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Conserved domains on  [gi|767994709|ref|XP_011523086|]
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keratin, type I cytoskeletal 15 isoform X1 [Homo sapiens]

Protein Classification

intermediate filament family protein( domain architecture ID 11981676)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 9.40e-140

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 403.15  E-value: 9.40e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 767994709  423 K 423
Cdd:pfam00038 313 R 313
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 9.40e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 403.15  E-value: 9.40e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 767994709  423 K 423
Cdd:pfam00038 313 R 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 122-427 6.92e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 6.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   122 KVRALEEANADLEVKIHDWYQKQTptSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELAL 201
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELE--ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   202 RQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHeewvppilqemKEFSSQLagqvnvemdaapgvDLTRV 281
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----------DELRAEL--------------TLLNE 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   282 LAEMREQYEAMAEKNRRDVEAWFfsktEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETE 361
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRL----EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   362 CRYATQLQQIQGL---IGGLEAQLSELRCEMEA-QNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI 427
Cdd:TIGR02168  894 SELEELSEELRELeskRSELRRELEELREKLAQlELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKI 963
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
148-432 3.54e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 148 SPECDYSQYFKTIEELRDKIMATTIDNSRVIlEI----DNARLAAddfrlKYENELA---LRQGVEADINGLRRVLDELT 220
Cdd:COG3206  108 DPLGEEASREAAIERLRKNLTVEPVKGSNVI-EIsytsPDPELAA-----AVANALAeayLEQNLELRREEARKALEFLE 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 221 LARTDLEMQIEGLNEELAYLKKNH-----EEWVPPILQEMKEFSSQLAgqvnvemdaapgvDLTRVLAEMREQYEAMAEK 295
Cdd:COG3206  182 EQLPELRKELEEAEAALEEFRQKNglvdlSEEAKLLLQQLSELESQLA-------------EARAELAEAEARLAALRAQ 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 296 NRRDVEAwffskteelnKEVASNTEMIQTSKTEITDLRRTMQELE----------IELQSQL-SMKAGLENSLAETECRY 364
Cdd:COG3206  249 LGSGPDA----------LPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIaALRAQLQQEAQRILASL 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994709 365 ATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLdiktRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG3206  319 EAELEALQAREASLQAQLAQLEARLAELPELEAELR----RLEREVEVARELYESLLQRLEEARLAEA 382
PRK11281 PRK11281
mechanosensitive channel MscK;
306-422 2.97e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 40.28  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  306 SKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAgLENSLAETEcryaTQLQQIQGLIGGLEAQLSEL 385
Cdd:PRK11281   80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767994709  386 RCEME-AQNQEYKMLldikTRLeQEIatyRSLLEGQDA 422
Cdd:PRK11281  155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 9.40e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 403.15  E-value: 9.40e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 767994709  423 K 423
Cdd:pfam00038 313 R 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 122-427 6.92e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 6.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   122 KVRALEEANADLEVKIHDWYQKQTptSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELAL 201
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELE--ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   202 RQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHeewvppilqemKEFSSQLagqvnvemdaapgvDLTRV 281
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----------DELRAEL--------------TLLNE 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   282 LAEMREQYEAMAEKNRRDVEAWFfsktEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETE 361
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRL----EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   362 CRYATQLQQIQGL---IGGLEAQLSELRCEMEA-QNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI 427
Cdd:TIGR02168  894 SELEELSEELRELeskRSELRRELEELREKLAQlELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKI 963
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 194-432 3.07e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 3.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   194 KYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEEL----AYLKKNHEEWVPPILQEMKEFSSQLAGQV--- 266
Cdd:TIGR02169  231 EKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLeelnKKIKDLGEEEQLRVKEKIGELEAEIASLErsi 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   267 ---NVEMDAAPG------VDLTRVLAEMREQYEAMAE------------KNRRDVEAWFFSKTEELNKEVASNTEMIQTS 325
Cdd:TIGR02169  311 aekERELEDAEErlakleAEIDKLLAEIEELEREIEEerkrrdklteeyAELKEELEDLRAELEEVDKEFAETRDELKDY 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   326 KTEITDLRRTMQELEIELQSQLSMKAGLENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTR 405
Cdd:TIGR02169  391 REKLEKLKREINELKRELDRLQEELQRLSEELADLN----AAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSK 466

