|
Name |
Accession |
Description |
Interval |
E-value |
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
6-542 |
6.45e-110 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 336.65 E-value: 6.45e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939 1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939 72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 326 LLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGLTQDPV-----------ENPG-----------KLKAPLG 383
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLfvlllllwifgGSLNidattvaiiglALMLLLR 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 384 LLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAM 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 461 LPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIP 538
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468
|
....
gi 767996413 539 LFSL 542
Cdd:pfam00939 469 LGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
39-536 |
3.01e-86 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 272.54 E-value: 3.01e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115 40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115 112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVI-----LLLLAWLWLQILFLGFNMVSDGTVAIFI 353
Cdd:cd01115 137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIgllylWFIFRLAVLIITIVLLAALAAITGLLPV 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 354 GIIMFIIPSKFpgltqdpvenpgklkAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVP 432
Cdd:cd01115 214 SVAIAIGAIVL---------------VFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLP 278
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 433 APAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLD 512
Cdd:cd01115 279 PFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSD 358
|
490 500
....*....|....*....|....
gi 767996413 513 MARAGFLLNIIGVLIIALAINSWG 536
Cdd:cd01115 359 FAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
140-535 |
1.42e-66 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 220.80 E-value: 1.42e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471 74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLWLQILFL-GFNMVSDGTVAIFIGIIMFIIPSK--------------- 363
Cdd:COG0471 111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWLVLYRLLPpEIKEVPGSKEVIREELAELGPLSRrekialaifaltvll 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 364 --FPGLTQDPVENPGKLKAPL----GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAI 436
Cdd:COG0471 188 wiTGSLHGIPIAVVALLGAVLllltGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 437 AIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARA 516
Cdd:COG0471 268 LLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKV 347
|
410
....*....|....*....
gi 767996413 517 GFLLNIIGVLIIALAINSW 535
Cdd:COG0471 348 GLPLNLIGLVVLLLLGPLW 366
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
33-535 |
5.69e-36 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 139.79 E-value: 5.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785 7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785 46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 269 cMSLCVCYSASIGGIATLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGT 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEV 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 349 VAIFIGIIMFIIPSKF-----PGLTQDPV-----ENPGKLKAP------------LGLLDWKTVNQ-KMPWNIVLLLGGG 405
Cdd:TIGR00785 231 DLWAKEELEEMGPMSFrekalLGIFLLALllwifGGSLGINASvvallavvlmlfLGIVTWKDIQKnKVAWNTLILFGGL 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 406 YALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCT 483
Cdd:TIGR00785 311 IGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALA 390
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 767996413 484 LATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 535
Cdd:TIGR00785 391 LSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
6-542 |
6.45e-110 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 336.65 E-value: 6.45e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939 1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939 72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 326 LLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGLTQDPV-----------ENPG-----------KLKAPLG 383
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLfvlllllwifgGSLNidattvaiiglALMLLLR 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 384 LLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAM 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 461 LPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIP 538
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468
|
....
gi 767996413 539 LFSL 542
Cdd:pfam00939 469 LGSL 472
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
39-536 |
3.01e-86 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 272.54 E-value: 3.01e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115 40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115 112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVI-----LLLLAWLWLQILFLGFNMVSDGTVAIFI 353
Cdd:cd01115 137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLIIgllylWFIFRLAVLIITIVLLAALAAITGLLPV 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 354 GIIMFIIPSKFpgltqdpvenpgklkAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVP 432
Cdd:cd01115 214 SVAIAIGAIVL---------------VFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLP 278
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 433 APAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLD 512
Cdd:cd01115 279 PFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSD 358
|
490 500
....*....|....*....|....
gi 767996413 513 MARAGFLLNIIGVLIIALAINSWG 536
Cdd:cd01115 359 FAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
140-535 |
1.42e-66 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 220.80 E-value: 1.42e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471 74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLWLQILFL-GFNMVSDGTVAIFIGIIMFIIPSK--------------- 363
Cdd:COG0471 111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWLVLYRLLPpEIKEVPGSKEVIREELAELGPLSRrekialaifaltvll 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 364 --FPGLTQDPVENPGKLKAPL----GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAI 436
Cdd:COG0471 188 wiTGSLHGIPIAVVALLGAVLllltGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 437 AIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARA 516
Cdd:COG0471 268 LLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKV 347
|
410
....*....|....*....
