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Conserved domains on  [gi|767998466|ref|XP_011524190|]
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WD repeat-containing protein 7 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 2.23e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767998466  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 1.31e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelQINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319   123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319   197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                  ....*...
gi 767998466  182 VTGILKVW 189
Cdd:COG2319   266 ADGTVRLW 273
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 2.23e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767998466  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
420-596 1.12e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  420 RLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDI 499
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLL----------------RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  500 FSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170
                  ....*....|....*..
gi 767998466  580 SDGSVYVWQMDTGALDR 596
Cdd:COG2319   266 ADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 1.31e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelQINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319   123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319   197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                  ....*...
gi 767998466  182 VTGILKVW 189
Cdd:COG2319   266 ADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 2.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   19 THCISAVLLTDDGATIVTGCHDGQICLWDLSVELQInprALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWDVSD 98
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                  ....
gi 767998466   99 GRCI 102
Cdd:cd00200   251 GECV 254
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767998466   454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 767998466    454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 7.32e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.52  E-value: 7.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466    22 ISAVLLTDDGATIVTGCHDGQICLWDL----SVELQI----------------NPRALLFGHTASITCLskaCASSDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466    82 IVSASESGEMCLWDVSDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998466   130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-95 1.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.00e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767998466     55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:smart00320    3 ELLKTLKGHTGPVTSV---AFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 2.23e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767998466  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-603 2.78e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  456 PHRTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLvppenCSARvQHCICS 535
Cdd:cd00200     1 LRRTLKGHTGGVTC------VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-----ASAD-GTYLAS 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767998466  536 VASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITA 603
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-597 1.09e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  407 LKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYpHQvsaryDQRYLI 486
Cdd:cd00200    52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-SP-----DGRILS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  487 SGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPEN---------CSARV---------------QHCICSVA----- 537
Cdd:cd00200   110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfvasssqdGTIKLwdlrtgkcvatltghTGEVNSVAfspdg 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767998466  538 -------SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRC 597
Cdd:cd00200   190 ekllsssSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
420-596 1.12e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  420 RLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDI 499
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLL----------------RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  500 FSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170
                  ....*....|....*..
gi 767998466  580 SDGSVYVWQMDTGALDR 596
Cdd:COG2319   266 ADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
458-594 1.88e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  458 RTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVA 537
Cdd:COG2319   198 RTLTGHTGAVRSV----AFSP--DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG------RLLASGS 265

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767998466  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319   266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
409-604 4.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 4.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYphqvSAryDQRYLISG 488
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----------------RTLTGHSGSVRSVAF----SP--DGRLLASG 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  489 GVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvQHcICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----KL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767998466  569 RPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG----ITAV 604
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgaVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 1.31e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelQINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319   123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319   197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                  ....*...
gi 767998466  182 VTGILKVW 189
Cdd:COG2319   266 ADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
10-189 3.77e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   10 IVLW----GR-----KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSvelQINPRALLFGHTASITCLSkacASSDKQ 80
Cdd:COG2319   144 VRLWdlatGKllrtlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVA---FSPDGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   81 YIVSASESGEMCLWDVSDGRCIEFTKlacTHTG-IQFYQFSvgnqREGRLLCHGHY-PEILVVDATSLEVLYSLvsKISP 158
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLT---GHSGsVRSVAFS----PDGRLLASGSAdGTVRLWDLATGELLRTL--TGHS 288

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767998466  159 DWISSMSIIRSHRtqedTVVALSVTGILKVW 189
Cdd:COG2319   289 GGVNSVAFSPDGK----LLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
16-189 5.22e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQInprALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSV---AFSPDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   96 VSDGRCIEftklacTHTGIQFYQFSVGNQREGRLLCHGHYPE-ILVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqe 174
Cdd:COG2319   317 LATGKLLR------TLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR--- 385

                         170
                  ....*....|....*
gi 767998466  175 dTVVALSVTGILKVW 189
Cdd:COG2319   386 -TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
409-594 1.27e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISG 488
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLL----------------RTLTGHTGAVRSV----AFSP--DGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  489 GVDFSVIIWDIFSGEMKHIFCVHGGEIT--------QLLVppencsarvqhcicSVASDHSVGLLSLREKKCIMLASRHL 560
Cdd:COG2319   139 SADGTVRLWDLATGKLLRTLTGHSGAVTsvafspdgKLLA--------------SGSDDGTVRLWDLATGKLLRTLTGHT 204