                          250       260       270
                   ....*....|....*....|....*....|.
gi 767994709   406 LEQEI----ATYRSLLEGQDAKMAGIAIREA 432
Cdd:TIGR02169  467 YEQELydlkEEYDRVEKELSKLQRELAEAEA 497
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
148-432 3.54e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 148 SPECDYSQYFKTIEELRDKIMATTIDNSRVIlEI----DNARLAAddfrlKYENELA---LRQGVEADINGLRRVLDELT 220
Cdd:COG3206  108 DPLGEEASREAAIERLRKNLTVEPVKGSNVI-EIsytsPDPELAA-----AVANALAeayLEQNLELRREEARKALEFLE 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 221 LARTDLEMQIEGLNEELAYLKKNH-----EEWVPPILQEMKEFSSQLAgqvnvemdaapgvDLTRVLAEMREQYEAMAEK 295
Cdd:COG3206  182 EQLPELRKELEEAEAALEEFRQKNglvdlSEEAKLLLQQLSELESQLA-------------EARAELAEAEARLAALRAQ 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 296 NRRDVEAwffskteelnKEVASNTEMIQTSKTEITDLRRTMQELE----------IELQSQL-SMKAGLENSLAETECRY 364
Cdd:COG3206  249 LGSGPDA----------LPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIaALRAQLQQEAQRILASL 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994709 365 ATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLdiktRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG3206  319 EAELEALQAREASLQAQLAQLEARLAELPELEAELR----RLEREVEVARELYESLLQRLEEARLAEA 382
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 180-392 7.95e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 7.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 180 EIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEWVPPILQEMKE-F 258
Cdd:COG4942   35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRAlY 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 259 SSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKnrrdveawffskTEELN---KEVASNTEMIQTSKTEITDLRRT 335
Cdd:COG4942  115 RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ------------AEELRadlAELAALRAELEAERAELEALLAE 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767994709 336 MQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQ 392
Cdd:COG4942  183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 180-432 1.55e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   180 EIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEWVPPILQEMKEFS 259
Cdd:TIGR02168  678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   260 SQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAW------FFSKTEELNKEVASNTEMIQTSKTEITDLR 333
Cdd:TIGR02168  758 ELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALrealdeLRAELTLLNEEAANLRERLESLERRIAATE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   334 RTMQELE---IELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEI 410
Cdd:TIGR02168  838 RRLEDLEeqiEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRREL 917

                          250       260
                   ....*....|....*....|..
gi 767994709   411 ATYRSLLEGQDAKMAGIAIREA 432
Cdd:TIGR02168  918 EELREKLAQLELRLEGLEVRID 939
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 186-432 2.16e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 186 LAADDFRLKYENELalrQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgQ 265
Cdd:COG4942   16 AAQADAAAEAEAEL---EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA----LEQELAALEAELA-E 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 266 VNVEMDAapgvdLTRVLAEMREQYEAM---AEKNRRDVEAWFFSKTEELNKEVASNT---EMIQTSKTEITDLRRTMQEL 339
Cdd:COG4942   88 LEKEIAE-----LRAELEAQKEELAELlraLYRLGRQPPLALLLSPEDFLDAVRRLQylkYLAPARREQAEELRADLAEL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 340 EIELQSQLSMKAGLENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKmlldiktRLEQEIATYRSLLEG 419
Cdd:COG4942  163 AALRAELEAERAELEALLAELE----EERAALEALKAERQKLLARLEKELAELAAELA-------ELQQEAEELEALIAR 231

                        250
                 ....*....|...
gi 767994709 420 QDAKMAGIAIREA 432
Cdd:COG4942  232 LEAEAAAAAERTP 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 105-426 1.23e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.64  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   105 EKITMQN----LNDRLASYLDKVRALEEANADL-------EVKIHDWYQKQTP------TSPECD-----YSQYFKTIEE 162
Cdd:pfam15921  487 KKMTLESsertVSDLTASLQEKERAIEATNAEItklrsrvDLKLQELQHLKNEgdhlrnVQTECEalklqMAEKDKVIEI 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   163 LRDKIM--------------ATTIDNSRVILEIDNARLAADDFRLkyenelaLRQGVEADINGLRRVLDELTLARTDLem 228
Cdd:pfam15921  567 LRQQIEnmtqlvgqhgrtagAMQVEKAQLEKEINDRRLELQEFKI-------LKDKKDAKIRELEARVSDLELEKVKL-- 637

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   229 qIEGLNEELAYLKknheewvppilqEMKEFSSQLAGQVNVEMDAapgvdltrvLAEMREQYEAMAEKnrrdveawFFSKT 308
Cdd:pfam15921  638 -VNAGSERLRAVK------------DIKQERDQLLNEVKTSRNE---------LNSLSEDYEVLKRN--------FRNKS 687

