0457  130 IEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
ZnF_C3H1 smart00356
zinc finger;
906-926 4.67e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 4.67e-04
                           10        20
                   ....*....|....*....|.
gi 767987143   906 ICDRYMNGTCPEGNSCKFAHG 926
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 857-882 1.98e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 767987143  857 FHCWMCGKNCNSEKQWQGHISSEKHK 882
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
905-926 5.06e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.25  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|...
gi 767987143  905 SICDRYM-NGTCPEGNSCKFAHG 926
Cdd:pfam00642   4 ELCRFFLrTGYCKYGDRCKFAHG 26
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.54e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 57.69  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143    6 EERRKRQQNIKEGLQF-------------IQSPLSYPGTQEQYAVYLRALVRN-----LFNEGNDVYREHDWNNSISQYT 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143   68 EALniadyakseeILIPKEIiekLYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPV---YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 767987143  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
36-183 4.19e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  36 AVYLRAL------VRNLFNEGNDVYREHDWNNSISQYTEALNIA-DYAKSeeilipkeiieklYINRIACYSNMGFHDKV 108
Cdd:COG0457   63 ADYEQALeldpddAEALNNLGLALQALGRYEEALEDYDKALELDpDDAEA-------------LYNLGLALLELGRYDEA 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767987143 109 LEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVRAEL 183
Cdd:COG0457  130 IEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-142 1.53e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  46 LFNEGNDVYREHDWNNSISQYTEALNIA-DYAKSeeilipkeiieklYINRIACYSNMGFHDKVLEDCNIVLSLNASNCK 124
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEA-------------LYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                         90
                 ....*....|....*...
gi 767987143 125 ALYRKSKALSDLGRYKKA 142
Cdd:COG0457   78 ALNNLGLALQALGRYEEA 95
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-183 2.48e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  55 REHDWNNSISQYTEALNIA------------------DYAKSEEILipKEIIE------KLYINRIACYSNMGFHDKVLE 110
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLGpenahaycelaelyleqgDYDEAIEAL--EKALKldpdcaRALLLLAELYLEQGDYEEAIA 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767987143 111 DCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVRAEL 183
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQL 272
ZnF_C3H1 smart00356
zinc finger;
906-926 4.67e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 4.67e-04
                           10        20
                   ....*....|....*....|.
gi 767987143   906 ICDRYMNGTCPEGNSCKFAHG 926
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHP 26
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
30-149 8.00e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.21  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  30 GTQEQYAVYLRA--LVRNLFNEGNDVYREHDWNNSISQYTEALNI-ADYAKseeilipkeiiekLYINRIACYSNMGFHD 106
Cdd:COG4785   58 LAAERIDRALALpdLAQLYYERGVAYDSLGDYDLAIADFDQALELdPDLAE-------------AYNNRGLAYLLLGDYD 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767987143 107 KVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKC 149
Cdd:COG4785  125 AALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKA 167
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 857-882 1.98e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 767987143  857 FHCWMCGKNCNSEKQWQGHISSEKHK 882
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 32-209 2.02e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143  32 QEQYAVYLRALVRN------LFNEGNDVYREHDWNNSISQYTEALNIA-DYAKseeilipkeiiekLYINRIACYSNMGF 104
Cdd:COG3914   95 EEALALYRRALALNpdnaeaLFNLGNLLLALGRLEEALAALRRALALNpDFAE-------------AYLNLGEALRRLGR 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987143 105 HDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVI-KLTQELAQKLGFKIRKAYVRAEL 183
Cdd:COG3914  162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHsNLLFALRQACDWEVYDRFEELLA 241

                        170       180
                 ....*....|....*....|....*.
gi 767987143 184 SLKSVPGDGATKALNHSVEDIEPDLL 209
Cdd:COG3914  242 ALARGPSELSPFALLYLPDDDPAELL 267
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
905-926 5.06e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.25  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|...
gi 767987143  905 SICDRYM-NGTCPEGNSCKFAHG 926
Cdd:pfam00642   4 ELCRFFLrTGYCKYGDRCKFAHG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH