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Conserved domains on  [gi|767967640|ref|XP_011543119|]
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von Willebrand factor C and EGF domain-containing protein isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 628-846 1.38e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  628 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 699
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  700 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 769
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  770 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 846
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC smart00214
von Willebrand factor (vWF) type C domain;
531-586 2.29e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640   531 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 586
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.32e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 4.82e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767967640   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 6.67e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767967640   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.26e-04
                          10        20
                  ....*....|....*....|....*....
gi 767967640  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 589-644 1.61e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640  589 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 644
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.45e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 36.25  E-value: 4.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767967640  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 628-846 1.38e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  628 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 699
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  700 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 769
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  770 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 846
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC smart00214
von Willebrand factor (vWF) type C domain;
531-586 2.29e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640   531 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 586
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.32e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 4.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767967640   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 6.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767967640   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 7.17e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 7.17e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.26e-04
                          10        20
                  ....*....|....*....|....*....
gi 767967640  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767967640 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 589-644 1.61e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640  589 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 644
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 1.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767967640  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 531-586 2.06e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640  531 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 586
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 2.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 2.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767967640   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.50e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.50e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767967640 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 711-845 3.75e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  711 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 785
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767967640  786 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 845
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.45e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767967640  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
VWC smart00214
von Willebrand factor (vWF) type C domain;
589-644 7.93e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 7.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640   589 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 644
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 8.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 767967640 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 628-846 1.38e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  628 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 699
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  700 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 769
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  770 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 846
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC smart00214
von Willebrand factor (vWF) type C domain;
531-586 2.29e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640   531 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 586
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.32e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767967640  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 676-846 3.50e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  676 TEAPVNCSSCPGPPTASPSR-PVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATfPGEPGASP----RLSPGP 750
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPtsaqPTAPPP 2841

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  751 STPPGAPTLPLA---SPGAP---QPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLS 824
Cdd:PHA03247 2842 PPGPPPPSLPLGgsvAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|..
gi 767967640  825 PTTSRLSTALAATTHPGPQQPP 846
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPL 2943
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 4.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 767967640   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
motB PRK12799
flagellar motor protein MotB; Reviewed
 707-851 4.97e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.55  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 707 TNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGasprlSPGPSTPPGAPTLPLASPgapqpppvTPERSFSASGAQIV 786
Cdd:PRK12799 288 TGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAA-----IPSPAVIPSSVTTQSATT--------TQASAVALSSAGVL 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767967640 787 SRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPR-VLSPTTSRLSTALAATthPGPQQPPVGASR 851
Cdd:PRK12799 355 PSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTgNITSTANGPTTSLPAA--PASNIPVSPTSR 418
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
678-846 5.57e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 5.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 678 APVNCSSCP---GPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPG------------EPGA 742
Cdd:PRK12323 373 GPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArqasargpggapAPAP 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 743 SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLltEASALSMMDPSPS---KTPITLLG 819
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDAAPAgwvAESIPDPA 530

                        170       180
                 ....*....|....*....|....*..
gi 767967640 820 PRVLSPTTSRLSTALAATTHPGPQQPP 846
Cdd:PRK12323 531 TADPDDAFETLAPAPAAAPAPRAAAAT 557
PHA03247 PHA03247
large tegument protein UL36; Provisional
 686-846 6.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  686 PGPPTASPSRPVLHLLQLLLRTNlmktqtlPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPG 765
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSE-------PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  766 APQPPPVT-PERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLsTALAATTHPGPQQ 844
Cdd:PHA03247 2630 SPSPAANEpDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLADPPPPPPTP 2708


                  ..
gi 767967640  845 PP 846
Cdd:PHA03247 2709 EP 2710
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 6.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767967640   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 7.17e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 7.17e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
PHA03378 PHA03378
EBNA-3B; Provisional
 706-846 7.28e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 706 RTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQI 785
Cdd:PHA03378 663 KPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPG 742

