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Conserved domains on  [gi|767993608|ref|XP_011522646|]
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chorionic somatomammotropin hormone-like 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
growth_hormone_like super family cl07831
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 35-172 8.69e-38

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


The actual alignment was detected with superfamily member cd10285:

Pssm-ID: 324147  Cd Length: 180  Bit Score: 131.03  E-value: 8.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608  35 LFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQKYSFLHdSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLI 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDF-----ERSYIPEEQRQSNKN-SPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLI 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767993608 115 ESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGVRVAPGVPNPGSPLA 172
Cdd:cd10285   75 QSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQ 131
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 35-172 8.69e-38

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 131.03  E-value: 8.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608  35 LFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQKYSFLHdSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLI 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDF-----ERSYIPEEQRQSNKN-SPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLI 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767993608 115 ESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGVRVAPGVPNPGSPLA 172
Cdd:cd10285   75 QSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQ 131
Hormone_1 pfam00103
Somatotropin hormone family;
29-157 7.85e-28

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 105.92  E-value: 7.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608   29 TVPLSRLFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQkysfLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLH 108
Cdd:pfam00103  26 RMSLEDLFDNATLLSHNMYNLASDMFTEF-----DENYAQGKG----YFIRRTTSCHTNSIHTPENREKAQQTSNEELLK 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767993608  109 ISLLLIESRLEPVRFLR----STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMG 157
Cdd:pfam00103  97 WSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFS 149
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 35-172 8.69e-38

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 131.03  E-value: 8.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608  35 LFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQKYSFLHdSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLI 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDF-----ERSYIPEEQRQSNKN-SPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLI 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767993608 115 ESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGVRVAPGVPNPGSPLA 172
Cdd:cd10285   75 QSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQ 131
Hormone_1 pfam00103
Somatotropin hormone family;
29-157 7.85e-28

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 105.92  E-value: 7.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608   29 TVPLSRLFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQkysfLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLH 108
Cdd:pfam00103  26 RMSLEDLFDNATLLSHNMYNLASDMFTEF-----DENYAQGKG----YFIRRTTSCHTNSIHTPENREKAQQTSNEELLK 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767993608  109 ISLLLIESRLEPVRFLR----STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMG 157
Cdd:pfam00103  97 WSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFS 149
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 35-157 3.79e-19

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 82.16  E-value: 3.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993608  35 LFKEAMLQAHRAHQLAIDTYQEFisswgMEAYITKEQKysflHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLI 114
Cdd:cd10284    1 LFDRAIPHAERVYHLSSEAYAEF-----EEKYIPGENP----PNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767993608 115 ESRLEPVRFLRSTFTNN----LVYDTSDSDDYHLLKDLEEGIQMLMG 157
Cdd:cd10284   72 QSWSEPLLHLHTVLANSkgtsLALLPKAKQVSEMLKLLEDGVETLSE 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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