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Conserved domains on  [gi|795264925|ref|XP_011920297|]
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PREDICTED: trophoblast glycoprotein [Cercocebus atys]

Protein Classification

LRRNT and LRR domain-containing protein( domain architecture ID 12183445)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 3.39e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 3.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  79 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 156
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 157 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHCLELASNHFLYLPrdVLAQLPSL 236
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 795264925 237 RHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.91e-13

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.91e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 795264925   294 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.15e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 795264925    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 3.39e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 3.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  79 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 156
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 157 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHCLELASNHFLYLPrdVLAQLPSL 236
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 795264925 237 RHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.91e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.91e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 795264925   294 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
91-154 9.71e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.71e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795264925   91 PYVRNLFLTGNQLAVLPAGAFARRPPLAELaalNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL---DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
67-295 9.27e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 9.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  67 ECSEAARTVKCVNR-NLTEVPTDLPPYVRNLFLTGNQLAVLPAG-------AFARRPPLAELAA--------LNLSGSRL 130
Cdd:PRK15370 174 DCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENlqgniktLYANSNQLTSIPAtlpdtiqeMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 131 DEVRagafEHLPS-LRQLDLSHNPLA-----------YLSPFAFSGSNASISAPSPLVELILnhivppddkrQNRSFEGM 198
Cdd:PRK15370 254 TELP----ERLPSaLQSLDLFHNKISclpenlpeelrYLSVYDNSIRTLPAHLPSGITHLNV----------QSNSLTAL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 199 VAAALVagralqGLHCLELASNHFLYLPRDVlaqLPSLRHLDLSNNSLVSLT----------YVSFRNLTHL-ESLhleD 267
Cdd:PRK15370 320 PETLPP------GLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPetlpptittlDVSRNALTNLpENL---P 387

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 795264925 268 NALKVLH--NGTLAEL-QGLPH--------VRVFLDNNP 295
Cdd:PRK15370 388 AALQIMQasRNNLVRLpESLPHfrgegpqpTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 209-298 1.83e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 209 LQGLHCLE--------LASNHFLYL-PRDVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLA 279
Cdd:cd21340   86 LENLTNLEelhienqrLPPGEKLTFdPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLD 162

                         90       100
                 ....*....|....*....|
gi 795264925 280 ELQGLPHVR-VFLDNNPwVC 298
Cdd:cd21340  163 LLSSWPSLReLDLTGNP-VC 181
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 265-345 4.06e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 4.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925   265 LEDNALKVLHNGTLAELQGLPHVRvfLDNNPWVCDCHMADMVTWLKQTEV-VQGKDRLTCAFPEKMRNRVLLELNSADLD 343
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 795264925   344 CD 345
Cdd:TIGR00864   80 CD 81
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.15e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 795264925    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-90 4.52e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 4.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 795264925   61 QCPALCECSeaARTVKCVNRNLTEVPTDLP 90
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 3.39e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 3.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  79 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 156
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 157 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHCLELASNHFLYLPrdVLAQLPSL 236
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 795264925 237 RHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.91e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.91e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 795264925   294 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-294 1.04e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  94 RNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAYLspfafsgsnasisaPS 173
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL--------------PE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 174 PLvelilnhivppddkrqnrsfegmvaaalvagRALQGLHCLELASNHFLYLPrDVLAQLPSLRHLDLSNNSLVSLTyVS 253
Cdd:COG4886  177 EL-------------------------------GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EP 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 795264925 254 FRNLTHLESLHLEDNALKvlhngTLAELQGLPHVRVF-LDNN 294
Cdd:COG4886  224 LANLTNLETLDLSNNQLT-----DLPELGNLTNLEELdLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
91-154 9.71e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.71e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795264925   91 PYVRNLFLTGNQLAVLPAGAFARRPPLAELaalNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL---DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
210-270 1.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795264925  210 QGLHCLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-294 9.84e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 9.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  79 NRNLTEVPTDLPPYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRldevragAFEHLPSLRQLDLSHNPLAYLs 158
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 159 PFAFSGsnasisapsplvelilnhivppddkrqnrsfegmvaaalvagraLQGLHCLELASNHFLYLPrDVLAQLPSLRH 238
Cdd:COG4886  129 PEELAN--------------------------------------------LTNLKELDLSNNQLTDLP-EPLGNLTNLKS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 795264925 239 LDLSNNSLVSLTyVSFRNLTHLESLHLEDNALKVLHNgTLAELQGLphVRVFLDNN 294
Cdd:COG4886  164 LDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNL--EELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
234-295 2.20e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795264925  234 PSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTlaeLQGLPHVRV-FLDNNP 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA---FSGLPSLRYlDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
209-295 2.61e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 2.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 209 LQGLHCLELASNHFLYLPRDvLAQLPSLRHLDLSNNSLVSLTyVSFRNLTHLESLHLEDNALKVLHngtlAELQGLPHVR 288
Cdd:COG4886  112 LTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP----EELGNLTNLK 185