                         170       180       190
                  ....*....|....*....|....*....|....
gi 767998466  561 FPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319   205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 2.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   19 THCISAVLLTDDGATIVTGCHDGQICLWDLSVELQInprALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWDVSD 98
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                  ....
gi 767998466   99 GRCI 102
Cdd:cd00200   251 GECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-274 3.39e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPralLFGHTASITCLSkacASSDKQYIVSASESGEMCLWD 95
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVA---FSPDGRILSSSSRDKTIKVWD 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   96 VSDGRCIefTKLACtHTG-IQFYQFSvgnqREGRLLCHGHYP-EILVVDATSLEVLYSLvsKISPDWISSMSIIRShrtq 173
Cdd:cd00200   122 VETGKCL--TTLRG-HTDwVNSVAFS----PDGTFVASSSQDgTIKLWDLRTGKCVATL--TGHTGEVNSVAFSPD---- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  174 EDTVVALSVTGILKVWivtseisDMQDTEPI--FEEESKPIYCqncqsisfCAFTQRSLLVVCSKYW---RVFDAGDYSL 248
Cdd:cd00200   189 GEKLLSSSSDGTIKLW-------DLSTGKCLgtLRGHENGVNS--------VAFSPDGYLLASGSEDgtiRVWDLRTGEC 253

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 767998466  249 LCSGPSENGQTW------TGGDFV--SSDK-VIIW 274
Cdd:cd00200   254 VQTLSGHTNSVTslawspDGKRLAsgSADGtIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
11-98 5.42e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPralLFGHTASITCLSkacASSDKQYIVSASESGE 90
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---LTGHTGAVTSVA---FSPDGRTLASGSADGT 395


                  ....*...
gi 767998466   91 MCLWDVSD 98
Cdd:COG2319   396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-588 7.36e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 7.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  458 RTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVA 537
Cdd:cd00200   171 ATLTGHTGEVNS------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGS 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767998466  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQ 588
Cdd:cd00200   239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
22-102 1.40e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELqinPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLATGKL 154


                  .
gi 767998466  102 I 102
Cdd:COG2319   155 L 155
WD40 COG2319
WD40 repeat [General function prediction only];
476-594 2.20e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  476 VSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARvqhcicSVASDHSVGLLSLREKKCIML 555
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA------SASADGTVRLWDLATGLLLRT 115

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767998466  556 ASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-95 1.09e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998466   22 ISAVLLTDDGATIVTGCHDGQICLWDLSVElqiNPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG---ECVQTLSGHTNSVTSL---AWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767998466   454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 767998466    454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-237 4.19e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466   60 LFGHTASITCLskaCASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLactHTG-IQFYQFSVGNQregRLLCHGHYPEI 138
Cdd:cd00200     5 LKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGpVRDVAASADGT---YLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466  139 LVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqedTVVALSVTGILKVWivtseisDMQDTEPIFEEE--SKPIYCqn 216
Cdd:cd00200    76 RLWDLETGECVRTLTG--HTSYVSSVAFSPDGR----ILSSSSRDKTIKVW-------DVETGKCLTTLRghTDWVNS-- 140

                         170       180
                  ....*....|....*....|.
gi 767998466  217 cqsisfCAFTQRSLLVVCSKY 237
Cdd:cd00200   141 ------VAFSPDGTFVASSSQ 155
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 7.32e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.52  E-value: 7.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466    22 ISAVLLTDDGATIVTGCHDGQICLWDL----SVELQI----------------NPRALLFGHTASITCLskaCASSDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998466    82 IVSASESGEMCLWDVSDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998466   130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-95 1.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.00e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767998466     55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:smart00320    3 ELLKTLKGHTGPVTSV---AFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 550-587 1.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 767998466    550 KKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVW 587
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
55-95 3.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767998466    55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:pfam00400    2 KLLKTLEGHTGSVTSL---AFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-47 5.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 5.18e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767998466     16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWD 47
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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