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Conserved domains on  [gi|768002470|ref|XP_011526323|]
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protein ENL isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 50-178 1.38e-76

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


:

Pssm-ID: 341125  Cd Length: 127  Bit Score: 239.01  E-value: 1.38e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  50 VRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVH 129
Cdd:cd16906    1 VKLEIGHSATLRKKPTPEGHTHDWTVFVRGANGSDISHFVEKVVFHLHESFPKPKRVVKEPPFEVTESGYAGFTLPIEIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768002470 130 FKNKEEPRKVCFTYDLFLNLegNPPVNHLRCEKLTFNNPTTEFRYKLLR 178
Cdd:cd16906   81 FKNKEEPKKVRFEYDLFLHL--GPPVNHLRTEKLTFKNPSEEFRRKLLK 127
AHD pfam17793
ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in ...
 536-596 5.31e-28

ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in AF-9.


:

Pssm-ID: 436050  Cd Length: 61  Bit Score: 106.48  E-value: 5.31e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002470  536 YTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLE 596
Cdd:pfam17793   1 YLEELLELQKKIMSLKDREVLQRVVDIIEETGNFEITNTTFDFDLCSLDRSTIKKLQEILS 61
 
Name Accession Description Interval E-value
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 50-178 1.38e-76

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341125  Cd Length: 127  Bit Score: 239.01  E-value: 1.38e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  50 VRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVH 129
Cdd:cd16906    1 VKLEIGHSATLRKKPTPEGHTHDWTVFVRGANGSDISHFVEKVVFHLHESFPKPKRVVKEPPFEVTESGYAGFTLPIEIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768002470 130 FKNKEEPRKVCFTYDLFLNLegNPPVNHLRCEKLTFNNPTTEFRYKLLR 178
Cdd:cd16906   81 FKNKEEPKKVRFEYDLFLHL--GPPVNHLRTEKLTFKNPSEEFRRKLLK 127
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 69-147 2.94e-36

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 130.26  E-value: 2.94e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768002470   69 FTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEpRKVCFTYDLFL 147
Cdd:pfam03366   1 HTHKWTVYVRGLDNEDISYFIKKVVFKLHPSFANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDE-KPVTIYHDLKL 78
AHD pfam17793
ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in ...
 536-596 5.31e-28

ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in AF-9.


Pssm-ID: 436050  Cd Length: 61  Bit Score: 106.48  E-value: 5.31e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002470  536 YTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLE 596
Cdd:pfam17793   1 YLEELLELQKKIMSLKDREVLQRVVDIIEETGNFEITNTTFDFDLCSLDRSTIKKLQEILS 61
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
70-150 7.36e-15

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 74.07  E-value: 7.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  70 THDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKvcFTYDLFLNL 149
Cdd:COG5033   35 THIWLVFVRAPGKEDIATIVKKVIFKLHPTFSNPTRTIESPPFEIKETGWGEFDIQIKIFFAEKAGEKT--IHFYLHFGD 112


                 .
gi 768002470 150 E 150
Cdd:COG5033  113 E 113
 
Name Accession Description Interval E-value
YEATS_AF-9_like cd16906
YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that ...
 50-178 1.38e-76

YEATS domain found in ENL and AF-9-like proteins; Yeast AFF9 is a YEATS domain protein that binds to modified histones, with a preference for crotonyllysine over acetyllysine. Histone crotonylation upregulates gene expression in an AF9-dependent manner. Sub-family also includes eleven-nineteen-leukemia protein ENL, which binds histones H3 and H1. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341125  Cd Length: 127  Bit Score: 239.01  E-value: 1.38e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  50 VRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVH 129
Cdd:cd16906    1 VKLEIGHSATLRKKPTPEGHTHDWTVFVRGANGSDISHFVEKVVFHLHESFPKPKRVVKEPPFEVTESGYAGFTLPIEIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768002470 130 FKNKEEPRKVCFTYDLFLNLegNPPVNHLRCEKLTFNNPTTEFRYKLLR 178
Cdd:cd16906   81 FKNKEEPKKVRFEYDLFLHL--GPPVNHLRTEKLTFKNPSEEFRRKLLK 127
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 69-147 2.94e-36

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 130.26  E-value: 2.94e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768002470   69 FTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEpRKVCFTYDLFL 147
Cdd:pfam03366   1 HTHKWTVYVRGLDNEDISYFIKKVVFKLHPSFANPVRVVKKPPFEVTETGWGEFEIRIKIYFKDKDE-KPVTIYHDLKL 78
YEATS cd16887
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 50-166 5.87e-34

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


Pssm-ID: 341123  Cd Length: 120  Bit Score: 125.08  E-value: 5.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  50 VRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVH 129
Cdd:cd16887    1 KPIVIGNVAEKIPKPEPDDNTHKWTVYVRSPTNEDLSSFIKKVTFKLHPSFPNPVRVVTDPPFEVEEVGWGEFPIEIKIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768002470 130 FKNKEEPrKVCFTYDLFLNLEG----NPPVNHLRCEKLTFN 166
Cdd:cd16887   81 FKDSNEK-PVTLSHFLKLHPDGsplkKPVVVSEKYDEIVFR 120
AHD pfam17793
ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in ...
 536-596 5.31e-28

ANC1 homology domain (AHD); This entry corresponds to the ANC1 homology domain (AHD) found in AF-9.


