NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767989364|ref|XP_011521155|]
View 

dynein axonemal assembly factor 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.79e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.79e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767989364 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
PHA03169 super family cl27451
hypothetical protein; Provisional
 296-508 4.65e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.42  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 375 aEGKEEPPGDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169  99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767989364 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169 175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.79e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.79e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767989364 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                        170
                 ....*....|...
gi 767989364 267 tvTVRLKHLTYLD 279
Cdd:COG4886  268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
166-302 2.11e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.24  E-value: 2.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364  166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRLCVLdlSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLTELIL--TNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767989364  244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PHA03169 PHA03169
hypothetical protein; Provisional
 296-508 4.65e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.42  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 375 aEGKEEPPGDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169  99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767989364 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169 175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 1.12e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 767989364 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.79e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.79e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767989364 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                        170
                 ....*....|...
gi 767989364 267 tvTVRLKHLTYLD 279
Cdd:COG4886  268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-279 9.24e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 9.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364  89 TKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI- 166
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 167 ENLEPLQKLDALNLSNNYIKTI-ENLSCLPVLNTLQMAHNHLETVEDiqHLQECLRLCVLDLSHNKLSDpeILSILESMP 245
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTD--LPEPLANLT 228

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767989364 246 DLRVLNLMGNPvIRQIPNYRrtvtvRLKHLTYLD 279
Cdd:COG4886  229 NLETLDLSNNQ-LTDLPELG-----NLTNLEELD 256
LRR_9 pfam14580
Leucine-rich repeat;
166-302 2.11e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.24  E-value: 2.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364  166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRLCVLdlSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLTELIL--TNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767989364  244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-263 6.42e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 6.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTI 188
Cdd:COG4886  186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767989364 189 ENLSCLPVLNTLQMAHNHLETVEdIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPN 263
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-279 1.32e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364  91 SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 170
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 171 PLQKLDALNLSNNyiktiENLSCLPVLNTLQMAHNHLETV-EDIQHLQEcLRlcVLDLSHNKLSDpeILSILESMPDLRV 249
Cdd:COG4886   94 DLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTN-LK--ELDLSNNQLTD--LPEPLGNLTNLKS 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 767989364 250 LNLMGNPvIRQIPNyrrtVTVRLKHLTYLD 279
Cdd:COG4886  164 LDLSNNQ-LTDLPE----ELGNLTNLKELD 188
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 221-265 5.55e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 46.47  E-value: 5.55e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767989364  221 RLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPVIRQIPNYR 265
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
151-207 1.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767989364  151 TELRCLFLQMNLLRKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNHL 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-255 7.93e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 7.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMN------LLRKIENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNqigaegAIALAKALQGNTTLTSLDLSVNRIGDeg 308

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767989364 188 ----IENLSCLPVLNTLQMAHNHLETVEDI---QHLQECLRLCVLDLSHNKLSDP---EILSILESMPDLRVLNLMGN 255
Cdd:COG5238  309 aialAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKN 386
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 151-192 1.98e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.98e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767989364  151 TELRCLFLQMNLLRKIENLEPLQKLDALNLS-NNYIKTIENLS 192
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
195-257 2.48e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767989364  195 PVLNTLQMAHNHLETVED--IQHLQeclRLCVLDLSHNKLS--DPEILSileSMPDLRVLNLMGNPV 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLS---NLKVLDLSNNLLTtlSPGAFS---GLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 173-218 6.24e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 6.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767989364  173 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLetVEDIQHLQE 218
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-279 6.92e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 6.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 102 LYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 181
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 182 NNYIKTIENLSCLPVLNtlqmahnhLETVEDIQHLQEclrLCVLDLSHNKLSDpeILSILESMPDLRVLNLMGNPvIRQI 261
Cdd:COG4886   86 LLGLTDLGDLTNLTELD--------LSGNEELSNLTN---LESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDL 151

                        170
                 ....*....|....*...
gi 767989364 262 PnyrrTVTVRLKHLTYLD 279
Cdd:COG4886  152 P----EPLGNLTNLKSLD 165
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-174 2.28e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767989364  129 TGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNllRKIENLEPLQK 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-257 2.46e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 122 IENLEEYTGLRCLWLQSNGIQK-----IENLEAQTELRCLFLQMNLLRK------IENLEPLQ-KLDALNLSNNyikTIE 189
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDrglrllAKGLKDLPpALEKLVLGRN---RLE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 190 NLSC------LPV---LNTLQMAHNHLeTVEDIQHLQECLR----LCVLDLSHNKLSDPEILSI---LESMPDLRVLNLM 253
Cdd:cd00116  151 GASCealakaLRAnrdLKELNLANNGI-GDAGIRALAEGLKancnLEVLDLNNNGLTDEGASALaetLASLKSLEVLNLG 229


                 ....
gi 767989364 254 GNPV 257
Cdd:cd00116  230 DNNL 233
PHA03169 PHA03169
hypothetical protein; Provisional
 296-508 4.65e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.42  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGmrsAEDNSPRVPLRLGEMTSSDDGENvpas 374
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTET---AEESRHGEKEERGQGGPSGSGSE---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 375 aEGKEEPPGDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDG 450
Cdd:PHA03169  99 -SVGSPTPSPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDS 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767989364 451 DGEPEGtlPAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 508
Cdd:PHA03169 175 PEEPEP--PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
PHA03169 PHA03169
hypothetical protein; Provisional
 302-508 9.54e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 42.27  E-value: 9.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 302 EKEERQQWESRERKKITDSIEALAMIKQRAEERKRQ--------RESQERGMRSAEDNSPRVPLRLGEMTSSDDGENVPA 373
Cdd:PHA03169  53 TSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGqggpsgsgSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 374 SAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAET-LLLSSPVEVKGEDGDG 452
Cdd:PHA03169 133 SHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSeTPTSSPPPQSPPDEPG 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767989364 453 EPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEG 508
Cdd:PHA03169 213 EPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRPGG 268
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 1.12e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 767989364 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-275 1.25e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMNLLRK------IENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238  257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqg 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 188 ----IENLSCLPVLNTLQMAHNHL--ETVEDI-QHLQECLRLCVLDLSHNKLSDPEILSILESM--PDLRVLNLMGNPVI 258
Cdd:COG5238  337 aialAKALQENTTLHSLDLSDNQIgdEGAIALaKYLEGNTTLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGNLIG 416

                        170
                 ....*....|....*..
gi 767989364 259 RQIpnyRRTVTVRLKHL 275
Cdd:COG5238  417 AEA---QQRLEQLLERI 430
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 173-279 1.33e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989364 173 QKLDALNLSNNYIKTI------ENLSCLPVLNTLQMAHNHL---ETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
Cdd:COG5238  180 NSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIgdeGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767989364 244 MPD---LRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 279
Cdd:COG5238  260 LKNnttVETLYLSGNQIGAEGAIALAKALQGNTTLTSLD 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH