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Conserved domains on  [gi|927203564|ref|XP_013845681|]
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protein FAM207A isoform X2 [Sus scrofa]

Protein Classification

FAM207/SLX9 family protein( domain architecture ID 10634010)

FAM207/SLX9 family protein similar to Saccharomyces cerevisiae ribosome biogenesis protein SLX9 that is involved in ribosome biogenesis, and is required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
87-209 2.70e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


:

Pssm-ID: 464660  Cd Length: 118  Bit Score: 108.13  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927203564   87 KAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAVVGDLQPLRDALPELLELEAGarrppaRRAASKPRPAEL 166
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETD------KSTKPSKQKSLK 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 927203564  167 SRMTAAQRLQLLEE-ERARFRELLASPAYRASPLLAIGQQLAQQ 209
Cdd:pfam15341  75 SKPGAAKRKKKLEKeERERFQKVLAHPSFKSNPFAALREHISNT 118
 
Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
87-209 2.70e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


Pssm-ID: 464660  Cd Length: 118  Bit Score: 108.13  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927203564   87 KAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAVVGDLQPLRDALPELLELEAGarrppaRRAASKPRPAEL 166
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETD------KSTKPSKQKSLK 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 927203564  167 SRMTAAQRLQLLEE-ERARFRELLASPAYRASPLLAIGQQLAQQ 209
Cdd:pfam15341  75 SKPGAAKRKKKLEKeERERFQKVLAHPSFKSNPFAALREHISNT 118
PTZ00121 PTZ00121
MAEBL; Provisional
73-193 3.77e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927203564   73 DARSVASIRRGAEAKAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAVVGDLqpLRDALPELLELEAGARRP 152
Cdd:PTZ00121 1526 EAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE--AKKAEEARIEEVMKLYEE 1603
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 927203564  153 PARRAASKPRPAELSRMTAAQrLQLLEEERARFRELLASPA 193
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEE-LKKAEEEKKKVEQLKKKEA 1643
 
Name Accession Description Interval E-value
SLX9 pfam15341
Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is ...
87-209 2.70e-30

Ribosome biogenesis protein SLX9; SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences.


Pssm-ID: 464660  Cd Length: 118  Bit Score: 108.13  E-value: 2.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927203564   87 KAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAVVGDLQPLRDALPELLELEAGarrppaRRAASKPRPAEL 166
Cdd:pfam15341   1 KFRLSKKDKRKIKREAFLSKIEKSKSALKRRKKKARRPSKKLVGDLDSLADALPELEEEETD------KSTKPSKQKSLK 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 927203564  167 SRMTAAQRLQLLEE-ERARFRELLASPAYRASPLLAIGQQLAQQ 209
Cdd:pfam15341  75 SKPGAAKRKKKLEKeERERFQKVLAHPSFKSNPFAALREHISNT 118
PTZ00121 PTZ00121
MAEBL; Provisional
73-193 3.77e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927203564   73 DARSVASIRRGAEAKAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAVVGDLqpLRDALPELLELEAGARRP 152
Cdd:PTZ00121 1526 EAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE--AKKAEEARIEEVMKLYEE 1603
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 927203564  153 PARRAASKPRPAELSRMTAAQrLQLLEEERARFRELLASPA 193
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEE-LKKAEEEKKKVEQLKKKEA 1643
PTZ00121 PTZ00121
MAEBL; Provisional
73-128 2.75e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 2.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 927203564   73 DARSVASIRRGAEAKAVLPKKEKLKLRRERWLQKIEAIKLAEQKRQAERRRRATAV 128
Cdd:PTZ00121 1162 DARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEA 1217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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