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   309 EELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENslaetecryatQLQQIQGLIGGLEAQLSELRCE 388
Cdd:pfam15921  688 EEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQK-----------QITAKRGQIDALQSKIQFLEEA 756

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 767994709   389 MEAQNQEYKMLLDIKTRLEQEIATYRSllegQDAKMAG 426
Cdd:pfam15921  757 MTNANKEKHFLKEEKNKLSQELSTVAT----EKNKMAG 790
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 206-426 2.56e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 206 EADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEfssqlagqVNVEMDAApGVDLTRVLAEM 285
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNE----LQAELEA--------LQAEIDKL-QAEIAEAEAEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 286 REQYEAMAE------KNRRDVEAW-----------FFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLS 348
Cdd:COG3883   82 EERREELGEraralyRSGGSVSYLdvllgsesfsdFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994709 349 MKAGLENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAG 426
Cdd:COG3883  162 LKAELEAAKAELE----AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 193-432 2.94e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 193 LKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppiLQEmkEFSSQLAGQVNVEMDA 272
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE-----AQA--EEYELLAELARLEQDI 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 273 APGVDLTRVLAEMREQYEAMAEKNRRDVEAwFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAG 352
Cdd:COG1196  305 ARLEERRRELEERLEELEEELAELEEELEE-LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 353 LENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG1196  384 LAEELLEAL----RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
PRK11281 PRK11281
mechanosensitive channel MscK;
306-422 2.97e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 40.28  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709  306 SKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAgLENSLAETEcryaTQLQQIQGLIGGLEAQLSEL 385
Cdd:PRK11281   80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767994709  386 RCEME-AQNQEYKMLldikTRLeQEIatyRSLLEGQDA 422
Cdd:PRK11281  155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 230-412 4.15e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   230 IEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgqvnvemdaapgvDLTRVLAEMREQYEAMAEKNRRDVEawffskte 309
Cdd:TIGR02169  683 LEGLKRELSSLQSELRR----IENRLDELSQELS-------------DASRKIGEIEKEIEQLEQEEEKLKE-------- 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709   310 elnkEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYA-TQLQQIQGLIGGLEAQLSELRCE 388
Cdd:TIGR02169  738 ----RLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEAR 813

                          170       180
                   ....*....|....*....|....
gi 767994709   389 MEAQNQEYKMLLDIKTRLEQEIAT 412
Cdd:TIGR02169  814 LREIEQKLNRLTLEKEYLEKEIQE 837
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 158-431 4.96e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 4.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 158 KTIEELRDKIMATTidnsrviLEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEEL 237
Cdd:COG1196  267 AELEELRLELEELE-------LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 238 AYLKKNHEEWVPPILQEMKEFSSQLAGQVNVEMDAAPGVD--LTRVLAEMREQYEAMAEKNRRDVEAwffSKTEELNKEV 315
Cdd:COG1196  340 EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEelEELAEELLEALRAAAELAAQLEELE---EAEEALLERL 416

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 316 ASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQgligGLEAQLSELRCEMEAQNQE 395
Cdd:COG1196  417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA----LLEAALAELLEELAEAAAR 492

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767994709 396 YKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIRE 431
Cdd:COG1196  493 LLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV 528
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 194-432 9.95e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 194 KYENELAL--RQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgqvnvemd 271
Cdd:COG1196  224 ELEAELLLlkLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEE----LELELEEAQAEEY-------- 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 272 aapgvDLTRVLAEMREQYEAMAEKNRRDVEAwffskTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKA 351
Cdd:COG1196  292 -----ELLAELARLEQDIARLEERRRELEER-----LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 352 GLENSLAETEcryATQLQQIQGLIGGLEAQLSELRcEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIRE 431
Cdd:COG1196  362 EAEEALLEAE---AELAEAEEELEELAEELLEALR-AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437


                 .
gi 767994709 432 A 432
Cdd:COG1196  438 E 438
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 203-392 9.99e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 37.60  E-value: 9.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 203 QGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgqvnvemdaapgvDLTRVL 282
Cdd:COG1579   13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELED----LEKEIKRLELEIE-------------EVEARI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994709 283 AEMREQyeAMAEKNRRDVEAwffskteeLNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETEC 362
Cdd:COG1579   76 KKYEEQ--LGNVRNNKEYEA--------LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKA 145

                        170       180       190
                 ....*....|....*....|....*....|
gi 767994709 363 RYATQLQQIQGLIGGLEAQLSELRCEMEAQ 392
Cdd:COG1579  146 ELDEELAELEAELEELEAEREELAAKIPPE 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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