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Conserved domains on  [gi|768032524|ref|XP_011543840|]
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phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KPBB_C super family cl44726
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
 731-816 3.52e-25

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


The actual alignment was detected with superfamily member pfam19292:

Pssm-ID: 437124  Cd Length: 238  Bit Score: 104.93  E-value: 3.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  731 ERQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSI-DGY----VLPSSTTR-EMTPHEIKFAVHVESVLNRVPQPE 804
Cdd:pfam19292  68 GPAGDWLQWRQRQGALGRVPDDFYAGVWDLLHHCKGLVIgDKLerrnRLDSELLLsEMTPGEKNFALRVEHLLNKIQAPE 147

                          90
                  ....*....|..
gi 768032524  805 YRQLLVEAIMVL 816
Cdd:pfam19292 148 YRQLTIEALMAL 159
Bac_rhamnosid6H super family cl46875
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial ...
 463-580 6.31e-17

Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.


The actual alignment was detected with superfamily member pfam00723:

Pssm-ID: 481215  Cd Length: 417  Bit Score: 84.04  E-value: 6.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  463 TVQNLLGELYGKAGlNQEWGLIRYISGLLRKKVEVlaeactdllshqkqlTVGLPPEpREKIISAPLPPEELTKLIYEAS 542
Cdd:pfam00723 316 AAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYS-SSSFISIPLAVKEYADGFVKAV 378

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768032524  543 GQ-DISIAVLTQEIVVYLAMYVRAQPSLFVEMLRLRIGL 580
Cdd:pfam00723 379 EEyANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
Bac_rhamnosid6H super family cl46875
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial ...
 7-100 1.45e-13

Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.


The actual alignment was detected with superfamily member pfam00723:

Pssm-ID: 481215  Cd Length: 417  Bit Score: 73.64  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524    7 FQVQEYREALEGILIrgkngirLVPELYAVPPNKvdeeyknphtvdrvpmgkvPHLWGQSLYILSSLLAEGFLAAGEIDP 86
Cdd:pfam00723 235 YGSFEYRSGLDASLL-------LLPILGFDPPDD-------------------PRILATLKYILDSLLSDGFLNSGESDP 288

                          90
                  ....*....|....
gi 768032524   87 LNRRFSTSVKPDVV 100
Cdd:pfam00723 289 LVRRYPEDVYPDVV 302
 
Name Accession Description Interval E-value
KPBB_C pfam19292
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
 731-816 3.52e-25

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


Pssm-ID: 437124  Cd Length: 238  Bit Score: 104.93  E-value: 3.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  731 ERQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSI-DGY----VLPSSTTR-EMTPHEIKFAVHVESVLNRVPQPE 804
Cdd:pfam19292  68 GPAGDWLQWRQRQGALGRVPDDFYAGVWDLLHHCKGLVIgDKLerrnRLDSELLLsEMTPGEKNFALRVEHLLNKIQAPE 147

                          90
                  ....*....|..
gi 768032524  805 YRQLLVEAIMVL 816
Cdd:pfam19292 148 YRQLTIEALMAL 159
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
 463-580 6.31e-17

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 84.04  E-value: 6.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  463 TVQNLLGELYGKAGlNQEWGLIRYISGLLRKKVEVlaeactdllshqkqlTVGLPPEpREKIISAPLPPEELTKLIYEAS 542
Cdd:pfam00723 316 AAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYS-SSSFISIPLAVKEYADGFVKAV 378

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768032524  543 GQ-DISIAVLTQEIVVYLAMYVRAQPSLFVEMLRLRIGL 580
Cdd:pfam00723 379 EEyANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
 7-100 1.45e-13

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 73.64  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524    7 FQVQEYREALEGILIrgkngirLVPELYAVPPNKvdeeyknphtvdrvpmgkvPHLWGQSLYILSSLLAEGFLAAGEIDP 86
Cdd:pfam00723 235 YGSFEYRSGLDASLL-------LLPILGFDPPDD-------------------PRILATLKYILDSLLSDGFLNSGESDP 288

                          90
                  ....*....|....
gi 768032524   87 LNRRFSTSVKPDVV 100
Cdd:pfam00723 289 LVRRYPEDVYPDVV 302
 
Name Accession Description Interval E-value
KPBB_C pfam19292
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
 731-816 3.52e-25

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


Pssm-ID: 437124  Cd Length: 238  Bit Score: 104.93  E-value: 3.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  731 ERQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSI-DGY----VLPSSTTR-EMTPHEIKFAVHVESVLNRVPQPE 804
Cdd:pfam19292  68 GPAGDWLQWRQRQGALGRVPDDFYAGVWDLLHHCKGLVIgDKLerrnRLDSELLLsEMTPGEKNFALRVEHLLNKIQAPE 147

                          90
                  ....*....|..
gi 768032524  805 YRQLLVEAIMVL 816
Cdd:pfam19292 148 YRQLTIEALMAL 159
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
 463-580 6.31e-17

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 84.04  E-value: 6.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524  463 TVQNLLGELYGKAGlNQEWGLIRYISGLLRKKVEVlaeactdllshqkqlTVGLPPEpREKIISAPLPPEELTKLIYEAS 542
Cdd:pfam00723 316 AAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYS-SSSFISIPLAVKEYADGFVKAV 378

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768032524  543 GQ-DISIAVLTQEIVVYLAMYVRAQPSLFVEMLRLRIGL 580
Cdd:pfam00723 379 EEyANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
 7-100 1.45e-13

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 73.64  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032524    7 FQVQEYREALEGILIrgkngirLVPELYAVPPNKvdeeyknphtvdrvpmgkvPHLWGQSLYILSSLLAEGFLAAGEIDP 86
Cdd:pfam00723 235 YGSFEYRSGLDASLL-------LLPILGFDPPDD-------------------PRILATLKYILDSLLSDGFLNSGESDP 288

                          90
                  ....*....|....
gi 768032524   87 LNRRFSTSVKPDVV 100
Cdd:pfam00723 289 LVRRYPEDVYPDVV 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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