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Conserved domains on  [gi|767977164|ref|XP_011533178|]
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homeobox protein CDX-2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 1.76e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


:

Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 108.68  E-value: 1.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 767977164  173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain super family cl47488
Homeodomain;
196-236 3.35e-11

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 57.51  E-value: 3.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767977164  196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 1.76e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 108.68  E-value: 1.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 767977164  173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain pfam00046
Homeodomain;
196-236 3.35e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 57.51  E-value: 3.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767977164  196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 196-236 1.09e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767977164   196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 196-236 2.93e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 52.25  E-value: 2.93e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767977164 196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 1.76e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 108.68  E-value: 1.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977164   93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 767977164  173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain pfam00046
Homeodomain;
196-236 3.35e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 57.51  E-value: 3.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767977164  196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 196-236 1.09e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767977164   196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 196-236 2.93e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 52.25  E-value: 2.93e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767977164 196 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSER 236
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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