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Conserved domains on  [gi|767915144|ref|XP_011531375|]
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striatin isoform X1 [Homo sapiens]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-808 3.59e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.22  E-value: 3.59e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 484 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 563
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 564 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 643
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 644 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 721
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 722 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 801
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 767915144 802 DALAKVF 808
Cdd:cd00200  282 DGTIRIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.52e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 154.20  E-value: 2.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144   49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767915144  129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-808 3.59e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.22  E-value: 3.59e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 484 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 563
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 564 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 643
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 644 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 721
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 722 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 801
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 767915144 802 DALAKVF 808
Cdd:cd00200  282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
480-807 2.05e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 2.05e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 480 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 559
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 560 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPaLSVFND 639
Cdd:COG2319  177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTG 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 640 TKelGIPASVDlVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHEDRH 716
Cdd:COG2319  245 HS--GSVRSVA-FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG-------VNSVAFSPdgkLL---ASGSDDGT 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 717 IKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYI 796
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTL 387

                        330
                 ....*....|.
gi 767915144 797 ASAGADALAKV 807
Cdd:COG2319  388 ASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.52e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 154.20  E-value: 2.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144   49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767915144  129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 724-763 1.28e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767915144   724 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 763
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
725-763 9.46e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.46e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767915144  725 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 763
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-808 3.59e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.22  E-value: 3.59e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 484 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 563
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 564 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 643
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 644 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 721
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 722 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 801
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                 ....*..
gi 767915144 802 DALAKVF 808
Cdd:cd00200  282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
480-807 2.05e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 2.05e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 480 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 559
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 560 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPaLSVFND 639
Cdd:COG2319  177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTG 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 640 TKelGIPASVDlVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHEDRH 716
Cdd:COG2319  245 HS--GSVRSVA-FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG-------VNSVAFSPdgkLL---ASGSDDGT 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 717 IKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYI 796
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTL 387

                        330
                 ....*....|.
gi 767915144 797 ASAGADALAKV 807
Cdd:COG2319  388 ASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.52e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 154.20  E-value: 2.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144   49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767915144  129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
480-766 5.47e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 5.47e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 480 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 559
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 560 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtevapalsvfnD 639
Cdd:COG2319  219 LASGSADGTVRLWDLATGK-----------LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-----------A 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 640 TKEL-----GIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAH 712
Cdd:COG2319  277 TGELlrtltGHSGGVNSVAFSPdGKLLASGSDDGTvRLWDLATGKLLRTLTGHTG-------AVRSVAFSPDGKTLASGS 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767915144 713 EDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 766
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
477-808 1.47e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 1.47e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 477 ALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSN 556
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-----------LLLRTLTGHTGAVRSVAFSPD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 557 GEQCYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtevapalsv 636
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGK-----------LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 637 fndtkelgipasvdlvssdpshmvasfskgytsifnmETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHE 713
Cdd:COG2319  192 -------------------------------------ATGKLLRTLTGHTGA-------VRSVAFSPdgkLL---ASGSA 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 714 DRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSK 793
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDG 300

                        330
                 ....*....|....*
gi 767915144 794 CYIASAGADALAKVF 808
Cdd:COG2319  301 KLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
540-808 4.20e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 4.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 540 TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTtnpnidpydsyDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSAD 619
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-----------AAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 620 GTLRLWNtteVAPALSVFNDTKELGIPASVDlVSSDpSHMVASFSKGYT-SIFNMETQQRILTLESNVDTtansscqINR 698
Cdd:COG2319  100 GTVRLWD---LATGLLLRTLTGHTGAVRSVA-FSPD-GKTLASGSADGTvRLWDLATGKLLRTLTGHSGA-------VTS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 699 VISHP---TLpisITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTA 775
Cdd:COG2319  168 VAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767915144 776 HrkkfEESIHDVAFHPSKCYIASAGADALAKVF 808
Cdd:COG2319  245 H----SGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-626 1.09e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 1.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 480 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 559
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-----------KCLGTLRGHENGVNSVAFSPDGYL 233

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767915144 560 CYSGGTDGLIQGWNTTNPnidpydsydpsVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 626
Cdd:cd00200  234 LASGSEDGTIRVWDLRTG-----------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
605-808 2.78e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 2.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 605 AYSAAHQRLLSCSADGTLRLWNTTEVAPALSvfndTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLES 684
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLL----LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767915144 685 NVDttansscQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 764
Cdd:COG2319   77 HTA-------AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767915144 765 ESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGADALAKVF 808
Cdd:COG2319  150 ATGKLLRTLTGH----SGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 724-763 1.28e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767915144   724 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 763
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
725-763 9.46e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.46e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767915144  725 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 763
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 481-520 6.61e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 6.61e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767915144   481 TWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWN 520
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 596-626 3.08e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.08e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767915144   596 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 626
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
594-626 3.95e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.95e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767915144  594 LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 626
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
482-520 5.90e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.90e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767915144  482 WNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWN 520
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 536-573 1.98e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767915144   536 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 573
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
536-573 1.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767915144  536 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 573
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 766-808 1.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767915144   766 SKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGADALAKVF 808
Cdd:smart00320   1 SGELLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
479-522 2.78e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.78e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767915144 479 RKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQ 522
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
767-808 5.18e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767915144  767 KTCIQEFTAHRKkfeeSIHDVAFHPSKCYIASAGADALAKVF 808
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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