Pssm-ID: 436050  Cd Length: 61  Bit Score: 106.48  E-value: 5.31e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002470  536 YTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLE 596
Cdd:pfam17793   1 YLEELLELQKKIMSLKDREVLQRVVDIIEETGNFEITNTTFDFDLCSLDRSTIKKLQEILS 61
YEATS_TFIID14_like cd16910
YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; ...
 63-172 4.34e-25

YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; YEATS domain containing proteins, which include Transcription initiation factor TFIID subunits 14 and 14b of Arabidopsis, shown to be part of the TFIID general transcriptional regulator complex in a two-hybrid screen. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341129  Cd Length: 131  Bit Score: 100.73  E-value: 4.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  63 KPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEpRKVCFT 142
Cdd:cd16910   16 KKADETHTHKWTVYVRGANNEDLSYFIKKVVFVLHPSFANPTRVVTEPPFEVTETGWGEFEIGITIHFKDDAE-KPVELT 94

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768002470 143 YDLFLNLEGNP-------PVNHLRCEKLTFNNPTTEF 172
Cdd:cd16910   95 HPLKLYPPPGSgppstkkPVVSEFYDEIVFVEPTEEF 131
YEATS_Yaf9_like cd16908
YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein ...
 61-178 4.93e-21

YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein essential in the function the NuA4 histone acetyltransferase complex and the SWR1-C ATP-dependent chromatin remodeling complex. Yaf9 shares structural similarity with histone chaperone Asf1, both exhibit histone H3 and H4 binding in vitro, and evidence supports both play a role in the same histone acetylation mechanism. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: `YNK7', `ENL', `AF-9', and `TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341127  Cd Length: 145  Bit Score: 89.65  E-value: 4.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  61 RKKPTT-EGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKV 139
Cdd:cd16908   18 EEKPKApPDHTHKWTVFVRGPDGEDLSYFIKKVVFKLHESYPNPNRTIEKPPFEVTETGWGEFEIQIKIYFVPEANEKPI 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768002470 140 CFTYDLFL----------NLEGNPPVNHLRCEKLTFNNPTTEFrYKLLR 178
Cdd:cd16908   98 TLYHMLKLhpyedtaendDLASGGPVVSVQYDEIVFNEPTEEF-YDILM 145
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 55-177 6.68e-18

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 80.37  E-value: 6.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  55 GHRAQ-LRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNK 133
Cdd:cd16909   10 GNIARyFGKKREEDGHTHQWTVYVKPYFNEDMSTYVKKVQFKLHESYANPLRVVTKPPYEVTETGWGEFEIIIKIFFIDP 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 768002470 134 EEPRKVCFTY-DLFLN----LEGNPPVNHLRCEKLTFNNPTTEFrYKLL 177
Cdd:cd16909   90 NERPVTLYHLlKLFQSdtnlMLGKKTLVSEFYDELIFQDPTAMM-YQLL 137
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 70-148 4.85e-15

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 71.84  E-value: 4.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  70 THDWMVFVRGP-EQCDIQHFVEKVVFWLHDSFpKPRRV--CKEPPYKVEESGYAGFIMPIEVHFKNKEEPRkVCFTYDLF 146
Cdd:cd16907   23 THKWMVYVRGPpEDPDIDHFVKKVRFFLHPSY-APNDVveVTKPPFHLTRRGWGEFPVRVQLHFKDPRNKP-VDIIHNLK 100


                 ..
gi 768002470 147 LN 148
Cdd:cd16907  101 LD 102
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
70-150 7.36e-15

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 74.07  E-value: 7.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470  70 THDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKvcFTYDLFLNL 149
Cdd:COG5033   35 THIWLVFVRAPGKEDIATIVKKVIFKLHPTFSNPTRTIESPPFEIKETGWGEFDIQIKIFFAEKAGEKT--IHFYLHFGD 112


                 .
gi 768002470 150 E 150
Cdd:COG5033  113 E 113
YEATS_Taf14_like cd16905
YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of ...
 88-145 2.20e-12

YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of TFIIF and TFIID transcription factor complexes, various chromatin-remodeling complexes (such as SWI/SNF, INO80, and RSC) and the NuA3 histone acetyltransferase complex. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. Specifically, Taf14 has been show to be a reader of lysine crotonylation, associated with active gene promoters and enhancers and binding acetyllysine on in histone H3. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341124  Cd Length: 118  Bit Score: 64.12  E-value: 2.20e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768002470  88 FVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKeePRKVCFTYDL 145
Cdd:cd16905   46 IFDKVTYHLHPTFENPIRTFKKPPFRLEEKGWGEFDMKIVLHFLDN--GGEFTITHDL 101
pYEATS pfam20305
prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to ...
 72-149 7.55e-10

prokaryotic YEATS domain; This entry represents a prokaryotic YEATS domain. pYEATS is fused to diverse effector domains, suggesting that the binding to a ligand activates an effector-based response against an invasive threat. It has been predicted to specifically recognize invader-induced modifications of macromolecules by acyl moieties (e.g. phage-encoded acylations of surface polysaccharides) to unleash the fused effectors through a conformational change.


Pssm-ID: 466455  Cd Length: 73  Bit Score: 55.37  E-value: 7.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002470   72 DWMVFVRGPEQCDIQhfVEKVVFWLHDSFPKPRRVCKEP--PYKVEESGYAGFIMPIEVHFKNKEEprkvcftYDLFLNL 149
Cdd:pfam20305   2 DVRLWVDGPDPVLLL--IESVEYTLHPTFPNPVRTVTDRngNFSLSLSAWGAFTVGAEVEFKDGGE-------IELERYL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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