gi 767996413 517 GFLLNIIGVLIIALAINSW 535
Cdd:COG0471 348 GLPLNLIGLVVLLLLGPLW 366
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
46-532 |
9.89e-37 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 140.85 E-value: 9.89e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 46 ALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpplshvstc 125
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--------------------------------------------- 35
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 126 qvavEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIvGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:cd00625 36 ----AIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALL 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 206 DQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhlTQCMSLCVCYSASIGGIAT 285
Cdd:cd00625 111 RKLGLSP------------------------------------------------------PVPLLLALAFAANIGGAAT 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 286 LTGTAPNLVLQGQINslfpqngnvVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFP 365
Cdd:cd00625 137 PIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKK 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 366 GLT---------------QDPVENPGKLKAPLGLL------DWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNK 424
Cdd:cd00625 208 FLLlallllllfvllfffLIPLGLIALLGALLLLLllvrglDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAEL 287
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 425 LTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASM-----AQAICLHPLYVMLPCTLATSLAFMLPVATPPN 499
Cdd:cd00625 288 LVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAEN 367
|
490 500 510
....*....|....*....|....*....|...
gi 767996413 500 AIVfsfgDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:cd00625 368 AGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
33-535 |
5.69e-36 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 139.79 E-value: 5.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785 7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785 46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 269 cMSLCVCYSASIGGIATLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGT 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEV 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 349 VAIFIGIIMFIIPSKF-----PGLTQDPV-----ENPGKLKAP------------LGLLDWKTVNQ-KMPWNIVLLLGGG 405
Cdd:TIGR00785 231 DLWAKEELEEMGPMSFrekalLGIFLLALllwifGGSLGINASvvallavvlmlfLGIVTWKDIQKnKVAWNTLILFGGL 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 406 YALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCT 483
Cdd:TIGR00785 311 IGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALA 390
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 767996413 484 LATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 535
Cdd:TIGR00785 391 LSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
137-480 |
1.09e-22 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 99.31 E-value: 1.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassn 216
Cdd:pfam03600 43 LLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP----- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 217 veegsnnptfelqePSPqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQ 296
Cdd:pfam03600 118 --------------PSP------------------------------------LLIALAFAANIGGTATPIGDPPNIIIA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 297 GQINSLFPQngnvvnfaswFSFAFPTMVILLLLAWLWLQILFLGFNMVSDGTVAIFIGIIMFIIPSKFPGL--------- 367
Cdd:pfam03600 148 SALGLSFGD----------FGFFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLlaisalvla 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 368 --------TQDPVENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLqsVPAPAIAII 439
Cdd:pfam03600 218 lvilgfllLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALAL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 767996413 440 LSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVML 480
Cdd:pfam03600 296 ILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
381-532 |
2.27e-10 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 62.33 E-value: 2.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 381 PLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIF 460
Cdd:pfam03600 24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996413 461 LPILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
382-532 |
8.38e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 54.75 E-value: 8.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 382 LGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFL 461
Cdd:COG1055 39 LGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLT 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996413 462 PILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 532
Cdd:COG1055 119 PVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVL 190
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
397-539 |
2.04e-07 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 53.36 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 397 NIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL 476
Cdd:cd01115 47 PAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPS 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 477 YVMLPCTLATSLAFML-PVATPPNAIV------FSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPL 539
Cdd:cd01115 127 RLLMPLAFAASIGGMLtLIGTPPNLVAsgylesLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAVLII 196
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
137-209 |
5.46e-04 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 42.45 E-value: 5.46e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996413 137 LLFFGGLL-VAIAVEHWNLHKRIALRVL-LIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLH 209
Cdd:COG0471 229 LLLFGGGLaLGAALEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
392-532 |
6.12e-04 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 42.42 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 392 QKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAI 471
Cdd:COG1055 266 KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATG 345
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996413 472 CLHPLY--VMLPCTLATSLafmLPVATPPNAIV----------FSFGDLkvldmARAGFLLNIIGVLIIALAI 532
Cdd:COG1055 346 NPEPLWlaLALGATLGGNL---TPIGSAANVIVlgiaekkgikISFGEF-----LKVGLPLTLLTLLIALLYL 410
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
54-214 |
1.45e-03 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 41.14 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 54 LPLAVTALFPLILF----PMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAV 129
Cdd:pfam03600 167 VALLLVGLLPLLLIfrklLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPE 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 130 EYLKD---SNLLFFGGLL-VAIAVEHWNLHKRIAlrVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:pfam03600 247 EALKAvdwSTLLFFAGLFiLVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324
|
....*....
gi 767996413 206 DQLHSSQAS 214
Cdd:pfam03600 325 PAAGLGDPD 333
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
137-208 |
4.64e-03 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 39.73 E-value: 4.64e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996413 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 208
Cdd:COG1055 57 LFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
383-532 |
8.57e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 38.77 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996413 383 GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLP 462
Cdd:cd01116 34 LSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVP 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996413 463 ILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDmaragFLLNIIGVLIIALAI 532
Cdd:cd01116 114 VTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFND-----FLLHMLPSVVLALVV 179
|
|
| |
