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Conserved domains on  [gi|768013466|ref|XP_011527479|]
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shieldin complex subunit 1 isoform X2 [Homo sapiens]

Protein Classification

shieldin complex subunit 1( domain architecture ID 10633241)

shieldin complex subunit 1 (SHLD1), a DUF4521 domain-containing protein, is a component of the shieldin complex, which plays an important role in the repair of DNA double-stranded breaks (DSBs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4521 pfam15021
Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally ...
 14-216 2.01e-139

Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally uncharacterized. The family includes the Chromosome 20 protein C20orf196.


:

Pssm-ID: 464452  Cd Length: 204  Bit Score: 387.99  E-value: 2.01e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   14 MAARDATSGSLSEESSALDLPSACDIRDYVLQGPSQEANSEAFSSLEFHSFPYSSDVDPDTSNLNIEQNNSWTAENFWLD 93
Cdd:pfam15021   1 MESQEATPSSQSEESSILDLPSVCDIRDYVLQRPSQEASSEAFSSVEFHSFPCSSDVDPDSSNLNTEQNDSWTSENFWLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   94 PAVKGQSE-KEEDDGLRKSLDRFYEMFGHPQPGSANSLSASVCKCLSQKITQLRGQESQKYALRSFQMARVIFNRDGCSV 172
Cdd:pfam15021  81 PSVKGQEEtKEEDDGLRKSLDRFYEMFGHPQPASGDPLSASVCQCLSQKISELEGQESQKYALRSFQMARVIFNRDGCSV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 768013466  173 LQRHSRDTHFYPLEEGSTSLDDEKPNPGLSKDITHFLLQQNVMK 216
Cdd:pfam15021 161 LQRHSRDTHFYPLEEGSVSLEDEKPTPGLSKDIIHFLLQQNVMK 204
 
Name Accession Description Interval E-value
DUF4521 pfam15021
Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally ...
 14-216 2.01e-139

Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally uncharacterized. The family includes the Chromosome 20 protein C20orf196.


Pssm-ID: 464452  Cd Length: 204  Bit Score: 387.99  E-value: 2.01e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   14 MAARDATSGSLSEESSALDLPSACDIRDYVLQGPSQEANSEAFSSLEFHSFPYSSDVDPDTSNLNIEQNNSWTAENFWLD 93
Cdd:pfam15021   1 MESQEATPSSQSEESSILDLPSVCDIRDYVLQRPSQEASSEAFSSVEFHSFPCSSDVDPDSSNLNTEQNDSWTSENFWLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   94 PAVKGQSE-KEEDDGLRKSLDRFYEMFGHPQPGSANSLSASVCKCLSQKITQLRGQESQKYALRSFQMARVIFNRDGCSV 172
Cdd:pfam15021  81 PSVKGQEEtKEEDDGLRKSLDRFYEMFGHPQPASGDPLSASVCQCLSQKISELEGQESQKYALRSFQMARVIFNRDGCSV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 768013466  173 LQRHSRDTHFYPLEEGSTSLDDEKPNPGLSKDITHFLLQQNVMK 216
Cdd:pfam15021 161 LQRHSRDTHFYPLEEGSVSLEDEKPTPGLSKDIIHFLLQQNVMK 204
 
Name Accession Description Interval E-value
DUF4521 pfam15021
Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally ...
 14-216 2.01e-139

Protein of unknown function (DUF4521); This family of vertebrate proteins is functionally uncharacterized. The family includes the Chromosome 20 protein C20orf196.


Pssm-ID: 464452  Cd Length: 204  Bit Score: 387.99  E-value: 2.01e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   14 MAARDATSGSLSEESSALDLPSACDIRDYVLQGPSQEANSEAFSSLEFHSFPYSSDVDPDTSNLNIEQNNSWTAENFWLD 93
Cdd:pfam15021   1 MESQEATPSSQSEESSILDLPSVCDIRDYVLQRPSQEASSEAFSSVEFHSFPCSSDVDPDSSNLNTEQNDSWTSENFWLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768013466   94 PAVKGQSE-KEEDDGLRKSLDRFYEMFGHPQPGSANSLSASVCKCLSQKITQLRGQESQKYALRSFQMARVIFNRDGCSV 172
Cdd:pfam15021  81 PSVKGQEEtKEEDDGLRKSLDRFYEMFGHPQPASGDPLSASVCQCLSQKISELEGQESQKYALRSFQMARVIFNRDGCSV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 768013466  173 LQRHSRDTHFYPLEEGSTSLDDEKPNPGLSKDITHFLLQQNVMK 216
Cdd:pfam15021 161 LQRHSRDTHFYPLEEGSVSLEDEKPTPGLSKDIIHFLLQQNVMK 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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