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Conserved domains on  [gi|767979489|ref|XP_011534629|]
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RING finger protein 212B isoform X4 [Homo sapiens]

Protein Classification

RING finger protein; RING finger protein 130( domain architecture ID 11616581)

RING finger protein may function as an E3 ubiquitin protein ligase that mediates the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin| RING finger protein 130 (RNF130) acts as an E3 ubiquitin-protein ligase that may have a role during the programmed cell death of hematopoietic cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RING-HC_RNF212B cd16747
RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; ...
 4-40 2.61e-19

RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; RNF212B is an uncharacterized protein with high sequence similarity with RNF212, a dosage-sensitive regulator of crossing-over during mammalian meiosis. RNF212B contains an N-terminal C3HC4-type RING-HC finger.


:

Pssm-ID: 438405  Cd Length: 37  Bit Score: 77.07  E-value: 2.61e-19
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767979489   4 FHCNQCFRKDGAHFFVTSCGHIFCKKCVTLEKCAVCG 40
Cdd:cd16747    1 FHCNKCFRRDGASFFITSCGHIFCEKCIKAEKCTVCG 37
 
Name Accession Description Interval E-value
RING-HC_RNF212B cd16747
RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; ...
 4-40 2.61e-19

RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; RNF212B is an uncharacterized protein with high sequence similarity with RNF212, a dosage-sensitive regulator of crossing-over during mammalian meiosis. RNF212B contains an N-terminal C3HC4-type RING-HC finger.


Pssm-ID: 438405  Cd Length: 37  Bit Score: 77.07  E-value: 2.61e-19
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767979489   4 FHCNQCFRKDGAHFFVTSCGHIFCKKCVTLEKCAVCG 40
Cdd:cd16747    1 FHCNKCFRRDGASFFITSCGHIFCEKCIKAEKCTVCG 37
zf-RING_5 pfam14634
zinc-RING finger domain;
5-41 1.76e-07

zinc-RING finger domain;


Pssm-ID: 434085 [Multi-domain]  Cd Length: 43  Bit Score: 46.27  E-value: 1.76e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767979489    5 HCNQCFRK--DGAHFFVTSCGHIFCKKCVTLE----KCAVCGT 41
Cdd:pfam14634   1 HCNKCFKElsKTRPFYLTSCGHIFCEECLTRLlqerQCPICKK 43
 
Name Accession Description Interval E-value
RING-HC_RNF212B cd16747
RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; ...
 4-40 2.61e-19

RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins; RNF212B is an uncharacterized protein with high sequence similarity with RNF212, a dosage-sensitive regulator of crossing-over during mammalian meiosis. RNF212B contains an N-terminal C3HC4-type RING-HC finger.


Pssm-ID: 438405  Cd Length: 37  Bit Score: 77.07  E-value: 2.61e-19
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767979489   4 FHCNQCFRKDGAHFFVTSCGHIFCKKCVTLEKCAVCG 40
Cdd:cd16747    1 FHCNKCFRRDGASFFITSCGHIFCEKCIKAEKCTVCG 37
RING-HC_RNF212-like cd16560
RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins; ...
 4-40 2.86e-13

RING finger, HC subclass, found in RING finger proteins RNF212, RNF212B and similar proteins; This subfamily includes RING finger protein RNF212, RNF212B, and their homologs. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for small ubiquitin-related modifier (SUMO) modification. RNF212B shows high sequence similarity with RNF212, but its biological function remains unclear. Members of this subfamily contain an N-terminal C3HC4-type RING-HC finger. Also included are two homologs of RNF212, meiotic procrossover factors Zip3 and ZHP-3, which have been identified in Saccharomyces cerevisiae and Caenorhabditis elegans, respectively. Budding yeast Zip3 is a small ubiquitin-related modifier (SUMO) E3 ligase implicated in the SUMO pathway of post-translational modification. It sumoylates chromosome axis proteins, thus promoting synaptonemal complex polymerization. It also acts as an Smt3 E3 ligase. Zip3 includes a SUMO Interacting Motif (SIM) and a modified C3HCHC2-type RING-HC finger that are important for Zip3 in vitro E3 ligase activity and necessary for SC polymerization and correct sporulation. ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and chiasma formation in Caenorhabditis elegans. It possesses a C3HC4-type RING-HC finger.


Pssm-ID: 438222  Cd Length: 42  Bit Score: 61.40  E-value: 2.86e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767979489   4 FHCNQCFRKDG--AHFFVTSCGHIFCKKCVTL---EKCAVCG 40
Cdd:cd16560    1 VHCNTCFQLPGdtSKFFLTSCGHIYCDACVGKgkrNKCKICG 42
zf-RING_5 pfam14634
zinc-RING finger domain;
5-41 1.76e-07

zinc-RING finger domain;


Pssm-ID: 434085 [Multi-domain]  Cd Length: 43  Bit Score: 46.27  E-value: 1.76e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767979489    5 HCNQCFRK--DGAHFFVTSCGHIFCKKCVTLE----KCAVCGT 41
Cdd:pfam14634   1 HCNKCFKElsKTRPFYLTSCGHIFCEECLTRLlqerQCPICKK 43
RING-HC_RNF212 cd16746
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; ...
 3-44 5.90e-07

RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins; RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger.


Pssm-ID: 438404  Cd Length: 48  Bit Score: 44.73  E-value: 5.90e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 767979489   3 WFHCNQCF---RKDGAHFFVTSCGHIFCKKCV---TLEKCAVCGTACK 44
Cdd:cd16746    1 RVFCNFCFqqpRPNCPSFILTNCGHVVCEACLqkgKKNECLVCKAPCR 48
RING-HC_ITT1-like cd23134
RING finger, HC subclass, found in Saccharomyces cerevisiae translation termination inhibitor ...
 4-32 1.78e-03

RING finger, HC subclass, found in Saccharomyces cerevisiae translation termination inhibitor protein ITT1 and similar proteins; ITT1 is a protein that modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA. ITT1 contains a typical C3HC4-type RING-HC finger.


Pssm-ID: 438496  Cd Length: 60  Bit Score: 35.37  E-value: 1.78e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 767979489   4 FHCNQCFR-KDGAHFFVTSCGHIFCKKCVT 32
Cdd:cd23134    5 YHCGICFEeKKGSDFIKLPCGHVFCRECLQ 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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