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Conserved domains on  [gi|767963230|ref|XP_011538240|]
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chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X5 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHGN super family cl47930
Chondroitin N-acetylgalactosaminyltransferase;
75-413 4.30e-46

Chondroitin N-acetylgalactosaminyltransferase;


The actual alignment was detected with superfamily member pfam05679:

Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 166.67  E-value: 4.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230   75 LKRQIAQLKQELQEMSEKMRSLQERRNVGANGigyqsnkeqapsdllefLHSQIDkaeVSIGAKLP-SEYGVIPFESFTL 153
Cdd:pfam05679  83 LSLELQKLRQEIIKLQREIKNMSELLPEGIDS-----------------LSWPLG---IPPPLNRPkSRFDVLRWDYFTE 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  154 MKVFqlemgltRHPEEKPVR---KDKRDELVEVIEAGLEVINNpdeddeqedEEGPLGEKLIFNEndFVEGYYRTERDKG 230
Cdd:pfam05679 143 THLY-------SADDGQPRRrldGADKEDLDDVINTAMEEINR---------NYRPRGRVLEFKQ--LLNGYRRFDPLRG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  231 TQYELffkkaDLTEY------------RHVTLFRPFGPLmKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIH 298
Cdd:pfam05679 205 MEYIL-----DLLLEykkyrgrtvpvrRRVYLQRPFSKV-EIIPMPYVTESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  299 Q-DKKIHLTVVYFGKEGLS-----KVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGEvLMFFCDVDIYF 372
Cdd:pfam05679 279 TgENVVLLLVVLYDPDEGQndvfaEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDS-LLFFCDVDMVF 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 767963230  373 SAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPP 413
Cdd:pfam05679 358 TPEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTS 398
 
Name Accession Description Interval E-value
CHGN pfam05679
Chondroitin N-acetylgalactosaminyltransferase;
75-413 4.30e-46

Chondroitin N-acetylgalactosaminyltransferase;


Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 166.67  E-value: 4.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230   75 LKRQIAQLKQELQEMSEKMRSLQERRNVGANGigyqsnkeqapsdllefLHSQIDkaeVSIGAKLP-SEYGVIPFESFTL 153
Cdd:pfam05679  83 LSLELQKLRQEIIKLQREIKNMSELLPEGIDS-----------------LSWPLG---IPPPLNRPkSRFDVLRWDYFTE 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  154 MKVFqlemgltRHPEEKPVR---KDKRDELVEVIEAGLEVINNpdeddeqedEEGPLGEKLIFNEndFVEGYYRTERDKG 230
Cdd:pfam05679 143 THLY-------SADDGQPRRrldGADKEDLDDVINTAMEEINR---------NYRPRGRVLEFKQ--LLNGYRRFDPLRG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  231 TQYELffkkaDLTEY------------RHVTLFRPFGPLmKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIH 298
Cdd:pfam05679 205 MEYIL-----DLLLEykkyrgrtvpvrRRVYLQRPFSKV-EIIPMPYVTESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  299 Q-DKKIHLTVVYFGKEGLS-----KVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGEvLMFFCDVDIYF 372
Cdd:pfam05679 279 TgENVVLLLVVLYDPDEGQndvfaEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDS-LLFFCDVDMVF 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 767963230  373 SAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPP 413
Cdd:pfam05679 358 TPEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTS 398
 
Name Accession Description Interval E-value
CHGN pfam05679
Chondroitin N-acetylgalactosaminyltransferase;
75-413 4.30e-46

Chondroitin N-acetylgalactosaminyltransferase;


Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 166.67  E-value: 4.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230   75 LKRQIAQLKQELQEMSEKMRSLQERRNVGANGigyqsnkeqapsdllefLHSQIDkaeVSIGAKLP-SEYGVIPFESFTL 153
Cdd:pfam05679  83 LSLELQKLRQEIIKLQREIKNMSELLPEGIDS-----------------LSWPLG---IPPPLNRPkSRFDVLRWDYFTE 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  154 MKVFqlemgltRHPEEKPVR---KDKRDELVEVIEAGLEVINNpdeddeqedEEGPLGEKLIFNEndFVEGYYRTERDKG 230
Cdd:pfam05679 143 THLY-------SADDGQPRRrldGADKEDLDDVINTAMEEINR---------NYRPRGRVLEFKQ--LLNGYRRFDPLRG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  231 TQYELffkkaDLTEY------------RHVTLFRPFGPLmKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIH 298
Cdd:pfam05679 205 MEYIL-----DLLLEykkyrgrtvpvrRRVYLQRPFSKV-EIIPMPYVTESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963230  299 Q-DKKIHLTVVYFGKEGLS-----KVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGEvLMFFCDVDIYF 372
Cdd:pfam05679 279 TgENVVLLLVVLYDPDEGQndvfaEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDS-LLFFCDVDMVF 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 767963230  373 SAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPP 413
Cdd:pfam05679 358 TPEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTS 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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