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Conserved domains on  [gi|768017912|ref|XP_011527272|]
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cadherin-like protein 26 isoform X1 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-245 7.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 7.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912 156 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 230
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 768017912 231 ATGTLMLFLSDINDN 245
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-141 1.68e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912  29 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 106
Cdd:cd11304    2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768017912 107 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 141
Cdd:cd11304   75 TDGG----------GPPLS--STATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-245 7.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 7.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912 156 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 230
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 768017912 231 ATGTLMLFLSDINDN 245
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
155-235 1.08e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912  155 EEGARPGTLLGTFNAMDPD----SQIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQ 229
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDlgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPL 81


                  ....*.
gi 768017912  230 TATGTL 235
Cdd:pfam00028  82 SSTATV 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 168-247 9.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 9.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912   168 NAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQTATGTLMLFLSDI 242
Cdd:smart00112   1 SATDADSgengKVTYSILsGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 768017912   243 NDNVP 247
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-141 1.68e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912  29 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 106
Cdd:cd11304    2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768017912 107 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 141
Cdd:cd11304   75 TDGG----------GPPLS--STATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
29-137 6.11e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 6.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912   29 YKVQIPEGRASQG-VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDISTDPetneGILNVIKPLDYETRPAQSLIIVVE 107
Cdd:pfam00028   1 YSASVPENAPVGTeVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 768017912  108 NEerlvfcergkLQPPRkaAASATVSVQVT 137
Cdd:pfam00028  75 DS----------GGPPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-143 8.46e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 8.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912    47 VQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVVENEErlvfcergklQPPRka 126
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG----------GPPL-- 63

                           90
                   ....*....|....*..
gi 768017912   127 AASATVSVQVTDANDPP 143
Cdd:smart00112  64 SSTATVTITVLDVNDNA 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-245 7.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 7.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912 156 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 230
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 768017912 231 ATGTLMLFLSDINDN 245
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
155-235 1.08e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912  155 EEGARPGTLLGTFNAMDPD----SQIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQ 229
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDlgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPL 81


                  ....*.
gi 768017912  230 TATGTL 235
Cdd:pfam00028  82 SSTATV 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 168-247 9.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 9.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912   168 NAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQTATGTLMLFLSDI 242
Cdd:smart00112   1 SATDADSgengKVTYSILsGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 768017912   243 NDNVP 247
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-141 1.68e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912  29 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 106
Cdd:cd11304    2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768017912 107 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 141
Cdd:cd11304   75 TDGG----------GPPLS--STATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
29-137 6.11e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 6.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912   29 YKVQIPEGRASQG-VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDISTDPetneGILNVIKPLDYETRPAQSLIIVVE 107
Cdd:pfam00028   1 YSASVPENAPVGTeVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 768017912  108 NEerlvfcergkLQPPRkaAASATVSVQVT 137
Cdd:pfam00028  75 DS----------GGPPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-143 8.46e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 8.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017912    47 VQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVVENEErlvfcergklQPPRka 126
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG----------GPPL-- 63

                           90
                   ....*....|....*..
gi 768017912   127 AASATVSVQVTDANDPP 143
Cdd:smart00112  64 SSTATVTITVLDVNDNA 80
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 129-199 8.17e-04

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 38.86  E-value: 8.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017912  129 SATVSVQVTDANDPPAFHPQSFIVNkeegarPGTLLGtfNAMDPD------SQIRYELVHDPAN-WVSVDKNSGVVIT 199
Cdd:pfam17963   1 TATVTVTVTPVNDAPVAVDDSVTVT------EDTVLA--NDSDPDgdpltiTSLTVTIVTAPANgTVTVNADGTLTYT 70
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 130-191 3.32e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 36.39  E-value: 3.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017912  130 ATVSVQVTDANDPPAFHPQSFIVNkEEGAR--PGTLLGtfNAMDPDSqiryelvhDPANWVSVD 191
Cdd:pfam17803   1 ATVTITVTGVNDAPVAVDDTATVD-EDTPVtiTGNVLA--NDTDVDG--------DTLTVTSVT 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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