                 ....*...
gi 795264925 289 VF-LDNNP 295
Cdd:COG4886  186 ELdLSNNQ 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
67-295 9.27e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 9.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  67 ECSEAARTVKCVNR-NLTEVPTDLPPYVRNLFLTGNQLAVLPAG-------AFARRPPLAELAA--------LNLSGSRL 130
Cdd:PRK15370 174 DCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENlqgniktLYANSNQLTSIPAtlpdtiqeMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 131 DEVRagafEHLPS-LRQLDLSHNPLA-----------YLSPFAFSGSNASISAPSPLVELILnhivppddkrQNRSFEGM 198
Cdd:PRK15370 254 TELP----ERLPSaLQSLDLFHNKISclpenlpeelrYLSVYDNSIRTLPAHLPSGITHLNV----------QSNSLTAL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 199 VAAALVagralqGLHCLELASNHFLYLPRDVlaqLPSLRHLDLSNNSLVSLT----------YVSFRNLTHL-ESLhleD 267
Cdd:PRK15370 320 PETLPP------GLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPetlpptittlDVSRNALTNLpENL---P 387

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 795264925 268 NALKVLH--NGTLAEL-QGLPH--------VRVFLDNNP 295
Cdd:PRK15370 388 AALQIMQasRNNLVRLpESLPHfrgegpqpTRIIVEYNP 426
LRR_8 pfam13855
Leucine rich repeat;
119-182 3.39e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.39e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795264925  119 ELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNAsisapspLVELILNH 182
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-------LRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 209-298 1.83e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 209 LQGLHCLE--------LASNHFLYL-PRDVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLA 279
Cdd:cd21340   86 LENLTNLEelhienqrLPPGEKLTFdPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLD 162

                         90       100
                 ....*....|....*....|
gi 795264925 280 ELQGLPHVR-VFLDNNPwVC 298
Cdd:cd21340  163 LLSSWPSLReLDLTGNP-VC 181
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 265-345 4.06e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 4.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925   265 LEDNALKVLHNGTLAELQGLPHVRvfLDNNPWVCDCHMADMVTWLKQTEV-VQGKDRLTCAFPEKMRNRVLLELNSADLD 343
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 795264925   344 CD 345
Cdd:TIGR00864   80 CD 81
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.15e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 795264925    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 234-268 1.78e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 795264925  234 PSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDN 268
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-270 2.03e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925 120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNASIsapsplveLILNhivppddkRQNRSFEGMV 199
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL--------RYLN--------LSNNNFTGSI 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795264925 200 AaalvaGRALQGLHCLELASNHFL-YLPRDVlAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:PLN00113 135 P-----RGSIPNLETLDLSNNMLSgEIPNDI-GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-90 4.52e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 4.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 795264925   61 QCPALCECSeaARTVKCVNRNLTEVPTDLP 90
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 228-294 3.62e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 3.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795264925 228 DVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgtlaeLQGLPHVRV-FLDNN 294
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN-----LENLVNLKKlYLGGN 78
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-189 5.58e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795264925  81 NLTEVPTDLP--PYVRNLFLTGNQLAVLPAgaFARrppLAELAALNLSGSRLDEVRAGAfeHLPSLRQLDLSHNPLAYLS 158
Cdd:COG4886  216 QLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGN---LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK 288

                         90       100       110
                 ....*....|....*....|....*....|.
gi 795264925 159 PFAFSGSNASISAPSPLVELILNHIVPPDDK 189
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLL 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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