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767967640 786 VSRWPP-LPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 846
Cdd:PHA03378 743 RARPPAaAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.26e-04
                          10        20
                  ....*....|....*....|....*....
gi 767967640  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767967640 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 685-857 1.53e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  685 CPGPPTASPSRPVLHLLQLLLRTnlmktqTLPTSPAGAHGPHSlalGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASP 764
Cdd:PHA03307   72 PPGPGTEAPANESRSTPTWSLST------LAPASPAREGSPTP---PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  765 G---APQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMmdPSPSKTPITLLGPRVLSPTTSRL-STALAATTHP 840
Cdd:PHA03307  143 SpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAASPRPPRRsSPISASASSP 220

                         170
                  ....*....|....*..
gi 767967640  841 GPQQPPVGASRGEESTM 857
Cdd:PHA03307  221 APAPGRSAADDAGASSS 237
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 589-644 1.61e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640  589 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 644
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
PHA03378 PHA03378
EBNA-3B; Provisional
 688-851 1.66e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 688 PPTASPSRPVLHLLQLLLRTNLMktQTLPTSPAGAHGPH------SLALGLTATFPGEPGASPRlSPGPST------PPG 755
Cdd:PHA03378 616 PETSAPRQWPMPLRPIPMRPLRM--QPITFNVLVFPTPHqppqveITPYKPTWTQIGHIPYQPS-PTGANTmlpiqwAPG 692

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 756 APTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPiTLLGPRVLSPTTSRLSTAL- 834
Cdd:PHA03378 693 TMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP-GRARPPAAAPGRARPPAAAp 771

                        170
                 ....*....|....*...
gi 767967640 835 -AATTHPGPQQPPVGASR 851
Cdd:PHA03378 772 gAPTPQPPPQAPPAPQQR 789
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 1.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767967640  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 531-586 2.06e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767967640  531 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 586
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
716-856 2.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 716 PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGT 795
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640 796 LLTEASAlsmmdPSPSKTPItllgPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEEST 856
Cdd:PRK12323 445 GGAPAPA-----PAPAAAPA----AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 2.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 2.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767967640   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.50e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.50e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767967640 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 711-845 3.75e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640  711 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 785
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767967640  786 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 845
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 746-846 4.14e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 746 LSPGPSTPPGAPTLPLASPGAPQPPPVTPersFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTpitllgPRVLSP 825
Cdd:PRK14950 360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR---PKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESAPK 430

                         90       100
                 ....*....|....*....|.
gi 767967640 826 TTSRLSTALAATTHPGPQQPP 846
Cdd:PRK14950 431 LTRAAIPVDEKPKYTPPAPPK 451
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.45e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767967640  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 233-261 4.81e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.30  E-value: 4.81e-03
                          10        20
                  ....*....|....*....|....*....
gi 767967640  233 CHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03379 PHA03379
EBNA-3A; Provisional
 651-847 6.22e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 651 LEEKQGLSPHGNVAFSKAGRSLHGDteapvncsscPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGP----H 726
Cdd:PHA03379 391 LMRAGKLTERAREALEKASEPTYGT----------PRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPlhdqH 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967640 727 SLALGLTATFPgePGASPRLSPGpSTPPGAPTLPLASPgAPQPPPVTP-ERSFSASGAQIVSRWP------PLPGTLLTE 799
Cdd:PHA03379 461 SMAPCPVAQLP--PGPLQDLEPG-DQLPGVVQDGRPAC-APVPAPAGPiVRPWEASLSQVPGVAFapvmpqPMPVEPVPV 536

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767967640 800 ASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPV 847
Cdd:PHA03379 537 PTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPS 584
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 202-223 6.50e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 34.69  E-value: 6.50e-03
                          10        20
                  ....*....|....*....|..
gi 767967640  202 KCSCRTGFHLHGNRHSCVDVNE 223
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
VWC smart00214
von Willebrand factor (vWF) type C domain;
589-644 7.93e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 7.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767967640   589 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 644
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 8.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 767967640 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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